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BRPI0318811B8 - derivados de ciclohexanol espirocíclicos - Google Patents

derivados de ciclohexanol espirocíclicos

Info

Publication number
BRPI0318811B8
BRPI0318811B8 BRPI0318811A BR0318811A BRPI0318811B8 BR PI0318811 B8 BRPI0318811 B8 BR PI0318811B8 BR PI0318811 A BRPI0318811 A BR PI0318811A BR 0318811 A BR0318811 A BR 0318811A BR PI0318811 B8 BRPI0318811 B8 BR PI0318811B8
Authority
BR
Brazil
Prior art keywords
spirocyclic
cyclohexanol derivatives
cyclohexanol
derivatives
medicaments
Prior art date
Application number
BRPI0318811A
Other languages
English (en)
Other versions
BRPI0318811B1 (pt
Inventor
Yvonne Kögel Babette
Sundermann Bernd
Henkel Birgitta
Hinze Claudia
Friderichs Elmar
Schick Hans
Sonnenschein Helmut
Linz Klaus
Jonathan Lipkin Michael
Aulenbacher Otto
Oberbörsch Stefan
Sarah Rose Valerie
Englberger Werner
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32185555&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0318811(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of BRPI0318811B1 publication Critical patent/BRPI0318811B1/pt
Publication of BRPI0318811B8 publication Critical patent/BRPI0318811B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/06—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing halogen atoms, or nitro or nitroso groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Psychiatry (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
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  • Gynecology & Obstetrics (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

derivados do ciclohexanol espirocíclicos. a invenção está relacionada com os derivados do ciclohexanol espirocíclicos, um método para a produção dos mesmos, medicamentos que incluem esses compostos e a utilização dos derivados do ciclohexanol espirocíclicos para a produção de medicamentos.
BRPI0318811A 2002-11-11 2003-11-05 derivados de ciclohexanol espirocíclicos BRPI0318811B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2002152667 DE10252667A1 (de) 2002-11-11 2002-11-11 Spirocyclische Cyclohexan-Derivate
DE102526672 2002-11-11
BRPI0315296 2003-11-05
PCT/EP2003/012305 WO2004043967A1 (de) 2002-11-11 2003-11-05 Spirocyclische cyclohexan-derivate

Publications (2)

Publication Number Publication Date
BRPI0318811B1 BRPI0318811B1 (pt) 2020-11-03
BRPI0318811B8 true BRPI0318811B8 (pt) 2021-05-25

Family

ID=32185555

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0315296A BRPI0315296B8 (pt) 2002-11-11 2003-11-05 derivados do ciclohexanol espirocíclicos, medicamento incluindo pelo menos um derivado do ciclohexano espirocíclico e uso de um derivado do ciclohexano espirocíclico
BRPI0318811A BRPI0318811B8 (pt) 2002-11-11 2003-11-05 derivados de ciclohexanol espirocíclicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0315296A BRPI0315296B8 (pt) 2002-11-11 2003-11-05 derivados do ciclohexanol espirocíclicos, medicamento incluindo pelo menos um derivado do ciclohexano espirocíclico e uso de um derivado do ciclohexano espirocíclico

Country Status (27)

Country Link
US (6) US7547707B2 (pt)
EP (4) EP2116544B1 (pt)
JP (4) JP4728645B2 (pt)
KR (2) KR101075810B1 (pt)
CN (2) CN100577664C (pt)
AR (2) AR041932A1 (pt)
AT (1) ATE441650T1 (pt)
AU (2) AU2003296563B2 (pt)
BR (2) BRPI0315296B8 (pt)
CA (1) CA2505555C (pt)
CO (1) CO5580765A2 (pt)
CY (2) CY1110558T1 (pt)
DE (2) DE10252667A1 (pt)
DK (2) DK2062898T3 (pt)
EC (1) ECSP055786A (pt)
ES (4) ES2438269T3 (pt)
IL (2) IL168473A (pt)
MX (1) MXPA05004959A (pt)
NO (2) NO331818B1 (pt)
NZ (1) NZ540575A (pt)
PE (1) PE20040830A1 (pt)
PL (2) PL215227B1 (pt)
PT (2) PT2062898E (pt)
RU (1) RU2354656C2 (pt)
SI (2) SI1560835T1 (pt)
WO (1) WO2004043967A1 (pt)
ZA (1) ZA200504725B (pt)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
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