BRPI0811993A2 - " hetarilanilinas como moduladores para beta-amiloide ". - Google Patents
" hetarilanilinas como moduladores para beta-amiloide ".Info
- Publication number
- BRPI0811993A2 BRPI0811993A2 BRPI0811993-7A2A BRPI0811993A BRPI0811993A2 BR PI0811993 A2 BRPI0811993 A2 BR PI0811993A2 BR PI0811993 A BRPI0811993 A BR PI0811993A BR PI0811993 A2 BRPI0811993 A2 BR PI0811993A2
- Authority
- BR
- Brazil
- Prior art keywords
- hetarilanilins
- beta
- amyloid modulators
- amyloid
- modulators
- Prior art date
Links
- 102000013455 Amyloid beta-Peptides Human genes 0.000 title 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07108004 | 2007-05-11 | ||
| PCT/EP2008/055290 WO2008138753A1 (en) | 2007-05-11 | 2008-04-30 | Hetarylanilines as modulators for amyloid beta |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0811993A2 true BRPI0811993A2 (pt) | 2014-11-18 |
Family
ID=39758855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0811993-7A2A BRPI0811993A2 (pt) | 2007-05-11 | 2008-04-30 | " hetarilanilinas como moduladores para beta-amiloide ". |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7910740B2 (pt) |
| EP (1) | EP2155740B1 (pt) |
| JP (1) | JP5264890B2 (pt) |
| KR (1) | KR101138045B1 (pt) |
| CN (1) | CN101675045B (pt) |
| AR (1) | AR066509A1 (pt) |
| AT (1) | ATE496915T1 (pt) |
| AU (1) | AU2008250436B2 (pt) |
| BR (1) | BRPI0811993A2 (pt) |
| CA (1) | CA2686754C (pt) |
| CL (1) | CL2008001347A1 (pt) |
| DE (1) | DE602008004769D1 (pt) |
| ES (1) | ES2358863T3 (pt) |
| IL (1) | IL201566A (pt) |
| MX (1) | MX2009012163A (pt) |
| PE (1) | PE20090248A1 (pt) |
| RU (1) | RU2009140182A (pt) |
| TW (1) | TW200904420A (pt) |
| WO (1) | WO2008138753A1 (pt) |
| ZA (1) | ZA200907585B (pt) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1757591A4 (en) * | 2004-05-26 | 2010-05-05 | Eisai R&D Man Co Ltd | ZIMTSÄUREAMIDVERBINDUNG |
| CN100577657C (zh) * | 2004-10-26 | 2010-01-06 | 卫材R&D管理有限公司 | 肉桂酰胺化合物的无定形物 |
| EP1950211A4 (en) * | 2005-11-18 | 2011-08-31 | Eisai R&D Man Co Ltd | PROCESS FOR PREPARING A CINEMA ACID AMID DERIVATIVE |
| EP1953151A4 (en) * | 2005-11-18 | 2010-06-02 | Eisai R&D Man Co Ltd | SALTS FROM A CYNNAMIDE COMPOUND OR SOLVATE THEREOF |
| TWI370130B (en) * | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| MY144960A (en) * | 2005-11-24 | 2011-11-30 | Eisai R&D Man Co Ltd | Morpholine type cinnamide compound |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| AR062095A1 (es) * | 2006-07-28 | 2008-10-15 | Eisai R&D Man Co Ltd | Profarmaco de compuesto cinamida |
| CA2673307A1 (en) | 2006-12-22 | 2008-07-03 | F. Hoffman-La Roche Ag | Spiro-piperidine derivatives |
| TW200848054A (en) * | 2007-02-28 | 2008-12-16 | Eisai R&D Man Co Ltd | Two cyclic oxomorpholine derivatives |
| CN101679360A (zh) * | 2007-05-16 | 2010-03-24 | 卫材R&D管理有限公司 | 一步生产肉桂酰胺衍生物的方法 |
| US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| MY150507A (en) | 2007-08-31 | 2014-01-30 | Eisai R&D Man Co Ltd | Polycyclic compound |
| BRPI0821141A2 (pt) * | 2007-12-21 | 2015-06-16 | Hoffmann La Roche | Derivados de heteroarila como antagonistas do receptor de orexina |
| US7923450B2 (en) | 2008-01-11 | 2011-04-12 | Hoffmann-La Roche Inc. | Modulators for amyloid beta |
| AU2009210070A1 (en) * | 2008-01-28 | 2009-08-06 | Eisai R & D Management Co., Ltd. | Crystalline cinnamide compounds or salts thereof |
| MX2010008700A (es) * | 2008-02-22 | 2010-08-30 | Hoffmann La Roche | Moduladores de beta-amiloide. |
| EP2334665B1 (en) * | 2008-10-09 | 2013-07-10 | F. Hoffmann-La Roche AG | Modulators for amyloid beta |
| AU2009311756B2 (en) * | 2008-11-06 | 2012-05-03 | Astrazeneca Ab | Modulators of amyloid beta. |
| CN102209537A (zh) * | 2008-11-10 | 2011-10-05 | 弗·哈夫曼-拉罗切有限公司 | 杂环γ分泌酶调节剂 |
| PA8854101A1 (es) * | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| AP2011005779A0 (en) | 2009-02-06 | 2011-08-31 | Ortho Mcneil Janssen Pharm | Novel susbstituted bicyclic heterocyclic compoundsas gamma secretase modulators. |
| TWI461425B (zh) * | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
| EP2427453B1 (en) * | 2009-05-07 | 2013-07-17 | Janssen Pharmaceuticals, Inc. | Substituted indazole and aza-indazole derivatives as gamma secretase modulators |
| UY32622A (es) * | 2009-05-12 | 2010-12-31 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) |
| BR112012000915A2 (pt) | 2009-07-15 | 2019-09-24 | Janssen Pharmaceuticals Inc | derivados de triazol e imidazol substituídos como moduladores de gama secretase. |
| EP2523955B1 (en) | 2010-01-15 | 2014-07-16 | Janssen Pharmaceuticals, Inc. | Novel substituted bicyclic triazole derivatives as gamma secretase modulators |
| US20110190269A1 (en) * | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| JP2014508794A (ja) | 2011-03-24 | 2014-04-10 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | γ−セクレターゼ調節剤としての新規な置換トリアゾリルピペラジンおよびトリアゾリルピペラジン誘導体 |
| ES2602794T3 (es) | 2011-03-31 | 2017-02-22 | Pfizer Inc | Piridinonas bicíclicas novedosas |
| AU2012285931B2 (en) | 2011-07-15 | 2017-01-12 | Cellzome Limited | Novel substituted indole derivatives as gamma secretase modulators |
| CN104583208B (zh) | 2012-05-16 | 2016-09-28 | 杨森制药公司 | 可用于治疗(尤其是)阿尔茨海默病的取代的3,4-二氢-2H-吡啶并[1,2-a]吡嗪-1,6-二酮衍生物 |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| WO2014096212A1 (en) | 2012-12-20 | 2014-06-26 | Janssen Pharmaceutica Nv | NOVEL TRICYCLIC 3,4-DIHYDRO-2H-PYRIDO[1,2-α]PYRAZINE-1,6-DIONE DERIVATIVES AS GAMMA SECRETASE MODULATORS |
| KR102171710B1 (ko) | 2013-01-17 | 2020-10-30 | 얀센 파마슈티카 엔.브이. | 감마 세크레타제 조절 인자로서의 신규 치환 피리도-피페라지논 유도체 |
| CN103664819A (zh) * | 2013-12-16 | 2014-03-26 | 山东汇海医药化工有限公司 | 一种2-氨基-4-甲基噻唑-5-甲酸乙酯的制备方法 |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| DK3253755T3 (da) | 2015-02-03 | 2020-09-28 | Pfizer | Hidtil ukendte cyclopropabenzofuranyl-pyridopyrazindioner |
| JP2019512491A (ja) * | 2016-03-11 | 2019-05-16 | エーシー・イミューン・エス・アー | 診断及び療法のための二環式化合物 |
| JP6956175B2 (ja) * | 2016-10-04 | 2021-11-02 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 二環式ヘテロアリール誘導体 |
| CN110194764B (zh) * | 2018-02-26 | 2022-08-16 | 云南大学 | 酰胺类化合物、其制备方法及用途 |
| SI3846903T1 (sl) | 2018-09-03 | 2024-02-29 | F. Hoffmann - La Roche Ag | Biciklični heteroarilni derivati |
| DK3894411T3 (da) | 2018-12-13 | 2024-08-19 | Hoffmann La Roche | 7-phenoxy-N-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-aminderivater og beslægtede forbindelser som gamma-sekretase-modulatorer til behandling af Alzheimers sygdom |
| CN114222732B (zh) * | 2019-10-28 | 2023-04-04 | 南京明德新药研发有限公司 | 一种尿酸促排剂及其合成方法和其在医药上的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID24372A (id) * | 1997-10-27 | 2000-07-13 | Agouron Pharma | SENYAWA-SENYAWA 4-AMINO-TIAZOL-2-IL SEBAGAI PENGHAMBAT-PENGHAMBAT CDKs |
| ATE288904T1 (de) * | 1998-06-18 | 2005-02-15 | Bristol Myers Squibb Co | Durch kohlenstoff substituierte aminothiazole als inhibitoren von zyclin-abhägigen kinasen |
| US20030176454A1 (en) * | 2000-05-15 | 2003-09-18 | Akira Yamada | N-coating heterocyclic compounds |
| MXPA05012281A (es) * | 2003-05-14 | 2006-05-19 | Torreypines Therapeutics Inc | Compuestos y uso de los mismos en la modulacion beta amiloide. |
| EP1757591A4 (en) * | 2004-05-26 | 2010-05-05 | Eisai R&D Man Co Ltd | ZIMTSÄUREAMIDVERBINDUNG |
| CN101098698A (zh) | 2004-12-01 | 2008-01-02 | 德福根有限公司 | 与离子通道尤其是Kv家族离子通道相互作用的5-羧酰胺基取代的噻唑衍生物 |
| US20060241038A1 (en) | 2005-04-20 | 2006-10-26 | Eisai Co., Ltd. | Therapeutic agent for Abeta related disorders |
| EP1953151A4 (en) | 2005-11-18 | 2010-06-02 | Eisai R&D Man Co Ltd | SALTS FROM A CYNNAMIDE COMPOUND OR SOLVATE THEREOF |
| EP1950211A4 (en) | 2005-11-18 | 2011-08-31 | Eisai R&D Man Co Ltd | PROCESS FOR PREPARING A CINEMA ACID AMID DERIVATIVE |
| MY144960A (en) * | 2005-11-24 | 2011-11-30 | Eisai R&D Man Co Ltd | Morpholine type cinnamide compound |
| US20070117839A1 (en) * | 2005-11-24 | 2007-05-24 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
| TWI378091B (en) * | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| AR059955A1 (es) | 2006-03-09 | 2008-05-14 | Eisai R&D Man Co Ltd | Compuestos policiclicos no peptidicos, medicamentos que los contienen, y usos para prevenir o tratar enfermedades causadas por la produccion de beta amiloide |
-
2008
- 2008-04-30 CA CA2686754A patent/CA2686754C/en not_active Expired - Fee Related
- 2008-04-30 AT AT08749887T patent/ATE496915T1/de active
- 2008-04-30 DE DE602008004769T patent/DE602008004769D1/de active Active
- 2008-04-30 KR KR1020097025780A patent/KR101138045B1/ko not_active Expired - Fee Related
- 2008-04-30 AU AU2008250436A patent/AU2008250436B2/en not_active Ceased
- 2008-04-30 ES ES08749887T patent/ES2358863T3/es active Active
- 2008-04-30 WO PCT/EP2008/055290 patent/WO2008138753A1/en not_active Ceased
- 2008-04-30 JP JP2010507876A patent/JP5264890B2/ja not_active Expired - Fee Related
- 2008-04-30 CN CN2008800140851A patent/CN101675045B/zh not_active Expired - Fee Related
- 2008-04-30 RU RU2009140182/04A patent/RU2009140182A/ru unknown
- 2008-04-30 MX MX2009012163A patent/MX2009012163A/es active IP Right Grant
- 2008-04-30 EP EP08749887A patent/EP2155740B1/en not_active Not-in-force
- 2008-04-30 BR BRPI0811993-7A2A patent/BRPI0811993A2/pt not_active Application Discontinuation
- 2008-05-05 US US12/114,852 patent/US7910740B2/en not_active Expired - Fee Related
- 2008-05-08 TW TW097117052A patent/TW200904420A/zh unknown
- 2008-05-08 CL CL2008001347A patent/CL2008001347A1/es unknown
- 2008-05-09 AR ARP080101972A patent/AR066509A1/es unknown
- 2008-05-09 PE PE2008000822A patent/PE20090248A1/es not_active Application Discontinuation
-
2009
- 2009-10-15 IL IL201566A patent/IL201566A/en active IP Right Grant
- 2009-10-28 ZA ZA200907585A patent/ZA200907585B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008250436B2 (en) | 2013-03-28 |
| ES2358863T3 (es) | 2011-05-16 |
| JP5264890B2 (ja) | 2013-08-14 |
| US7910740B2 (en) | 2011-03-22 |
| IL201566A (en) | 2013-08-29 |
| JP2010526847A (ja) | 2010-08-05 |
| ATE496915T1 (de) | 2011-02-15 |
| AR066509A1 (es) | 2009-08-26 |
| WO2008138753A1 (en) | 2008-11-20 |
| CA2686754C (en) | 2014-10-28 |
| US20080280948A1 (en) | 2008-11-13 |
| KR101138045B1 (ko) | 2012-04-24 |
| EP2155740A1 (en) | 2010-02-24 |
| MX2009012163A (es) | 2009-12-01 |
| CN101675045A (zh) | 2010-03-17 |
| EP2155740B1 (en) | 2011-01-26 |
| DE602008004769D1 (en) | 2011-03-10 |
| ZA200907585B (en) | 2010-07-28 |
| KR20100008791A (ko) | 2010-01-26 |
| CA2686754A1 (en) | 2008-11-20 |
| IL201566A0 (en) | 2010-05-31 |
| TW200904420A (en) | 2009-02-01 |
| CN101675045B (zh) | 2012-11-28 |
| AU2008250436A1 (en) | 2008-11-20 |
| PE20090248A1 (es) | 2009-03-27 |
| RU2009140182A (ru) | 2011-06-20 |
| CL2008001347A1 (es) | 2009-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |