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BR9507200A - Melhora da eficácia de drogas por deuteração - Google Patents

Melhora da eficácia de drogas por deuteração

Info

Publication number
BR9507200A
BR9507200A BR9507200A BR9507200A BR9507200A BR 9507200 A BR9507200 A BR 9507200A BR 9507200 A BR9507200 A BR 9507200A BR 9507200 A BR9507200 A BR 9507200A BR 9507200 A BR9507200 A BR 9507200A
Authority
BR
Brazil
Prior art keywords
drug
deuteration
isotope
drug efficacy
deuterated
Prior art date
Application number
BR9507200A
Other languages
English (en)
Inventor
Robert R Foster
Richard Lewanczuk
Gilles Caille
Original Assignee
Isotechnika Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isotechnika Inc filed Critical Isotechnika Inc
Publication of BR9507200A publication Critical patent/BR9507200A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
BR9507200A 1994-03-25 1995-03-27 Melhora da eficácia de drogas por deuteração BR9507200A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21789794A 1994-03-25 1994-03-25
PCT/CA1995/000154 WO1995026325A2 (en) 1994-03-25 1995-03-27 Enhancement of the efficacy of drugs by deuteration

Publications (1)

Publication Number Publication Date
BR9507200A true BR9507200A (pt) 1997-09-16

Family

ID=22812932

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9507200A BR9507200A (pt) 1994-03-25 1995-03-27 Melhora da eficácia de drogas por deuteração

Country Status (12)

Country Link
US (1) US5846514A (pt)
EP (1) EP0751926B1 (pt)
JP (1) JP3696884B2 (pt)
KR (2) KR100477070B1 (pt)
CN (1) CN1087725C (pt)
AT (1) ATE372966T1 (pt)
AU (1) AU707748B2 (pt)
BR (1) BR9507200A (pt)
CA (1) CA2186371A1 (pt)
DE (1) DE69535592T2 (pt)
ES (1) ES2293638T3 (pt)
WO (1) WO1995026325A2 (pt)

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ATE372966T1 (de) 2007-09-15
KR100477070B1 (ko) 2006-04-21
DE69535592D1 (de) 2007-10-25
MX9604309A (es) 1998-05-31
AU1944195A (en) 1995-10-17
CN1148843A (zh) 1997-04-30
JP3696884B2 (ja) 2005-09-21
JPH09510717A (ja) 1997-10-28
DE69535592T2 (de) 2008-06-12
EP0751926A1 (en) 1997-01-08
AU707748B2 (en) 1999-07-22
KR20040068613A (ko) 2004-07-31
US5846514A (en) 1998-12-08
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CN1087725C (zh) 2002-07-17

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