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BR9803807A - Processo para produção de protéina. - Google Patents

Processo para produção de protéina.

Info

Publication number
BR9803807A
BR9803807A BR9803807-9A BR9803807A BR9803807A BR 9803807 A BR9803807 A BR 9803807A BR 9803807 A BR9803807 A BR 9803807A BR 9803807 A BR9803807 A BR 9803807A
Authority
BR
Brazil
Prior art keywords
protein production
protein
untransformed
endogenous
culturing
Prior art date
Application number
BR9803807-9A
Other languages
English (en)
Other versions
BR9803807B1 (pt
Inventor
Karsten Hellmuth
Rual Lopez-Ulibarri
Anne Francoise Mayer
Heinrich Winfried Schlieker
Adolphus Van Loon
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9803807A publication Critical patent/BR9803807A/pt
Publication of BR9803807B1 publication Critical patent/BR9803807B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Patente de Invenção:<B>"PROCESSO PARA PRODUçãO DE PROTEìNA".<D>A presente invenção refere-se a um processo para a preparação de uma proteína endógena ou heteróloga por cultivo de uma célula eucariótica transformada ou não-transformada.
BRPI9803807-9A 1997-10-01 1998-09-30 processo para preparação de uma enzima heteróloga através do cultivo de uma célula eucariótica transformada. BR9803807B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97117021 1997-10-01

Publications (2)

Publication Number Publication Date
BR9803807A true BR9803807A (pt) 2000-03-28
BR9803807B1 BR9803807B1 (pt) 2010-11-03

Family

ID=8227420

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9803807-9A BR9803807B1 (pt) 1997-10-01 1998-09-30 processo para preparação de uma enzima heteróloga através do cultivo de uma célula eucariótica transformada.

Country Status (12)

Country Link
US (1) US6204012B1 (pt)
EP (2) EP1659173A1 (pt)
JP (1) JP4162774B2 (pt)
KR (1) KR100572426B1 (pt)
CN (1) CN1215175C (pt)
AU (1) AU748187B2 (pt)
BR (1) BR9803807B1 (pt)
CA (1) CA2249061C (pt)
DE (1) DE69834533T2 (pt)
DK (1) DK0911416T3 (pt)
ES (1) ES2264181T3 (pt)
IN (1) IN188151B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451572B1 (en) 1998-06-25 2002-09-17 Cornell Research Foundation, Inc. Overexpression of phytase genes in yeast systems
US6511699B1 (en) * 1999-03-31 2003-01-28 Cornell Research Foundation, Inc. Enzymes with improved phytase activity
US6841370B1 (en) 1999-11-18 2005-01-11 Cornell Research Foundation, Inc. Site-directed mutagenesis of Escherichia coli phytase
AU2002356880A1 (en) * 2001-10-31 2003-05-12 Phytex, Llc Phytase-containing animal food and method
KR100429331B1 (ko) * 2002-01-29 2004-04-29 재단법인 목암생명공학연구소 재조합 효모를 이용한 에스에이치엘케이엔-1 단백질의대량생산방법
DK1543106T3 (da) * 2002-07-15 2007-08-13 Immunex Corp Fremgangsmåder og medier til kontrol af sialylering af proteiner, der dannes af mammaliaceller
AU2003272410A1 (en) 2002-09-13 2004-04-30 Cornell Research Foundation, Inc. Using mutations to improve aspergillus phytases
EP2287326A1 (en) 2003-08-08 2011-02-23 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
SI1684719T1 (sl) * 2003-11-14 2012-07-31 Baxter Int Sestavki alfa antitripsina in postopki zdravljenja ob uporabi takih sestavkov
EP2009093A3 (en) * 2004-09-22 2009-04-08 Bioworks, Inc. Transgenic strains of trichoderma and their use in biocontrol
US20070105768A1 (en) * 2004-11-10 2007-05-10 Rajiv Nayar Dry recombinant human alpha 1-antitrypsin formulation
US9410175B2 (en) 2005-03-24 2016-08-09 Dsm Ip Assets B.V. Process for microbial production of a valuable compound
US7919297B2 (en) * 2006-02-21 2011-04-05 Cornell Research Foundation, Inc. Mutants of Aspergillus niger PhyA phytase and Aspergillus fumigatus phytase
EP2013338B1 (en) * 2006-04-28 2014-01-01 C5-6 Technologies, Inc. Thermostable cellulase and methods of use
WO2008017066A2 (en) * 2006-08-03 2008-02-07 Cornell Research Foundation, Inc. Phytases with improved thermal stability
US8143023B2 (en) 2007-01-26 2012-03-27 Novozymes A/S Method for methanol independent induction from methanol inducible promoters in Pichia
US8192734B2 (en) 2007-07-09 2012-06-05 Cornell University Compositions and methods for bone strengthening
BRPI0908308B1 (pt) * 2008-03-24 2021-01-12 Archer Daniels Midland Company. cepa h. polymorpha, e processo para a fabricação de etanol
GB201308828D0 (en) * 2013-03-12 2013-07-03 Verenium Corp Phytase
GB201308843D0 (en) 2013-03-14 2013-07-03 Verenium Corp Phytase formulation
CN103159531A (zh) * 2013-04-17 2013-06-19 广西新方向化学工业有限公司 一种含多种植物醇和中微量元素螯合的液体肥料及其制备方法
WO2015012890A1 (en) 2013-07-25 2015-01-29 Verenium Corporation Phytase
EP3217807A4 (en) 2014-11-11 2018-09-12 Clara Foods Co. Methods and compositions for egg white protein production
CN104928271A (zh) * 2015-07-06 2015-09-23 唐亚军 一种木聚糖酶的制备方法
CN105200101B (zh) * 2015-10-19 2019-04-16 华中农业大学 一种毕赤酵母菌体重复发酵表达外源蛋白的方法
HRP20250315T1 (hr) 2019-07-11 2025-06-06 Clara Foods Co. Sastav napitka koji sadrži rekombinantni protein ovomukoid
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
WO2025077804A1 (en) * 2023-10-12 2025-04-17 Chengdu Kanghua Biological Products Co., Ltd. Methanol monitoring method for the fermentation process of methanotrophic yeast

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0423890A3 (en) 1984-07-27 1991-07-03 Unilever Nv Use of oxidoreductases in bleaching and/or detergent compositions and their preparation by microorganisms engineered by recombinant dna technology
US4855231A (en) 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast
NL8601454A (nl) * 1986-06-05 1988-01-04 Unilever Nv Werkwijze voor het bereiden van een catalase-vrij oxidoreductase en van een catalase-vrije oxidoreductase bevattende gist, en gebruik daarvan.
DE3765978D1 (de) * 1986-11-24 1990-12-13 Unilever Nv Verfahren zur herstellung einer catalasefreien, oxidase enthaltenden hefe und deren verwendung.
DE3789866T2 (de) 1987-07-17 1994-09-22 Rhein Biotech Gesellschaft Fuer Neue Biotechnologische Prozesse Und Produkte Mbh, 40595 Duesseldorf DNA-Moleküle, die für FMDH-Kontrollabschnitte und Strukturgene für ein Protein mit FMDH-Aktivität kodieren, sowie deren Anwendung.
IL91765A0 (en) * 1988-09-26 1990-06-10 Salk Inst Biotech Ind Mixed feed recombinant yeast fermentation
US5667986A (en) * 1989-10-18 1997-09-16 Delta Biotechnology Limited Yeast promoter for expressing heterologous polypeptides
JPH06503231A (ja) * 1991-09-18 1994-04-14 アムジエン・インコーポレーテツド 胆汁酸塩を含有するｂ型肝炎ワクチン製剤
DE69535097T2 (de) 1994-04-25 2006-12-28 Dsm Ip Assets B.V. Polypeptide mit phytase Wirkung
US6068995A (en) * 1994-10-25 2000-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Method for producing protein
KR0161148B1 (ko) * 1995-10-11 1998-11-16 김은영 재조합 메탄올 자화 효모를 사용한 이종 단백질의 생산방법
CA2231948C (en) 1997-03-25 2010-05-18 F. Hoffmann-La Roche Ag Modified phytases

Also Published As

Publication number Publication date
DE69834533T2 (de) 2006-10-12
EP0911416A3 (en) 2000-01-19
AU8715798A (en) 1999-04-22
EP1659173A1 (en) 2006-05-24
DE69834533D1 (de) 2006-06-22
AU748187B2 (en) 2002-05-30
KR19990036734A (ko) 1999-05-25
EP0911416B1 (en) 2006-05-17
KR100572426B1 (ko) 2006-06-21
US6204012B1 (en) 2001-03-20
EP0911416A2 (en) 1999-04-28
CN1215175C (zh) 2005-08-17
JPH11169173A (ja) 1999-06-29
DK0911416T3 (da) 2006-08-14
JP4162774B2 (ja) 2008-10-08
BR9803807B1 (pt) 2010-11-03
ES2264181T3 (es) 2006-12-16
CA2249061C (en) 2009-02-24
CN1218112A (zh) 1999-06-02
CA2249061A1 (en) 1999-04-01
IN188151B (pt) 2002-08-24

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Free format text: DSM IP ASSETS B.V. (NL)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 03/11/2010, OBSERVADAS AS CONDICOES LEGAIS.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 03.11.2020