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MX2009012163A - Hetarilanilinas como moduladores para beta-amiloide. - Google Patents

Hetarilanilinas como moduladores para beta-amiloide.

Info

Publication number
MX2009012163A
MX2009012163A MX2009012163A MX2009012163A MX2009012163A MX 2009012163 A MX2009012163 A MX 2009012163A MX 2009012163 A MX2009012163 A MX 2009012163A MX 2009012163 A MX2009012163 A MX 2009012163A MX 2009012163 A MX2009012163 A MX 2009012163A
Authority
MX
Mexico
Prior art keywords
formula
modulators
amyloid beta
hetarylanilines
hetaryl
Prior art date
Application number
MX2009012163A
Other languages
English (en)
Inventor
Synese Jolidon
Alexander Flohr
Thomas Luebbers
Helmut Jacobsen
Karlheinz Baumann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009012163A publication Critical patent/MX2009012163A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La invención se refiere a compuestos de la fórmula (ver fórmula I) en la que hetarilo I es (ver fórmulas (a), (b) y (c)) hetarilo II es (ver fórmulas (d), (e) y (f)) o a sales de adición de ácido farmacéuticamente activas. Se ha descubierto que los presentes compuestos de la fórmula I son moduladores del amiloide beta y, por tanto, pueden ser útiles para el tratamiento o prevención de una enfermedad asociada con la deposición de ß-amiloide en el cerebro, en particular la enfermedad de Alzheimer.
MX2009012163A 2007-05-11 2008-04-30 Hetarilanilinas como moduladores para beta-amiloide. MX2009012163A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07108004 2007-05-11
PCT/EP2008/055290 WO2008138753A1 (en) 2007-05-11 2008-04-30 Hetarylanilines as modulators for amyloid beta

Publications (1)

Publication Number Publication Date
MX2009012163A true MX2009012163A (es) 2009-12-01

Family

ID=39758855

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012163A MX2009012163A (es) 2007-05-11 2008-04-30 Hetarilanilinas como moduladores para beta-amiloide.

Country Status (20)

Country Link
US (1) US7910740B2 (es)
EP (1) EP2155740B1 (es)
JP (1) JP5264890B2 (es)
KR (1) KR101138045B1 (es)
CN (1) CN101675045B (es)
AR (1) AR066509A1 (es)
AT (1) ATE496915T1 (es)
AU (1) AU2008250436B2 (es)
BR (1) BRPI0811993A2 (es)
CA (1) CA2686754C (es)
CL (1) CL2008001347A1 (es)
DE (1) DE602008004769D1 (es)
ES (1) ES2358863T3 (es)
IL (1) IL201566A (es)
MX (1) MX2009012163A (es)
PE (1) PE20090248A1 (es)
RU (1) RU2009140182A (es)
TW (1) TW200904420A (es)
WO (1) WO2008138753A1 (es)
ZA (1) ZA200907585B (es)

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EP2334665B1 (en) * 2008-10-09 2013-07-10 F. Hoffmann-La Roche AG Modulators for amyloid beta
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TWI461425B (zh) * 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
EP2427453B1 (en) * 2009-05-07 2013-07-17 Janssen Pharmaceuticals, Inc. Substituted indazole and aza-indazole derivatives as gamma secretase modulators
UY32622A (es) * 2009-05-12 2010-12-31 Astrazeneca Ab Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)
BR112012000915A2 (pt) 2009-07-15 2019-09-24 Janssen Pharmaceuticals Inc derivados de triazol e imidazol substituídos como moduladores de gama secretase.
EP2523955B1 (en) 2010-01-15 2014-07-16 Janssen Pharmaceuticals, Inc. Novel substituted bicyclic triazole derivatives as gamma secretase modulators
US20110190269A1 (en) * 2010-02-01 2011-08-04 Karlheinz Baumann Gamma secretase modulators
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KR102171710B1 (ko) 2013-01-17 2020-10-30 얀센 파마슈티카 엔.브이. 감마 세크레타제 조절 인자로서의 신규 치환 피리도-피페라지논 유도체
CN103664819A (zh) * 2013-12-16 2014-03-26 山东汇海医药化工有限公司 一种2-氨基-4-甲基噻唑-5-甲酸乙酯的制备方法
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
DK3253755T3 (da) 2015-02-03 2020-09-28 Pfizer Hidtil ukendte cyclopropabenzofuranyl-pyridopyrazindioner
JP2019512491A (ja) * 2016-03-11 2019-05-16 エーシー・イミューン・エス・アー 診断及び療法のための二環式化合物
JP6956175B2 (ja) * 2016-10-04 2021-11-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 二環式ヘテロアリール誘導体
CN110194764B (zh) * 2018-02-26 2022-08-16 云南大学 酰胺类化合物、其制备方法及用途
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Also Published As

Publication number Publication date
AU2008250436B2 (en) 2013-03-28
ES2358863T3 (es) 2011-05-16
JP5264890B2 (ja) 2013-08-14
US7910740B2 (en) 2011-03-22
IL201566A (en) 2013-08-29
JP2010526847A (ja) 2010-08-05
ATE496915T1 (de) 2011-02-15
AR066509A1 (es) 2009-08-26
WO2008138753A1 (en) 2008-11-20
CA2686754C (en) 2014-10-28
US20080280948A1 (en) 2008-11-13
KR101138045B1 (ko) 2012-04-24
EP2155740A1 (en) 2010-02-24
CN101675045A (zh) 2010-03-17
EP2155740B1 (en) 2011-01-26
DE602008004769D1 (en) 2011-03-10
ZA200907585B (en) 2010-07-28
KR20100008791A (ko) 2010-01-26
BRPI0811993A2 (pt) 2014-11-18
CA2686754A1 (en) 2008-11-20
IL201566A0 (en) 2010-05-31
TW200904420A (en) 2009-02-01
CN101675045B (zh) 2012-11-28
AU2008250436A1 (en) 2008-11-20
PE20090248A1 (es) 2009-03-27
RU2009140182A (ru) 2011-06-20
CL2008001347A1 (es) 2009-05-29

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