BRPI0812563A2 - Metabólitos do inibidor de janus quinase de (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3 ciclopentilpropanonitrila - Google Patents

Metabólitos do inibidor de janus quinase de (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3 ciclopentilpropanonitrila

Info

Publication number: BRPI0812563A2
Authority: BR; Brazil
Prior art keywords: cyclepentilpropanonitrila; metabolies; pirazol; pyrrolo; pyrimidin
Prior art date: 2007-06-13

Application number

BRPI0812563-5A2A

Other languages

English (en)

Inventor

James D Rodgers

Argyrios G Arvanitis

Jack Guoen Shi

Original Assignee

Incyte Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-13

Filing date

2008-06-12

Publication date

2015-02-10

2008-06-12 Application filed by Incyte Corp filed Critical Incyte Corp

2015-02-10 Publication of BRPI0812563A2 publication Critical patent/BRPI0812563A2/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Transplantation (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)

BRPI0812563-5A2A 2007-06-13 2008-06-12 Metabólitos do inibidor de janus quinase de (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3 ciclopentilpropanonitrila BRPI0812563A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US94369507P	2007-06-13	2007-06-13
PCT/US2008/066658 WO2008157207A2 (en)	2007-06-13	2008-06-12	Metabolites of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-lh-pyrazol-l-yl)-3- cyclopentylpropanenitrile

Publications (1)

Publication Number	Publication Date
BRPI0812563A2 true BRPI0812563A2 (pt)	2015-02-10

Family

ID=40029276

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0812563-5A2A BRPI0812563A2 (pt)	2007-06-13	2008-06-12	Metabólitos do inibidor de janus quinase de (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3 ciclopentilpropanonitrila

Country Status (25)

Country	Link
US (5)	US7834022B2 (pt)
EP (1)	EP2173751B1 (pt)
JP (1)	JP5479331B2 (pt)
KR (1)	KR20100049008A (pt)
CN (1)	CN101815717B (pt)
AR (1)	AR067024A1 (pt)
AU (1)	AU2008266182B8 (pt)
BR (1)	BRPI0812563A2 (pt)
CA (1)	CA2689158C (pt)
CL (1)	CL2008001709A1 (pt)
CO (1)	CO6251255A2 (pt)
CR (1)	CR11149A (pt)
EA (1)	EA017790B1 (pt)
EC (1)	ECSP099821A (pt)
ES (1)	ES2448868T3 (pt)
GE (1)	GEP20125534B (pt)
IL (1)	IL202429A0 (pt)
MX (2)	MX339139B (pt)
NZ (1)	NZ581801A (pt)
PL (1)	PL2173751T3 (pt)
PT (1)	PT2173751E (pt)
TW (1)	TWI426911B (pt)
UA (1)	UA99465C2 (pt)
WO (1)	WO2008157207A2 (pt)
ZA (1)	ZA200908820B (pt)

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ES2448868T3 (es)	2014-03-17
CA2689158C (en)	2015-10-06
AU2008266182A8 (en)	2014-09-18
US20170326144A1 (en)	2017-11-16
US8889697B2 (en)	2014-11-18
IL202429A0 (en)	2010-06-30
CO6251255A2 (es)	2011-02-21
MX339139B (es)	2016-05-13
ECSP099821A (es)	2010-01-29
EA017790B1 (ru)	2013-03-29
EP2173751B1 (en)	2013-11-27
ZA200908820B (en)	2013-05-29
MX2009013403A (es)	2010-02-24
NZ581801A (en)	2012-04-27
GEP20125534B (en)	2012-05-25
CN101815717B (zh)	2014-06-25
CN101815717A (zh)	2010-08-25
CL2008001709A1 (es)	2008-11-03
AU2008266182B8 (en)	2014-09-18
US20080312258A1 (en)	2008-12-18
TWI426911B (zh)	2014-02-21
PT2173751E (pt)	2014-02-14
US20150164900A1 (en)	2015-06-18
US10463667B2 (en)	2019-11-05
US7834022B2 (en)	2010-11-16
US20110082159A1 (en)	2011-04-07
HK1141020A1 (en)	2010-10-29
EA201070012A1 (ru)	2010-06-30
JP5479331B2 (ja)	2014-04-23
EP2173751A2 (en)	2010-04-14
JP2010529208A (ja)	2010-08-26
AR067024A1 (es)	2009-09-30
AU2008266182B2 (en)	2014-05-08
CA2689158A1 (en)	2008-12-24
KR20100049008A (ko)	2010-05-11
CR11149A (es)	2010-02-04
WO2008157207A3 (en)	2009-02-26
AU2008266182A1 (en)	2008-12-24
WO2008157207A2 (en)	2008-12-24
PL2173751T3 (pl)	2014-04-30
US20200038404A1 (en)	2020-02-06
UA99465C2 (en)	2012-08-27
TW200911264A (en)	2009-03-16

Publication	Publication Date	Title
BRPI0812563A2 (pt)	2015-02-10	Metabólitos do inibidor de janus quinase de (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3 ciclopentilpropanonitrila
IL287708A (en)	2021-12-01	Janus kinase inhibitor salts
HRP20181912T1 (hr)	2019-03-22	Derivati pirolo[2,3-d]pirimidina kao inhibitori janus kinaze
DK1797099T3 (da)	2010-11-29	Piperidinylamino-thieno[2,3-D]pyrimidinforbindelser
DK2201012T3 (da)	2014-09-08	Pyrrolo[2,3-d]pyrimidinderivater som proteinkinase b-hæmmere
IL192298A0 (en)	2011-08-01	Heterocyclic janus kinase 3 inhibitors
EP1951684A4 (en)	2011-01-12	BIARYLMETAPYRIMIDINKINASEINHIBITOREN
AP2007004061A0 (en)	2007-08-31	Pyrrolopyrazoles, potent kinase inhibitors
IL201064A0 (en)	2010-05-17	Janus kinase inhibitor compounds, compositions comprising the same and uses thereof
EP1778693A4 (en)	2009-11-11	AS KINASEINHIBITORS USEFUL COMPOUNDS OF TRICYCLIC HETEROARYL
HK1118819A (en)	2009-02-20	Kinase inhibitors
HK1121739A (en)	2009-04-30	Kinase inhibitors

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