BR9708109A - Uso de (+)-alfa-(2,3-dimetoxifenil)-1-[2-(4-fluorofenil)etil]-4-piperidinametanol no tratamento de distúrbios depressivos e distúrbios bipolares - Google Patents

Uso de (+)-alfa-(2,3-dimetoxifenil)-1-[2-(4-fluorofenil)etil]-4-piperidinametanol no tratamento de distúrbios depressivos e distúrbios bipolares

Info

Publication number: BR9708109A
Authority: BR; Brazil
Prior art keywords: disorders; piperidinamethanol; dimethoxyphenyl; fluorophenyl; alpha
Prior art date: 1996-03-21

Application number

BR9708109A

Other languages

English (en)

Inventor

Cesare Mondadori

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-21

Filing date

1997-02-21

Publication date

1999-07-27

1997-02-21 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1999-07-27 Publication of BR9708109A publication Critical patent/BR9708109A/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)

BR9708109A 1996-03-21 1997-02-21 Uso de (+)-alfa-(2,3-dimetoxifenil)-1-[2-(4-fluorofenil)etil]-4-piperidinametanol no tratamento de distúrbios depressivos e distúrbios bipolares BR9708109A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP96400591A EP0796619A1 (en)	1996-03-21	1996-03-21	Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders
PCT/US1997/002597 WO1997034603A1 (en)	1996-03-21	1997-02-21	USE OF (+)-α-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL IN TREATING DEPRESSIVE DISORDERS AND BIPOLAR DISORDERS

Publications (1)

Publication Number	Publication Date
BR9708109A true BR9708109A (pt)	1999-07-27

Family

ID=8225234

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9708109A BR9708109A (pt)	1996-03-21	1997-02-21	Uso de (+)-alfa-(2,3-dimetoxifenil)-1-[2-(4-fluorofenil)etil]-4-piperidinametanol no tratamento de distúrbios depressivos e distúrbios bipolares

Country Status (22)

Country	Link
US (2)	US6022877A (pt)
EP (2)	EP0796619A1 (pt)
JP (1)	JP4165906B2 (pt)
KR (1)	KR100423018B1 (pt)
CN (1)	CN1114406C (pt)
AR (1)	AR006281A1 (pt)
AT (1)	ATE219672T1 (pt)
AU (1)	AU704435B2 (pt)
BR (1)	BR9708109A (pt)
CA (1)	CA2250077C (pt)
DE (1)	DE69713571T2 (pt)
DK (1)	DK0888114T3 (pt)
ES (1)	ES2175356T3 (pt)
HU (1)	HU226675B1 (pt)
IL (1)	IL126022A (pt)
NO (2)	NO316788B1 (pt)
NZ (1)	NZ331448A (pt)
PT (1)	PT888114E (pt)
SI (1)	SI0888114T1 (pt)
TW (1)	TW517048B (pt)
WO (1)	WO1997034603A1 (pt)
ZA (1)	ZA972345B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0796619A1 (en) *	1996-03-21	1997-09-24	Merrell Pharmaceuticals Inc.	Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders
US6713627B2 (en)	1998-03-13	2004-03-30	Aventis Pharmaceuticals Inc.	Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
TWI249526B (en) *	1998-03-13	2006-02-21	Aventis Pharma Inc	Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
SK284858B6 (sk) *	1998-08-28	2006-01-05	Aventis Pharmaceuticals Inc.	Použitie R-(+)-alfa-(2,3-dimetoxyfenyl)-1-[2-(4-fluórfenyl)etyl]- 4-piperidínmetanolu na prípravu liečiva na liečenie obštrukčného spánkového apnoe
US6939879B2 (en)	1998-08-28	2005-09-06	Aventis Pharmaceuticals Inc.	Use of R (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol for the treatment of substance induced insomnia
US6277864B1 (en)	1998-08-28	2001-08-21	Aventis Pharmaceuticals Inc.	Use of R- +)-α-(2,3-dimethoxyphenyl-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol for the treatment of sleep disorders
US20020099076A1 (en) *	2000-05-25	2002-07-25	Richard Scheyer D.	Use of (+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol or its prodrug in the treatment of symptoms of dementia and dopamine induced psychosis
US20020115695A1 (en) *	2000-11-07	2002-08-22	Paralkar Vishwas M.	Combination therapies for the stimulation of bone growth
CN1527830A (zh) *	2001-01-31	2004-09-08	�Ʒ�	用作pde4同工酶的抑制剂的醚衍生物
WO2009152647A1 (zh) *	2008-06-20	2009-12-23	江苏恩华药业股份有限公司	芳烷基哌啶衍生物及其在制备镇痛、镇静药物中的应用
US8188119B2 (en) *	2008-10-24	2012-05-29	Eisai R&D Management Co., Ltd	Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same

Family Cites Families (17)

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Publication number	Priority date	Publication date	Assignee	Title
US4912117A (en) *	1985-07-02	1990-03-27	Merrell Dow Pharmaceuticals Inc.	Novel chemical compounds
US5021428A (en) *	1985-07-02	1991-06-04	Merrell Dow Pharmaceuticals Inc.	Novel chemical compounds for the prophylactic treatment of migraine
US5169096A (en) *	1985-07-02	1992-12-08	Merrell Dow Pharmaceuticals Inc.	N-aralkyl-piperidine-methanol derivatives
US4783471A (en) *	1985-07-02	1988-11-08	Merrell Dow Pharmaceuticals Inc.	N-aralkyl piperidine methanol derivatives and the uses thereof
US4762842A (en) *	1985-10-01	1988-08-09	Eli Lilly And Company	Selective method for blocking 5HT2 receptors
US4877798A (en) *	1987-11-23	1989-10-31	Merrell Dow Pharmaceuticals Inc.	Treatment of fibromyalgia
JPH02138214A (ja) *	1987-12-10	1990-05-28	Merrell Dow Pharmaceut Inc	不安を治療する方法
US5064838A (en) *	1988-01-21	1991-11-12	Merrell Dow Pharmaceuticals	1,4-disubstituted-piperidinyl compounds as pain relievers
EP0325063B1 (en) *	1988-01-21	1994-03-09	Merrell Dow Pharmaceuticals Inc.	Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
ZA891901B (en) *	1988-03-17	1989-11-29	Merrell Dow Pharma	Method for the treatment of the extrapyramidal side effects associated with neuroleptic therapy
US4902691A (en) *	1988-12-19	1990-02-20	Eli Lilly And Company	Heteroalkylamides of (8-β)-1-alkyl-6-(substituted)ergolines useful for blocking 5HT2 receptors
US5106855A (en) *	1989-12-20	1992-04-21	Merrell Dow Pharmaceuticals Inc.	Method for the treatment of glaucoma
JP2869512B2 (ja) *	1990-06-01	1999-03-10	メレルダウファーマスーティカルズインコーポレイテッド	（＋）―α―（２，３―ジメトキシフェニル）―１―［２―（４―フルオロフェニル）エチル］―４―ピペリジンメタノール
US5643784A (en) *	1990-12-04	1997-07-01	H, Lundbeck A/S	Indan derivatives
US5618824A (en) *	1994-03-09	1997-04-08	Merrell Pharmaceuticals Inc.	Treatment of obsessive-compulsive disorders with 5-HT2 antagonists
PL327600A1 (en) *	1995-12-22	1998-12-21	Lilly Co Eli	Method of treating depressions
EP0796619A1 (en) *	1996-03-21	1997-09-24	Merrell Pharmaceuticals Inc.	Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders

1996
- 1996-03-21 EP EP96400591A patent/EP0796619A1/en not_active Withdrawn
1997
- 1997-02-21 AU AU19631/97A patent/AU704435B2/en not_active Ceased
- 1997-02-21 NZ NZ331448A patent/NZ331448A/en unknown
- 1997-02-21 HU HU9902135A patent/HU226675B1/hu not_active IP Right Cessation
- 1997-02-21 DK DK97907698T patent/DK0888114T3/da active
- 1997-02-21 PT PT97907698T patent/PT888114E/pt unknown
- 1997-02-21 BR BR9708109A patent/BR9708109A/pt not_active Application Discontinuation
- 1997-02-21 IL IL12602297A patent/IL126022A/xx not_active IP Right Cessation
- 1997-02-21 ES ES97907698T patent/ES2175356T3/es not_active Expired - Lifetime
- 1997-02-21 KR KR10-1998-0707435A patent/KR100423018B1/ko not_active Expired - Fee Related
- 1997-02-21 CN CN97193148A patent/CN1114406C/zh not_active Expired - Fee Related
- 1997-02-21 WO PCT/US1997/002597 patent/WO1997034603A1/en not_active Ceased
- 1997-02-21 JP JP53346797A patent/JP4165906B2/ja not_active Expired - Fee Related
- 1997-02-21 AT AT97907698T patent/ATE219672T1/de not_active IP Right Cessation
- 1997-02-21 EP EP97907698A patent/EP0888114B1/en not_active Expired - Lifetime
- 1997-02-21 CA CA002250077A patent/CA2250077C/en not_active Expired - Fee Related
- 1997-02-21 DE DE69713571T patent/DE69713571T2/de not_active Expired - Lifetime
- 1997-02-21 SI SI9730363T patent/SI0888114T1/xx unknown
- 1997-03-17 TW TW086103292A patent/TW517048B/zh not_active IP Right Cessation
- 1997-03-18 ZA ZA9702345A patent/ZA972345B/xx unknown
- 1997-03-19 AR ARP970101085A patent/AR006281A1/es unknown
1998
- 1998-02-19 US US09/026,323 patent/US6022877A/en not_active Expired - Lifetime
- 1998-09-18 NO NO19984348A patent/NO316788B1/no not_active IP Right Cessation
2000
- 2000-10-30 US US09/699,647 patent/US6380216B1/en not_active Expired - Fee Related
2003
- 2003-07-11 NO NO20033184A patent/NO20033184D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
IL126022A (en)	2003-11-23
NO316788B1 (no)	2004-05-10
IL126022A0 (en)	1999-05-09
SI0888114T1 (en)	2002-10-31
HK1019702A1 (en)	2000-02-25
EP0888114B1 (en)	2002-06-26
DE69713571T2 (de)	2003-02-20
HU226675B1 (en)	2009-06-29
NO984348D0 (no)	1998-09-18
AU704435B2 (en)	1999-04-22
NO20033184D0 (no)	2003-07-11
DE69713571D1 (de)	2002-08-01
EP0796619A1 (en)	1997-09-24
CA2250077A1 (en)	1997-09-25
CN1213968A (zh)	1999-04-14
ATE219672T1 (de)	2002-07-15
KR100423018B1 (ko)	2004-05-17
EP0888114A1 (en)	1999-01-07
TW517048B (en)	2003-01-11
HUP9902135A3 (en)	2001-05-28
DK0888114T3 (da)	2002-10-07
ZA972345B (en)	1997-09-25
AU1963197A (en)	1997-10-10
PT888114E (pt)	2002-11-29
WO1997034603A1 (en)	1997-09-25
NZ331448A (en)	2000-06-23
HUP9902135A2 (hu)	1999-11-29
CN1114406C (zh)	2003-07-16
KR20000064711A (ko)	2000-11-06
US6380216B1 (en)	2002-04-30
AR006281A1 (es)	1999-08-11
NO984348L (no)	1998-09-18
ES2175356T3 (es)	2002-11-16
CA2250077C (en)	2003-10-07
NO20033184L (no)	1998-09-18
US6022877A (en)	2000-02-08
JP4165906B2 (ja)	2008-10-15
JP2000506887A (ja)	2000-06-06

Publication	Publication Date	Title
ATE114467T1 (de)	1994-12-15	(+)-alpha-(2,3 dimethoxyphenyl)-1-(2- (fluorophenyl)ethyl>-4-piperidinmethanol.
DE69731225D1 (de)	2004-11-18	Chirurgisches handstück
DE69715482D1 (de)	2002-10-24	Herstellung von 1,1,1,3,3-Pentachlorbutan und von 1,1,1,3,3-Pentafluorbutan
DE69729817D1 (de)	2004-08-19	Behandlung von Aldehyd-fixierten Geweben
BR9708109A (pt)	1999-07-27	Uso de (+)-alfa-(2,3-dimetoxifenil)-1-[2-(4-fluorofenil)etil]-4-piperidinametanol no tratamento de distúrbios depressivos e distúrbios bipolares
NO984836L (no)	1998-12-16	Substituerte benzylaminer og deres anvendelse for behandling av depresjon
FI951060L (fi)	1995-09-09	Formulaatioita ja hoitomenetelmiä
DE69727240D1 (de)	2004-02-19	Kombinationen enthaltend vx478, zidovudin und 3tc zur behandlung von hiv
FI971127A7 (fi)	1997-03-18	2,4-diaminopyrimidiini-3-oksidin tai jonkin sen suolan käyttö kollagee nin kypsymis- ja rakentumishäiriöiden hoitamiseen
CY2482B1 (en)	2005-06-03	Paroxetine in treatment of depression.
PT925039E (pt)	2002-06-28	Aparelhos para tratamento de ortopedia funcional dento facial e parodontologia
BG104914A (en)	2001-10-31	Paroxetine maleate
DE59711240D1 (de)	2004-02-26	Verwendung von flupirtin zur therapie und prophylaxe von myokardinfarkt, schockniere und schocklunge
PT1052991E (pt)	2003-08-29	Utilizacao de loperamida para o tratamento de infeccoes microbianas
HUP0202145A3 (en)	2003-02-28	The use of r(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol for the treatment of sleep disorders
BR1100532A (pt)	2000-06-06	(+)-alfa-(2,3-dimetoxifenil)-1-[2-(4-fluorfenil)etil]-4-pipe ridinometanol e composição contendo o mesmo
ITMI940151A0 (it)	1994-01-31	Impianto dentale perfezionato
GB9603766D0 (en)	1996-04-24	2-(Fluroenonyl) - carbapenems, compositions and methods of use
ITPR960023A0 (it)	1996-05-22	Manipolo per elettrobisturi
KR970056712U (ko)	1997-11-10	조정식 미용 의자
IT1286876B1 (it)	1998-07-17	Procedimento per la preparazione e la conservazione di succo di limone fresco
FR2743721B1 (fr)	1998-04-03	Association mineralo-phytotherapique sous forme galenique unitaire de comprimes
UA43435C2 (uk)	2001-12-17	Композиція інгредієнтів для гіркої настоянки "старовинна"
ES1033501Y (es)	1997-02-01	Aparato limpiador de dentaduras postizas y similares.
IT1280387B1 (it)	1998-01-20	Uso di 2, 3-diidro-4(1h)-chinazolinoni e di composizioni farmaceutiche che li contengono nel trattamento dei disturbi

Legal Events

Date	Code	Title	Description
2006-12-19	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2007-08-21	B25D	Requested change of name of applicant approved	Owner name: AVENTIS PHARMACEUTICALS INC. (US) Free format text: ALTERADO DE: HOECHST MARION ROUSSEL, INC.
2007-08-21	B25G	Requested change of headquarter approved	Owner name: AVENTIS PHARMACEUTICALS INC. (US) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070033918/RJ DE 19/03/2007.
2007-11-06	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE, DE ACORDO COM ART. 36 DA LPI (LEI 9279/96).