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AU2001244700A1 - Process for producing amine derivatives - Google Patents

Process for producing amine derivatives

Info

Publication number
AU2001244700A1
AU2001244700A1 AU2001244700A AU4470001A AU2001244700A1 AU 2001244700 A1 AU2001244700 A1 AU 2001244700A1 AU 2001244700 A AU2001244700 A AU 2001244700A AU 4470001 A AU4470001 A AU 4470001A AU 2001244700 A1 AU2001244700 A1 AU 2001244700A1
Authority
AU
Australia
Prior art keywords
amine derivatives
secretion
inhibiting
accumulation
action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001244700A
Inventor
Kaneyoshi Kato
Hiroyuki Tawada
Makoto Yamashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of AU2001244700A1 publication Critical patent/AU2001244700A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

This invention provides a convenient and industrially advantageous process producing amine derivatives having the action of inhibiting the secretion and accumulation of amyloid beta protein. <CHEM> In Compound (I), the ether linkage is selectively cleaved without cleaving the amide linkage present in the same molecule and tertiary amines are not converted into quaternary salts, and thus Amine Derivative (V) with good qualities having the action of inhibiting the secretion and accumulation of amyloid beta protein can be obtained in high yield.
AU2001244700A 2000-04-03 2001-04-02 Process for producing amine derivatives Abandoned AU2001244700A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000-105398 2000-04-03
JP2000105398 2000-04-03
PCT/JP2001/002845 WO2001074756A1 (en) 2000-04-03 2001-04-02 Process for producing amine derivatives

Publications (1)

Publication Number Publication Date
AU2001244700A1 true AU2001244700A1 (en) 2001-10-15

Family

ID=18618765

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001244700A Abandoned AU2001244700A1 (en) 2000-04-03 2001-04-02 Process for producing amine derivatives

Country Status (11)

Country Link
US (1) US6784314B2 (en)
EP (1) EP1270545B1 (en)
KR (1) KR100769504B1 (en)
CN (4) CN100486957C (en)
AT (1) ATE413379T1 (en)
AU (1) AU2001244700A1 (en)
CA (1) CA2404736C (en)
CY (1) CY1108727T1 (en)
DE (1) DE60136446D1 (en)
ES (1) ES2312423T3 (en)
WO (1) WO2001074756A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2471531A1 (en) * 2001-12-26 2003-07-10 Takeda Chemical Industries, Ltd. Agents for treating mild cognitive impairment
CN100540546C (en) * 2004-05-05 2009-09-16 弗·哈夫曼-拉罗切有限公司 Arylsulfonylbenzodioxanes for modulating 5-HT6 receptors, 5-HT2A receptors, or both
JP5315611B2 (en) 2004-06-23 2013-10-16 小野薬品工業株式会社 Compound having S1P receptor binding ability and use thereof
CA2591810A1 (en) 2004-12-21 2006-06-29 F.Hoffmann-La Roche Ag Chroman derivatives and uses thereof in the treatment of cns disorders
PL1831191T3 (en) * 2004-12-21 2008-10-31 Hoffmann La Roche Chroman derivatives and their use as 5-ht receptor ligands
RU2388748C2 (en) * 2004-12-21 2010-05-10 Ф. Хоффманн-Ля Рош Аг Tetralin and indane derivatives and use thereof as 5-ht antagonists
JP4560551B2 (en) * 2004-12-21 2010-10-13 エフ．ホフマン−ラ ロシュ アーゲー Tetralin and indane derivatives and uses thereof
KR100899061B1 (en) * 2004-12-21 2009-05-25 에프. 호프만-라 로슈 아게 Tetralin and indane derivatives and uses thereof
ES2359735T3 (en) * 2005-11-03 2011-05-26 F. Hoffmann-La Roche Ag ARYLSULPHONYL CHROMANES AS 5-HT6 INHIBITORS.
KR101066306B1 (en) * 2006-06-20 2011-09-20 에프. 호프만-라 로슈 아게 Tetralin and indene derivatives and uses thereof
AU2007263076A1 (en) * 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Arylsulfonyl naphthalene derivatives and uses thereof
BRPI0713502A2 (en) * 2006-06-20 2012-03-13 F. Hoffmann-La Roche Ag arylsulfonamidyl tetraline derivatives and uses of these

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3630903A1 (en) 1986-09-11 1988-03-24 Thomae Gmbh Dr K NEW TETRAHYDRONAPHTHALINE AND INDANDERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THEM
DE3807813A1 (en) 1988-03-10 1989-09-21 Thomae Gmbh Dr K NEW BENZOCYCLOHEPEN DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3901814A1 (en) 1988-07-28 1990-02-01 Bayer Ag SUBSTITUTED AMINOMETHYLZETRALINE AND ITS HETEROCYCLIC ANALOG
WO1992015558A1 (en) 1991-03-01 1992-09-17 Zeria Pharmaceutical Co., Ltd. Indian derivative and thromboxane antagonist containing the same
AU2565595A (en) 1994-05-28 1995-12-21 Smithkline Beecham Plc Amide derivatives having 5ht1d-antagonist activity
ES2098186B1 (en) 1995-02-09 1998-02-01 Consejo Superior Investigacion PHARMACEUTICAL COMPOSITIONS BASED ON AMINOMETHYLINDOLS FOR THERAPEUTIC APPLICATION AS NEUROPROTECTORS IN PARKINSON AND ALZHEIMER DISEASES.
WO1998006691A2 (en) 1996-08-14 1998-02-19 Warner-Lambert Company Low molecular weight dendritic compounds as pharmaceutical agents
US6048877A (en) 1997-02-21 2000-04-11 Bristol-Myers Squibb Company Tetralone derivatives as antiarrhythmic agents
JP3868096B2 (en) * 1997-02-27 2007-01-17 武田薬品工業株式会社 AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME AND AGENT
WO1998038156A1 (en) 1997-02-27 1998-09-03 Takeda Chemical Industries, Ltd. Amine compounds, their production and use as amyloid-beta production inhibitors
JP4367982B2 (en) * 1997-07-18 2009-11-18 武田薬品工業株式会社 Production method of optical isomers

Also Published As

Publication number Publication date
EP1270545A4 (en) 2005-10-12
EP1270545A1 (en) 2003-01-02
US6784314B2 (en) 2004-08-31
CN1422244A (en) 2003-06-04
WO2001074756A1 (en) 2001-10-11
CN101058543B (en) 2010-05-26
CN1680332A (en) 2005-10-12
KR100769504B1 (en) 2007-10-23
CA2404736C (en) 2011-12-06
ES2312423T3 (en) 2009-03-01
EP1270545B1 (en) 2008-11-05
CY1108727T1 (en) 2014-04-09
ATE413379T1 (en) 2008-11-15
CN1680280A (en) 2005-10-12
DE60136446D1 (en) 2008-12-18
KR20020089424A (en) 2002-11-29
US20030139602A1 (en) 2003-07-24
CN101058543A (en) 2007-10-24
CA2404736A1 (en) 2002-10-02
CN100349872C (en) 2007-11-21
CN100486957C (en) 2009-05-13

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