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BR9910098A - Derivados de carbapenem, utilização dos mesmos e compostos intermediários dos mesmos - Google Patents

Derivados de carbapenem, utilização dos mesmos e compostos intermediários dos mesmos

Info

Publication number
BR9910098A
BR9910098A BR9910098-3A BR9910098A BR9910098A BR 9910098 A BR9910098 A BR 9910098A BR 9910098 A BR9910098 A BR 9910098A BR 9910098 A BR9910098 A BR 9910098A
Authority
BR
Brazil
Prior art keywords
same
carbapenem
derivatives
intermediate compounds
compound
Prior art date
Application number
BR9910098-3A
Other languages
English (en)
Inventor
Hiroshi Matsui
Original Assignee
Kyoto Pharma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP10122499A external-priority patent/JP2000344772A/ja
Priority claimed from JP10203730A external-priority patent/JP2000344773A/ja
Application filed by Kyoto Pharma Ind filed Critical Kyoto Pharma Ind
Publication of BR9910098A publication Critical patent/BR9910098A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE CARBAPENEM, UTILIZAçãO DOS MESMOS E COMPOSTOS INTERMEDIáRIOS DOS MESMOS"<D>. Um composto carbapenem da fórmula (I) em que R¹ é um modificador hidrolisável no corpo vivo, R² e R³ são iguais ou diferentes e cada um é uma alquila inferior, R é como definido no relatório. O composto carbapenem (I) da presente invenção é superior na absorção no trato digestivo quando da administração oral e mostra propriedade antibacteriana suficiente contra uma ampla faixa de espécies de bactérias. Conseq³entemente, o composto é extremamente útil para a profilaxia e tratamento de doenças infecciosas (particularmente infecção bacteriana).
BR9910098-3A 1998-05-01 1999-04-28 Derivados de carbapenem, utilização dos mesmos e compostos intermediários dos mesmos BR9910098A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10122499A JP2000344772A (ja) 1998-05-01 1998-05-01 カルバペネム誘導体、その用途およびその中間体化合物
JP10203730A JP2000344773A (ja) 1998-07-17 1998-07-17 カルバペネム誘導体、およびその用途並びにその中間体化合物
PCT/JP1999/002301 WO1999057121A1 (en) 1998-05-01 1999-04-28 Carbapenem derivatives, utilization thereof and intermediate compounds of the same

Publications (1)

Publication Number Publication Date
BR9910098A true BR9910098A (pt) 2000-12-26

Family

ID=26459604

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910098-3A BR9910098A (pt) 1998-05-01 1999-04-28 Derivados de carbapenem, utilização dos mesmos e compostos intermediários dos mesmos

Country Status (24)

Country Link
US (1) US6410525B1 (pt)
EP (1) EP1078927B1 (pt)
KR (1) KR100589030B1 (pt)
CN (1) CN1163494C (pt)
AR (1) AR018335A1 (pt)
AT (1) ATE337321T1 (pt)
AU (1) AU760386B2 (pt)
BG (1) BG105004A (pt)
BR (1) BR9910098A (pt)
CA (1) CA2330641A1 (pt)
CO (1) CO5011051A1 (pt)
CZ (1) CZ292623B6 (pt)
DE (1) DE69932927D1 (pt)
HU (1) HUP0101735A3 (pt)
ID (1) ID27081A (pt)
NO (1) NO20005480L (pt)
NZ (1) NZ508493A (pt)
PL (1) PL343728A1 (pt)
RU (1) RU2222540C2 (pt)
SK (1) SK16382000A3 (pt)
TR (1) TR200003199T2 (pt)
TW (1) TW528750B (pt)
WO (1) WO1999057121A1 (pt)
YU (1) YU66700A (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100568841B1 (ko) 2000-07-19 2006-04-10 에프. 호프만-라 로슈 아게 엔도텔린-전환 효소의 억제제로서의 피롤리딘 유도체
RU2289582C2 (ru) * 2001-05-21 2006-12-20 Киото Фармасьютикал Индастриз, Лтд. Соединение карбапенема
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7205291B2 (en) * 2001-11-05 2007-04-17 Dainippon Sumitomo Pharma Co., Ltd. Carbapenem compounds
JPWO2004089954A1 (ja) 2003-04-08 2006-07-06 大日本住友製薬株式会社 新規なカルバペネム化合物
WO2006025475A1 (ja) * 2004-09-03 2006-03-09 Dainippon Sumitomo Pharma Co., Ltd. 新規なカルバペネム化合物
JPWO2006103999A1 (ja) * 2005-03-25 2008-09-04 大日本住友製薬株式会社 新規なカルバペネム化合物
RU2008108215A (ru) * 2005-08-31 2009-10-10 Вайет (Us) 9-аминокарбонилзамещенные производные глицилциклинов
CN101376656A (zh) * 2007-08-30 2009-03-04 山东轩竹医药科技有限公司 培南衍生物
HK1219233A1 (zh) 2013-03-15 2017-03-31 Kala Pharmaceuticals, Inc. 美罗培南衍生物及其用途
JP7437847B2 (ja) * 2018-10-01 2024-02-26 アリクサ ファーマシューティカルズ、インコーポレイテッド レレバクタムの誘導体およびその使用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
US4539332A (en) * 1983-11-14 1985-09-03 Merck & Co., Inc. 2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists
JPS60233076A (ja) 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
FI81576C (fi) 1984-12-25 1990-11-12 Sankyo Co Foerfarande foer framstaellning av derivat av 6-(1-hydroxietyl)-2-(1,2-disubstituerade-4-pyrrolidinyltio)-2- karbapenem-3-karboxylsyra, vilka aer anvaendbara som laekemedel.
IE60588B1 (en) 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
EP0337637B1 (en) 1988-04-01 1994-11-30 Sankyo Company Limited 2-(Heterocyclylthio)carbapenem derivatives their preparation and their use as antibiotics
US5242914A (en) 1988-04-01 1993-09-07 Sankyo Company, Limited 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics
NZ237191A (en) * 1990-02-23 1992-12-23 Sankyo Co 2-((substituted amide) substituted heterocyclylthio) carbpen-2-em derivatives and pharmaceutical compositions
AU644008B2 (en) 1990-08-10 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds, and their production and use
US5712267A (en) 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
JP3048196B2 (ja) * 1991-06-20 2000-06-05 第一製薬株式会社 カルバペネム誘導体
US5360798A (en) 1991-07-04 1994-11-01 Shionogi Seiyaku Kabushiki Kaisha Aminooxypyrrolidinylthiocarbapenem compounds
CA2241092C (en) 1995-12-21 2004-04-27 Sankyo Company, Limited 1-methylcarbapenem derivatives

Also Published As

Publication number Publication date
BG105004A (en) 2001-08-31
TW528750B (en) 2003-04-21
EP1078927B1 (en) 2006-08-23
AU3627299A (en) 1999-11-23
HUP0101735A2 (hu) 2001-12-28
NZ508493A (en) 2002-06-28
CA2330641A1 (en) 1999-11-11
EP1078927A4 (en) 2003-01-08
ID27081A (id) 2001-02-22
PL343728A1 (en) 2001-09-10
RU2222540C2 (ru) 2004-01-27
KR20010043196A (ko) 2001-05-25
ATE337321T1 (de) 2006-09-15
CN1163494C (zh) 2004-08-25
HUP0101735A3 (en) 2002-02-28
AR018335A1 (es) 2001-11-14
SK16382000A3 (sk) 2001-05-10
AU760386B2 (en) 2003-05-15
CZ292623B6 (cs) 2003-11-12
DE69932927D1 (de) 2006-10-05
TR200003199T2 (tr) 2001-03-21
NO20005480D0 (no) 2000-10-31
KR100589030B1 (ko) 2006-06-13
WO1999057121A1 (en) 1999-11-11
CO5011051A1 (es) 2001-02-28
EP1078927A1 (en) 2001-02-28
US6410525B1 (en) 2002-06-25
CZ20003954A3 (cs) 2001-04-11
CN1307578A (zh) 2001-08-08
YU66700A (sh) 2003-01-31
NO20005480L (no) 2000-12-20

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.