BR9911123B1 - compostos derivados de diàxido de benzotiepina-1,1, processo para sua preparaÇço e seu uso, medicamentos contendo-os e processo para a preparaÇço desses. - Google Patents

compostos derivados de diàxido de benzotiepina-1,1, processo para sua preparaÇço e seu uso, medicamentos contendo-os e processo para a preparaÇço desses.

Info

Publication number: BR9911123B1
Authority: BR; Brazil
Prior art keywords: processes; preparation; benzothiepine; derivative compounds; medicaments containing
Prior art date: 1998-06-10

Application number

BRPI9911123-3A

Other languages

English (en)

Other versions

BR9911123A (pt

Inventor

Wendelin Frick

Alfons Enhsen

Heiner Glombik

Hubert Heuer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-10

Filing date

1999-05-29

Publication date

2010-12-14

1999-05-29 Application filed filed Critical

2006-01-03 Publication of BR9911123A publication Critical patent/BR9911123A/pt

2010-12-14 Publication of BR9911123B1 publication Critical patent/BR9911123B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Polymers & Plastics (AREA)
Urology & Nephrology (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BRPI9911123-3A 1998-06-10 1999-05-29 compostos derivados de diàxido de benzotiepina-1,1, processo para sua preparaÇço e seu uso, medicamentos contendo-os e processo para a preparaÇço desses. BR9911123B1 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19825804A DE19825804C2 (de)	1998-06-10	1998-06-10	1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
PCT/EP1999/003743 WO1999064409A2 (de)	1998-06-10	1999-05-29	Benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Publications (2)

Publication Number	Publication Date
BR9911123A BR9911123A (pt)	2006-01-03
BR9911123B1 true BR9911123B1 (pt)	2010-12-14

Family

ID=7870440

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BRPI9912188-3A BR9912188B1 (pt)	1998-06-10	1999-05-28	compostos derivados de 1,1-diàxido de benzo(b)tiepina, processo para sua preparaÇço, e seu uso, medicamentos contendo-os e processo para a preparaÇço desses.
BRPI9911123-3A BR9911123B1 (pt)	1998-06-10	1999-05-29	compostos derivados de diàxido de benzotiepina-1,1, processo para sua preparaÇço e seu uso, medicamentos contendo-os e processo para a preparaÇço desses.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
BRPI9912188-3A BR9912188B1 (pt)	1998-06-10	1999-05-28	compostos derivados de 1,1-diàxido de benzo(b)tiepina, processo para sua preparaÇço, e seu uso, medicamentos contendo-os e processo para a preparaÇço desses.

Country Status (25)

Country	Link
US (1)	US6387944B1 (pt)
EP (2)	EP1086092B1 (pt)
JP (2)	JP4374426B2 (pt)
KR (2)	KR100681721B1 (pt)
CN (2)	CN1127497C (pt)
AR (2)	AR018633A1 (pt)
AT (2)	ATE227715T1 (pt)
AU (2)	AU753275B2 (pt)
BR (2)	BR9912188B1 (pt)
CA (2)	CA2334775C (pt)
CZ (2)	CZ297989B6 (pt)
DE (3)	DE19825804C2 (pt)
DK (2)	DK1086092T3 (pt)
ES (2)	ES2182535T3 (pt)
HU (2)	HU229761B1 (pt)
ID (2)	ID28695A (pt)
IL (1)	IL140078A (pt)
NO (1)	NO327075B1 (pt)
NZ (1)	NZ508681A (pt)
PL (2)	PL196074B1 (pt)
PT (2)	PT1086092E (pt)
RU (2)	RU2215001C2 (pt)
TR (2)	TR200003634T2 (pt)
WO (2)	WO1999064410A1 (pt)
ZA (2)	ZA200007060B (pt)

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US6221897B1 (en) *	1998-06-10	2001-04-24	Aventis Pharma Deutschland Gmbh	Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
WO2000038721A1 (en)	1998-12-23	2000-07-06	G.D. Searle Llc	Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
SE0000772D0 (sv)	2000-03-08	2000-03-08	Astrazeneca Ab	Chemical compounds
CN1217927C (zh) *	2000-12-21	2005-09-07	阿文蒂斯药物德国有限公司	新的1,2－二苯基氮杂环丁烷酮、其制备方法、含有所述化合物的药物及其在治疗脂质代谢病症中的应用
DE10064402A1 (de) *	2000-12-21	2002-06-27	Aventis Pharma Gmbh	Diphenylazetidinonderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
EG26979A (en)	2000-12-21	2015-03-01	Astrazeneca Ab	Chemical compounds
WO2003018024A1 (de) *	2001-08-22	2003-03-06	Aventis Pharma Deutschland Gmbh	Kombinationspräparate von 1,4- benzothiepin-1,1-dioxidderivaten mit weiteren wirkstoffen und deren verwendung
GB0121337D0 (en)	2001-09-04	2001-10-24	Astrazeneca Ab	Chemical compounds
GB0121621D0 (en)	2001-09-07	2001-10-31	Astrazeneca Ab	Chemical compounds
GB0121622D0 (en)	2001-09-07	2001-10-31	Astrazeneca Ab	Chemical compounds
PL216023B1 (pl)	2001-09-08	2014-02-28	Astrazeneca Ab	Pochodna benzotiadiazepiny, kompozycja farmaceutyczna zawierajaca pochodna benzotiadiazepiny oraz zastosowania pochodnej benzotiadiazepiny
WO2003061604A2 (en)	2002-01-17	2003-07-31	Pharmacia Corporation	Novel alkyl/aryl hydroxy or keto thiepines.
GB0209467D0 (en)	2002-04-25	2002-06-05	Astrazeneca Ab	Chemical compounds
GB0213669D0 (en)	2002-06-14	2002-07-24	Astrazeneca Ab	Chemical compounds
SE0201937D0 (sv)	2002-06-20	2002-06-20	Astrazeneca Ab	Therapeutic agents
FR2848452B1 (fr) *	2002-12-12	2007-04-06	Aventis Pharma Sa	Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer
US20040138145A1 (en) *	2002-12-12	2004-07-15	Aventis Pharma S.A.	Application of intestinal biliary acid reuptake inhibitors for the prevention and treatment of alzheimer's disease
GB0304194D0 (en)	2003-02-25	2003-03-26	Astrazeneca Ab	Chemical compounds
GB0307918D0 (en)	2003-04-05	2003-05-14	Astrazeneca Ab	Therapeutic use
DE102006053636B4 (de) *	2006-11-14	2008-09-18	Sanofi-Aventis Deutschland Gmbh	Neue mit Cyclohexylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate und deren Verwendung
DE102006053635B4 (de) *	2006-11-14	2011-06-30	Sanofi-Aventis Deutschland GmbH, 65929	Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
US20100221513A1 (en) *	2008-09-05	2010-09-02	Wisconsin Alumni Research Foundation	Self sintering transparent nanoporous thin-films for use in self-cleaning, anti-fogging, anti-corrosion, anti-erosion electronic and optical applications
EP2575821B1 (en)	2010-05-26	2015-08-12	Satiogen Pharmaceuticals, Inc.	Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
AU2011326871B2 (en)	2010-11-04	2015-02-12	Albireo Ab	IBAT inhibitors for the treatment of liver diseases
WO2012064267A1 (en)	2010-11-08	2012-05-18	Albireo Ab	A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder
CA2852957C (en)	2011-10-28	2020-08-04	Lumena Pharmaceuticals, Inc.	Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
JP6217938B2 (ja)	2011-10-28	2017-10-25	ルメナファーマシューティカルズエルエルシー	小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤
EP2968262A1 (en)	2013-03-15	2016-01-20	Lumena Pharmaceuticals, Inc.	Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease
WO2014144650A2 (en)	2013-03-15	2014-09-18	Lumena Pharmaceuticals, Inc.	Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
JO3301B1 (ar)	2013-04-26	2018-09-16	Albireo Ab	تعديلات بلورية على إيلوبيكسيبات
KR20220082931A (ko)	2014-06-25	2022-06-17	이에이 파마 가부시키가이샤	고형 제제 및 그의 착색 방지 또는 착색 감소 방법
EP3012252A1 (en)	2014-10-24	2016-04-27	Ferring BV	Crystal modifications of elobixibat
US10441605B2 (en)	2016-02-09	2019-10-15	Albireo Ab	Oral cholestyramine formulation and use thereof
US10441604B2 (en)	2016-02-09	2019-10-15	Albireo Ab	Cholestyramine pellets and methods for preparation thereof
JP6954926B2 (ja)	2016-02-09	2021-10-27	アルビレオ・アクチボラグ	経口コレスチラミン製剤及びその使用
CN108601745B (zh)	2016-02-09	2021-12-07	阿尔比里奥公司	口服考来烯胺制剂及其用途
US10786529B2 (en)	2016-02-09	2020-09-29	Albireo Ab	Oral cholestyramine formulation and use thereof
WO2019032026A1 (en)	2017-08-09	2019-02-14	Albireo Ab	CHOLESTYRAMINE GRANULES, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE
JP7328207B2 (ja)	2017-08-09	2023-08-16	アルビレオ・アクチボラグ	コレスチラミンペレット、経口コレスチラミン製剤、及びそれらの使用
EP3802504B1 (en)	2018-06-05	2023-01-18	Albireo AB	Benzothia(di)azepine compounds and their use as bile acid modulators
US10793534B2 (en)	2018-06-05	2020-10-06	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
MX2020013839A (es)	2018-06-20	2021-03-25	Albireo Ab	Formulacion farmaceutica de odevixibat.
US11801226B2 (en)	2018-06-20	2023-10-31	Albireo Ab	Pharmaceutical formulation of odevixibat
US11549878B2 (en)	2018-08-09	2023-01-10	Albireo Ab	In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US10722457B2 (en)	2018-08-09	2020-07-28	Albireo Ab	Oral cholestyramine formulation and use thereof
US11007142B2 (en)	2018-08-09	2021-05-18	Albireo Ab	Oral cholestyramine formulation and use thereof
DK3921028T3 (da)	2019-02-06	2023-01-23	Albireo Ab	Benzothiadiazepinforbindelser og anvendelse deraf som galdesyremodulatorer
EP3921027B1 (en)	2019-02-06	2023-07-19	Albireo AB	Benzothiazepine compounds and their use as bile acid modulators
US10975045B2 (en)	2019-02-06	2021-04-13	Aibireo AB	Benzothiazepine compounds and their use as bile acid modulators
US10941127B2 (en)	2019-02-06	2021-03-09	Albireo Ab	Benzothiadiazepine compounds and their use as bile acid modulators
BR112021015815A2 (pt)	2019-02-12	2022-01-18	Mirum Pharmaceuticals Inc	Métodos para tratar colestase
HUE065571T2 (hu)	2019-12-04	2024-06-28	Albireo Ab	Benzotia(di)azepin vegyületek és alkalmazásuk epesav modulátorként
CN114761080B (zh)	2019-12-04	2024-07-23	阿尔比里奥公司	苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
TWI871392B (zh)	2019-12-04	2025-02-01	瑞典商艾爾比瑞歐公司	苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
AR120682A1 (es)	2019-12-04	2022-03-09	Albireo Ab	Compuestos de benzotiadiazepina y su uso como moduladores del ácido biliar
US11014898B1 (en)	2020-12-04	2021-05-25	Albireo Ab	Benzothiazepine compounds and their use as bile acid modulators
AR120674A1 (es)	2019-12-04	2022-03-09	Albireo Ab	Compuestos de benzotiazepina y su uso como ácido biliar
WO2021110884A1 (en)	2019-12-04	2021-06-10	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
CN114786772B (zh)	2019-12-04	2024-04-09	阿尔比里奥公司	苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
JP7695242B2 (ja)	2019-12-04	2025-06-18	アルビレオ・アクチボラグ	ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
CA3158184A1 (en)	2019-12-04	2021-08-10	Albireo Ab	Benzothiadiazepine compounds and their use as bile acid modulators
JP7748451B2 (ja)	2020-08-03	2025-10-02	アルビレオ・アクチボラグ	ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
WO2022029101A1 (en)	2020-08-03	2022-02-10	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
EP4243831A1 (en)	2020-11-12	2023-09-20	Albireo AB	Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
KR20230117393A (ko)	2020-12-04	2023-08-08	알비레오 에이비	벤조티아(디)아제핀 화합물 및 담즙산 조절제로서의용도
TW202313579A (zh)	2021-06-03	2023-04-01	瑞典商艾爾比瑞歐公司	苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
CA3257752A1 (en)	2022-06-09	2023-12-14	Albireo Ab	Treating hepatitis
US20240067617A1 (en)	2022-07-05	2024-02-29	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
JP2025539895A (ja)	2022-12-09	2025-12-09	アルビレオ・アクチボラグ	腎臓の疾患の治療におけるａｓｂｔ阻害剤
WO2025146508A1 (en)	2024-01-05	2025-07-10	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
WO2025146507A1 (en)	2024-01-05	2025-07-10	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5994391A (en) *	1994-09-13	1999-11-30	G.D. Searle And Company	Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
ES2155136T3 (es) *	1994-09-13	2001-05-01	Monsanto Co	Nuevas benzotiepinas que tienen actividad como inhibidores del transporte de acido biliar iliaco y la captacion de taurocolato.
CN1515567A (zh) *	1996-03-11	2004-07-28	G.D.ɪ��˾	具有作为回肠胆汁酸转运和牛磺胆酸盐吸收抑制剂活性的新的苯并噻庚因
US6221897B1 (en) *	1998-06-10	2001-04-24	Aventis Pharma Deutschland Gmbh	Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
CA2337307A1 (en) *	1998-08-20	2000-03-02	Osamu Nishimura	Quaternary ammonium salts and their use

1998
- 1998-06-10 DE DE19825804A patent/DE19825804C2/de not_active Expired - Lifetime
1999
- 1999-05-28 EP EP99927784A patent/EP1086092B1/de not_active Expired - Lifetime
- 1999-05-28 RU RU2001101491/04A patent/RU2215001C2/ru not_active IP Right Cessation
- 1999-05-28 PL PL344827A patent/PL196074B1/pl unknown
- 1999-05-28 ES ES99927784T patent/ES2182535T3/es not_active Expired - Lifetime
- 1999-05-28 WO PCT/EP1999/003701 patent/WO1999064410A1/de not_active Ceased
- 1999-05-28 AT AT99927784T patent/ATE227715T1/de active
- 1999-05-28 BR BRPI9912188-3A patent/BR9912188B1/pt not_active IP Right Cessation
- 1999-05-28 JP JP2000553419A patent/JP4374426B2/ja not_active Expired - Fee Related
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- 1999-05-28 HU HU0102256 patent/HU229761B1/hu not_active IP Right Cessation
- 1999-05-28 DE DE59903411T patent/DE59903411D1/de not_active Expired - Lifetime
- 1999-05-28 ID IDW20002562A patent/ID28695A/id unknown
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- 1999-05-28 CN CN99807171A patent/CN1127497C/zh not_active Expired - Fee Related
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Also Published As

Publication number	Publication date
NO327075B1 (no)	2009-04-20
HUP0102256A1 (hu)	2001-12-28
WO1999064409A3 (de)	2000-03-02
CN1305487A (zh)	2001-07-25
PL196074B1 (pl)	2007-12-31
DK1086113T3 (da)	2004-05-24
CZ20004592A3 (cs)	2001-04-11
PT1086113E (pt)	2004-06-30
RU2215001C2 (ru)	2003-10-27
ID28695A (id)	2001-06-28
KR100562184B1 (ko)	2006-03-20
PL345901A1 (en)	2002-01-14
ATE227715T1 (de)	2002-11-15
HK1039490A1 (en)	2002-04-26
JP3374129B2 (ja)	2003-02-04
ATE259372T1 (de)	2004-02-15
PL196057B1 (pl)	2007-11-30
TR200003634T2 (tr)	2001-06-21
CN1305469A (zh)	2001-07-25
CZ297989B6 (cs)	2007-05-16
PT1086092E (pt)	2003-03-31
CN1152039C (zh)	2004-06-02
BR9912188A (pt)	2001-04-10
CA2334773A1 (en)	1999-12-16
ID26876A (id)	2001-02-15
PL344827A1 (en)	2001-11-19
DE19825804A1 (de)	1999-12-16
TR200003632T2 (tr)	2001-04-20
IL140078A (en)	2004-08-31
EP1086092A1 (de)	2001-03-28
NO20006251D0 (no)	2000-12-08
CN1127497C (zh)	2003-11-12
JP4374426B2 (ja)	2009-12-02
CZ20004591A3 (cs)	2001-04-11
CZ297925B6 (cs)	2007-05-02
WO1999064409A2 (de)	1999-12-16
ES2182535T3 (es)	2003-03-01
HU229761B1 (hu)	2014-06-30
ES2215387T3 (es)	2004-10-01
HUP0102256A3 (en)	2002-04-29
AU752633B2 (en)	2002-09-26
NO20006251L (no)	2001-02-07
KR20010052682A (ko)	2001-06-25
EP1086092B1 (de)	2002-11-13
HK1036799A1 (en)	2002-01-18
ZA200007060B (en)	2001-07-18
KR100681721B1 (ko)	2007-02-15
HUP0102554A3 (en)	2002-12-28
CA2334775A1 (en)	1999-12-16
EP1086113A2 (de)	2001-03-28
HU228570B1 (en)	2013-04-29
IL140078A0 (en)	2002-02-10
AR018633A1 (es)	2001-11-28
AR018634A1 (es)	2001-11-28
AU4501999A (en)	1999-12-30
DK1086092T3 (da)	2003-03-10
ZA200007061B (en)	2001-07-18
WO1999064410A1 (de)	1999-12-16
EP1086113B1 (de)	2004-02-11
DE59908522D1 (de)	2004-03-18
US6387944B1 (en)	2002-05-14
JP2002517491A (ja)	2002-06-18
JP2002517490A (ja)	2002-06-18
DE19825804C2 (de)	2000-08-24
AU4503199A (en)	1999-12-30
DE59903411D1 (de)	2002-12-19
BR9912188B1 (pt)	2010-12-14
AU753275B2 (en)	2002-10-10
KR20010052701A (ko)	2001-06-25
CA2334775C (en)	2009-10-13
CA2334773C (en)	2009-05-26
BR9911123A (pt)	2006-01-03
HUP0102554A1 (hu)	2001-10-28
RU2220141C2 (ru)	2003-12-27
NZ508681A (en)	2002-06-28

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2009-04-28	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2009-04-28	B15K	Others concerning applications: alteration of classification	Free format text: ALTERADA DA INT.CL: C07D 337/08, A61K 31/38, A61K 31/382, A61K 31/7028, A61K 31/7042, A61K 38/00, A61P 1/16, A61P 3/06, A61P 9/10, A61P 13/04, C07H 7/06, C07H 15/26, C07K 5/033, C07K 5/06, C07K 5/068, C08G 65/329 Ipc: C07D 337/08 (2009.01), A61K 31/38 (2009.01), A61K
2010-03-30	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2010-12-14	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 14/12/2010, OBSERVADAS AS CONDICOES LEGAIS.
2021-01-05	B21A	Patent or certificate of addition expired [chapter 21.1 patent gazette]	Free format text: PATENTE EXTINTA EM 14.12.2020