BR9608404A - Processo para armazenar células sanguìneas vermelhas. - Google Patents
Processo para armazenar células sanguìneas vermelhas.Info
- Publication number
- BR9608404A BR9608404A BR9608404-9A BR9608404A BR9608404A BR 9608404 A BR9608404 A BR 9608404A BR 9608404 A BR9608404 A BR 9608404A BR 9608404 A BR9608404 A BR 9608404A
- Authority
- BR
- Brazil
- Prior art keywords
- red blood
- blood cells
- stored
- levels
- adenosine triphosphate
- Prior art date
Links
- 210000003743 erythrocyte Anatomy 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 abstract 2
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 abstract 2
- 239000004254 Ammonium phosphate Substances 0.000 abstract 1
- 206010018910 Haemolysis Diseases 0.000 abstract 1
- 229910000148 ammonium phosphate Inorganic materials 0.000 abstract 1
- 235000019289 ammonium phosphates Nutrition 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 abstract 1
- 230000008588 hemolysis Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"PROCESSO PARA ARMAZENAR CéLULAS SANGUìNEAS VERMELHAS". é descrito m procedimento de armazenamento a 4°C, de custo efetivo, que preserva a qualidade das células vermelhas e prolonga a sobrevivência in vivo, pós-transfusão. A preservação dos níveis de trifosfato de adenosina e a redução na hemólise e na produção vesicular da membrana de células sanguíneas vermelhas, armazenadas a 4°C, por períodos de tempo prolongados, é conseguida pela remoção de oxigênio a partir das mesmas no momento de armazenamento. Os níveis de trifosfato de adenosina das células sanguíneas vermelhas armazenadas aumentados pela adição de fosfato de amónio.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/473,675 US5624794A (en) | 1995-06-05 | 1995-06-05 | Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas |
| PCT/US1996/009005 WO1996039026A1 (en) | 1995-06-05 | 1996-06-05 | Method using oxygen removal for extending the useful shelf-life of refrigerated red blood cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9608404A true BR9608404A (pt) | 1999-11-30 |
Family
ID=23880537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9608404-9A BR9608404A (pt) | 1995-06-05 | 1996-06-05 | Processo para armazenar células sanguìneas vermelhas. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5624794A (pt) |
| EP (1) | EP0830058B1 (pt) |
| JP (1) | JP4303786B2 (pt) |
| KR (1) | KR100395033B1 (pt) |
| CN (1) | CN1153512C (pt) |
| AT (1) | ATE232359T1 (pt) |
| AU (1) | AU710467B2 (pt) |
| BR (1) | BR9608404A (pt) |
| CA (1) | CA2223130C (pt) |
| DE (1) | DE69626204T2 (pt) |
| ES (1) | ES2194993T3 (pt) |
| RU (1) | RU2181542C2 (pt) |
| WO (1) | WO1996039026A1 (pt) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6162396A (en) * | 1997-04-26 | 2000-12-19 | The Regents Of The University Of California | Blood storage device and method for oxygen removal |
| US5789151A (en) * | 1997-05-15 | 1998-08-04 | The Regents Of The University Of California | Prolonged cold storage of red blood cells by oxygen removal and additive usage |
| US20030215784A1 (en) * | 1998-07-21 | 2003-11-20 | Dumont Larry Joe | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US7498156B2 (en) * | 1998-07-21 | 2009-03-03 | Caridianbct Biotechnologies, Llc | Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components |
| US20070099170A1 (en) * | 1998-07-21 | 2007-05-03 | Navigant Biotechnologies, Inc. | Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate |
| US7049110B2 (en) * | 1998-07-21 | 2006-05-23 | Gambro, Inc. | Inactivation of West Nile virus and malaria using photosensitizers |
| US7220747B2 (en) | 1999-07-20 | 2007-05-22 | Gambro, Inc. | Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer |
| US7985588B2 (en) * | 2000-06-02 | 2011-07-26 | Caridianbct Biotechnologies, Llc | Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light |
| TW590780B (en) * | 2000-06-02 | 2004-06-11 | Gambro Inc | Additive solutions containing riboflavin |
| US7648699B2 (en) * | 2000-06-02 | 2010-01-19 | Caridianbct Biotechnologies, Llc | Preventing transfusion related complications in a recipient of a blood transfusion |
| US6548241B1 (en) | 2000-11-28 | 2003-04-15 | Gambro, Inc. | Storage solution containing photosensitizer for inactivation of biological contaminants |
| CA2467087A1 (en) * | 2001-11-16 | 2003-05-30 | Hemanext, Llc | Additive solution for blood preservation |
| WO2003043571A2 (en) * | 2001-11-16 | 2003-05-30 | Hollinger Digital, Inc. | Method for extending the useful shelf-life of refrigerated red blood cells by nutrient supplementation |
| US8828226B2 (en) | 2003-03-01 | 2014-09-09 | The Trustees Of Boston University | System for assessing the efficacy of stored red blood cells using microvascular networks |
| US9314014B2 (en) * | 2004-02-18 | 2016-04-19 | University Of Maryland, Baltimore | Compositions and methods for the storage of red blood cells |
| CN1325518C (zh) * | 2005-09-09 | 2007-07-11 | 李勇 | 人细胞膜抗原的保存方法及磁性粒子包被人细胞膜抗原 |
| ES2389784T3 (es) * | 2006-09-21 | 2012-10-31 | Kyphon SÀRL | Fosfato de diamonio y otras sales de amonio y su uso para prevenir la coagulación de la sangre |
| EP2205285A2 (en) * | 2007-08-01 | 2010-07-14 | CaridianBCT Biotechnologies, LLC | Pathogen inactivation of whole blood |
| WO2009026073A1 (en) * | 2007-08-22 | 2009-02-26 | Caridianbct Biotechnologies, Llc | Prevention of transfusion related acute lung injury using riboflavin and light |
| US8871434B2 (en) * | 2008-03-21 | 2014-10-28 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
| US8968992B2 (en) * | 2008-03-21 | 2015-03-03 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
| US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
| CN102711865B (zh) * | 2009-10-12 | 2015-08-19 | 新健康科学股份有限公司 | 具有氧和二氧化碳消耗能力的血液贮藏袋系统和消耗装置 |
| JP2013507447A (ja) | 2009-10-12 | 2013-03-04 | ニュー ヘルス サイエンシーズ、インク． | 酸素減損装置及び赤血球から酸素を除去する方法 |
| US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US12089589B2 (en) | 2009-10-12 | 2024-09-17 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| EP2490751B1 (en) | 2009-10-23 | 2016-11-09 | Fenwal, Inc. | Methods and systems for providing red blood cell products with reduced plasma |
| ES2959120T3 (es) | 2010-08-25 | 2024-02-20 | Hemanext Inc | Método para potenciar la calidad y la supervivencia de glóbulos rojos durante el almacenamiento |
| PT2635114T (pt) * | 2010-11-05 | 2020-06-16 | New Health Sciences Inc | Irradiação de glóbulos vermelhos e armazenamento anaeróbico |
| CA2826969C (en) | 2010-11-29 | 2019-02-19 | New York Blood Center, Inc. | Method of blood pooling and storage |
| JP2014510731A (ja) | 2011-03-16 | 2014-05-01 | メイヨー ファンデーション フォー メディカル エデュケーション アンド リサーチ | 赤血球製剤および血小板製剤の有効貯蔵を延ばすための方法および材料 |
| US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
| WO2013022491A1 (en) * | 2011-03-28 | 2013-02-14 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
| JP2014518283A (ja) * | 2011-07-05 | 2014-07-28 | ニュー・ヘルス・サイエンシーズ・インコーポレイテッド | 赤血球の長期保存システムおよび使用方法 |
| ES2984863T3 (es) | 2011-08-10 | 2024-10-31 | Hemanext Inc | Dispositivo integrado de filtrado de leucocitos, oxígeno y/o agotamiento de CO2, y separación de plasma |
| WO2013049118A1 (en) | 2011-09-26 | 2013-04-04 | Rich Products Corporation | Method for living tissue preservation |
| US9977037B2 (en) | 2012-05-22 | 2018-05-22 | New Health Sciences, Inc. | Capillary network devices and methods of use |
| EP4032402A1 (en) * | 2012-11-30 | 2022-07-27 | Rich Technologies Holding Company, LLC | Erythrocyte preservation system |
| US9877476B2 (en) | 2013-02-28 | 2018-01-30 | New Health Sciences, Inc. | Gas depletion and gas addition devices for blood treatment |
| KR101653937B1 (ko) * | 2014-03-13 | 2016-09-02 | 미즈 가부시키가이샤 | 수소 함유 생체 적용액의 제조 방법 및 그것을 위한 외장체 |
| KR20250033333A (ko) | 2015-03-10 | 2025-03-07 | 헤마넥스트 인코포레이티드 | 산소 감소 1회용 키트, 장치 및 이의 사용 방법 |
| WO2016172645A1 (en) | 2015-04-23 | 2016-10-27 | New Health Sciences, Inc. | Anaerobic blood storage containers |
| ES3042959T3 (en) | 2015-05-18 | 2025-11-24 | Hemanext Inc | Methods for the storage of whole blood, and compositions thereof |
| US11147876B2 (en) | 2016-05-27 | 2021-10-19 | Hemanext Inc. | Anaerobic blood storage and pathogen inactivation method |
| EP3474922A1 (en) | 2016-06-23 | 2019-05-01 | New Health Sciences, Inc. | Methods for managing adverse events in patient populations requiring transfusion |
| EP3708174B1 (en) | 2017-05-19 | 2022-10-12 | Hemanext Inc. | Methods and treatment of trauma |
| CN107873696B (zh) * | 2017-11-14 | 2020-12-11 | 上海市血液中心 | 一种熊科动物红细胞保存液及其应用 |
| US12447177B2 (en) | 2018-11-16 | 2025-10-21 | Hemanext Inc. | Methods for managing adverse events in patients with inflammation |
| CN110447634A (zh) * | 2019-06-27 | 2019-11-15 | 浙江省疾病预防控制中心 | 一种猴红细胞保存液及应用 |
| CN110199987A (zh) * | 2019-07-22 | 2019-09-06 | 深圳市未来细胞生命科技有限公司 | 一种间充质干细胞保存液及其保存方法和应用 |
| CN114288484B (zh) * | 2021-12-10 | 2023-01-03 | 中国人民解放军军事科学院军事医学研究院 | 低氧过滤血袋系统、血袋系统以及血液处理方法 |
| WO2024064723A1 (en) | 2022-09-20 | 2024-03-28 | Hemanext Inc. | Oxygen reduced blood for use in the treatment of traumatic brain injury accompanied by hemorrhagic shock |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267269A (en) * | 1980-02-05 | 1981-05-12 | Baxter Travenol Laboratories, Inc. | Red cell storage solution |
| DE3364674D1 (en) * | 1982-04-27 | 1986-08-28 | Wellcome Found | Tricyclic compounds, preparation, use and intermediates |
| DE3225408A1 (de) * | 1982-07-07 | 1984-01-12 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Waessrige loesung zum suspendieren und lagern von zellen, insbesondere erythrozyten |
| US4585735A (en) * | 1984-07-19 | 1986-04-29 | American National Red Cross | Prolonged storage of red blood cells |
| FR2581289A1 (fr) * | 1985-05-06 | 1986-11-07 | Rgl Transfusion Sanguine Centr | Solution synthetique pour la conservation prolongee de concentres erythrocytaires |
| DE3722984A1 (de) * | 1987-07-11 | 1989-01-19 | Biotest Pharma Gmbh | Waessrige loesung zum suspendieren und lagern von zellen, insbesondere erythrozyten |
| SU1718766A1 (ru) * | 1990-01-30 | 1992-03-15 | Ленинградский научно-исследовательский институт гематологии и переливания крови | Способ консервировани эритроцитов крови |
| US5476764A (en) * | 1994-09-16 | 1995-12-19 | The Regents Of The University Of California | Method using CO for extending the useful shelf-life of refrigerated red blood cells |
-
1995
- 1995-06-05 US US08/473,675 patent/US5624794A/en not_active Expired - Fee Related
-
1996
- 1996-06-05 ES ES96918133T patent/ES2194993T3/es not_active Expired - Lifetime
- 1996-06-05 KR KR1019970708873A patent/KR100395033B1/ko not_active Expired - Fee Related
- 1996-06-05 AU AU60470/96A patent/AU710467B2/en not_active Ceased
- 1996-06-05 AT AT96918133T patent/ATE232359T1/de not_active IP Right Cessation
- 1996-06-05 WO PCT/US1996/009005 patent/WO1996039026A1/en not_active Ceased
- 1996-06-05 RU RU98100105/14A patent/RU2181542C2/ru active
- 1996-06-05 JP JP50143097A patent/JP4303786B2/ja not_active Expired - Lifetime
- 1996-06-05 DE DE69626204T patent/DE69626204T2/de not_active Expired - Fee Related
- 1996-06-05 EP EP96918133A patent/EP0830058B1/en not_active Expired - Lifetime
- 1996-06-05 CN CNB961960531A patent/CN1153512C/zh not_active Expired - Fee Related
- 1996-06-05 BR BR9608404-9A patent/BR9608404A/pt not_active Application Discontinuation
- 1996-06-05 CA CA002223130A patent/CA2223130C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0830058A4 (en) | 1999-04-14 |
| CN1153512C (zh) | 2004-06-16 |
| JP4303786B2 (ja) | 2009-07-29 |
| DE69626204T2 (de) | 2003-12-11 |
| EP0830058A1 (en) | 1998-03-25 |
| AU710467B2 (en) | 1999-09-23 |
| EP0830058B1 (en) | 2003-02-12 |
| CA2223130C (en) | 2005-02-08 |
| ATE232359T1 (de) | 2003-02-15 |
| KR100395033B1 (ko) | 2003-12-31 |
| KR19990022393A (ko) | 1999-03-25 |
| AU6047096A (en) | 1996-12-24 |
| CN1195965A (zh) | 1998-10-14 |
| JPH11506777A (ja) | 1999-06-15 |
| DE69626204D1 (de) | 2003-03-20 |
| RU2181542C2 (ru) | 2002-04-27 |
| CA2223130A1 (en) | 1996-12-12 |
| WO1996039026A1 (en) | 1996-12-12 |
| ES2194993T3 (es) | 2003-12-01 |
| US5624794A (en) | 1997-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EG | Technical examination (opinion): publication of technical examination (opinion) | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |