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BRPI0508107A - derivados de indazol e composições farmacêuticas contendo os mesmos - Google Patents

derivados de indazol e composições farmacêuticas contendo os mesmos

Info

Publication number
BRPI0508107A
BRPI0508107A BRPI0508107-6A BRPI0508107A BRPI0508107A BR PI0508107 A BRPI0508107 A BR PI0508107A BR PI0508107 A BRPI0508107 A BR PI0508107A BR PI0508107 A BRPI0508107 A BR PI0508107A
Authority
BR
Brazil
Prior art keywords
same
pharmaceutical compositions
compositions containing
indazole derivatives
formula
Prior art date
Application number
BRPI0508107-6A
Other languages
English (en)
Inventor
Nidhi Arora
Tobias Gabriel
David Michael Goldstein
Teresa Alejandra Trejo-Martin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0508107A publication Critical patent/BRPI0508107A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)

Abstract

DERIVADOS DE INDAZOL E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS. Composto da fórmula I: ou sais, solvatos ou pró-drogas farmaceuticamente aceitáveis dos mesmos, em que m, k, B, R¬ 1¬, R¬ 2¬ e R¬ 3¬ são aqueles definidos aqui e as composições que compreenden os mesmos. São também fornecidos processos para a preparação de compostos da fórmula I e para a utilização dos mesmos no tratamento de distúrbios mediados por p38 em um paciente.
BRPI0508107-6A 2004-02-27 2005-02-22 derivados de indazol e composições farmacêuticas contendo os mesmos BRPI0508107A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54858504P 2004-02-27 2004-02-27
PCT/EP2005/001816 WO2005085206A1 (en) 2004-02-27 2005-02-22 Indazole derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
BRPI0508107A true BRPI0508107A (pt) 2007-07-17

Family

ID=34919378

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508107-6A BRPI0508107A (pt) 2004-02-27 2005-02-22 derivados de indazol e composições farmacêuticas contendo os mesmos

Country Status (13)

Country Link
US (1) US7495015B2 (pt)
EP (1) EP1747202A1 (pt)
JP (1) JP2007523937A (pt)
KR (1) KR20060114022A (pt)
CN (1) CN1922150A (pt)
AU (1) AU2005219518A1 (pt)
BR (1) BRPI0508107A (pt)
CA (1) CA2557268A1 (pt)
IL (1) IL177260A0 (pt)
NO (1) NO20064010L (pt)
RU (1) RU2006134022A (pt)
WO (1) WO2005085206A1 (pt)
ZA (1) ZA200606619B (pt)

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US9149463B2 (en) * 2007-09-18 2015-10-06 The Board Of Trustees Of The Leland Standford Junior University Methods and compositions of treating a Flaviviridae family viral infection
US8940730B2 (en) 2007-09-18 2015-01-27 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions of treating a Flaviviridae family viral infection
US9101628B2 (en) * 2007-09-18 2015-08-11 The Board Of Trustees Of The Leland Stanford Junior University Methods and composition of treating a flaviviridae family viral infection
WO2009039246A2 (en) * 2007-09-18 2009-03-26 Stanford University Methods of treating a flaviviridae family viral infection, compositions for treating a flaviviridae family viral infection, and screening assays for identifying compositions for treating a flaviviridae family viral infection
JP2012520885A (ja) * 2009-03-18 2012-09-10 ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー フラビウイルス科ウイルス感染症を治療する方法および組成物
EP2408449A4 (en) 2009-03-18 2012-08-08 Univ Leland Stanford Junior METHOD AND COMPOSITIONS FOR TREATING FLAVIVIRIDAE VIRUS INFECTIONS
US9326987B2 (en) * 2010-09-08 2016-05-03 Glaxo Group Limited Indazole derivatives for use in the treatment of influenza virus infection
WO2012078674A1 (en) * 2010-12-06 2012-06-14 Confluence Life Sciences, Inc. Substituted indole/indazole-pyrimidinyl compounds
BR112013028733B1 (pt) 2011-05-12 2022-05-10 Nerviano Medical Sciences S.R.L Derivados de indazol substituiídos ativos como inibidores de quinase
CN106279119B (zh) * 2015-05-27 2020-06-16 上海海和药物研究开发有限公司 一种新型激酶抑制剂的制备及其应用
DE102015012050A1 (de) * 2015-09-15 2017-03-16 Merck Patent Gmbh Verbindungen als ASIC-Inhibitoren und deren Verwendungen
KR20200067170A (ko) 2017-10-05 2020-06-11 풀크럼 쎄러퓨틱스, 인코포레이티드 FSHD의 치료를 위하여 DUX4 및 하류 유전자 발현을 저감시키는 p38 키나제 저해제
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CN110117278B (zh) * 2018-02-07 2022-07-19 石家庄以岭药业股份有限公司 烷氧基苯并五元(六元)杂环胺类化合物及其药物用途
CN108586432B (zh) * 2018-05-31 2020-08-25 温州医科大学 一种3-(吲哚-5-基)-吲唑衍生物及其应用

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JP2007523937A (ja) 2007-08-23
IL177260A0 (en) 2006-12-10
RU2006134022A (ru) 2008-04-10
WO2005085206A1 (en) 2005-09-15
AU2005219518A1 (en) 2005-09-15
US7495015B2 (en) 2009-02-24
EP1747202A1 (en) 2007-01-31
KR20060114022A (ko) 2006-11-03
CA2557268A1 (en) 2005-09-15
CN1922150A (zh) 2007-02-28
ZA200606619B (en) 2008-08-27
NO20064010L (no) 2006-09-25

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