BR9912188B1 - compostos derivados de 1,1-diàxido de benzo(b)tiepina, processo para sua preparaÇço, e seu uso, medicamentos contendo-os e processo para a preparaÇço desses. - Google Patents

compostos derivados de 1,1-diàxido de benzo(b)tiepina, processo para sua preparaÇço, e seu uso, medicamentos contendo-os e processo para a preparaÇço desses.

Info

Publication number: BR9912188B1
Authority: BR; Brazil
Prior art keywords: preparation; thiepine; benzo; medicaments containing; dioxide derivatives
Prior art date: 1998-06-10

Application number

BRPI9912188-3A

Other languages

English (en)

Other versions

BR9912188A (pt

Inventor

Wenderlin Frick

Alfons Enhsen

Heiner Glombik

Hubert Heuer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-10

Filing date

1999-05-28

Publication date

2010-12-14

1999-05-28 Application filed filed Critical

2001-04-10 Publication of BR9912188A publication Critical patent/BR9912188A/pt

2010-12-14 Publication of BR9912188B1 publication Critical patent/BR9912188B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
Biophysics (AREA)
Epidemiology (AREA)
Polymers & Plastics (AREA)
Diabetes (AREA)
Hematology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Urology & Nephrology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BRPI9912188-3A 1998-06-10 1999-05-28 compostos derivados de 1,1-diàxido de benzo(b)tiepina, processo para sua preparaÇço, e seu uso, medicamentos contendo-os e processo para a preparaÇço desses. BR9912188B1 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19825804A DE19825804C2 (de)	1998-06-10	1998-06-10	1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
PCT/EP1999/003701 WO1999064410A1 (de)	1998-06-10	1999-05-28	BENZO(b)THIEPIN-1,1-DIOXIDDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG

Publications (2)

Publication Number	Publication Date
BR9912188A BR9912188A (pt)	2001-04-10
BR9912188B1 true BR9912188B1 (pt)	2010-12-14

Family

ID=7870440

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BRPI9912188-3A BR9912188B1 (pt)	1998-06-10	1999-05-28	compostos derivados de 1,1-diàxido de benzo(b)tiepina, processo para sua preparaÇço, e seu uso, medicamentos contendo-os e processo para a preparaÇço desses.
BRPI9911123-3A BR9911123B1 (pt)	1998-06-10	1999-05-29	compostos derivados de diàxido de benzotiepina-1,1, processo para sua preparaÇço e seu uso, medicamentos contendo-os e processo para a preparaÇço desses.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
BRPI9911123-3A BR9911123B1 (pt)	1998-06-10	1999-05-29	compostos derivados de diàxido de benzotiepina-1,1, processo para sua preparaÇço e seu uso, medicamentos contendo-os e processo para a preparaÇço desses.

Country Status (25)

Country	Link
US (1)	US6387944B1 (pt)
EP (2)	EP1086092B1 (pt)
JP (2)	JP4374426B2 (pt)
KR (2)	KR100681721B1 (pt)
CN (2)	CN1127497C (pt)
AR (2)	AR018634A1 (pt)
AT (2)	ATE227715T1 (pt)
AU (2)	AU753275B2 (pt)
BR (2)	BR9912188B1 (pt)
CA (2)	CA2334775C (pt)
CZ (2)	CZ297989B6 (pt)
DE (3)	DE19825804C2 (pt)
DK (2)	DK1086092T3 (pt)
ES (2)	ES2182535T3 (pt)
HU (2)	HU229761B1 (pt)
ID (2)	ID28695A (pt)
IL (1)	IL140078A (pt)
NO (1)	NO327075B1 (pt)
NZ (1)	NZ508681A (pt)
PL (2)	PL196074B1 (pt)
PT (2)	PT1086092E (pt)
RU (2)	RU2215001C2 (pt)
TR (2)	TR200003634T2 (pt)
WO (2)	WO1999064410A1 (pt)
ZA (2)	ZA200007060B (pt)

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US6642268B2 (en)	1994-09-13	2003-11-04	G.D. Searle & Co.	Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6221897B1 (en) *	1998-06-10	2001-04-24	Aventis Pharma Deutschland Gmbh	Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
ATE242007T1 (de)	1998-12-23	2003-06-15	Searle Llc	Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen
SE0000772D0 (sv)	2000-03-08	2000-03-08	Astrazeneca Ab	Chemical compounds
EG26979A (en)	2000-12-21	2015-03-01	Astrazeneca Ab	Chemical compounds
DE10064402A1 (de) *	2000-12-21	2002-06-27	Aventis Pharma Gmbh	Diphenylazetidinonderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
KR100833089B1 (ko) *	2000-12-21	2008-05-29	사노피-아벤티스 도이칠란트 게엠베하	신규한 1,2-디페닐아제티딘온 및 당해 화합물을 함유하는 지질 대사 장애를 치료하기 위한 약제학적 조성물
PL366851A1 (en) *	2001-08-22	2005-02-07	Aventis Pharma Deutschland Gmbh	Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances, and the use thereof
GB0121337D0 (en)	2001-09-04	2001-10-24	Astrazeneca Ab	Chemical compounds
GB0121622D0 (en)	2001-09-07	2001-10-31	Astrazeneca Ab	Chemical compounds
GB0121621D0 (en)	2001-09-07	2001-10-31	Astrazeneca Ab	Chemical compounds
CN1582151A (zh)	2001-09-08	2005-02-16	阿斯特拉曾尼卡有限公司	用于治疗高脂血症、具有回肠胆汁酸转运(ibat)抑制活性的苯并硫氮杂䓬和苯并硫杂二氮杂䓬衍生物
EP1465885A4 (en)	2002-01-17	2005-04-27	Pharmacia Corp	NOVEL ALKYL / ARYL HYDROXY OR CETOTHIEPINE COMPOUNDS AS INHIBITORS OF BILIARY ACID TRANSPORT OF THE ILEAL TYPE AND ABSORPTION OF TAUROCHOLATE
GB0209467D0 (en)	2002-04-25	2002-06-05	Astrazeneca Ab	Chemical compounds
GB0213669D0 (en)	2002-06-14	2002-07-24	Astrazeneca Ab	Chemical compounds
SE0201937D0 (sv)	2002-06-20	2002-06-20	Astrazeneca Ab	Therapeutic agents
FR2848452B1 (fr) *	2002-12-12	2007-04-06	Aventis Pharma Sa	Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer
US20040138145A1 (en) *	2002-12-12	2004-07-15	Aventis Pharma S.A.	Application of intestinal biliary acid reuptake inhibitors for the prevention and treatment of alzheimer's disease
GB0304194D0 (en)	2003-02-25	2003-03-26	Astrazeneca Ab	Chemical compounds
GB0307918D0 (en)	2003-04-05	2003-05-14	Astrazeneca Ab	Therapeutic use
DE102006053636B4 (de) *	2006-11-14	2008-09-18	Sanofi-Aventis Deutschland Gmbh	Neue mit Cyclohexylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate und deren Verwendung
DE102006053635B4 (de) *	2006-11-14	2011-06-30	Sanofi-Aventis Deutschland GmbH, 65929	Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
US20100221513A1 (en) *	2008-09-05	2010-09-02	Wisconsin Alumni Research Foundation	Self sintering transparent nanoporous thin-films for use in self-cleaning, anti-fogging, anti-corrosion, anti-erosion electronic and optical applications
EP3593802A3 (en)	2010-05-26	2020-03-25	Satiogen Pharmaceuticals, Inc.	Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
BR112013010157B1 (pt)	2010-11-04	2020-02-04	Albireo Ab	iinibidores do ibat, seus usos, e composição e combinações farmacêuticas
US20130236541A1 (en)	2010-11-08	2013-09-12	Albireo Ab	Pharmaceutical combination comprising an ibat inhibitor and a bile acid binder
BR112014010223B8 (pt)	2011-10-28	2021-02-23	Lumena Pharmaceuticals Llc	uso de uma composição compreendendo inibidores de reciclagem de ácido de bílis e forma de dosagem pediátrica
AU2012328453B2 (en)	2011-10-28	2017-05-04	Shire Human Genetic Therapies, Inc.	Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
BR112015023646A2 (pt)	2013-03-15	2017-07-18	Lumena Pharmaceuticals Inc	inibidores de ácidos biliares de reciclagem para tratamento de colangite esclerosante primária e doença inflamatória do intestino
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KR20220082931A (ko)	2014-06-25	2022-06-17	이에이 파마 가부시키가이샤	고형 제제 및 그의 착색 방지 또는 착색 감소 방법
EP3012252A1 (en)	2014-10-24	2016-04-27	Ferring BV	Crystal modifications of elobixibat
EP3413878B1 (en)	2016-02-09	2021-04-14	Albireo AB	Oral cholestyramine formulation and use thereof
US10441605B2 (en)	2016-02-09	2019-10-15	Albireo Ab	Oral cholestyramine formulation and use thereof
US10786529B2 (en)	2016-02-09	2020-09-29	Albireo Ab	Oral cholestyramine formulation and use thereof
RU2750944C2 (ru)	2016-02-09	2021-07-06	Альбирео Аб	Пероральный состав холестирамина и его применение
US10441604B2 (en)	2016-02-09	2019-10-15	Albireo Ab	Cholestyramine pellets and methods for preparation thereof
CA3071182A1 (en)	2017-08-09	2019-02-14	Albireo Ab	Cholestyramine pellets, oral cholestyramine formulations and use thereof
EP3664781A1 (en)	2017-08-09	2020-06-17	Albireo AB	Cholestyramine granules, oral cholestyramine formulations and use thereof
EP3802504B1 (en)	2018-06-05	2023-01-18	Albireo AB	Benzothia(di)azepine compounds and their use as bile acid modulators
US10793534B2 (en)	2018-06-05	2020-10-06	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
US11801226B2 (en)	2018-06-20	2023-10-31	Albireo Ab	Pharmaceutical formulation of odevixibat
PT3810581T (pt)	2018-06-20	2025-03-05	Albireo Ab	Modificações cristalinas de odevixibat
US11007142B2 (en)	2018-08-09	2021-05-18	Albireo Ab	Oral cholestyramine formulation and use thereof
US11549878B2 (en)	2018-08-09	2023-01-10	Albireo Ab	In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US10722457B2 (en)	2018-08-09	2020-07-28	Albireo Ab	Oral cholestyramine formulation and use thereof
AU2020218908B2 (en)	2019-02-06	2025-01-23	Albireo Ab	Benzothiadiazepine compounds and their use as bile acid modulators
CA3127408A1 (en)	2019-02-06	2020-08-13	Albireo Ab	Benzothiazepine compounds and their use as bile acid modulators
US10975045B2 (en)	2019-02-06	2021-04-13	Aibireo AB	Benzothiazepine compounds and their use as bile acid modulators
US10941127B2 (en)	2019-02-06	2021-03-09	Albireo Ab	Benzothiadiazepine compounds and their use as bile acid modulators
BR112021015799A2 (pt)	2019-02-12	2022-01-18	Mirum Pharmaceuticals Inc	Métodos para aumentar o crescimento em pacientes pediátricos com doença colestática do fígado
WO2021110886A1 (en)	2019-12-04	2021-06-10	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
HUE065571T2 (hu)	2019-12-04	2024-06-28	Albireo Ab	Benzotia(di)azepin vegyületek és alkalmazásuk epesav modulátorként
TWI867107B (zh)	2019-12-04	2024-12-21	瑞典商艾爾比瑞歐公司	苯并噻(二)氮呯化合物及其作為膽酸調節劑之用途
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ES2972045T3 (es)	2019-12-04	2024-06-10	Albireo Ab	Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar
ES3029063T3 (en)	2019-12-04	2025-06-23	Albireo Ab	Benzothiadiazepine compounds and their use as bile acid modulators
US11014898B1 (en)	2020-12-04	2021-05-25	Albireo Ab	Benzothiazepine compounds and their use as bile acid modulators
MX2022006731A (es)	2019-12-04	2022-06-09	Albireo Ab	Compuestos de benzoti(di)azepina y su uso como moduladores del acido biliar.
CA3158181A1 (en)	2019-12-04	2021-06-10	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
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WO2022029101A1 (en)	2020-08-03	2022-02-10	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
AU2021379076A1 (en)	2020-11-12	2023-06-08	Albireo Ab	Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
KR20230117393A (ko)	2020-12-04	2023-08-08	알비레오 에이비	벤조티아(디)아제핀 화합물 및 담즙산 조절제로서의용도
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CN119343140A (zh)	2022-06-09	2025-01-21	阿尔比里奥公司	治疗肝炎
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Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5994391A (en) *	1994-09-13	1999-11-30	G.D. Searle And Company	Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
PT781278E (pt) *	1994-09-13	2001-08-30	Monsanto Co	Novas benzotiepinas com actividade inibidora do transporte de acido biliar ileal e da remocao do taurocolato
CA2248586A1 (en) *	1996-03-11	1997-09-18	G.D. Searle & Co.	Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6221897B1 (en) *	1998-06-10	2001-04-24	Aventis Pharma Deutschland Gmbh	Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
US6096780A (en) *	1998-08-20	2000-08-01	Takeda Chemical Industries, Ltd.	Quaternary ammonium salts and their use

1998
- 1998-06-10 DE DE19825804A patent/DE19825804C2/de not_active Expired - Lifetime
1999
- 1999-05-28 AT AT99927784T patent/ATE227715T1/de active
- 1999-05-28 KR KR1020007013964A patent/KR100681721B1/ko not_active Expired - Fee Related
- 1999-05-28 JP JP2000553419A patent/JP4374426B2/ja not_active Expired - Fee Related
- 1999-05-28 PL PL344827A patent/PL196074B1/pl unknown
- 1999-05-28 EP EP99927784A patent/EP1086092B1/de not_active Expired - Lifetime
- 1999-05-28 US US09/719,047 patent/US6387944B1/en not_active Expired - Lifetime
- 1999-05-28 PT PT99927784T patent/PT1086092E/pt unknown
- 1999-05-28 WO PCT/EP1999/003701 patent/WO1999064410A1/de not_active Ceased
- 1999-05-28 AU AU45019/99A patent/AU753275B2/en not_active Ceased
- 1999-05-28 RU RU2001101491/04A patent/RU2215001C2/ru not_active IP Right Cessation
- 1999-05-28 CA CA002334775A patent/CA2334775C/en not_active Expired - Fee Related
- 1999-05-28 TR TR2000/03634T patent/TR200003634T2/xx unknown
- 1999-05-28 ID IDW20002562A patent/ID28695A/id unknown
- 1999-05-28 DK DK99927784T patent/DK1086092T3/da active
- 1999-05-28 BR BRPI9912188-3A patent/BR9912188B1/pt not_active IP Right Cessation
- 1999-05-28 CZ CZ20004592A patent/CZ297989B6/cs not_active IP Right Cessation
- 1999-05-28 HU HU0102256 patent/HU229761B1/hu not_active IP Right Cessation
- 1999-05-28 DE DE59903411T patent/DE59903411D1/de not_active Expired - Lifetime
- 1999-05-28 CN CN99807171A patent/CN1127497C/zh not_active Expired - Fee Related
- 1999-05-28 ES ES99927784T patent/ES2182535T3/es not_active Expired - Lifetime
- 1999-05-29 KR KR1020007013931A patent/KR100562184B1/ko not_active Expired - Lifetime
- 1999-05-29 BR BRPI9911123-3A patent/BR9911123B1/pt not_active IP Right Cessation
- 1999-05-29 WO PCT/EP1999/003743 patent/WO1999064409A2/de not_active Ceased
- 1999-05-29 IL IL14007899A patent/IL140078A/en not_active IP Right Cessation
- 1999-05-29 DE DE59908522T patent/DE59908522D1/de not_active Expired - Lifetime
- 1999-05-29 AT AT99927802T patent/ATE259372T1/de active
- 1999-05-29 JP JP2000553418A patent/JP3374129B2/ja not_active Expired - Lifetime
- 1999-05-29 CN CNB998071722A patent/CN1152039C/zh not_active Expired - Lifetime
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- 1999-05-29 DK DK99927802T patent/DK1086113T3/da active
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- 1999-05-29 RU RU2001101499/04A patent/RU2220141C2/ru active
- 1999-05-29 EP EP99927802A patent/EP1086113B1/de not_active Expired - Lifetime
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- 1999-06-08 AR ARP990102716A patent/AR018634A1/es active IP Right Grant
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2000
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Also Published As

Publication number	Publication date
RU2220141C2 (ru)	2003-12-27
PL196057B1 (pl)	2007-11-30
TR200003634T2 (tr)	2001-06-21
EP1086092A1 (de)	2001-03-28
HUP0102256A3 (en)	2002-04-29
IL140078A0 (en)	2002-02-10
KR20010052701A (ko)	2001-06-25
CZ297925B6 (cs)	2007-05-02
ID28695A (id)	2001-06-28
HK1039490A1 (en)	2002-04-26
AU752633B2 (en)	2002-09-26
AU4503199A (en)	1999-12-30
DE19825804C2 (de)	2000-08-24
JP3374129B2 (ja)	2003-02-04
JP2002517491A (ja)	2002-06-18
EP1086092B1 (de)	2002-11-13
ATE227715T1 (de)	2002-11-15
CN1152039C (zh)	2004-06-02
PT1086113E (pt)	2004-06-30
TR200003632T2 (tr)	2001-04-20
CN1305469A (zh)	2001-07-25
CA2334775A1 (en)	1999-12-16
NO20006251L (no)	2001-02-07
NO327075B1 (no)	2009-04-20
NZ508681A (en)	2002-06-28
WO1999064410A1 (de)	1999-12-16
CA2334775C (en)	2009-10-13
WO1999064409A3 (de)	2000-03-02
ZA200007060B (en)	2001-07-18
ATE259372T1 (de)	2004-02-15
WO1999064409A2 (de)	1999-12-16
DE59903411D1 (de)	2002-12-19
ZA200007061B (en)	2001-07-18
AU4501999A (en)	1999-12-30
HU228570B1 (en)	2013-04-29
CN1305487A (zh)	2001-07-25
CZ20004591A3 (cs)	2001-04-11
JP4374426B2 (ja)	2009-12-02
DK1086092T3 (da)	2003-03-10
JP2002517490A (ja)	2002-06-18
HUP0102256A1 (hu)	2001-12-28
IL140078A (en)	2004-08-31
ES2182535T3 (es)	2003-03-01
US6387944B1 (en)	2002-05-14
ID26876A (id)	2001-02-15
CN1127497C (zh)	2003-11-12
ES2215387T3 (es)	2004-10-01
KR20010052682A (ko)	2001-06-25
RU2215001C2 (ru)	2003-10-27
AR018633A1 (es)	2001-11-28
AR018634A1 (es)	2001-11-28
NO20006251D0 (no)	2000-12-08
HK1036799A1 (en)	2002-01-18
BR9911123A (pt)	2006-01-03
PL344827A1 (en)	2001-11-19
EP1086113B1 (de)	2004-02-11
DE19825804A1 (de)	1999-12-16
HUP0102554A3 (en)	2002-12-28
KR100681721B1 (ko)	2007-02-15
BR9912188A (pt)	2001-04-10
CA2334773A1 (en)	1999-12-16
DK1086113T3 (da)	2004-05-24
DE59908522D1 (de)	2004-03-18
AU753275B2 (en)	2002-10-10
KR100562184B1 (ko)	2006-03-20
PL345901A1 (en)	2002-01-14
CZ297989B6 (cs)	2007-05-16
HUP0102554A1 (hu)	2001-10-28
PT1086092E (pt)	2003-03-31
PL196074B1 (pl)	2007-12-31
EP1086113A2 (de)	2001-03-28
BR9911123B1 (pt)	2010-12-14
CA2334773C (en)	2009-05-26
CZ20004592A3 (cs)	2001-04-11
HU229761B1 (hu)	2014-06-30

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BR9912980B1 (pt)	2013-10-22	Composição farmacêutica administrável oralmente, tablete de mascar contendo a mesma e utilização da mesma
ATE242258T1 (de)	2003-06-15	Hypolipidemische 1,4-benzothiazepin-1,1-dioxide
BR9707839A (pt)	1999-07-27	Primido-Ú5,4-D¾-primidas medicamentos contendo esses compostos sua aplicação e processo para a sua preparação
DE69009315D1 (de)	1994-07-07	Cinnamamidderivate.
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BRPI9810519B1 (pt)	2012-02-22	derivados de 4''-substituìdo-9-desoxo-9a-aza-9a-homoeritromicina a e composição farmacêutica compreendendo os mesmos.
DE69020512D1 (de)	1995-08-03	Etikettendruckgerät.
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BR9814774B1 (pt)	2010-10-05	processo para a preparação de (-)cis-3-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-piperidi na e intermediários para sua preparação.
PT100902A (pt)	1993-11-30	Derivados de mupirocina, uteis como agentes antibacterianos e antimicoplasmaticos,e processo para a sua preparacao
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PT1053224E (pt)	2002-12-31	Bifenilsulfonilcianamida, processo para a sua preparacao e sua utilizacao como medicamento
PT1157020E (pt)	2003-01-31	1,2,3,4,5,6-hexa-hidro-2,6-metano-3-benzazocin-10-ois substituidos processo para a sua preparacao e sua utilizacao como medicamentos
BR9202327A (pt)	1993-01-19	Composto heterociclico,processo para a sua preparacao,preparado farmaceutico e processo para a sua preparacao
BR9803237B1 (pt)	2009-05-05	derivados de uréia, composição farmacêutica e processo para sua preparação.
FI955142A7 (fi)	1995-10-27	Bentso(f)kinoksaliinidionijohdannaisia, niiden valmistus ja käyttö lää kkeinä
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DE69013215D1 (de)	1994-11-17	Elektrophotographisches Druckgerät.

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