BR9508633A - Composição preparação de vacina estojo e processos para criar ou sustentar uma resposta imune protetora ou adaptadora a um antígeno em um hospedeiro e para induzir uma resposta imune protetora contra um organismo bacteriano enterotóxico - Google Patents
Composição preparação de vacina estojo e processos para criar ou sustentar uma resposta imune protetora ou adaptadora a um antígeno em um hospedeiro e para induzir uma resposta imune protetora contra um organismo bacteriano enterotóxicoInfo
- Publication number
- BR9508633A BR9508633A BR9508633A BR9508633A BR9508633A BR 9508633 A BR9508633 A BR 9508633A BR 9508633 A BR9508633 A BR 9508633A BR 9508633 A BR9508633 A BR 9508633A BR 9508633 A BR9508633 A BR 9508633A
- Authority
- BR
- Brazil
- Prior art keywords
- immune response
- protective
- antigen
- sustain
- induce
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 230000028993 immune response Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000001681 protective effect Effects 0.000 title 2
- 230000033289 adaptive immune response Effects 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 title 1
- 231100000249 enterotoxic Toxicity 0.000 title 1
- 230000002242 enterotoxic effect Effects 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 101710146739 Enterotoxin Proteins 0.000 abstract 2
- 239000000147 enterotoxin Substances 0.000 abstract 2
- 231100000655 enterotoxin Toxicity 0.000 abstract 2
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 229940126578 oral vaccine Drugs 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Carbon And Carbon Compounds (AREA)
- Dental Preparations (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/296,848 US6019982A (en) | 1994-08-26 | 1994-08-26 | Mutant enterotoxin effective as a non-toxic oral adjuvant |
| PCT/US1995/009005 WO1996006627A1 (en) | 1994-08-26 | 1995-07-18 | Mutant enterotoxin effective as a non-toxic oral adjuvant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9508633A true BR9508633A (pt) | 1997-09-30 |
Family
ID=23143827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9508633A BR9508633A (pt) | 1994-08-26 | 1995-07-18 | Composição preparação de vacina estojo e processos para criar ou sustentar uma resposta imune protetora ou adaptadora a um antígeno em um hospedeiro e para induzir uma resposta imune protetora contra um organismo bacteriano enterotóxico |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6019982A (pt) |
| EP (1) | EP0777490B1 (pt) |
| JP (1) | JP3860208B2 (pt) |
| KR (1) | KR100399258B1 (pt) |
| CN (1) | CN1182868C (pt) |
| AT (1) | ATE326231T1 (pt) |
| AU (1) | AU709779B2 (pt) |
| BR (1) | BR9508633A (pt) |
| CA (1) | CA2198586C (pt) |
| CZ (1) | CZ298131B6 (pt) |
| DE (1) | DE69534992T2 (pt) |
| DK (1) | DK0777490T3 (pt) |
| ES (1) | ES2265148T3 (pt) |
| FI (1) | FI120137B (pt) |
| HU (1) | HU222985B1 (pt) |
| NO (1) | NO317942B1 (pt) |
| NZ (1) | NZ291262A (pt) |
| PL (1) | PL182667B1 (pt) |
| PT (1) | PT777490E (pt) |
| RU (1) | RU2160606C2 (pt) |
| WO (1) | WO1996006627A1 (pt) |
| ZA (1) | ZA956412B (pt) |
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9513371D0 (en) * | 1995-06-30 | 1995-09-06 | Biocine Spa | Immunogenic detoxified mutant toxins |
| US7141244B1 (en) * | 1992-03-02 | 2006-11-28 | Chiron Srl | Helicobacter pylori proteins useful for vaccines and diagnostics |
| WO1993018150A1 (en) * | 1992-03-02 | 1993-09-16 | Biocine S.P.A. | Helicobacter pylori proteins useful for vaccines and diagnostics |
| DE69434000T3 (de) | 1993-10-05 | 2008-11-06 | UCB Pharma Ltd., Slough | Impfstoffzusammensetzungen |
| GB9326174D0 (en) * | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
| JPH10502366A (ja) * | 1994-07-01 | 1998-03-03 | リカン・リミテッド | ヘリコバクター・ピロリ抗原タンパク質調製品およびイムノアッセイ |
| US6019982A (en) * | 1994-08-26 | 2000-02-01 | The Administrators Of The Tulane Educational Fund | Mutant enterotoxin effective as a non-toxic oral adjuvant |
| FR2726472B1 (fr) * | 1994-11-07 | 1997-01-31 | Pf Medicament | Proteine porteuse a effet adjuvant, complexe immunogene la contenant, leur procede de preparation, sequence nucleotidique et vaccin |
| GB9626864D0 (en) * | 1996-12-24 | 1997-02-12 | Smithkline Beecham Biolog | Vaccine |
| PT909323E (pt) * | 1996-01-04 | 2007-06-04 | Novartis Vaccines & Diagnostic | ''bacterioferritina de helicobacter pilori'' |
| GB9622660D0 (en) * | 1996-10-31 | 1997-01-08 | Biocine Spa | Immunogenic detoxified mutant toxin |
| US20060002949A1 (en) * | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| US20060002959A1 (en) * | 1996-11-14 | 2006-01-05 | Government Of The United States | Skin-sctive adjuvants for transcutaneous immuization |
| US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
| US6036953A (en) * | 1996-11-29 | 2000-03-14 | The General Hospital Corporation | Heterologous antigens in live cell V. cholerae strains |
| US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
| EP0998557A2 (en) * | 1997-07-21 | 2000-05-10 | North American Vaccine, Inc. | Modified immunogenic pneumolysin, compositions and their use as vaccines |
| US7459524B1 (en) * | 1997-10-02 | 2008-12-02 | Emergent Product Development Gaithersburg Inc. | Chlamydia protein, sequence and uses thereof |
| US20040258703A1 (en) * | 1997-11-14 | 2004-12-23 | The Government Of The Us, As Represented By The Secretary Of The Army | Skin-active adjuvants for transcutaneous immunization |
| US6033673A (en) * | 1998-03-18 | 2000-03-07 | The Administrators Of Tulane Educational Fund | Double mutant enterotoxin for use as an adjuvant |
| WO1999047165A1 (en) * | 1998-03-18 | 1999-09-23 | The Administrators Of The Tulane Educational Fund | Production of purified mutant enterotoxin for use as an adjuvant |
| EP1105490A1 (en) | 1998-08-20 | 2001-06-13 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein c of chlamydia |
| US6693087B1 (en) | 1998-08-20 | 2004-02-17 | Aventis Pasteur Limited | Nucleic acid molecules encoding POMP91A protein of Chlamydia |
| US6686339B1 (en) | 1998-08-20 | 2004-02-03 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia |
| GB9819484D0 (en) * | 1998-09-07 | 1998-10-28 | Univ Bristol | Therapeutic agents |
| US6589529B1 (en) * | 1998-10-30 | 2003-07-08 | Children's Hospital Medical Center | Rotavirus subunit vaccine |
| WO2000051634A1 (en) * | 1999-03-03 | 2000-09-08 | The Kitasato Institute | Vaccine preparations containing fatty acids as constituent |
| US7115730B1 (en) | 1999-04-27 | 2006-10-03 | Chiron Srl | Immunogenic detoxified mutant E. coli LT-A-toxin |
| GB9919468D0 (en) | 1999-08-17 | 1999-10-20 | Smithkline Beecham Biolog | Vaccine |
| WO2001019998A1 (en) * | 1999-09-15 | 2001-03-22 | Mogam Biotechnology Research Institute | Novel detoxified mutants of escherichia coli heat-labile enterotoxin |
| US7384640B1 (en) | 1999-09-30 | 2008-06-10 | Wyeth Holdings Corporation | Mutant cholera holotoxin as an adjuvant |
| JP4889175B2 (ja) * | 1999-10-18 | 2012-03-07 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 感染性因子に対する免疫応答を刺激するための組成物および方法 |
| EP1227837B1 (en) | 1999-10-22 | 2008-05-21 | Aventis Pasteur Limited | Method of inducing and/or enhancing an immune response to tumor antigens |
| EP1792995A3 (en) | 2000-05-08 | 2007-06-13 | Sanofi Pasteur Limited | Chlamydia secretory locus orf and uses thereof |
| ATE513913T1 (de) | 2000-05-10 | 2011-07-15 | Sanofi Pasteur Ltd | Durch mage minigene kodierte immunogene polypeptide und ihre verwendungen |
| MY128159A (en) * | 2000-06-30 | 2007-01-31 | Wyeth Corp | Methods and composition for oral vaccination |
| JP2004506086A (ja) | 2000-08-25 | 2004-02-26 | アベンティス、パストゥール、リミテッド | インフルエンザ菌感染症の予防用ワクチンとしてのインフルエンザ菌リポ多糖内部コアオリゴ糖エピトープ |
| CA2420601A1 (en) * | 2000-08-31 | 2003-02-26 | The Kitasato Institute | Vaccine preparation containing fatty acid as component |
| CA2437899C (en) * | 2001-02-13 | 2012-05-15 | Gregory M. Glenn | Vaccine for transcutaneous immunization against etec-caused traveler's diarrhea |
| AU2002252378B2 (en) | 2001-03-19 | 2007-10-18 | Intercell Usa, Inc. | Transcutaneous immunostimulation |
| EP1404368B1 (en) | 2001-06-07 | 2009-12-09 | Wyeth Holdings Corporation | Mutant forms of cholera holotoxin as an adjuvant |
| CA2449670A1 (en) | 2001-06-07 | 2002-12-12 | Wyeth Holdings Corporation | Mutant forms of cholera holotoxin as an adjuvant |
| US20050175629A1 (en) * | 2001-08-31 | 2005-08-11 | Giuseppe Del Giudice | Helicobacter pylori vaccination |
| GB0121998D0 (en) * | 2001-09-11 | 2001-10-31 | Acambis Res Ltd | Attenuated bacteria useful in vaccines |
| US20040013687A1 (en) * | 2002-05-31 | 2004-01-22 | Thomas Jefferson University | Compositions and methods for transepithelial molecular transport |
| CA2491568A1 (en) * | 2002-08-27 | 2004-03-11 | Dow Agrosciences Llc | Use of escherichia coli heat labile toxin as an adjuvant in birds and poultry |
| AU2003278496A1 (en) * | 2002-11-14 | 2004-06-03 | Pfizer Products Inc. | Use of rmlt as a marker antigen for vaccines and as a synergistic adjuvant with amphigen |
| US20060069052A1 (en) * | 2003-02-14 | 2006-03-30 | David Hone | DNA vaccines that expresses mutant ADP-ribosyItransferase toxins which display reduced, or are devoid of, ADP-ribosyltransferase activity |
| WO2004073603A2 (en) * | 2003-02-14 | 2004-09-02 | Aeras Global Tuberculosis Vaccine Foundation | Dna vaccine that expresses mutant adp-ribosyltransferase toxins which display reduced, or are devoid of, adp-ribosyltransferase activity |
| US8685718B2 (en) * | 2003-05-20 | 2014-04-01 | New York University | Mucosal immunization to prevent prion infection |
| WO2005019412A2 (en) | 2003-05-20 | 2005-03-03 | New York University | Mucosal immunization to prevent prion infection |
| AU2004268375B2 (en) | 2003-09-02 | 2010-01-28 | Glaxosmithkline Biologicals S.A. | Vaccine |
| RU2250780C9 (ru) * | 2003-11-17 | 2005-12-10 | ГНУ Научно-исследовательский институт пушного звероводства и кролиководства им. В.А. Афанасьева | Штамм бактерий escherichia coli № рпмб, предназначенный для защиты пушных зверей от токсикозов, вызванных энтеротоксинами кишечных бактерий |
| WO2005079841A2 (en) * | 2003-12-09 | 2005-09-01 | Iomai Corporation | Gm1 binding deficient exotoxins for use as immunoadjuvants |
| RU2305558C2 (ru) * | 2004-12-09 | 2007-09-10 | Михаил Петрович Костинов | Способ лечения хронических заболеваний лор-органов вирусной, бактериальной и смешанной вирусно-бактериальной этиологии у вич-инфицированных детей и подростков |
| GB0503337D0 (en) | 2005-02-17 | 2005-03-23 | Glaxosmithkline Biolog Sa | Compositions |
| GB0505518D0 (en) * | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| CN100387719C (zh) * | 2005-05-09 | 2008-05-14 | 中国农业科学院生物技术研究所 | 编码大肠杆菌热敏毒素基因及其表达载体和用途 |
| CA2621666A1 (en) * | 2005-09-09 | 2007-03-15 | Universitaet Zuerich | Antigens for vaccination against and detection of mycoplasma suis |
| WO2007091911A1 (fr) * | 2006-02-09 | 2007-08-16 | Institut Problem Pererabotki Uglevodorodov Sibirskogo Otdeleniya Rossiiskoi Akademii Nauk | Sorbant, procédé de fabrication et procédé de séchage d'hydrocarbures |
| AU2007219615B2 (en) | 2006-03-03 | 2013-11-28 | Promis Neurosciences Inc. | Methods and compositions to treat and detect misfolded-SOD1 mediated diseases |
| US8652782B2 (en) | 2006-09-12 | 2014-02-18 | Longhorn Vaccines & Diagnostics, Llc | Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids |
| US8097419B2 (en) | 2006-09-12 | 2012-01-17 | Longhorn Vaccines & Diagnostics Llc | Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009 |
| US8080645B2 (en) | 2007-10-01 | 2011-12-20 | Longhorn Vaccines & Diagnostics Llc | Biological specimen collection/transport compositions and methods |
| US9481912B2 (en) | 2006-09-12 | 2016-11-01 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and identifying nucleic acid sequences in biological samples |
| WO2008143676A1 (en) | 2007-05-23 | 2008-11-27 | The Uab Research Foundation | Detoxified pneumococcal neuraminidase and uses thereof |
| BRPI0721746B1 (pt) * | 2007-07-18 | 2021-08-31 | Development Center For Biotechnology | Polipeptídeo isolado, vacina, ácido nucléico isolado, vetor e células transformadas de bactérias e fungos |
| DE102007037301A1 (de) * | 2007-08-07 | 2009-02-12 | BSH Bosch und Siemens Hausgeräte GmbH | Hausgeräteanordnung |
| US9683256B2 (en) | 2007-10-01 | 2017-06-20 | Longhorn Vaccines And Diagnostics, Llc | Biological specimen collection and transport system |
| US11041215B2 (en) | 2007-08-24 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | PCR ready compositions and methods for detecting and identifying nucleic acid sequences |
| EP2185196B1 (en) | 2007-08-27 | 2014-06-11 | Longhorn Vaccines & Diagnostics, LLC | Immunogenic compositions and methods |
| US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| US8597663B2 (en) | 2007-09-11 | 2013-12-03 | University Of Guelph | Polysaccharide immunogens from Clostridium difficile |
| EP2535428B1 (en) | 2007-10-01 | 2015-09-09 | Longhorn Vaccines and Diagnostics, LLC | Biological specimen collection and transport system and methods of use |
| US11041216B2 (en) | 2007-10-01 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples |
| AU2009267070A1 (en) * | 2008-07-01 | 2010-01-07 | The George Washington University | Multivalent antihelminthic vaccine |
| US7927586B2 (en) * | 2008-07-08 | 2011-04-19 | South Dakota State University | Vaccine for porcine post-weaning diarrhea caused by enterotoxigenic Escherichia coli |
| BRPI0923649A2 (pt) | 2008-12-24 | 2016-01-19 | Netherlands Vaccine Inst | polipeptídeos de pneumolisina (ply) de streptococcus pneumoniae modificados. |
| AR077636A1 (es) | 2009-07-08 | 2011-09-14 | Abbott Biologicals Bv | Vacuna viral y uso de la misma |
| WO2012101509A2 (en) | 2011-01-28 | 2012-08-02 | Sanofi Pasteur Sa | Immunological compositions against hiv |
| CN104203272A (zh) | 2012-01-26 | 2014-12-10 | 长角牛疫苗和诊断有限责任公司 | 复合抗原序列及疫苗 |
| JP6014666B2 (ja) | 2012-06-20 | 2016-10-25 | 国立大学法人 東京大学 | 粘膜免疫賦活化剤及びhpv感染症治療用経口医薬組成物 |
| WO2014044690A1 (en) | 2012-09-18 | 2014-03-27 | Valneva Austria Gmbh | Improved vaccines |
| WO2014140938A2 (en) | 2013-03-14 | 2014-09-18 | Centre Hospitalier Universitaire Vaudois | Immunological methods |
| US10098940B2 (en) | 2014-06-20 | 2018-10-16 | University Of Saskatchewan | Exotoxin/thermolysin compositions and methods and uses for treating or preventing laminitis |
| WO2016183292A1 (en) | 2015-05-14 | 2016-11-17 | Longhorn Vaccines And Diagnostics, Llc | Rapid methods for the extraction of nucleic acids from biological samples |
| EP3359651A1 (en) | 2015-10-05 | 2018-08-15 | THE UNITED STATES OF AMERICA, represented by the S | Human rota virus g9p[6]strain and use as a vaccine |
| CA3004494A1 (en) | 2015-11-09 | 2017-05-18 | The University Of British Columiba | Epitopes in amyloid beta mid-region and conformationally-selective antibodies thereto |
| KR20180094876A (ko) | 2015-11-09 | 2018-08-24 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 아밀로이드 베타 에피토프 및 이에 대한 항체 |
| US10772969B2 (en) | 2015-11-09 | 2020-09-15 | The University Of British Columbia | N-terminal epitopes in amyloid beta and conformationally-selective antibodies thereto |
| AU2017299858B2 (en) | 2016-07-18 | 2024-07-25 | Promis Neurosciences, Inc. | Antibodies to Amyloid beta |
| GB201614799D0 (en) | 2016-09-01 | 2016-10-19 | Glaxosmithkline Biologicals Sa | Compositions |
| US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
| US12286469B2 (en) | 2017-07-18 | 2025-04-29 | The University Of British Columbia | Humanized antibodies binding to amyloid-beta (A-beta) |
| CN110075290A (zh) * | 2018-01-25 | 2019-08-02 | 吴夙钦 | 流感黏膜疫苗组合物及其制备方法与应用 |
| IT201900007060A1 (it) | 2019-05-21 | 2020-11-21 | St Superiore Di Sanita | Cellule tumorali ingegnerizzate e loro usi |
| IT201900012540A1 (it) | 2019-07-22 | 2021-01-22 | Humanitas Mirasole Spa | Inibitori di CHI3L1 e loro usi |
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| IE20210235A1 (en) | 2020-10-20 | 2023-08-16 | Longhorn Vaccines & Diagnostics Llc | Immunogenic antigens |
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| JP2849632B2 (ja) * | 1988-04-08 | 1999-01-20 | 社団法人北里研究所 | ワクチン製剤 |
| SU1678373A1 (ru) * | 1989-10-18 | 1991-09-23 | Киевский Научно-Исследовательский Институт Эпидемиологии И Инфекционных Болезней Им.Л.В.Громашевского | Способ иммунокоррекции при зат жных формах гепатита |
| IL101715A (en) * | 1991-05-02 | 2005-06-19 | Amgen Inc | Recombinant dna-derived cholera toxin subunit analogs |
| IT1253009B (it) * | 1991-12-31 | 1995-07-10 | Sclavo Ricerca S R L | Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini |
| GB9326174D0 (en) * | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
| US6019982A (en) * | 1994-08-26 | 2000-02-01 | The Administrators Of The Tulane Educational Fund | Mutant enterotoxin effective as a non-toxic oral adjuvant |
| US6033673A (en) * | 1998-03-18 | 2000-03-07 | The Administrators Of Tulane Educational Fund | Double mutant enterotoxin for use as an adjuvant |
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1994
- 1994-08-26 US US08/296,848 patent/US6019982A/en not_active Expired - Lifetime
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1995
- 1995-07-18 ES ES95928662T patent/ES2265148T3/es not_active Expired - Lifetime
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