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DE602008004769D1 - Hetarylaniline als modulatoren für amyloid beta - Google Patents

Hetarylaniline als modulatoren für amyloid beta

Info

Publication number
DE602008004769D1
DE602008004769D1 DE602008004769T DE602008004769T DE602008004769D1 DE 602008004769 D1 DE602008004769 D1 DE 602008004769D1 DE 602008004769 T DE602008004769 T DE 602008004769T DE 602008004769 T DE602008004769 T DE 602008004769T DE 602008004769 D1 DE602008004769 D1 DE 602008004769D1
Authority
DE
Germany
Prior art keywords
hetarylaniline
modulatoren
für
als
amyloid beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602008004769T
Other languages
German (de)
Inventor
Karlheinz Baumann
Alexander Flohr
Helmut Jacobsen
Synese Jolidon
Thomas Luebbers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE602008004769D1 publication Critical patent/DE602008004769D1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE602008004769T 2007-05-11 2008-04-30 Hetarylaniline als modulatoren für amyloid beta Active DE602008004769D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07108004 2007-05-11
PCT/EP2008/055290 WO2008138753A1 (en) 2007-05-11 2008-04-30 Hetarylanilines as modulators for amyloid beta

Publications (1)

Publication Number Publication Date
DE602008004769D1 true DE602008004769D1 (en) 2011-03-10

Family

ID=39758855

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602008004769T Active DE602008004769D1 (en) 2007-05-11 2008-04-30 Hetarylaniline als modulatoren für amyloid beta

Country Status (20)

Country Link
US (1) US7910740B2 (en)
EP (1) EP2155740B1 (en)
JP (1) JP5264890B2 (en)
KR (1) KR101138045B1 (en)
CN (1) CN101675045B (en)
AR (1) AR066509A1 (en)
AT (1) ATE496915T1 (en)
AU (1) AU2008250436B2 (en)
BR (1) BRPI0811993A2 (en)
CA (1) CA2686754C (en)
CL (1) CL2008001347A1 (en)
DE (1) DE602008004769D1 (en)
ES (1) ES2358863T3 (en)
IL (1) IL201566A (en)
MX (1) MX2009012163A (en)
PE (1) PE20090248A1 (en)
RU (1) RU2009140182A (en)
TW (1) TW200904420A (en)
WO (1) WO2008138753A1 (en)
ZA (1) ZA200907585B (en)

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WO2005115990A1 (en) * 2004-05-26 2005-12-08 Eisai R & D Management Co., Ltd. Cinnamide compound
ES2338904T3 (en) * 2004-10-26 2010-05-13 EISAI R&D MANAGEMENT CO., LTD. FORM AMORFA OF CINAMIDE COMPOUNDS.
WO2007058304A1 (en) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Salts of cynnamide compound or solvates thereof
AU2006316005A1 (en) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Process for production of cinnamamide derivative
TWI370130B (en) * 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
MY144960A (en) * 2005-11-24 2011-11-30 Eisai R&D Man Co Ltd Morpholine type cinnamide compound
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
US7737141B2 (en) * 2006-07-28 2010-06-15 Eisai R&D Management Co., Ltd. Prodrug of cinnamide compound
MX2009006454A (en) 2006-12-22 2009-06-26 Hoffmann La Roche Spiro-piperidine derivatives.
TW200848054A (en) * 2007-02-28 2008-12-16 Eisai R&D Man Co Ltd Two cyclic oxomorpholine derivatives
CN101679360A (en) * 2007-05-16 2010-03-24 卫材R&D管理有限公司 One-step method for producing cinnamamide derivative
US7935815B2 (en) * 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
CA2694401C (en) 2007-08-31 2012-12-04 Eisai R&D Management Co., Ltd. Polycyclic compound
WO2009080533A1 (en) * 2007-12-21 2009-07-02 F. Hoffmann-La Roche Ag Heteroaryl derivatives as orexin receptor antagonists
ATE535515T1 (en) 2008-01-11 2011-12-15 Hoffmann La Roche MODULATORS FOR AMYLOID BETA
CA2712095A1 (en) * 2008-01-28 2009-08-06 Eisai R&D Management Co., Ltd. Crystalline cinnamide compounds or salts thereof
EP2257541B1 (en) * 2008-02-22 2013-08-14 F. Hoffmann-La Roche AG Modulators for amyloid beta
MX2011003246A (en) 2008-10-09 2011-04-21 Hoffmann La Roche Modulators for amyloid beta.
CN102272133A (en) * 2008-11-06 2011-12-07 阿斯利康(瑞典)有限公司 Modulators of amyloid beta
EP2355817A1 (en) * 2008-11-10 2011-08-17 F. Hoffmann-La Roche AG Heterocyclic gamma secretase modulators
PA8854101A1 (en) * 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm IMIDAZOL BICYCLIC DERIVATIVES REPLACED AS MODULATORS OF GAMMA SECRETASA
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
EP2393804B1 (en) 2009-02-06 2014-04-16 Janssen Pharmaceuticals, Inc. Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators
TWI461425B (en) 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc Novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives as gamma secretase modulators
ES2431619T3 (en) * 2009-05-07 2013-11-27 Janssen Pharmaceuticals, Inc. Indazole and aza-indazole derivatives substituted as gamma-secretase modulators
UY32622A (en) * 2009-05-12 2010-12-31 Astrazeneca Ab NEW COMPOUNDS FOR THE TREATMENT OF PATHOLOGIES RELATED TO AB (BETA)
JP2012532912A (en) 2009-07-15 2012-12-20 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド Substituted triazole and imidazole derivatives as gamma secretase modulators
AU2011206634B2 (en) 2010-01-15 2014-11-13 Cellzome Limited Novel substituted bicyclic triazole derivatives as gamma secretase modulators
US20110190269A1 (en) * 2010-02-01 2011-08-04 Karlheinz Baumann Gamma secretase modulators
US8486967B2 (en) 2010-02-17 2013-07-16 Hoffmann-La Roche Inc. Heteroaryl substituted piperidines
WO2012126984A1 (en) 2011-03-24 2012-09-27 Janssen Pharmaceuticals, Inc. Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators
EP2691393B1 (en) 2011-03-31 2016-09-14 Pfizer Inc Novel bicyclic pyridinones
KR101913135B1 (en) 2011-07-15 2018-10-30 얀센 파마슈티칼즈, 인코포레이티드 Novel substituted indole derivatives as gamma secretase modulators
EP2850083B1 (en) 2012-05-16 2016-04-27 Janssen Pharmaceuticals, Inc. Substituted 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives useful for the treatment of (inter alia) alzheimer's disease
UA110688C2 (en) 2012-09-21 2016-01-25 Пфайзер Інк. Bicyclic pirydynony
JP6275161B2 (en) 2012-12-20 2018-02-07 ヤンセン ファーマシューティカ エヌ．ベー． Novel tricyclic 3,4-dihydro-2H-pyrido [1,2-a] pyrazine-1,6-dione derivatives as gamma secretase modulators
CN104936958B (en) 2013-01-17 2019-07-26 詹森药业有限公司 Novel substituted pyrido-piperazinone derivatives as modulators of gamma secretase
CN103664819A (en) * 2013-12-16 2014-03-26 山东汇海医药化工有限公司 Preparation method of ethyl 2-amino-4-methylthiazole-5-carboxylate
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
WO2016125048A1 (en) 2015-02-03 2016-08-11 Pfizer Inc. Novel cyclopropabenzofuranyl pyridopyrazinediones
KR20240036709A (en) * 2016-03-11 2024-03-20 에이씨 이뮨 에스에이 Bicyclic compounds for diagnosis and therapy
EP3523304B1 (en) * 2016-10-04 2021-01-27 H. Hoffnabb-La Roche Ag Bicyclic heteroaryl derivatives
CN110194764B (en) * 2018-02-26 2022-08-16 云南大学 Amide compound, preparation method and application thereof
PL3846903T3 (en) 2018-09-03 2024-05-06 F. Hoffmann-La Roche Ag Bicyclic heteroaryl derivatives
PH12021551387A1 (en) 2018-12-13 2022-05-16 Hoffmann La Roche 7-phenoxy-n-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma-secretase modulators for the treatment of alzheimer`s disease
CN114222732B (en) * 2019-10-28 2023-04-04 南京明德新药研发有限公司 Uric acid excretion promoter, synthesis method thereof and application thereof in medicine

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RO119463B1 (en) * 1997-10-27 2004-11-30 Agouron Pharmaceuticals, Inc. 4-amino-thiazole derivatives and their use as cdk inhibitors
ES2237919T4 (en) * 1998-06-18 2007-05-01 Bristol-Myers Squibb Company AMINOTIAZOL INHIBITORS REPLACED WITH CARBON OF CYCLINE DEPENDENT KINASES.
US20030176454A1 (en) * 2000-05-15 2003-09-18 Akira Yamada N-coating heterocyclic compounds
BRPI0410348A (en) * 2003-05-14 2006-05-30 Torreypines Therapeutics Inc compounds and uses thereof in amyloid-beta modulation
WO2005115990A1 (en) * 2004-05-26 2005-12-08 Eisai R & D Management Co., Ltd. Cinnamide compound
BRPI0516915A (en) * 2004-12-01 2008-03-11 Devgen Nv 5-carboxamido substituted thiazole derivatives which interact with ion channels, particularly with ion channels of the kv family
US20060241038A1 (en) 2005-04-20 2006-10-26 Eisai Co., Ltd. Therapeutic agent for Abeta related disorders
AU2006316005A1 (en) 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Process for production of cinnamamide derivative
WO2007058304A1 (en) 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Salts of cynnamide compound or solvates thereof
US20070117839A1 (en) * 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
MY144960A (en) * 2005-11-24 2011-11-30 Eisai R&D Man Co Ltd Morpholine type cinnamide compound
EP1992618B1 (en) 2006-03-09 2012-01-18 Eisai R&D Management Co., Ltd. Polycyclic cinnamide derivative
TWI378091B (en) * 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives

Also Published As

Publication number Publication date
KR20100008791A (en) 2010-01-26
ES2358863T3 (en) 2011-05-16
AU2008250436A1 (en) 2008-11-20
ZA200907585B (en) 2010-07-28
JP2010526847A (en) 2010-08-05
EP2155740A1 (en) 2010-02-24
MX2009012163A (en) 2009-12-01
US7910740B2 (en) 2011-03-22
WO2008138753A1 (en) 2008-11-20
CN101675045B (en) 2012-11-28
ATE496915T1 (en) 2011-02-15
CL2008001347A1 (en) 2009-05-29
AR066509A1 (en) 2009-08-26
CN101675045A (en) 2010-03-17
PE20090248A1 (en) 2009-03-27
IL201566A0 (en) 2010-05-31
CA2686754A1 (en) 2008-11-20
KR101138045B1 (en) 2012-04-24
RU2009140182A (en) 2011-06-20
EP2155740B1 (en) 2011-01-26
BRPI0811993A2 (en) 2014-11-18
US20080280948A1 (en) 2008-11-13
CA2686754C (en) 2014-10-28
IL201566A (en) 2013-08-29
TW200904420A (en) 2009-02-01
JP5264890B2 (en) 2013-08-14
AU2008250436B2 (en) 2013-03-28

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