DE69626204D1 - Die beseitigung von sauerstoff beinhaltendes verfahren zur verlängerung der nutzbaren bevorratungszeit von gekühlten roten blutkörperchen - Google Patents
Die beseitigung von sauerstoff beinhaltendes verfahren zur verlängerung der nutzbaren bevorratungszeit von gekühlten roten blutkörperchenInfo
- Publication number
- DE69626204D1 DE69626204D1 DE69626204T DE69626204T DE69626204D1 DE 69626204 D1 DE69626204 D1 DE 69626204D1 DE 69626204 T DE69626204 T DE 69626204T DE 69626204 T DE69626204 T DE 69626204T DE 69626204 D1 DE69626204 D1 DE 69626204D1
- Authority
- DE
- Germany
- Prior art keywords
- blood cells
- red blood
- extending
- oxygen
- removal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000003743 erythrocyte Anatomy 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 abstract 2
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000004254 Ammonium phosphate Substances 0.000 abstract 1
- 206010018910 Haemolysis Diseases 0.000 abstract 1
- 229910000148 ammonium phosphate Inorganic materials 0.000 abstract 1
- 235000019289 ammonium phosphates Nutrition 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 abstract 1
- 238000011010 flushing procedure Methods 0.000 abstract 1
- 230000008588 hemolysis Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000011261 inert gas Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/473,675 US5624794A (en) | 1995-06-05 | 1995-06-05 | Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas |
| PCT/US1996/009005 WO1996039026A1 (en) | 1995-06-05 | 1996-06-05 | Method using oxygen removal for extending the useful shelf-life of refrigerated red blood cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69626204D1 true DE69626204D1 (de) | 2003-03-20 |
| DE69626204T2 DE69626204T2 (de) | 2003-12-11 |
Family
ID=23880537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69626204T Expired - Fee Related DE69626204T2 (de) | 1995-06-05 | 1996-06-05 | Die beseitigung von sauerstoff beinhaltendes verfahren zur verlängerung der nutzbaren bevorratungszeit von gekühlten roten blutkörperchen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5624794A (de) |
| EP (1) | EP0830058B1 (de) |
| JP (1) | JP4303786B2 (de) |
| KR (1) | KR100395033B1 (de) |
| CN (1) | CN1153512C (de) |
| AT (1) | ATE232359T1 (de) |
| AU (1) | AU710467B2 (de) |
| BR (1) | BR9608404A (de) |
| CA (1) | CA2223130C (de) |
| DE (1) | DE69626204T2 (de) |
| ES (1) | ES2194993T3 (de) |
| RU (1) | RU2181542C2 (de) |
| WO (1) | WO1996039026A1 (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6162396A (en) * | 1997-04-26 | 2000-12-19 | The Regents Of The University Of California | Blood storage device and method for oxygen removal |
| US5789151A (en) * | 1997-05-15 | 1998-08-04 | The Regents Of The University Of California | Prolonged cold storage of red blood cells by oxygen removal and additive usage |
| US20030215784A1 (en) * | 1998-07-21 | 2003-11-20 | Dumont Larry Joe | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US7049110B2 (en) * | 1998-07-21 | 2006-05-23 | Gambro, Inc. | Inactivation of West Nile virus and malaria using photosensitizers |
| US20070099170A1 (en) * | 1998-07-21 | 2007-05-03 | Navigant Biotechnologies, Inc. | Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate |
| US7498156B2 (en) * | 1998-07-21 | 2009-03-03 | Caridianbct Biotechnologies, Llc | Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components |
| US7220747B2 (en) | 1999-07-20 | 2007-05-22 | Gambro, Inc. | Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer |
| TW590780B (en) * | 2000-06-02 | 2004-06-11 | Gambro Inc | Additive solutions containing riboflavin |
| US7648699B2 (en) * | 2000-06-02 | 2010-01-19 | Caridianbct Biotechnologies, Llc | Preventing transfusion related complications in a recipient of a blood transfusion |
| US7985588B2 (en) * | 2000-06-02 | 2011-07-26 | Caridianbct Biotechnologies, Llc | Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light |
| US6548241B1 (en) | 2000-11-28 | 2003-04-15 | Gambro, Inc. | Storage solution containing photosensitizer for inactivation of biological contaminants |
| AU2002348283A1 (en) * | 2001-11-16 | 2003-06-10 | Hemanext, Llc | Additive solution for blood preservation |
| CA2467223A1 (en) * | 2001-11-16 | 2003-05-30 | Hollinger Digital, Inc. | Method for extending the useful shelf-life of refrigerated red blood cells by nutrient supplementation |
| US8828226B2 (en) | 2003-03-01 | 2014-09-09 | The Trustees Of Boston University | System for assessing the efficacy of stored red blood cells using microvascular networks |
| US9314014B2 (en) | 2004-02-18 | 2016-04-19 | University Of Maryland, Baltimore | Compositions and methods for the storage of red blood cells |
| CN1325518C (zh) * | 2005-09-09 | 2007-07-11 | 李勇 | 人细胞膜抗原的保存方法及磁性粒子包被人细胞膜抗原 |
| ES2389784T3 (es) * | 2006-09-21 | 2012-10-31 | Kyphon SÀRL | Fosfato de diamonio y otras sales de amonio y su uso para prevenir la coagulación de la sangre |
| RU2010107157A (ru) * | 2007-08-01 | 2011-09-10 | Каридианбст Байотекнолоджиз, Ллс (Us) | Инактивация патогенов цельной крови |
| WO2009026073A1 (en) * | 2007-08-22 | 2009-02-26 | Caridianbct Biotechnologies, Llc | Prevention of transfusion related acute lung injury using riboflavin and light |
| US8968992B2 (en) * | 2008-03-21 | 2015-03-03 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
| US8871434B2 (en) * | 2008-03-21 | 2014-10-28 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
| BR112012008682A2 (pt) * | 2009-10-12 | 2017-06-20 | New Health Sciences Inc | "dispositivo de depleção de oxigênio, e, método para remover oxigênio de células vermelhas do sangue." |
| US9199016B2 (en) * | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
| NZ599891A (en) * | 2009-10-12 | 2014-06-27 | New Health Sciences Inc | Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities |
| US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US12089589B2 (en) | 2009-10-12 | 2024-09-17 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| EP2490751B1 (de) | 2009-10-23 | 2016-11-09 | Fenwal, Inc. | Verfahren und systeme zur bereitstellung von erythrozytenprodukten mit reduziertem plasma |
| PT2608816T (pt) | 2010-08-25 | 2023-10-12 | Dartmouth College | Método para melhorar a qualidade e a sobrevivência dos glóbulos vermelhos durante o armazenamento |
| EP3539381B1 (de) | 2010-11-05 | 2023-05-24 | Hemanext Inc. | Bestrahlung von roten blutkörperchen und anaerobe lagerung |
| EP2645854B1 (de) | 2010-11-29 | 2017-10-18 | New York Blood Center, Inc. | Verfahren zur sammlung und lagerung von blut |
| AU2012228972A1 (en) | 2011-03-16 | 2013-10-24 | Dynasil Biomedical Corporation | Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations |
| EP2691160A4 (de) * | 2011-03-28 | 2015-04-08 | New Health Sciences Inc | Verfahren und system zur entfernung von sauerstoff und kohlendioxid während einer erythrozytenbehandlung mithilfe eines trägen trägergases und verteileranordnung |
| US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
| PT2729000T (pt) | 2011-07-05 | 2023-04-10 | Hemanext Inc | Um método para o armazenamento prolongado de glóbulos vermelhos |
| EP3533507B1 (de) | 2011-08-10 | 2022-03-30 | Hemanext Inc. | Integrierte leukozyten-, sauerstoff- und/oder co2-abreicherung und filtervorrichtung zum trennen von plasma |
| JP6046727B2 (ja) | 2011-09-26 | 2016-12-21 | アドバンスド プリザベイションズ テクノロジーズ リミテッド ライアビリティー カンパニー | 生体組織の保存方法 |
| US9977037B2 (en) | 2012-05-22 | 2018-05-22 | New Health Sciences, Inc. | Capillary network devices and methods of use |
| CA2892006C (en) * | 2012-11-30 | 2023-01-24 | Advanced Preservations Technologies, Llc | Erythrocyte preservation method |
| EP3967143B1 (de) | 2013-02-28 | 2025-05-21 | Hemanext Inc. | Gasanreicherungsvorrichtung zur blutbehandlung und zugehöriges verfahren |
| EP2985028B1 (de) * | 2014-03-13 | 2019-05-22 | MIZ Co., Ltd. | Verfahren und vorrichtung zur herstellung einer wasserstoffhaltigen biologischen applikationsflüssigkeit |
| EP3970731B1 (de) | 2015-03-10 | 2025-11-19 | Hemanext Inc. | Einweg-kits zur sauerstoffreduktion, vorrichtungen und verfahren zur verwendung davon |
| BR112017022417B1 (pt) | 2015-04-23 | 2022-07-19 | Hemanext Inc | Dispositivo de armazenamento de sangue para armazenar sangue depletado de oxigênio e método para reduzir a saturação de oxigênio do sangue durante o armazenamento |
| CN114748503B (zh) | 2015-05-18 | 2025-09-30 | 希玛奈克斯特股份有限公司 | 储存全血的方法及其组合物 |
| EP4049677B1 (de) | 2016-05-27 | 2025-12-10 | Hemanext Inc. | Anaerobe blutlagerung und verfahren zur inaktivierung von pathogenen |
| EP3474922A1 (de) | 2016-06-23 | 2019-05-01 | New Health Sciences, Inc. | Verfahren zur verwaltung von unerwünschten ereignissen in patientenpopulationen, die eine transfusion benötigen |
| ES2935691T3 (es) | 2017-05-19 | 2023-03-09 | Hemanext Inc | Procedimientos y tratamiento de traumatismos |
| CN107873696B (zh) * | 2017-11-14 | 2020-12-11 | 上海市血液中心 | 一种熊科动物红细胞保存液及其应用 |
| US12447177B2 (en) | 2018-11-16 | 2025-10-21 | Hemanext Inc. | Methods for managing adverse events in patients with inflammation |
| CN110447634A (zh) * | 2019-06-27 | 2019-11-15 | 浙江省疾病预防控制中心 | 一种猴红细胞保存液及应用 |
| CN110199987A (zh) * | 2019-07-22 | 2019-09-06 | 深圳市未来细胞生命科技有限公司 | 一种间充质干细胞保存液及其保存方法和应用 |
| CN114288484B (zh) * | 2021-12-10 | 2023-01-03 | 中国人民解放军军事科学院军事医学研究院 | 低氧过滤血袋系统、血袋系统以及血液处理方法 |
| CA3268336A1 (en) | 2022-09-20 | 2024-03-28 | Hemanext Inc. | REDUCED OXYGEN BLOOD INTENDED FOR USE IN THE TREATMENT OF TRAUMATIC BRAIN INJURY ACCOMPANIED BY HEMORRHAGIC SHOCK |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267269A (en) * | 1980-02-05 | 1981-05-12 | Baxter Travenol Laboratories, Inc. | Red cell storage solution |
| EP0093381B1 (de) * | 1982-04-27 | 1986-07-23 | The Wellcome Foundation Limited | Tricyclische Verbindungen, ihre Herstellung und Verwendung sowie Zwischenprodukte |
| DE3225408A1 (de) * | 1982-07-07 | 1984-01-12 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Waessrige loesung zum suspendieren und lagern von zellen, insbesondere erythrozyten |
| US4585735A (en) * | 1984-07-19 | 1986-04-29 | American National Red Cross | Prolonged storage of red blood cells |
| FR2581289A1 (fr) * | 1985-05-06 | 1986-11-07 | Rgl Transfusion Sanguine Centr | Solution synthetique pour la conservation prolongee de concentres erythrocytaires |
| DE3722984A1 (de) * | 1987-07-11 | 1989-01-19 | Biotest Pharma Gmbh | Waessrige loesung zum suspendieren und lagern von zellen, insbesondere erythrozyten |
| SU1718766A1 (ru) * | 1990-01-30 | 1992-03-15 | Ленинградский научно-исследовательский институт гематологии и переливания крови | Способ консервировани эритроцитов крови |
| US5476764A (en) * | 1994-09-16 | 1995-12-19 | The Regents Of The University Of California | Method using CO for extending the useful shelf-life of refrigerated red blood cells |
-
1995
- 1995-06-05 US US08/473,675 patent/US5624794A/en not_active Expired - Fee Related
-
1996
- 1996-06-05 WO PCT/US1996/009005 patent/WO1996039026A1/en not_active Ceased
- 1996-06-05 JP JP50143097A patent/JP4303786B2/ja not_active Expired - Lifetime
- 1996-06-05 KR KR1019970708873A patent/KR100395033B1/ko not_active Expired - Fee Related
- 1996-06-05 AT AT96918133T patent/ATE232359T1/de not_active IP Right Cessation
- 1996-06-05 RU RU98100105/14A patent/RU2181542C2/ru active
- 1996-06-05 BR BR9608404-9A patent/BR9608404A/pt not_active Application Discontinuation
- 1996-06-05 CA CA002223130A patent/CA2223130C/en not_active Expired - Lifetime
- 1996-06-05 EP EP96918133A patent/EP0830058B1/de not_active Expired - Lifetime
- 1996-06-05 DE DE69626204T patent/DE69626204T2/de not_active Expired - Fee Related
- 1996-06-05 CN CNB961960531A patent/CN1153512C/zh not_active Expired - Fee Related
- 1996-06-05 AU AU60470/96A patent/AU710467B2/en not_active Ceased
- 1996-06-05 ES ES96918133T patent/ES2194993T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11506777A (ja) | 1999-06-15 |
| KR100395033B1 (ko) | 2003-12-31 |
| CA2223130A1 (en) | 1996-12-12 |
| EP0830058B1 (de) | 2003-02-12 |
| CN1153512C (zh) | 2004-06-16 |
| ES2194993T3 (es) | 2003-12-01 |
| CA2223130C (en) | 2005-02-08 |
| EP0830058A4 (de) | 1999-04-14 |
| BR9608404A (pt) | 1999-11-30 |
| CN1195965A (zh) | 1998-10-14 |
| AU710467B2 (en) | 1999-09-23 |
| JP4303786B2 (ja) | 2009-07-29 |
| EP0830058A1 (de) | 1998-03-25 |
| RU2181542C2 (ru) | 2002-04-27 |
| AU6047096A (en) | 1996-12-24 |
| WO1996039026A1 (en) | 1996-12-12 |
| DE69626204T2 (de) | 2003-12-11 |
| KR19990022393A (ko) | 1999-03-25 |
| US5624794A (en) | 1997-04-29 |
| ATE232359T1 (de) | 2003-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8339 | Ceased/non-payment of the annual fee |