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BR9710054A - Aparelhos para separar compostos de teste para um efeito sobre um sistema bioquìmico e para detectar ummefeito de um composto de teste sobre um sistema bioquìmico, processos de determinação de se uma amostra contém um composto capaz de afetar um sistema bioquìmico, de separação de uma pluralidade de compostos de teste para um efeito sobre um sistema bioquìmico e usos de um sistema microfluido e de um substrato de ensaio. - Google Patents

Aparelhos para separar compostos de teste para um efeito sobre um sistema bioquìmico e para detectar ummefeito de um composto de teste sobre um sistema bioquìmico, processos de determinação de se uma amostra contém um composto capaz de afetar um sistema bioquìmico, de separação de uma pluralidade de compostos de teste para um efeito sobre um sistema bioquìmico e usos de um sistema microfluido e de um substrato de ensaio.

Info

Publication number
BR9710054A
BR9710054A BR9710054-4A BR9710054A BR9710054A BR 9710054 A BR9710054 A BR 9710054A BR 9710054 A BR9710054 A BR 9710054A BR 9710054 A BR9710054 A BR 9710054A
Authority
BR
Brazil
Prior art keywords
effect
biochemical system
test
test compounds
biochemical
Prior art date
Application number
BR9710054-4A
Other languages
English (en)
Inventor
John Wallace Parce
Anne R Kopf-Sill
Luc J Bousse
Original Assignee
Caliper Techn Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/671,987 external-priority patent/US5942443A/en
Application filed by Caliper Techn Corp filed Critical Caliper Techn Corp
Publication of BR9710054A publication Critical patent/BR9710054A/pt

Links

Classifications

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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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Abstract

"APARELHOS PARA SEPARAR COMPOSTOS DE TESTE PARA UM EFEITO SOBRE UM SISTEMA BIOQUìMICO E PARA DETECTAR UM EFEITO DE UM COMPOSTO DE TESTE SOBRE UM SISTEMA BIOQUìMICO, PROCESSOS DE DETERMINAçãO DE SE UMA AMOSTRA CONTéM UM COMPOSTO CAPAZ DE AFETAR UM SISTEMA BIOQUìMICO, DE SEPARAçãO DE UMA PLURALIDADE DE COMPOSTOS DE TESTE PARA UM EFEITO SOBRE UM SISTEMA BIOQUìMICO E USOS DE UM SISTEMA MICROFLUIDO E DE UM SUBSTRATO E ENSAIO". A presente invenção fornece dispositivos e processos mocrofluídicos que são úteis para a realização de ensaios de separação de alta passagem. Em particular, os dispositivos e processos da invenção são úteis na separação de grandes números de diferentes compostos por seus efeitos em uma variedade de sistemas químicos, e preferivelmente, bioquímicos. O dispositivo inclui uma série de canais (110,112) e um canal reagente opcional (114) fabricados na superfície do substrato. Pelo menos um desses canais terá tipicamente dimensões transversais muito pequenas, por exemplo, na faixa de cerca de 0,1 <109>m. O dispositivo também inclui reservatórios (104,106,108) dispostos e conectados na forma fluida às extremidades dos canais (110, 114). Como ilustrado, o canal de amostra (112) é utilizado para introduzir a pluralidade de diferentes compostos de teste no dispositivo. Como tal, esse canal é geralmente conectado de forma fluida a uma fonte de grandes números de compostos de teste separados que irão ser individualmente introduzidos no canal de amostra (112) e subseq³entemente no canal (110).
BR9710054-4A 1996-06-28 1997-06-24 Aparelhos para separar compostos de teste para um efeito sobre um sistema bioquìmico e para detectar ummefeito de um composto de teste sobre um sistema bioquìmico, processos de determinação de se uma amostra contém um composto capaz de afetar um sistema bioquìmico, de separação de uma pluralidade de compostos de teste para um efeito sobre um sistema bioquìmico e usos de um sistema microfluido e de um substrato de ensaio. BR9710054A (pt)

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US08/671,987 US5942443A (en) 1996-06-28 1996-06-28 High throughput screening assay systems in microscale fluidic devices
US08/761,575 US6046056A (en) 1996-06-28 1996-12-06 High throughput screening assay systems in microscale fluidic devices
PCT/US1997/010894 WO1998000231A1 (en) 1996-06-28 1997-06-24 High-throughput screening assay systems in microscale fluidic devices

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