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BRPI0515860A - derivados de tetralin e indano, e uso dos mesmos - Google Patents

derivados de tetralin e indano, e uso dos mesmos

Info

Publication number
BRPI0515860A
BRPI0515860A BRPI0515860-5A BRPI0515860A BRPI0515860A BR PI0515860 A BRPI0515860 A BR PI0515860A BR PI0515860 A BRPI0515860 A BR PI0515860A BR PI0515860 A BRPI0515860 A BR PI0515860A
Authority
BR
Brazil
Prior art keywords
tetralin
formula
compounds
indane derivatives
indane
Prior art date
Application number
BRPI0515860-5A
Other languages
English (en)
Inventor
Robert Greenhouse
Ralph New Harris Iii
Saul Jaime-Figueroa
James M Kress
David Bruce Repke
Russell Stephen Stabler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0515860A publication Critical patent/BRPI0515860A/pt
Publication of BRPI0515860B1 publication Critical patent/BRPI0515860B1/pt
Publication of BRPI0515860B8 publication Critical patent/BRPI0515860B8/pt

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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE TETRALIN E INDANO, E USO DOS MESMOS". Compostos da fórmula I: ou sais farmaceuticamente aceitáveis dos mesmos, onde m,p,q, Ar, R e R são conforme aqui definidos. Também são fornecidos métodos para preparar compostos de fórmula I, composições compreendendo compostos de fórmula I, e usos dos compostos de fórmula I na preparação de medicamentos.
BRPI0515860A 2004-12-21 2005-12-15 derivados de tetralin e indano, seus usos, e composição farmacêutica BRPI0515860B8 (pt)

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US63803004P 2004-12-21 2004-12-21
US60/638,030 2004-12-21
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AU2005318550A1 (en) 2006-06-29
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AR055012A1 (es) 2007-08-01
HK1117500A1 (en) 2009-01-16
CN101119965A (zh) 2008-02-06
CA2591937A1 (en) 2006-06-29
NO20073051L (no) 2007-06-27
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US8889906B2 (en) 2014-11-18
DK1831159T3 (da) 2010-03-22
ATE455755T1 (de) 2010-02-15
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CA2591937C (en) 2013-08-06
US9670151B2 (en) 2017-06-06
NO339065B1 (no) 2016-11-07
US20210284606A1 (en) 2021-09-16
US20060167255A1 (en) 2006-07-27
RU2396255C2 (ru) 2010-08-10
US20170247321A1 (en) 2017-08-31
HRP20100181T1 (hr) 2010-05-31
BRPI0515860B8 (pt) 2021-05-25
WO2006066790A1 (en) 2006-06-29
PL1831159T3 (pl) 2010-06-30
MY144050A (en) 2011-07-29
US20200115333A1 (en) 2020-04-16
CY1111032T1 (el) 2015-06-11
US20080293751A1 (en) 2008-11-27
KR100901035B1 (ko) 2009-06-04
SI1831159T1 (sl) 2010-04-30
DE602005019098D1 (de) 2010-03-11
TWI344951B (en) 2011-07-11
PT1831159E (pt) 2010-03-03
BRPI0515860B1 (pt) 2021-05-04
ZA200705122B (en) 2008-09-25
AU2005318550B2 (en) 2011-04-07
TW200633964A (en) 2006-10-01
US7312359B2 (en) 2007-12-25
RU2007122408A (ru) 2009-01-27
US8093424B2 (en) 2012-01-10
US20120088837A1 (en) 2012-04-12
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US20180319743A1 (en) 2018-11-08
EP1831159A1 (en) 2007-09-12
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US20150266817A1 (en) 2015-09-24
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