EA201892200A1 - Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге - Google Patents
Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денгеInfo
- Publication number
- EA201892200A1 EA201892200A1 EA201892200A EA201892200A EA201892200A1 EA 201892200 A1 EA201892200 A1 EA 201892200A1 EA 201892200 A EA201892200 A EA 201892200A EA 201892200 A EA201892200 A EA 201892200A EA 201892200 A1 EA201892200 A1 EA 201892200A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- ingibitors
- indol
- virus replication
- derivative compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
- 208000001490 Dengue Diseases 0.000 abstract 3
- 206010012310 Dengue fever Diseases 0.000 abstract 3
- 208000036142 Viral infection Diseases 0.000 abstract 3
- 208000025729 dengue disease Diseases 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 229940124597 therapeutic agent Drugs 0.000 abstract 3
- 230000009385 viral infection Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 150000002475 indoles Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Настоящее изобретение относится к замещенным соединениям индола, к способам предупреждения или лечения вирусных инфекций денге с помощью применения указанных соединений, а также относится к указанным соединениям для применения в качестве лечебного средства, более предпочтительно для применения в качестве лечебного средства для лечения или предупреждения вирусных инфекций денге. Настоящее изобретение дополнительно относится к фармацевтическим композициям или комбинированным препаратам на основе соединений, к композициям или препаратам для применения в качестве лечебного средства, более предпочтительно для предупреждения или лечения вирусных инфекций денге. Настоящее изобретение также относится к способам получения соединений.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16163482 | 2016-04-01 | ||
| PCT/EP2017/057662 WO2017167952A1 (en) | 2016-04-01 | 2017-03-31 | Substituted indole compound derivatives as dengue viral replication inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201892200A1 true EA201892200A1 (ru) | 2019-03-29 |
Family
ID=55650310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201892200A EA201892200A1 (ru) | 2016-04-01 | 2017-03-31 | Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10730884B2 (ru) |
| EP (1) | EP3436004B1 (ru) |
| JP (2) | JP7007290B2 (ru) |
| KR (1) | KR102359766B1 (ru) |
| CN (1) | CN109069482B (ru) |
| AU (1) | AU2017240076A1 (ru) |
| BR (1) | BR112018068956A2 (ru) |
| CA (1) | CA3013408A1 (ru) |
| CL (1) | CL2018002784A1 (ru) |
| CO (1) | CO2018009996A2 (ru) |
| CR (1) | CR20180494A (ru) |
| EA (1) | EA201892200A1 (ru) |
| EC (1) | ECSP18073264A (ru) |
| ES (1) | ES3010298T3 (ru) |
| IL (1) | IL261947A (ru) |
| MA (1) | MA44502A (ru) |
| MX (1) | MX2018011786A (ru) |
| PH (1) | PH12018502026A1 (ru) |
| SG (1) | SG11201808237UA (ru) |
| SV (1) | SV2018005750A (ru) |
| WO (1) | WO2017167952A1 (ru) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MX2018011784A (es) | 2016-03-31 | 2019-02-13 | Janssen Pharmaceuticals Inc | Derivados de indol sustituidos como inhibidores de la replicacion virica del dengue. |
| WO2017167953A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| ES3010298T3 (en) | 2016-04-01 | 2025-04-02 | Janssen Pharmaceuticals Inc | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| LT3630724T (lt) | 2017-05-22 | 2021-08-25 | Janssen Pharmaceuticals, Inc. | Pakeistieji indolino dariniai, kaip dengės viruso replikacijos inhibitoriai |
| CA3060583C (en) | 2017-05-22 | 2024-06-04 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| CN108586404A (zh) * | 2018-06-12 | 2018-09-28 | 湖南大学 | 一种n-芳基萘并呋喃酮亚胺类化合物的合成方法 |
| CN108947948B (zh) * | 2018-06-12 | 2021-07-20 | 湖南大学 | 一种n-芳基萘并呋喃酮亚胺类化合物及其合成方法 |
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| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| CA2468202A1 (en) | 2001-12-12 | 2003-06-19 | Conforma Therapeutics Corporation | Assays and implements for determining and modulating hsp90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| BRPI0516751A (pt) * | 2004-09-30 | 2008-09-16 | Tibotec Pharm Ltd | pirimidinas bicìclicas que inibem hcv |
| RU2007130896A (ru) | 2005-01-14 | 2009-02-20 | Дженелэбс Текнолоджиз, Инк. (Us) | Индольные производные для лечения вирусных инфекций |
| AU2006221080A1 (en) | 2005-02-09 | 2006-09-14 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| WO2009039248A2 (en) * | 2007-09-18 | 2009-03-26 | Stanford University | Methods of treating a flaviviridae family viral infection and compositions for treating a flaviviridae family viral infection |
| EP2293671A4 (en) | 2008-06-03 | 2012-03-21 | Siga Technologies Inc | SMALL MOLECULAR INHIBITORS FOR TREATING OR PREVENTING DENGUE INFECTIONS |
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| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JP6452119B2 (ja) | 2013-10-23 | 2019-01-16 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | カルボキサミド誘導体およびｂ型肝炎の処置のための医薬品としてのその使用 |
| SI3099687T1 (en) | 2014-01-31 | 2018-08-31 | Bristol-Myers Squibb Company | Macrocycles with hetrocyclic p2' groups as factor xia inhibitors |
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| KR102478309B1 (ko) * | 2014-10-01 | 2022-12-15 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 １치환 또는 ２치환 인돌 |
| NO2721243T3 (ru) | 2014-10-01 | 2018-10-20 | ||
| PH12017501272B1 (en) | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) * | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) * | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| PL3370698T3 (pl) | 2015-11-03 | 2022-04-25 | Zoetis Services Llc | Kompozyty polimerowe zol-żel i ich zastosowania |
| DK3436444T3 (da) | 2016-03-31 | 2020-07-27 | Takeda Pharmaceuticals Co | Heterocyklisk forbindelse |
| WO2017167953A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| MX2018011784A (es) | 2016-03-31 | 2019-02-13 | Janssen Pharmaceuticals Inc | Derivados de indol sustituidos como inhibidores de la replicacion virica del dengue. |
| SG11201808388QA (en) | 2016-04-01 | 2018-10-30 | Signal Pharm Llc | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
| ES3010298T3 (en) | 2016-04-01 | 2025-04-02 | Janssen Pharmaceuticals Inc | Substituted indole compound derivatives as dengue viral replication inhibitors |
| WO2017173256A1 (en) | 2016-04-01 | 2017-10-05 | Kite Pharma, Inc. | Chimeric antigen and t cell receptors and methods of use |
| PL3436457T3 (pl) | 2016-04-01 | 2022-11-28 | Basf Se | Związki bicykliczne |
| KR102120815B1 (ko) | 2016-04-01 | 2020-06-12 | 카이트 파마 인코포레이티드 | 키메라 수용체 및 그의 사용 방법 |
| KR102389096B1 (ko) | 2016-04-01 | 2022-04-25 | 암젠 인크 | Flt3에 대한 키메라 수용체 및 이의 사용 방법 |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| LT3630724T (lt) | 2017-05-22 | 2021-08-25 | Janssen Pharmaceuticals, Inc. | Pakeistieji indolino dariniai, kaip dengės viruso replikacijos inhibitoriai |
| CA3060583C (en) | 2017-05-22 | 2024-06-04 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
-
2017
- 2017-03-31 ES ES17714752T patent/ES3010298T3/es active Active
- 2017-03-31 AU AU2017240076A patent/AU2017240076A1/en not_active Abandoned
- 2017-03-31 MA MA044502A patent/MA44502A/fr unknown
- 2017-03-31 SG SG11201808237UA patent/SG11201808237UA/en unknown
- 2017-03-31 KR KR1020187027650A patent/KR102359766B1/ko active Active
- 2017-03-31 JP JP2018549980A patent/JP7007290B2/ja active Active
- 2017-03-31 US US16/088,198 patent/US10730884B2/en active Active
- 2017-03-31 MX MX2018011786A patent/MX2018011786A/es unknown
- 2017-03-31 CR CR20180494A patent/CR20180494A/es unknown
- 2017-03-31 BR BR112018068956A patent/BR112018068956A2/pt not_active Application Discontinuation
- 2017-03-31 CN CN201780022068.1A patent/CN109069482B/zh active Active
- 2017-03-31 EP EP17714752.7A patent/EP3436004B1/en active Active
- 2017-03-31 CA CA3013408A patent/CA3013408A1/en not_active Abandoned
- 2017-03-31 EA EA201892200A patent/EA201892200A1/ru unknown
- 2017-03-31 WO PCT/EP2017/057662 patent/WO2017167952A1/en not_active Ceased
-
2018
- 2018-09-21 PH PH12018502026A patent/PH12018502026A1/en unknown
- 2018-09-21 CO CONC2018/0009996A patent/CO2018009996A2/es unknown
- 2018-09-26 IL IL261947A patent/IL261947A/en unknown
- 2018-09-28 SV SV2018005750A patent/SV2018005750A/es unknown
- 2018-09-28 EC ECSENADI201873264A patent/ECSP18073264A/es unknown
- 2018-09-28 CL CL2018002784A patent/CL2018002784A1/es unknown
-
2021
- 2021-10-15 JP JP2021169228A patent/JP2022009166A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022009166A (ja) | 2022-01-14 |
| US20190276467A1 (en) | 2019-09-12 |
| CL2018002784A1 (es) | 2018-12-14 |
| ES3010298T3 (en) | 2025-04-02 |
| CR20180494A (es) | 2019-01-29 |
| KR102359766B1 (ko) | 2022-02-07 |
| BR112018068956A2 (pt) | 2019-01-22 |
| KR20180130502A (ko) | 2018-12-07 |
| PH12018502026A1 (en) | 2019-02-11 |
| EP3436004B1 (en) | 2024-12-11 |
| AU2017240076A1 (en) | 2018-08-09 |
| EP3436004A1 (en) | 2019-02-06 |
| MA44502A (fr) | 2019-02-06 |
| SV2018005750A (es) | 2018-11-15 |
| SG11201808237UA (en) | 2018-10-30 |
| JP7007290B2 (ja) | 2022-01-24 |
| JP2019511502A (ja) | 2019-04-25 |
| CN109069482A (zh) | 2018-12-21 |
| US10730884B2 (en) | 2020-08-04 |
| WO2017167952A1 (en) | 2017-10-05 |
| EP3436004C0 (en) | 2024-12-11 |
| MX2018011786A (es) | 2019-05-20 |
| CN109069482B (zh) | 2022-04-05 |
| CA3013408A1 (en) | 2017-10-05 |
| ECSP18073264A (es) | 2018-10-31 |
| IL261947A (en) | 2018-10-31 |
| CO2018009996A2 (es) | 2018-09-28 |
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