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BR9811465A - N-triazolil-2-indolcarboxamidas e sua utilização como agonistas de cck-a. - Google Patents

N-triazolil-2-indolcarboxamidas e sua utilização como agonistas de cck-a.

Info

Publication number
BR9811465A
BR9811465A BR9811465-4A BR9811465A BR9811465A BR 9811465 A BR9811465 A BR 9811465A BR 9811465 A BR9811465 A BR 9811465A BR 9811465 A BR9811465 A BR 9811465A
Authority
BR
Brazil
Prior art keywords
cck
indolcarboxamides
triazolyl
agonists
compounds
Prior art date
Application number
BR9811465-4A
Other languages
English (en)
Inventor
Eric Bignon
Jean-Pierre Bras
Cointet Paul De
Pierre Despeyroux
Daniel Frehel
Danielle Gully
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of BR9811465A publication Critical patent/BR9811465A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Patente de Invenção: <B>"N-TRIAZOLIL-2-INDOLCARBOXAMIDAS E SUA UTILIZAçãO COMO AGONISTAS DE CCK-A"<D>. A invenção tem por objeto os compostos de fórmula (I) nos quais R~ 1~, R~ 4~, X~ 1~, X~ 2~, X~ 3~, X~ 4~, Y~ 1~, Y~ 2~ e Y~ 3~ são conforme definidos na reivindicação 1. Estes compostos possuem uma atividade agonista parcial ou total dos receptores CCK-A e são úteis para o tratamento de distúrbios alimentares, da obesidade, da discinesia tardia e dos problemas da esfera gastrointestinal.
BR9811465-4A 1997-05-13 1998-05-06 N-triazolil-2-indolcarboxamidas e sua utilização como agonistas de cck-a. BR9811465A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9705850A FR2763337B1 (fr) 1997-05-13 1997-05-13 Nouveaux derives du triazole, un procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR1998/000905 WO1998051686A1 (fr) 1997-05-13 1998-05-06 N-triazolyl-2-indolecarboxamides et leur utilisation comme agonistes de cck-a

Publications (1)

Publication Number Publication Date
BR9811465A true BR9811465A (pt) 2000-09-12

Family

ID=9506830

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9811465-4A BR9811465A (pt) 1997-05-13 1998-05-06 N-triazolil-2-indolcarboxamidas e sua utilização como agonistas de cck-a.

Country Status (35)

Country Link
EP (1) EP0984960B1 (pt)
JP (1) JP2001524980A (pt)
KR (1) KR20010012541A (pt)
CN (1) CN1263528A (pt)
AR (1) AR011729A1 (pt)
AT (1) ATE232207T1 (pt)
AU (1) AU725530B2 (pt)
BR (1) BR9811465A (pt)
CA (1) CA2289573A1 (pt)
CO (1) CO4940485A1 (pt)
CZ (1) CZ289484B6 (pt)
DE (1) DE69811223T2 (pt)
DK (1) DK0984960T3 (pt)
DZ (1) DZ2486A1 (pt)
EE (1) EE9900524A (pt)
ES (1) ES2190081T3 (pt)
FR (1) FR2763337B1 (pt)
GT (1) GT199800068A (pt)
HR (1) HRP980258B1 (pt)
HU (1) HUP0002763A3 (pt)
ID (1) ID22911A (pt)
IL (1) IL132903A0 (pt)
IS (1) IS5235A (pt)
NO (1) NO995513L (pt)
NZ (1) NZ500637A (pt)
PL (1) PL336772A1 (pt)
RU (1) RU2175323C2 (pt)
SI (1) SI0984960T1 (pt)
SK (1) SK154299A3 (pt)
TR (1) TR199902795T2 (pt)
TW (1) TW396155B (pt)
UY (1) UY24997A1 (pt)
WO (1) WO1998051686A1 (pt)
YU (1) YU57999A (pt)
ZA (1) ZA983997B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2802530B1 (fr) * 1999-12-17 2002-02-22 Sanofi Synthelabo Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2,4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant
FR2815963B1 (fr) * 2000-10-26 2003-02-28 Sanofi Synthelabo Nouveaux derives du triazole et les compositions pharmaceutiques les contenant
CN1471525A (zh) * 2000-10-26 2004-01-28 ʥŵ��-�ϳ�ʵ���ҹ�˾ 三唑衍生物和含有它们的药物组合物
HUP0004741A2 (hu) * 2000-11-28 2002-12-28 Sanofi-Synthelabo Kémiai eljárás tiazolszármazékok előállítására és új intermedier
ES2256560T3 (es) * 2001-10-12 2006-07-16 Bayer Pharmaceuticals Corporation Heterociclos de 5 mienbros que contienen nitrogeno sustituidos con felino para el tratamiento de la obesidad.
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
DE10237722A1 (de) * 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase
DE60316709T2 (de) * 2002-10-03 2008-07-17 F. Hoffmann-La Roche Ag Indole-3-carbonsaüreamide als glucokinase (gk) aktivatoren
EP1479677A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH New indole derivatives as factor xa inhibitors
EP1532980A1 (en) * 2003-11-24 2005-05-25 Novo Nordisk A/S N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes
GB0403038D0 (en) * 2004-02-11 2004-03-17 Novartis Ag Organic compounds
RU2415134C9 (ru) * 2005-08-15 2011-05-27 Этерна Центарис ГмбХ Способ лечения или профилактики физиологических и/или патофизиологических состояний, опосредуемых рецепторами, стимулирующими секрецию гормона роста, триазолы и фармацевтическая композиция на их основе
CA2676222A1 (en) 2007-01-26 2008-07-31 Merck & Co., Inc. Substituted aminopyrimidines as cholecystokinin-1 receptor modulators
PE20110105A1 (es) * 2008-07-15 2011-02-25 Novartis Ag Derivados de heteroarilo como inhibidores de dgat1
MY161243A (en) * 2009-06-09 2017-04-14 Actelion Pharmaceuticals Ltd Fluorinated aminotriazole derivatives
EP2490653B1 (de) * 2009-10-22 2017-01-11 Henkel AG & Co. KGaA Mittel zur temporären verformung keratinhaltiger fasern, enthaltend eine nichtionische, mittels propylenoxid modifizierte stärke und ein filmbildendes und/oder festigendes kationisches polymer
CN106928147A (zh) * 2017-03-14 2017-07-07 华东师范大学 三环二萜类似物及其制备方法、及其在制备抗前列腺癌药物中的应用
CN107271623A (zh) * 2017-07-27 2017-10-20 青岛啤酒股份有限公司 基于人体饱腹感的啤酒可饮性评价方法
CN114945560B (zh) 2019-10-07 2024-08-13 卡尔优普公司 Gpr119激动剂
CN115667277A (zh) 2020-02-28 2023-01-31 卡尔优普公司 Gpr40激动剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2701708B1 (fr) * 1993-02-19 1995-05-19 Sanofi Elf Dérivés de 2-amido-4-phénylthiazoles polysubstitués, procédé de préparation, composition pharmaceutique et utilisation de ces dérivés pour la préparation d'un médicament.
FR2703995B1 (fr) * 1993-04-16 1995-07-21 Sanofi Elf 5-acylamino 1,2,4-thiadiazoles, leur preparation et compositions pharmaceutiques en contenant.

Also Published As

Publication number Publication date
YU57999A (sh) 2002-06-19
EE9900524A (et) 2000-06-15
HRP980258B1 (en) 2002-08-31
NO995513D0 (no) 1999-11-11
DE69811223T2 (de) 2003-11-27
EP0984960B1 (fr) 2003-02-05
HUP0002763A2 (hu) 2001-06-28
JP2001524980A (ja) 2001-12-04
NO995513L (no) 2000-01-12
CN1263528A (zh) 2000-08-16
ATE232207T1 (de) 2003-02-15
FR2763337A1 (fr) 1998-11-20
AR011729A1 (es) 2000-08-30
DZ2486A1 (fr) 2003-02-01
HRP980258A2 (en) 1999-02-28
CO4940485A1 (es) 2000-07-24
SK154299A3 (en) 2000-05-16
CZ400699A3 (cs) 2000-02-16
TR199902795T2 (xx) 2000-02-21
AU7659998A (en) 1998-12-08
CA2289573A1 (fr) 1998-11-19
ID22911A (id) 1999-12-16
TW396155B (en) 2000-07-01
DE69811223D1 (de) 2003-03-13
EP0984960A1 (fr) 2000-03-15
NZ500637A (en) 2000-11-24
GT199800068A (es) 1999-11-11
WO1998051686A1 (fr) 1998-11-19
AU725530B2 (en) 2000-10-12
ES2190081T3 (es) 2003-07-16
FR2763337B1 (fr) 1999-08-20
HUP0002763A3 (en) 2002-05-28
IS5235A (is) 1999-10-29
RU2175323C2 (ru) 2001-10-27
IL132903A0 (en) 2001-03-19
DK0984960T3 (da) 2003-05-26
ZA983997B (en) 1999-11-12
PL336772A1 (en) 2000-07-17
KR20010012541A (ko) 2001-02-15
CZ289484B6 (cs) 2002-01-16
SI0984960T1 (en) 2003-06-30
UY24997A1 (es) 2000-10-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A,8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1890 DE 27/03/2007.