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BRPI0819026A2 - "método para produzir um gel aquoso de adapaleno e gel aquoso de adapaleno" - Google Patents

"método para produzir um gel aquoso de adapaleno e gel aquoso de adapaleno"

Info

Publication number
BRPI0819026A2
BRPI0819026A2 BRPI0819026A BRPI0819026A BRPI0819026A2 BR PI0819026 A2 BRPI0819026 A2 BR PI0819026A2 BR PI0819026 A BRPI0819026 A BR PI0819026A BR PI0819026 A BRPI0819026 A BR PI0819026A BR PI0819026 A2 BRPI0819026 A2 BR PI0819026A2
Authority
BR
Brazil
Prior art keywords
adapalene gel
aqueous
producing
aqueous adapalene
gel
Prior art date
Application number
BRPI0819026A
Other languages
English (en)
Inventor
Ebel Maurice
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Publication of BRPI0819026A2 publication Critical patent/BRPI0819026A2/pt
Publication of BRPI0819026B1 publication Critical patent/BRPI0819026B1/pt
Publication of BRPI0819026B8 publication Critical patent/BRPI0819026B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BRPI0819026A 2007-11-27 2008-11-27 método para produzir um gel aquoso de adapaleno e gel aquoso de adapaleno BRPI0819026B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99661807P 2007-11-27 2007-11-27
EP07121665A EP2065032A1 (en) 2007-11-27 2007-11-27 A method for producing adapalene gels
PCT/EP2008/066339 WO2009068610A1 (en) 2007-11-27 2008-11-27 A method for producing adapalene gels

Publications (3)

Publication Number Publication Date
BRPI0819026A2 true BRPI0819026A2 (pt) 2017-04-04
BRPI0819026B1 BRPI0819026B1 (pt) 2020-05-05
BRPI0819026B8 BRPI0819026B8 (pt) 2021-05-25

Family

ID=39247232

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0819026A BRPI0819026B8 (pt) 2007-11-27 2008-11-27 método para produzir um gel aquoso de adapaleno e gel aquoso de adapaleno

Country Status (13)

Country Link
US (1) US8404220B2 (pt)
EP (3) EP2065032A1 (pt)
JP (2) JP5526035B2 (pt)
KR (1) KR101563379B1 (pt)
CN (2) CN103830163B (pt)
AR (1) AR071737A1 (pt)
AU (1) AU2008328764B2 (pt)
BR (1) BRPI0819026B8 (pt)
CA (1) CA2706379A1 (pt)
ES (2) ES2887225T3 (pt)
MX (1) MX2010005432A (pt)
RU (1) RU2476203C2 (pt)
WO (1) WO2009068610A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1684782T3 (en) 2003-10-03 2015-11-02 Thorn Bioscience Llc PROCEDURE FOR SYNCHRONIZING OVULATION FOR TEMPORARY REGULATED BREEDING WITHOUT BROWN DETECTION
FR2910320B1 (fr) 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
BRPI1014362A2 (pt) 2009-04-23 2016-04-05 Pennatek Llc método e composição para sincronizar o tempo de inseminação
FR2969492B1 (fr) 2010-12-23 2013-07-05 Galderma Res & Dev Mousses dermatologiques obtenues a partir d'un gel ou d'une suspension contenant de l'adapalene
CN102274159A (zh) * 2011-07-12 2011-12-14 广东东阳光药业有限公司 一种经皮渗透给药的维甲酸类药物组合物及其制备方法
FR2991177B1 (fr) 2012-06-01 2014-12-19 Galderma Res & Dev Compositions topiques, contenant un retinoide, de type emulsion huile dans eau sans emulsionnant
CN103099775B (zh) * 2012-10-08 2014-12-31 天津金耀集团有限公司 阿达帕林凝胶
AU2013352054A1 (en) 2012-11-28 2015-06-04 United-Ah Ii, Llc Method for synchronizing time of insemination in gilts
TW201625218A (zh) * 2014-04-18 2016-07-16 Ｊｂｓ聯合動物保健有限責任公司 製造含ｇｎｒｈ凝膠之方法
CN105411999A (zh) * 2015-11-23 2016-03-23 安徽新和成皖南药业有限公司 一种阿达帕林凝胶的制备方法
US9987239B1 (en) 2017-03-14 2018-06-05 Rey Ventures, LLC Pharmaceutical retinoid preparation for topical use
CN108066332A (zh) * 2017-12-21 2018-05-25 兆科药业（广州）有限公司 一种凝胶制剂中阿达帕林的分散工艺
JPWO2019240290A1 (ja) * 2018-06-16 2021-06-24 ロート製薬株式会社 外用組成物
US12133907B2 (en) 2021-01-07 2024-11-05 Actera Ingredients, Inc. Lipophilic third generation retinoid
CN116139071A (zh) * 2022-12-29 2023-05-23 江苏知原药业股份有限公司 一种阿达帕林凝胶及其制备方法
EP4534072A1 (en) 2023-10-06 2025-04-09 Dr. August Wolff GmbH & Co. KG Arzneimittel Non-aqueous pharmaceutical gel formulation containing dissolved adapalene

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU85849A1 (fr) 1985-04-11 1986-11-05 Cird Derives benzonaphtaleniques,leur procede de preparation et leur application dans les domaines pharmaceutiques et cosmetiques
FR2636061B1 (fr) 1988-09-07 1990-11-09 Cird Procede de preparation de derives de l'adamantane-1
US7820186B2 (en) * 2001-12-21 2010-10-26 Galderma Research & Development Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt
FR2833841B1 (fr) * 2001-12-21 2005-07-22 Galderma Res & Dev Gel comprenant au moins un retinoide et du peroxyde de benzoyle
BRPI0307550B8 (pt) * 2002-03-12 2021-05-25 Galderma Res & Dev composição farmacêutica em gel tópica, de adapaleno 0,3%
BR0315953A (pt) * 2002-12-12 2005-09-13 Galderma Res & Dev Composição despigmentante, processo para a preparação de uma composição, usos da composição e processo cosmético não - terapêutico para o embelezamento da pele
FR2871377B1 (fr) * 2004-06-11 2007-08-24 Galderma Res & Dev Gel depigmentant hydroalcoolique comprenant du mequinol et de l'adapalene
KR20070091613A (ko) * 2004-11-08 2007-09-11 그렌마크 파머수티칼스 엘티디. 항여드름 화합물 및 항생제 화합물을 함유하는 국소적 제약조성물
AU2006290364B2 (en) * 2005-09-16 2012-07-05 Galderma Research & Development Composition comprising at least one naphthoic acid derivative and at least one compound of polyurethane polymer type or derivatives thereof, preparation processes therefor and uses thereof
US20080175810A1 (en) * 2007-01-22 2008-07-24 Jerry Zhang Topical compositions for cosmetic and pharmaceutical use

Also Published As

Publication number Publication date
JP2011504912A (ja) 2011-02-17
ES2887225T3 (es) 2021-12-22
AU2008328764A1 (en) 2009-06-04
EP2224906B1 (en) 2014-02-19
AU2008328764B2 (en) 2013-11-21
WO2009068610A1 (en) 2009-06-04
EP2224906A1 (en) 2010-09-08
EP2065032A1 (en) 2009-06-03
CN101878022A (zh) 2010-11-03
CN103830163B (zh) 2016-12-07
KR20100098539A (ko) 2010-09-07
EP2460513A1 (en) 2012-06-06
CN101878022B (zh) 2014-02-19
MX2010005432A (es) 2010-06-02
US8404220B2 (en) 2013-03-26
US20100280121A1 (en) 2010-11-04
CN103830163A (zh) 2014-06-04
BRPI0819026B1 (pt) 2020-05-05
JP5526035B2 (ja) 2014-06-18
KR101563379B1 (ko) 2015-10-26
RU2476203C2 (ru) 2013-02-27
JP2014101373A (ja) 2014-06-05
ES2464455T3 (es) 2014-06-02
EP2460513B1 (en) 2021-07-21
CA2706379A1 (en) 2009-06-04
RU2010126103A (ru) 2012-01-10
AR071737A1 (es) 2010-07-14
BRPI0819026B8 (pt) 2021-05-25

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 05/05/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/11/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2750 DE 19-09-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.