BR9908156A - Processo para efetuar uma cristalização em estado sólido de um composto orgânico molecular alotrópico em uma partìcula de tamanho e forma definidos,partìcula estável na estocagem, e, processo para efetuar uma cristalização em estado sólido de uma mistura contendo pelo menos um composto orgânico alotrópico molecular. - Google Patents
Processo para efetuar uma cristalização em estado sólido de um composto orgânico molecular alotrópico em uma partìcula de tamanho e forma definidos,partìcula estável na estocagem, e, processo para efetuar uma cristalização em estado sólido de uma mistura contendo pelo menos um composto orgânico alotrópico molecular.Info
- Publication number
- BR9908156A BR9908156A BR9908156-3A BR9908156A BR9908156A BR 9908156 A BR9908156 A BR 9908156A BR 9908156 A BR9908156 A BR 9908156A BR 9908156 A BR9908156 A BR 9908156A
- Authority
- BR
- Brazil
- Prior art keywords
- allotropic
- solid state
- particle
- state crystallization
- stable
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 10
- 238000002425 crystallisation Methods 0.000 title abstract 5
- 230000008025 crystallization Effects 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 150000002894 organic compounds Chemical class 0.000 title abstract 5
- 239000007787 solid Substances 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title 1
- 210000002784 stomach Anatomy 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000004005 microsphere Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Abstract
"PROCESSO PARA EFETUAR UMA CRISTALIZAçãO EM ESTADO SóLIDO DE UM COMPOSTO ORGâNICO MOLECULAR ALOTRóPICO EM UMA PARTìCULA DE TAMANHO E FORMA DEFINIDOS, PARTìCULA ESTáVEL NA ESTOCAGEM, E, PROCESSO PARA EFETUAR UMA CRISTALIZAçãO EM ESTADO SóLIDO DE UMA MISTURA CONTENDO PELO MENOS UM COMPOSTO ORGâNICO ALOTRóPICO MOLECULAR". A presente invenção proporciona partículas moldadas estáveis em estocagem, de compostos orgânicos alotrópicos. As partículas da presente invenção podem ser moldadas de acordo com a aplicação desejada. As formas preferidas de tais partículas são microsferas, particularmente aquelas que têm diâmetros de aproximadamente 1 a aproximadamente 1.000 microns. As partículas estáveis moldadas da presente invenção são particularmente bem adaptadas para a fabricação de formulações farmacêuticas, particularmente onde a liberação retardada e a biodisponibilidade uniforme são desejadas. As partículas estáveis em estocagem são formadas por uma cristalização em estado sólido de compostos orgânicos alotrópicos. O processo de cristalização em estado sólido da presente invenção fornece um meio para atingir uma forma cristalina estável em estocagem do citado composto alotrópico sem perda ou deterioração das dimensões da partícula original.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/030,388 US6287693B1 (en) | 1998-02-25 | 1998-02-25 | Stable shaped particles of crystalline organic compounds |
| PCT/IB1999/000233 WO1999043304A1 (en) | 1998-02-25 | 1999-02-10 | Stable shaped particles of crystalline organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9908156A true BR9908156A (pt) | 2000-10-31 |
Family
ID=21853984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9908156-3A BR9908156A (pt) | 1998-02-25 | 1999-02-10 | Processo para efetuar uma cristalização em estado sólido de um composto orgânico molecular alotrópico em uma partìcula de tamanho e forma definidos,partìcula estável na estocagem, e, processo para efetuar uma cristalização em estado sólido de uma mistura contendo pelo menos um composto orgânico alotrópico molecular. |
Country Status (34)
| Country | Link |
|---|---|
| US (7) | US6287693B1 (pt) |
| EP (4) | EP1056444B1 (pt) |
| JP (2) | JP4885357B2 (pt) |
| KR (1) | KR100726315B1 (pt) |
| CN (2) | CN1146407C (pt) |
| AR (3) | AR018107A1 (pt) |
| AT (2) | ATE345779T1 (pt) |
| AU (1) | AU747779B2 (pt) |
| BR (1) | BR9908156A (pt) |
| CA (1) | CA2319176C (pt) |
| CL (1) | CL2010001333A1 (pt) |
| CY (1) | CY1118522T1 (pt) |
| CZ (1) | CZ301042B6 (pt) |
| DE (2) | DE69934099T2 (pt) |
| DK (3) | DK2085075T3 (pt) |
| EE (1) | EE05019B1 (pt) |
| ES (3) | ES2609284T3 (pt) |
| HU (1) | HUP0101271A3 (pt) |
| ID (1) | ID26523A (pt) |
| IL (2) | IL137970A0 (pt) |
| MY (1) | MY138375A (pt) |
| NO (1) | NO331804B1 (pt) |
| NZ (1) | NZ505987A (pt) |
| PE (1) | PE20000393A1 (pt) |
| PL (1) | PL196369B1 (pt) |
| PT (1) | PT2085075T (pt) |
| RU (1) | RU2225708C2 (pt) |
| SA (1) | SA99200098B1 (pt) |
| TR (1) | TR200002462T2 (pt) |
| TW (1) | TWI256308B (pt) |
| UA (1) | UA73470C2 (pt) |
| UY (1) | UY25404A1 (pt) |
| WO (1) | WO1999043304A1 (pt) |
| ZA (1) | ZA991058B (pt) |
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| US20040028746A1 (en) * | 2002-08-06 | 2004-02-12 | Sonke Svenson | Crystalline drug particles prepared using a controlled precipitation (recrystallization) process |
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| TWI359675B (en) | 2003-07-10 | 2012-03-11 | Dey L P | Bronchodilating β-agonist compositions |
| CA2532874A1 (en) * | 2003-07-22 | 2005-02-03 | Baxter International Inc. | Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof |
| SI1691787T1 (sl) * | 2003-12-04 | 2008-10-31 | Pfizer Prod Inc | Postopek za pripravo farmacevtskih produktov iz več delcev |
| PL1718258T3 (pl) | 2004-02-23 | 2009-08-31 | Euro Celtique Sa | Odporne na nadużywanie transdermalne urządzenie do podawania opioidu |
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| FR2939326B1 (fr) * | 2008-12-10 | 2011-04-01 | Univ Joseph Fourier | Procede et dispositif de controle d'une cristallisation. |
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| US9351924B2 (en) | 2011-03-11 | 2016-05-31 | Snu R&Db Foundation | Drug delivery system including laminated structure |
| EP3936133A1 (en) | 2011-11-23 | 2022-01-12 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
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-
1998
- 1998-02-25 US US09/030,388 patent/US6287693B1/en not_active Expired - Lifetime
-
1999
- 1999-02-10 EP EP99902729A patent/EP1056444B1/en not_active Expired - Lifetime
- 1999-02-10 AT AT99902729T patent/ATE345779T1/de active
- 1999-02-10 ID IDW20001723A patent/ID26523A/id unknown
- 1999-02-10 EP EP09156268.6A patent/EP2085075B1/en not_active Expired - Lifetime
- 1999-02-10 ES ES09156268.6T patent/ES2609284T3/es not_active Expired - Lifetime
- 1999-02-10 BR BR9908156-3A patent/BR9908156A/pt not_active Application Discontinuation
- 1999-02-10 NZ NZ505987A patent/NZ505987A/en not_active IP Right Cessation
- 1999-02-10 HU HU0101271A patent/HUP0101271A3/hu unknown
- 1999-02-10 KR KR1020007009352A patent/KR100726315B1/ko not_active Expired - Fee Related
- 1999-02-10 ES ES99902729T patent/ES2275334T3/es not_active Expired - Lifetime
- 1999-02-10 DK DK09156268.6T patent/DK2085075T3/en active
- 1999-02-10 AU AU22936/99A patent/AU747779B2/en not_active Expired
- 1999-02-10 CZ CZ20003047A patent/CZ301042B6/cs not_active IP Right Cessation
- 1999-02-10 DK DK06022834T patent/DK1772141T3/da active
- 1999-02-10 CN CNB998032794A patent/CN1146407C/zh not_active Expired - Fee Related
- 1999-02-10 RU RU2000124327/15A patent/RU2225708C2/ru not_active IP Right Cessation
- 1999-02-10 ZA ZA9901058A patent/ZA991058B/xx unknown
- 1999-02-10 JP JP2000533103A patent/JP4885357B2/ja not_active Expired - Fee Related
- 1999-02-10 PT PT91562686T patent/PT2085075T/pt unknown
- 1999-02-10 CN CNB2004100076469A patent/CN100528140C/zh not_active Expired - Fee Related
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2000
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2001
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2002
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2003
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