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BRPI0616801B8 - "forma polimórfica de 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofenocarboxamida, seus processos de preparação e seus usos, medicamento, e processo para prevenção de coagulação de sangue in vitro - Google Patents

"forma polimórfica de 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofenocarboxamida, seus processos de preparação e seus usos, medicamento, e processo para prevenção de coagulação de sangue in vitro

Info

Publication number
BRPI0616801B8
BRPI0616801B8 BRPI0616801A BRPI0616801A BRPI0616801B8 BR PI0616801 B8 BRPI0616801 B8 BR PI0616801B8 BR PI0616801 A BRPI0616801 A BR PI0616801A BR PI0616801 A BRPI0616801 A BR PI0616801A BR PI0616801 B8 BRPI0616801 B8 BR PI0616801B8
Authority
BR
Brazil
Prior art keywords
oxo
thiophenecarboxamide
oxazolidin
morpholinyl
chloro
Prior art date
Application number
BRPI0616801A
Other languages
English (en)
Inventor
Grunenberg Alfons
Keil Birgit
R Thomas Christian
Arnold Braun Gerhard
Lenz Jana
Original Assignee
Bayer Healthcare Ag
Bayer Ip Gmbh
Bayer Pharma AG
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37691766&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0616801(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE102005047563A external-priority patent/DE102005047563A1/de
Priority claimed from DE102005047564A external-priority patent/DE102005047564A1/de
Application filed by Bayer Healthcare Ag, Bayer Ip Gmbh, Bayer Pharma AG, Bayer Schering Pharma Ag filed Critical Bayer Healthcare Ag
Publication of BRPI0616801A2 publication Critical patent/BRPI0616801A2/pt
Publication of BRPI0616801B1 publication Critical patent/BRPI0616801B1/pt
Publication of BRPI0616801B8 publication Critical patent/BRPI0616801B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

forma polimórfica e a forma amorfa de 5-cloro-n({5s)-2-oxo-3[4-(3-oxo-4-morfolinil)-fenil]1-3-oxazolidin-5-il{-metil)-2-tiofenocarboxamida. a presente invenção refere-se a uma polimórfica e à forma amorfa de 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morfolinil)-fenil]-1 ,3-oxazolidin-5-il}-metil)-2-tiofenocarboxamida, a processos para a sua preparação, a medicamentos compreendendo essas formas e ao seu uso no controle de doenças.
BRPI0616801A 2005-10-04 2006-09-22 "forma polimórfica de 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofenocarboxamida, seus processos de preparação e seus usos, medicamento, e processo para prevenção de coagulação de sangue in vitro BRPI0616801B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE102005047563A DE102005047563A1 (de) 2005-10-04 2005-10-04 Neue polymorphe Form von 5-Chlor-N-{(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl)-methyl)-2-thiophencarboxamid
DE102005047564A DE102005047564A1 (de) 2005-10-04 2005-10-04 Amorphe Form von 5-Chlor-N-({(5S)2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl)-methyl)-2-thiophencarboxamid
DE102005047564.7 2005-10-04
DE102005047563.9 2005-10-04
PCT/EP2006/009202 WO2007039132A1 (de) 2005-10-04 2006-09-22 Neue polymorphe form und die amorphe form von 5-chlor-n- ( { ( 5s ) -2-0x0-3-[4-( 3-oxo-4-morpholinyl) - phenyl] -1,3-oxazolidin-5-yl} -methyl) -2- thiophencarboxamid

Publications (3)

Publication Number Publication Date
BRPI0616801A2 BRPI0616801A2 (pt) 2011-06-28
BRPI0616801B1 BRPI0616801B1 (pt) 2020-08-25
BRPI0616801B8 true BRPI0616801B8 (pt) 2021-05-25

Family

ID=37691766

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0616801A BRPI0616801B8 (pt) 2005-10-04 2006-09-22 "forma polimórfica de 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofenocarboxamida, seus processos de preparação e seus usos, medicamento, e processo para prevenção de coagulação de sangue in vitro

Country Status (22)

Country Link
US (1) US8188270B2 (pt)
EP (1) EP1934208B1 (pt)
JP (1) JP5416408B2 (pt)
KR (1) KR101364400B1 (pt)
AT (1) ATE502937T1 (pt)
AU (1) AU2006299126B2 (pt)
BR (1) BRPI0616801B8 (pt)
CA (2) CA2624310C (pt)
CR (1) CR9863A (pt)
DE (1) DE502006009169D1 (pt)
DK (1) DK1934208T3 (pt)
EC (1) ECSP088341A (pt)
IL (1) IL190204A (pt)
MY (1) MY145616A (pt)
NO (1) NO341632B1 (pt)
NZ (1) NZ567092A (pt)
PL (1) PL1934208T3 (pt)
PT (1) PT1934208E (pt)
RU (2) RU2578602C2 (pt)
SG (1) SG166126A1 (pt)
SV (1) SV2009002858A (pt)
WO (1) WO2007039132A1 (pt)

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IL190204A (en) 2014-08-31
RU2578602C2 (ru) 2016-03-27
CA2624310A1 (en) 2007-04-12
SV2009002858A (es) 2009-07-28
KR20080050465A (ko) 2008-06-05
ECSP088341A (es) 2008-06-30
JP5416408B2 (ja) 2014-02-12
WO2007039132A1 (de) 2007-04-12
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NO20082059L (no) 2008-04-30
CA2823159C (en) 2014-10-21
RU2429236C2 (ru) 2011-09-20
SG166126A1 (en) 2010-11-29
AU2006299126A1 (en) 2007-04-12
CA2624310C (en) 2014-01-07
EP1934208A1 (de) 2008-06-25
ATE502937T1 (de) 2011-04-15
HK1125103A1 (en) 2009-07-31
RU2008116834A (ru) 2009-11-10
JP2009510140A (ja) 2009-03-12
EP1934208B1 (de) 2011-03-23
IL190204A0 (en) 2008-11-03
BRPI0616801A2 (pt) 2011-06-28
DK1934208T3 (da) 2011-07-18
BRPI0616801B1 (pt) 2020-08-25
DE502006009169D1 (en) 2011-05-05
RU2011115874A (ru) 2012-10-27
PT1934208E (pt) 2011-06-01
MY145616A (en) 2012-03-15
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US20100152189A1 (en) 2010-06-17
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