AR046229A1 - Procesos para la preparacion de cefalosporina 3-(2-vinilo sustituido) altamente pura - Google Patents
Procesos para la preparacion de cefalosporina 3-(2-vinilo sustituido) altamente puraInfo
- Publication number
- AR046229A1 AR046229A1 ARP040104059A ARP040104059A AR046229A1 AR 046229 A1 AR046229 A1 AR 046229A1 AR P040104059 A ARP040104059 A AR P040104059A AR P040104059 A ARP040104059 A AR P040104059A AR 046229 A1 AR046229 A1 AR 046229A1
- Authority
- AR
- Argentina
- Prior art keywords
- pivoxil
- cefditoren
- highly pure
- amorphous
- pivoxil cefditoren
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- HOKIDJSKDBPKTQ-UHFFFAOYSA-N 3-(acetyloxymethyl)-7-[(5-amino-5-carboxypentanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C(NC(=O)CCCC(N)C(O)=O)C12 HOKIDJSKDBPKTQ-UHFFFAOYSA-N 0.000 title 1
- 229920002554 vinyl polymer Polymers 0.000 title 1
- KMIPKYQIOVAHOP-YLGJWRNMSA-N cefditoren Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1\C=C/C=1SC=NC=1C KMIPKYQIOVAHOP-YLGJWRNMSA-N 0.000 abstract 9
- 229960004069 cefditoren Drugs 0.000 abstract 9
- 229950009297 pivoxil Drugs 0.000 abstract 9
- 239000012535 impurity Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
Abstract
La presente se relaciona con un proceso para preparar formas amorfa y cristalina altamente puras de pivoxil cefditoren y composiciones farmacéuticas que comprenden formas amorfa y cristalina altamente puras de pivoxil cefditoren. También se relaciona con un método para tratar infecciones utilizando formas amorfa y cristalina altamente puras de pivoxil cefditoren. El pivoxil cefditoren altamente puro tiene una pureza superior a 98.5% y contiene menos de 1.0% de impurezas de isómero E y menos de 1% de la impureza del isómero D2. Reivindicación 6: Un proceso para preparar pivoxil cefditoren cristalino a partir de pivoxil cefditoren amorfo proceso que comprende: a) i) agregar pivoxil cefditoren amorfo a un solvente orgánico que opcionalmente contenga agua y/o ii) agregar un solvente orgánico que opcionalmente contenga agua a pivoxil cefditoren amorfo; b) cristalizar el producto a partir de la mezcla de la reacción; y c) aislar el pivoxil cefditoren cristalino.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1368DE2003 | 2003-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046229A1 true AR046229A1 (es) | 2005-11-30 |
Family
ID=34566866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040104059A AR046229A1 (es) | 2003-11-07 | 2004-11-05 | Procesos para la preparacion de cefalosporina 3-(2-vinilo sustituido) altamente pura |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1689755A2 (es) |
| JP (1) | JP2007510709A (es) |
| CN (1) | CN1902207A (es) |
| AR (1) | AR046229A1 (es) |
| WO (1) | WO2005044824A2 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7459550B2 (en) | 2003-07-04 | 2008-12-02 | Orchid Chemicals & Pharmaceuticals Ltd. | Process for the preparation of Cefditoren |
| WO2006024900A1 (en) * | 2004-08-31 | 2006-03-09 | Ranbaxy Laboratories Limited | Highly pure cefditoren pivoxil |
| US20090111997A1 (en) * | 2005-11-23 | 2009-04-30 | Aaron Cote | Method of Generating Amorphous Solid for Water-Insoluble Pharmaceuticals |
| CN101560216B (zh) * | 2009-05-27 | 2011-06-15 | 上海交通大学 | 头孢妥仑酯的制备方法 |
| KR101561963B1 (ko) * | 2013-05-23 | 2015-10-22 | 영진약품공업 주식회사 | 세프디토렌 피복실의 신규 결정 형태 및 이의 제조 방법 |
| CN106117244B (zh) * | 2016-06-24 | 2018-10-19 | 瑞阳制药有限公司 | 头孢妥仑匹酯的精制方法 |
| CN106243128B (zh) * | 2016-07-30 | 2018-09-04 | 济南康和医药科技有限公司 | 一种头孢妥仑匹酯的精制方法 |
| CN107422056B (zh) * | 2017-08-17 | 2020-04-24 | 山东裕欣药业有限公司 | 一种特戊酸碘甲酯的气相色谱检测方法及其制备方法 |
| CN109053768A (zh) * | 2018-08-07 | 2018-12-21 | 中国医药集团总公司四川抗菌素工业研究所 | 一种无定型头孢妥仑酯的制备方法 |
| CN109336904B (zh) * | 2018-11-21 | 2020-06-09 | 山东罗欣药业集团股份有限公司 | 一种头孢妥仑匹酯的制备方法 |
| CN110251467A (zh) * | 2019-06-26 | 2019-09-20 | 北京济美堂医药研究有限公司 | 一种无定形态头孢妥仑匹酯组合物的制备方法 |
| CN116332956A (zh) * | 2023-01-16 | 2023-06-27 | 浙江东邦药业有限公司 | 一种无定型头孢妥仑匹酯的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9712072A (pt) * | 1996-09-20 | 1999-08-24 | Meiji Seika Kaisha | Subst-ncia cristalina de defditoren pivoxil e a produ-Æo da mesma |
| IL137004A0 (en) * | 1998-01-07 | 2001-06-14 | Meiji Seika Kaisha | Crystallographically stable amorphous cephalosporin compositions and process for producing the same |
| JP2001131071A (ja) * | 1999-10-29 | 2001-05-15 | Meiji Seika Kaisha Ltd | 非晶質および非晶質を含有する医薬組成物 |
-
2004
- 2004-11-01 JP JP2006538976A patent/JP2007510709A/ja not_active Withdrawn
- 2004-11-01 WO PCT/IB2004/003571 patent/WO2005044824A2/en not_active Ceased
- 2004-11-01 EP EP04798757A patent/EP1689755A2/en not_active Withdrawn
- 2004-11-01 CN CNA2004800397561A patent/CN1902207A/zh active Pending
- 2004-11-05 AR ARP040104059A patent/AR046229A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005044824A2 (en) | 2005-05-19 |
| CN1902207A (zh) | 2007-01-24 |
| JP2007510709A (ja) | 2007-04-26 |
| EP1689755A2 (en) | 2006-08-16 |
| WO2005044824A3 (en) | 2005-07-14 |
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| FB | Suspension of granting procedure |