CH429760A - Verfahren zur Herstellung neuer pharmazeutisch wertvoller Verbindungen - Google Patents
Verfahren zur Herstellung neuer pharmazeutisch wertvoller VerbindungenInfo
- Publication number
- CH429760A CH429760A CH1147162A CH1147162A CH429760A CH 429760 A CH429760 A CH 429760A CH 1147162 A CH1147162 A CH 1147162A CH 1147162 A CH1147162 A CH 1147162A CH 429760 A CH429760 A CH 429760A
- Authority
- CH
- Switzerland
- Prior art keywords
- phenyl
- formula
- compounds
- thienyl
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims description 20
- 238000002360 preparation method Methods 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 12
- 125000004432 carbon atom Chemical group C* 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 125000001544 thienyl group Chemical group 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 7
- 125000002947 alkylene group Chemical group 0.000 claims description 6
- 239000002585 base Substances 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 125000002887 hydroxy group Chemical class [H]O* 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 4
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 claims description 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 4
- 229910052744 lithium Inorganic materials 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- ANRQGKOBLBYXFM-UHFFFAOYSA-M phenylmagnesium bromide Chemical compound Br[Mg]C1=CC=CC=C1 ANRQGKOBLBYXFM-UHFFFAOYSA-M 0.000 claims description 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical class 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000003513 alkali Substances 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 150000004820 halides Chemical class 0.000 claims description 2
- 229910052740 iodine Inorganic materials 0.000 claims description 2
- 239000011630 iodine Substances 0.000 claims description 2
- 239000000155 melt Substances 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 150000007522 mineralic acids Chemical class 0.000 claims description 2
- 150000007524 organic acids Chemical class 0.000 claims description 2
- 235000005985 organic acids Nutrition 0.000 claims description 2
- 239000001294 propane Substances 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 229930192474 thiophene Natural products 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DED37431A DE1194424B (de) | 1961-11-10 | 1961-11-10 | Verfahren zur Herstellung von basischen Thiophenderivaten |
| DED40401A DE1199783B (de) | 1962-11-30 | 1962-11-30 | Verfahren zur Herstellung von basischen Thiophenderivaten |
| DED40465A DE1213851B (de) | 1961-11-10 | 1962-12-07 | Verfahren zur Herstellung neuer pharmazeutisch wertvoller Thiophenverbindungen |
| DED40471A DE1219038B (de) | 1962-12-08 | 1962-12-08 | Verfahren zur Herstellung von Thiophenverbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH429760A true CH429760A (de) | 1967-02-15 |
Family
ID=45560586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1147162A CH429760A (de) | 1961-11-10 | 1962-09-28 | Verfahren zur Herstellung neuer pharmazeutisch wertvoller Verbindungen |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE628104A (da) |
| BR (1) | BR6243797D0 (da) |
| CH (1) | CH429760A (da) |
| DE (2) | DE1194424B (da) |
| DK (2) | DK105813C (da) |
| FI (2) | FI42572C (da) |
| GB (1) | GB970445A (da) |
| SE (2) | SE311168B (da) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1921453C3 (de) * | 1969-04-26 | 1973-04-19 | Degussa | Basische Dithienylderivate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB646198A (en) * | 1946-02-28 | 1950-11-15 | Winthrop Stearns Inc | Improvements in or relating to the preparation of antispasmodic agents |
| GB657301A (en) * | 1948-02-25 | 1951-09-19 | Wellcome Found | Improvements in and relating to the preparation of substituted amino-alcohols and derivatives thereof |
| GB702269A (en) * | 1950-01-06 | 1954-01-13 | Wellcome Found | Tertiary allylamines of therapeutic value and the production thereof |
-
1961
- 1961-11-10 DE DED37431A patent/DE1194424B/de active Pending
-
1962
- 1962-09-28 CH CH1147162A patent/CH429760A/de unknown
- 1962-10-11 FI FI621835A patent/FI42572C/fi active
- 1962-10-15 BR BR143797/62A patent/BR6243797D0/pt unknown
- 1962-10-16 GB GB39127/62A patent/GB970445A/en not_active Expired
- 1962-11-07 SE SE11930/62A patent/SE311168B/xx unknown
- 1962-11-09 DK DK483762AA patent/DK105813C/da active
- 1962-11-09 DK DK246264AA patent/DK105595C/da active
- 1962-12-07 DE DED40465A patent/DE1213851B/de active Pending
-
1963
- 1963-02-06 BE BE628104A patent/BE628104A/fr unknown
- 1963-11-29 SE SE13233/63A patent/SE309601B/xx unknown
-
1969
- 1969-04-24 FI FI691216A patent/FI42577C/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| DE1194424B (de) | 1965-06-10 |
| SE311168B (da) | 1969-06-02 |
| BE628104A (fr) | 1963-05-29 |
| FI42577C (fi) | 1970-09-14 |
| DE1213851B (de) | 1966-04-07 |
| BR6243797D0 (pt) | 1973-05-24 |
| DK105595C (da) | 1966-10-17 |
| FI42572C (fi) | 1970-09-14 |
| DK105813C (da) | 1966-11-14 |
| SE309601B (da) | 1969-03-31 |
| GB970445A (en) | 1964-09-23 |
| FI42577B (da) | 1970-06-01 |
| FI42572B (da) | 1970-06-01 |
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