BRPI0816519A2 - Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio - Google Patents

Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio

Info

Publication number: BRPI0816519A2
Authority: BR; Brazil
Prior art keywords: atracurium salt; preparing; atracurium; salt; isomerically enriched
Prior art date: 2007-10-29

Application number

Other languages

English (en)

Inventor

Oded Arad

Original Assignee

Chemagis Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-29

Filing date

2008-10-07

Publication date

2015-03-24

2008-10-07 Application filed by Chemagis Ltd filed Critical Chemagis Ltd

2015-03-24 Publication of BRPI0816519A2 publication Critical patent/BRPI0816519A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BRPI0816519 2007-10-29 2008-10-07 Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio BRPI0816519A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US98344007P	2007-10-29	2007-10-29
PCT/IL2008/001329 WO2009057086A1 (en)	2007-10-29	2008-10-07	Novel r,r'-atracurium salts

Publications (1)

Publication Number	Publication Date
BRPI0816519A2 true BRPI0816519A2 (pt)	2015-03-24

Family

ID=40259082

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0816519 BRPI0816519A2 (pt)	2007-10-29	2008-10-07	Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio

Country Status (6)

Country	Link
US (1)	US8354537B2 (pt)
EP (1)	EP2197848A1 (pt)
AU (1)	AU2008320380A1 (pt)
BR (1)	BRPI0816519A2 (pt)
CA (1)	CA2702535A1 (pt)
WO (1)	WO2009057086A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0808272A2 (pt)	2007-03-08	2014-07-08	Chemagis Ltd	"método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio"
AU2008231470A1 (en) *	2007-03-26	2008-10-02	Chemagis Ltd.	(1R,1'R)-atracurium salts separation process
EP2142510A1 (en)	2007-05-01	2010-01-13	Chemagis Ltd.	Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
WO2009007946A1 (en) *	2007-07-09	2009-01-15	Chemagis Ltd.	Process for producing cisatracurium and associated intermediates
BRPI0809893A2 (pt) *	2007-05-01	2014-09-30	Chemagis Ltd	Processo para prepar um sal de (1r-cis) - [(3,4 - dimetoxifenil) metil] - 1, 2,3,4 - tetraidro - 6,7 - dimetoxi - 2 - metil - 2 - carboxietil - isoquinolínio"
BRPI0811687A2 (pt) *	2007-06-18	2015-02-18	Chemagis Ltd	MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO
EP2283005A4 (en) *	2008-05-01	2011-08-31	Chemagis Ltd	CISATRACURIUM DERIVATIVES, PREPARATION AND USES THEREOF
CN104292161B (zh) *	2014-09-19	2016-06-22	大道隆达（北京）医药科技发展有限公司	一种顺苯磺阿曲库铵的精制方法
CN113045493B (zh) *	2020-06-22	2022-04-01	连云港贵科药业有限公司	一种顺苯磺阿曲库铵的提纯方法
CN114014806B (zh) *	2021-12-03	2024-11-12	江苏诚信药业有限公司	一种新晶型顺苯磺酸阿曲库铵及其结晶方法

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US4491665A (en)	1979-10-19	1985-01-01	Burroughs Wellcome Co.	Method of preparing isomers of bis isoquinolinium compounds
US4701460A (en)	1980-12-17	1987-10-20	Burroughs Wellcome Co.	Long duration neuromuscular blocking agents
GB8418303D0 (en)	1984-07-18	1984-08-22	Wellcome Found	Compounds
BG41897A1 (en)	1985-07-19	1987-09-15	Ivanov	Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation
JPS62265266A (ja)	1986-05-13	1987-11-18	Takasago Corp	Ｎ−アシル−テトラヒドロイソキノリン類の製造法
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GB9015473D0 (en)	1990-07-13	1990-08-29	Wellcome Found	Neuromuscular blocking agents
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DE19535762A1 (de)	1995-09-26	1997-03-27	Basf Ag	Verfahren zur Racematspaltung
US5684154A (en)	1996-02-16	1997-11-04	Abbott Laboratories	Process for the preparation and isolation of atracurium besylate
TR199902330T2 (xx)	1997-03-25	2000-02-21	Glaxo Group Limited	Ultra k�sa etkili n�rom�sk�ler blokerler olarak ikameli izokuinolinler.
MXPA02001545A (es)	1999-08-13	2002-08-30	Akzo Nobel Nv	Uso de queladores quimicos como agentes de reversion para el bloqueo neuromuscular inducido por farmaco.
CA2433284A1 (en)	2000-12-29	2002-07-11	Pfizer Limited	Reference standards and processes for determining the purity or stability of amlodipine maleate
US20060009485A1 (en)	2005-06-23	2006-01-12	Chemagis Ltd	Method of reprocessing quaternary ammonium-containing neuromuscular blocking agents
EP1951248A4 (en)	2005-11-14	2011-05-25	Peter D Winch	NEW COLORED SOLUTIONS OF INJECTABLE MEDICINAL PRODUCTS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS
KR20070080108A (ko)	2006-02-06	2007-08-09	주식회사종근당	질소의 알파 위치에 비대칭탄소가 있는 라세믹 유도체의광학 이성질체 분리 방법
CN101588803B (zh)	2006-12-06	2013-03-20	康乃尔研究基金会有限公司	中等持续时间神经肌肉阻断剂及其拮抗剂
BRPI0808272A2 (pt)	2007-03-08	2014-07-08	Chemagis Ltd	"método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio"
CN100531734C (zh)	2007-03-13	2009-08-26	黄乐群	阿曲库铵冷冻干燥组合物
AU2008231470A1 (en)	2007-03-26	2008-10-02	Chemagis Ltd.	(1R,1'R)-atracurium salts separation process
WO2009007946A1 (en)	2007-07-09	2009-01-15	Chemagis Ltd.	Process for producing cisatracurium and associated intermediates
BRPI0809893A2 (pt)	2007-05-01	2014-09-30	Chemagis Ltd	Processo para prepar um sal de (1r-cis) - [(3,4 - dimetoxifenil) metil] - 1, 2,3,4 - tetraidro - 6,7 - dimetoxi - 2 - metil - 2 - carboxietil - isoquinolínio"
EP2142510A1 (en)	2007-05-01	2010-01-13	Chemagis Ltd.	Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
BRPI0811687A2 (pt)	2007-06-18	2015-02-18	Chemagis Ltd	MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO
CN101337936B (zh)	2007-07-06	2011-03-23	江苏恒瑞医药股份有限公司	一种用柱色谱法纯化苯磺酸阿曲库铵的方法
CN101337935B (zh)	2007-07-06	2011-01-12	江苏恒瑞医药股份有限公司	一种用两相萃取法纯化苯磺酸阿曲库铵的方法
ITMI20080319A1 (it)	2008-02-28	2009-08-29	Recordati Chem Pharm	Processo per la risoluzione di derivati isochinolinici
EP2283005A4 (en)	2008-05-01	2011-08-31	Chemagis Ltd	CISATRACURIUM DERIVATIVES, PREPARATION AND USES THEREOF
IT1396543B1 (it)	2008-07-16	2012-12-14	Farmabios Spa	Processo per la purificazione di bloccanti neuromuscolari
CN101475530A (zh)	2009-01-16	2009-07-08	东英（江苏）药业有限公司	通过制备液相色谱法分离纯化顺苯磺酸阿曲库铵的方法
CN101845017A (zh)	2009-03-24	2010-09-29	天津市炜杰科技有限公司	苯磺酸阿曲库铵类中间体的制备方法
WO2010128518A2 (en)	2009-05-04	2010-11-11	Gland Pharma Limited	Novel process for the preparation of cisatracurium besylate
WO2010128519A1 (en)	2009-05-04	2010-11-11	Kumar C Jairaj	A method for detecting neuropathy and predicting foot ulcer development in human beings with health conditions like diabetes mellitus

2008
- 2008-10-07 EP EP08844602A patent/EP2197848A1/en not_active Withdrawn
- 2008-10-07 BR BRPI0816519 patent/BRPI0816519A2/pt not_active IP Right Cessation
- 2008-10-07 CA CA2702535A patent/CA2702535A1/en not_active Abandoned
- 2008-10-07 US US12/739,789 patent/US8354537B2/en not_active Expired - Fee Related
- 2008-10-07 WO PCT/IL2008/001329 patent/WO2009057086A1/en not_active Ceased
- 2008-10-07 AU AU2008320380A patent/AU2008320380A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20100234602A1 (en)	2010-09-16
WO2009057086A1 (en)	2009-05-07
EP2197848A1 (en)	2010-06-23
CA2702535A1 (en)	2009-05-07
AU2008320380A1 (en)	2009-05-07
US8354537B2 (en)	2013-01-15

Publication	Publication Date	Title
BRPI0816519A2 (pt)	2015-03-24	Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio
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Legal Events

Date	Code	Title	Description
2015-12-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 7A ANUIDADE.
2016-04-05	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.