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BR9811252A - Processo para preparação de compostos farmacêuticos - Google Patents

Processo para preparação de compostos farmacêuticos

Info

Publication number
BR9811252A
BR9811252A BR9811252-0A BR9811252A BR9811252A BR 9811252 A BR9811252 A BR 9811252A BR 9811252 A BR9811252 A BR 9811252A BR 9811252 A BR9811252 A BR 9811252A
Authority
BR
Brazil
Prior art keywords
preparing pharmaceutical
pharmaceutical compounds
early
compounds
epoxidation
Prior art date
Application number
BR9811252-0A
Other languages
English (en)
Inventor
David W Hoard
Eric D Moher
Vinod F Patel
Original Assignee
Lilly Co Eli
Univ Hawaii
Univ Wayne State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Univ Hawaii, Univ Wayne State filed Critical Lilly Co Eli
Publication of BR9811252A publication Critical patent/BR9811252A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção:<B>"PROCESSO PARA PREPARAçãO DE COMPOSTOS FARMACêUTICOS"<D>. Podem ser preparados compostos de Criptoficina utilizando uma etapa de epoxidação precoce no processo sintético sob as condições estipuladas neste relatório. Esta invenção também refere-se a novos intermediários produzidos através deste processo de epoxidação precoce.
BR9811252-0A 1997-02-26 1998-02-25 Processo para preparação de compostos farmacêuticos BR9811252A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3911697P 1997-02-26 1997-02-26
US3911497P 1997-02-26 1997-02-26
PCT/US1998/003655 WO1998038158A1 (en) 1997-02-26 1998-02-25 Process for preparing pharmaceutical compounds

Publications (1)

Publication Number Publication Date
BR9811252A true BR9811252A (pt) 2000-09-26

Family

ID=26715826

Family Applications (2)

Application Number Title Priority Date Filing Date
BR9811252-0A BR9811252A (pt) 1997-02-26 1998-02-25 Processo para preparação de compostos farmacêuticos
BR9807265-0A BR9807265A (pt) 1997-02-26 1998-02-25 Processo de epoxidação seletiva para preparação de compostos farmacêuticos

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR9807265-0A BR9807265A (pt) 1997-02-26 1998-02-25 Processo de epoxidação seletiva para preparação de compostos farmacêuticos

Country Status (17)

Country Link
US (1) US6143909A (pt)
EP (2) EP0861838A3 (pt)
JP (2) JP2002512603A (pt)
KR (2) KR20000075623A (pt)
CN (2) CN1252788A (pt)
AU (2) AU738999B2 (pt)
BR (2) BR9811252A (pt)
CA (2) CA2281104A1 (pt)
CZ (1) CZ9902998A3 (pt)
EA (2) EA199900770A1 (pt)
ID (2) ID24527A (pt)
IL (2) IL131205A0 (pt)
NO (2) NO994049L (pt)
NZ (1) NZ336918A (pt)
PL (2) PL335478A1 (pt)
TR (2) TR199902065T2 (pt)
WO (2) WO1998038158A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977387A (en) * 1996-08-30 1999-11-02 Eli Lilly And Company Process for preparing pharmaceutical compounds
AU4253997A (en) * 1996-09-06 1998-03-26 Eli Lilly And Company Process and novel intermediates
IL142565A0 (en) * 1998-10-16 2002-03-10 Lilly Co Eli Stereoselective process for producing antineoplastic agents
AU1930100A (en) * 1998-12-07 2000-06-26 Eli Lilly And Company Crotylboration process to produce cryptophycin compounds
WO2000034253A2 (en) * 1998-12-07 2000-06-15 Eli Lilly And Company Intermediates and reaction sequence to produce said intermediates useful for the preparation of antineoplastic and antifungal cryptophycin derivatives
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
EP1751279A4 (en) * 2004-05-05 2008-03-19 Univ Minnesota NUCLEIC ACIDS AND POLYPEPTIDES INVOLVED IN THE PREPARATION OF CRYPTOPHYCIN
CN101962323B (zh) * 2010-07-16 2013-06-05 中国人民解放军第二军医大学 2-丙烯酰x基-3-取代苯基丙酸类化合物及其用途
CN111333560B (zh) * 2020-04-13 2024-01-23 合肥工业大学 一种制备螺环β-内酰胺的方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946835A (en) * 1988-07-15 1990-08-07 Merck & Co., Inc. Antifungal fermentation product and method
US4868208A (en) * 1988-07-15 1989-09-19 Merck & Co., Inc. Antifungal agent and method
US4845086A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
US4845085A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
JPH04504416A (ja) * 1989-02-17 1992-08-06 コセルコ・ミモトープス・ピィ・ティ・ワイ．エル・ティ・ディ． ペプチドの使用方法と合成方法
US5256802A (en) * 1990-04-03 1993-10-26 Miles Inc. Process for the production of oxiranes
EP0672049A4 (en) * 1992-11-06 1997-10-15 Chiron Mimotopes Pty Ltd SUPPORT FOR THE SYNTHESIS OF MODULE POLYMERS.
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
US5952298A (en) * 1993-12-21 1999-09-14 The University Of Hawaii Cryptophycins
CA2179490A1 (en) * 1993-12-21 1995-06-29 Trimurtulu Golakoti New cryptophycins
CA2202480A1 (en) * 1994-10-14 1996-04-25 Jane Charlotte Moores Porphyrin labeling of polynucleotides
JP4181632B2 (ja) * 1995-03-07 2008-11-19 ユニバーシティ オブ ハワイ 新規合成クリプトフィシン類
US5843992A (en) * 1995-03-31 1998-12-01 Nippon Chemiphar Co., Ltd. Epoxysuccinic acid derivatives
US5700826A (en) * 1995-06-07 1997-12-23 Ontogen Corporation 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
WO1997008334A1 (en) * 1995-08-30 1997-03-06 University Of Hawaii Cryptophycins from aberrant biosynthesis
JP2000502351A (ja) * 1995-12-22 2000-02-29 イーライ・リリー・アンド・カンパニー 医薬化合物
AU724312B2 (en) * 1996-02-07 2000-09-14 Buckman Laboratories International, Inc. Synergistic antimicrobial compositions containing an ionene polymer and a salt of dodecylamine and methods of using the same
ATE201018T1 (de) * 1996-02-27 2001-05-15 Lilly Co Eli Cryptophycinderivate und ihre verwendung als antimikrotubuli mittel
CA2263420A1 (en) * 1996-08-30 1998-03-05 James Edward Ray Pharmaceutical compounds
IL128610A (en) * 1996-08-30 2004-07-25 Lilly Co Eli Cryptophycin compound and its use as a medicament for treating neoplasm
AU4169897A (en) * 1996-08-30 1998-03-19 Eli Lilly And Company Pharmaceutical compounds
US6025506A (en) * 1997-02-21 2000-02-15 Dsm N.V. Process for preparing an optically active phenylglycidyl acid derivative
TW438787B (en) * 1997-02-27 2001-06-07 Tanabe Seiyaku Co Process for preparing optically active trans-3-substituted glycidic acid ester

Also Published As

Publication number Publication date
ID22984A (id) 1999-12-23
ID24527A (id) 2000-07-20
WO1998038164A1 (en) 1998-09-03
EA002547B1 (ru) 2002-06-27
AU6667298A (en) 1998-09-18
IL131162A0 (en) 2001-01-28
NO994083D0 (no) 1999-08-24
EP0861838A2 (en) 1998-09-02
CA2281108A1 (en) 1998-09-03
NO994049D0 (no) 1999-08-23
EP0861838A3 (en) 1998-12-09
AU6667198A (en) 1998-09-18
NO994083L (no) 1999-10-25
PL335347A1 (en) 2000-04-25
NO994049L (no) 1999-08-23
CA2281104A1 (en) 1998-09-03
US6143909A (en) 2000-11-07
CN1252788A (zh) 2000-05-10
JP2002513403A (ja) 2002-05-08
EP0861839A1 (en) 1998-09-02
CZ9902998A3 (cs) 2002-10-16
JP2002512603A (ja) 2002-04-23
BR9807265A (pt) 2000-05-23
WO1998038158A1 (en) 1998-09-03
AU738999B2 (en) 2001-10-04
EA199900770A1 (ru) 2000-04-24
TR199902064T2 (xx) 2001-10-22
PL335478A1 (en) 2000-04-25
NZ336918A (en) 2001-11-30
TR199902065T2 (xx) 2000-02-21
KR20000075671A (ko) 2000-12-26
KR20000075623A (ko) 2000-12-26
CN1255121A (zh) 2000-05-31
IL131205A0 (en) 2001-01-28
EA199900772A1 (ru) 2000-04-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, 7A, 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.