BR9910674A - Derivados de primidin-aminometil-piridina, seu preparo e seu uso no controle de bactérias helicobacter - Google Patents
Derivados de primidin-aminometil-piridina, seu preparo e seu uso no controle de bactérias helicobacterInfo
- Publication number
- BR9910674A BR9910674A BR9910674-4A BR9910674A BR9910674A BR 9910674 A BR9910674 A BR 9910674A BR 9910674 A BR9910674 A BR 9910674A BR 9910674 A BR9910674 A BR 9910674A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- pyrimidine
- radical
- hydrogen
- control
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE PIRIMIDIN-AMINOMETIL-PIRIDINA, SEU PREPARO E SEU USO NO CONTROLE DE BACTéRIAS HELICOBACTER"<D>. Compostos da fórmula (I) na qual R1, R2 e R3 são hidrogênio, C1-4 alquila ou halogênio, R4, R5, R6 e R9 são hidrogênio ou C1-4 alquila, R7 e R8 são hidrogênio, C1-4 alquila, C1-4 alcóxi ou halogênio, A é C1-7 alquileno, C2-7 alquenileno, C3-7 cicloalquileno ou fenileno, G é hidrogênio, hidroxila, C1-7 alquila, C1-4 alquila a qual é completa ou principalmente substituída por flúor, C2-7 alquenila, C3-7 cicloalquila, um radical mono ou di-C1-4 alquilcarbamoíla ou tiocarbamoíla, um radical N-C1-4 alquil-N'-cianoamidino, um radical 1-N-C1-4-alquilamino-2-nitroetileno, um radical N-2-propinil-N'-cianoamidino, um radical aminosulfonilamidino, o radical -N(R10)R11, a parte do composto da fórmula (I) ligada a A (incluindo X e via X), o radical glicopiranosídeo ou um sistema cíclico ou um sistema bicíclico o qual é não substituído ou substituído por R12 e R13 e o qual é selecionado do grupo consistindo em benzeno, naftaleno, furano, tiofeno, pirrol, oxazol, oxazolina, oxazolidinona, isoxazol, tiazol, tiazolina, isotiazol, imidazol, imidazolina, pirazol, triazol, tetrazol, tiadiazol, 1-óxido de tiadiazol, oxadiazol, piridina, N-óxido de piridina, pirimidina, halopirimidina, piperidina, triazina, piridona, benzimidazol, imidazopiridina, benzotiazol, benzoxazol, quinolina e imidazopiridazina, X é O (oxigênio), N-C1-4 alquila, NH ou S, Y é O (oxigênio), N-C1-4 alquila, NH, S, 1,4-piperazinileno ou 1,4-piperidinileno, Z é O (oxigênio), N-C1-4 alquila, NH ou S ou CO, m é um número de 1 a 7, n é um número de 0 a 4, t é o número 0, 1 ou 2 e u é o número 0 ou 1 e seus sais, são adequados para o controle de bactérias Helicobacter.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98109408 | 1998-05-23 | ||
| PCT/EP1999/003477 WO1999061439A1 (en) | 1998-05-23 | 1999-05-20 | Pyrimidin-aminomethyl-pyridine derivatives, their preparation and their use in the control of helicobacter bacteria |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9910674A true BR9910674A (pt) | 2001-01-30 |
Family
ID=8231991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9910674-4A BR9910674A (pt) | 1998-05-23 | 1999-05-20 | Derivados de primidin-aminometil-piridina, seu preparo e seu uso no controle de bactérias helicobacter |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6395732B1 (pt) |
| EP (1) | EP1091957B1 (pt) |
| JP (1) | JP2002516324A (pt) |
| KR (1) | KR20010025095A (pt) |
| CN (1) | CN1302297A (pt) |
| AT (1) | ATE284880T1 (pt) |
| AU (1) | AU759629B2 (pt) |
| BR (1) | BR9910674A (pt) |
| CA (1) | CA2332932A1 (pt) |
| DE (1) | DE69922655T2 (pt) |
| DK (1) | DK1091957T3 (pt) |
| EA (1) | EA003553B1 (pt) |
| ES (1) | ES2234261T3 (pt) |
| HU (1) | HUP0102409A3 (pt) |
| IL (1) | IL139530A0 (pt) |
| NZ (1) | NZ508170A (pt) |
| PL (1) | PL345271A1 (pt) |
| PT (1) | PT1091957E (pt) |
| SI (1) | SI1091957T1 (pt) |
| TR (1) | TR200003451T2 (pt) |
| WO (1) | WO1999061439A1 (pt) |
| ZA (1) | ZA200006633B (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999061438A1 (en) | 1998-05-23 | 1999-12-02 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Quinoline-aminomethyl-pyridyl derivatives with anti-helicobacter activity |
| AR035966A1 (es) | 2001-05-18 | 2004-07-28 | Altana Pharma Ag | Un compuesto de bencilaminopirimidina, un medicamento que lo comprende y el uso del mismo |
| AR035967A1 (es) * | 2001-05-18 | 2004-07-28 | Altana Pharma Ag | Un compuesto de piridilmetilaminopirimidina, un medicamento que lo comprende y el uso del mismo |
| CN1642422A (zh) | 2002-03-15 | 2005-07-20 | 西巴特殊化学品控股有限公司 | 4－氨基嘧啶及其在表面抗菌处理中的应用 |
| RU2228930C1 (ru) * | 2003-05-20 | 2004-05-20 | ООО "Исследовательский институт химического разнообразия" | Замещенные 3-пиридилметиламины и фокусированная библиотека |
| JP5229567B2 (ja) * | 2005-12-30 | 2013-07-03 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｃｅｔｐ阻害剤 |
| US8931778B2 (en) * | 2013-03-15 | 2015-01-13 | Critsuccess Llc | Functional jewelry |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0264883A3 (en) | 1986-10-21 | 1990-04-04 | Banyu Pharmaceutical Co., Ltd. | Substituted pyridine derivatives |
| JPH0812671A (ja) * | 1994-06-30 | 1996-01-16 | Yoshitomi Pharmaceut Ind Ltd | ピリジン化合物 |
| US6162809A (en) * | 1994-07-10 | 2000-12-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyridylthio compounds for controlling helicobacter bacteria |
| CA2249222C (en) * | 1996-03-21 | 2005-11-08 | Banyu Pharmaceutical Co., Ltd. | Aminopyridine derivatives |
-
1999
- 1999-05-20 NZ NZ508170A patent/NZ508170A/en unknown
- 1999-05-20 AT AT99926348T patent/ATE284880T1/de not_active IP Right Cessation
- 1999-05-20 CN CN99806530A patent/CN1302297A/zh active Pending
- 1999-05-20 US US09/700,681 patent/US6395732B1/en not_active Expired - Fee Related
- 1999-05-20 EA EA200001230A patent/EA003553B1/ru not_active IP Right Cessation
- 1999-05-20 BR BR9910674-4A patent/BR9910674A/pt not_active IP Right Cessation
- 1999-05-20 PT PT99926348T patent/PT1091957E/pt unknown
- 1999-05-20 AU AU43645/99A patent/AU759629B2/en not_active Ceased
- 1999-05-20 HU HU0102409A patent/HUP0102409A3/hu unknown
- 1999-05-20 DK DK99926348T patent/DK1091957T3/da active
- 1999-05-20 ES ES99926348T patent/ES2234261T3/es not_active Expired - Lifetime
- 1999-05-20 KR KR1020007013165A patent/KR20010025095A/ko not_active Withdrawn
- 1999-05-20 TR TR2000/03451T patent/TR200003451T2/xx unknown
- 1999-05-20 JP JP2000550845A patent/JP2002516324A/ja active Pending
- 1999-05-20 IL IL13953099A patent/IL139530A0/xx unknown
- 1999-05-20 DE DE69922655T patent/DE69922655T2/de not_active Expired - Fee Related
- 1999-05-20 WO PCT/EP1999/003477 patent/WO1999061439A1/en not_active Ceased
- 1999-05-20 CA CA002332932A patent/CA2332932A1/en not_active Abandoned
- 1999-05-20 PL PL99345271A patent/PL345271A1/xx not_active Application Discontinuation
- 1999-05-20 EP EP99926348A patent/EP1091957B1/en not_active Expired - Lifetime
- 1999-05-20 SI SI9930751T patent/SI1091957T1/xx unknown
-
2000
- 2000-11-15 ZA ZA200006633A patent/ZA200006633B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6395732B1 (en) | 2002-05-28 |
| EA003553B1 (ru) | 2003-06-26 |
| SI1091957T1 (en) | 2005-06-30 |
| NZ508170A (en) | 2003-07-25 |
| HUP0102409A2 (hu) | 2001-12-28 |
| EP1091957A1 (en) | 2001-04-18 |
| ZA200006633B (en) | 2001-08-23 |
| PT1091957E (pt) | 2005-05-31 |
| AU759629B2 (en) | 2003-04-17 |
| IL139530A0 (en) | 2001-11-25 |
| CA2332932A1 (en) | 1999-12-02 |
| HK1036067A1 (en) | 2001-12-21 |
| EP1091957B1 (en) | 2004-12-15 |
| DE69922655T2 (de) | 2006-03-02 |
| HUP0102409A3 (en) | 2003-01-28 |
| CN1302297A (zh) | 2001-07-04 |
| ES2234261T3 (es) | 2005-06-16 |
| KR20010025095A (ko) | 2001-03-26 |
| PL345271A1 (en) | 2001-12-03 |
| ATE284880T1 (de) | 2005-01-15 |
| WO1999061439A1 (en) | 1999-12-02 |
| DE69922655D1 (de) | 2005-01-20 |
| JP2002516324A (ja) | 2002-06-04 |
| EA200001230A1 (ru) | 2001-06-25 |
| AU4364599A (en) | 1999-12-13 |
| TR200003451T2 (tr) | 2001-04-20 |
| DK1091957T3 (da) | 2005-04-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2002221344C1 (en) | Antiviral agents | |
| DK72784A (da) | Imidazo-heterocycliske forbindelser | |
| JP7184646B2 (ja) | ビアリールモノバクタム化合物および細菌感染治療のためのそれの使用方法 | |
| ES2402882T3 (es) | Monobactamas puenteadas utilizables como inhibidores de beta-lactamasa | |
| BR9910674A (pt) | Derivados de primidin-aminometil-piridina, seu preparo e seu uso no controle de bactérias helicobacter | |
| NZ532317A (en) | Substituted diphenyl heterocycles useful for treating hepatitis C virus (HCV) infection | |
| AR030186A1 (es) | Compuesto antibacteriano 3-aminoquinazolina-2,4-diona, composicion farmaceutica que lo comprende y su uso para fabricarla | |
| ATE370129T1 (de) | Substituierte isoxazole und deren verwendung als antibiotika | |
| JP2018507235A5 (pt) | ||
| BR0108853A (pt) | Imidazotriazinonas e seu emprego. | |
| PT94521B (pt) | Processo para a preparacao de 5,11-di-hidro-6h-dipirido-{3,2-b:2',3'-e}{1,4}-diazepino-6-onas e tionas e de composicoes farmaceutica para o tratamento ou a profilaxia da sida | |
| DE3664912D1 (en) | 5-(azolyloxyphenylcarbamoyl)-barbituric acid derivatives as active agents in anthelmics | |
| CA2398988A1 (en) | Anti acid-fast bacterial agent containing pyridonecarboxylic acids as active ingredient | |
| AR054625A1 (es) | Compuestos de oxazolidinona,procedimiento para prepararlos,composiciones farmaceuticas que los contienen,y uso como agentes antimicrobianos. | |
| KR940006584A (ko) | 멀미 및 구토 치료용 6-헤데로시클릭-4-아미노-1,3,4,5-테트라하이드로벤즈[cd]인돌 | |
| KR970005844B1 (ko) | 새로운 세파로스포린 화합물 및 항균제 | |
| BRPI0615201A2 (pt) | derivado de indol ou um sal farmaceuticamente aceitÁvel do mesmo, composiÇço farmacÊutica, uso de um derivativo de (indol-3-il) heterociclo, e, mÉtodo de tratamento da dor | |
| ES2187064T3 (es) | Derivados de azetidinona para el tratamiento de infecciones por hcmv. | |
| EP0209751A2 (en) | Cephalosporin derivatives and bactericides containing the same | |
| WO2018237349A1 (en) | Inhibitors of typed 1 methionyl-trna synthetase and methods of using them | |
| NO20054794L (no) | 7 ([1, 4] dioksan-2-yl)-benzotiazolderivater som adenosinreseptorligander | |
| CO5690575A2 (es) | Composiciones farmaceuticas de liberacion mantenida que contienen aplindore y sus derivados | |
| KR870004993A (ko) | 세팔로스포린 화합물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007. |