MX9604309A - Aumento de la eficacia de drogas por deuteracion. - Google Patents
Aumento de la eficacia de drogas por deuteracion.Info
- Publication number
- MX9604309A MX9604309A MX9604309A MX9604309A MX9604309A MX 9604309 A MX9604309 A MX 9604309A MX 9604309 A MX9604309 A MX 9604309A MX 9604309 A MX9604309 A MX 9604309A MX 9604309 A MX9604309 A MX 9604309A
- Authority
- MX
- Mexico
- Prior art keywords
- nifedipine
- drugs
- isotope
- molecular
- deuterated
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000002547 new drug Substances 0.000 abstract 2
- 229960001597 nifedipine Drugs 0.000 abstract 2
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000001346 gas chromatography-isotope ratio mass spectrometry Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invencion se refiere a un procedimiento para aumentar la eficacia de productos farmacéuticos o drogas conocidas y a las drogas mejoradas así producidas , por el cambio de la forma isotopica de la estructura molecular de la droga conocida. Más particularmente, la presente invencion se refiere a la modificacion de la estructura molecular de drogas conocidas, que contienen uno o más átomos de hidrogeno, por la deuteracion de uno o más de estos átomos de hidrogeno en átomos de deuterio. La droga resultante se altera significantemente y tiene una actividad mejorada sobre la droga conocida. Más
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21789794A | 1994-03-25 | 1994-03-25 | |
| US217897 | 1994-03-25 | ||
| PCT/CA1995/000154 WO1995026325A2 (en) | 1994-03-25 | 1995-03-27 | Enhancement of the efficacy of drugs by deuteration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9604309A true MX9604309A (es) | 1998-05-31 |
| MXPA96004309A MXPA96004309A (es) | 1998-10-23 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| US5846514A (en) | 1998-12-08 |
| WO1995026325A3 (en) | 1995-12-14 |
| DE69535592D1 (de) | 2007-10-25 |
| KR20040068613A (ko) | 2004-07-31 |
| CN1087725C (zh) | 2002-07-17 |
| DE69535592T2 (de) | 2008-06-12 |
| CN1148843A (zh) | 1997-04-30 |
| JPH09510717A (ja) | 1997-10-28 |
| EP0751926A1 (en) | 1997-01-08 |
| WO1995026325A2 (en) | 1995-10-05 |
| BR9507200A (pt) | 1997-09-16 |
| AU1944195A (en) | 1995-10-17 |
| ATE372966T1 (de) | 2007-09-15 |
| KR100477070B1 (ko) | 2006-04-21 |
| CA2186371A1 (en) | 1995-10-05 |
| AU707748B2 (en) | 1999-07-22 |
| EP0751926B1 (en) | 2007-09-12 |
| JP3696884B2 (ja) | 2005-09-21 |
| ES2293638T3 (es) | 2008-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO1995026325A3 (en) | Enhancement of the efficacy of drugs by deuteration | |
| WO1995026325B1 (en) | Enhancement of the efficacy of drugs by deuteration | |
| ATE314388T1 (de) | Deuterierte und undeuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agentien | |
| MY120279A (en) | Use of a celecoxib composition for fast pain relief | |
| BR9916857A (pt) | 4 heteroaril diarilaminas | |
| NZ502358A (en) | Hydrogel composition comprising a biologically active substance combined with a macromer | |
| FR2597851B1 (fr) | Nouveaux borates mixtes a base de terres rares, leur preparation et leur application comme luminophores | |
| EP0657486A3 (en) | Fluorine-modified silicone, process for its production and cosmetics containing it. | |
| FR2671083B1 (fr) | Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques. | |
| MXPA03007885A (es) | Norbuprenorfina n-but-3-enilo y metodos de uso. | |
| NZ509172A (en) | Antimalarial agents | |
| ATE283762T1 (de) | Sauerstoffbindende zusammensetzung und methoden zu ihrer herstellung | |
| BR9908211A (pt) | Agente quìmico para melhorar as propriedades de engenharia dos solos | |
| DK0821588T3 (da) | Levobupivacain og anvendelse heraf som et anæstetikum til gravide kvinder | |
| ITMI911038A0 (it) | Processo per l'assorbimento di gas residui in particolare azoto, mediante una lega getter a base di bario non evaporato | |
| DK1076561T3 (da) | Kombinationsterapi til behandlingen af tumorer | |
| MD970269A (en) | Clavulanates | |
| ES2150929T3 (es) | Procedimiento para la obtencion de 3,7-dialquilxantinas a partir de 3-alquilxantinas. | |
| DK9390D0 (da) | Kondenserede benzapiner | |
| DE4092406A1 (es) | ||
| CA2302033A1 (en) | Methods and compositions for enhanced wound healing | |
| ZA200205639B (en) | Pseudopolymorph of (-)-cis-2-(chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy-1-methyl) piperidinyl]-4H-1-benzopyran-4-one. | |
| 李松 et al. | Molecular Dynamic Studies on Nonquaternary Reactivators | |
| BG104839A (en) | Chrystalline form of paroxetine | |
| WO2003024394A3 (en) | Method of treating benign prostatic hyperplasia and other beingn porstate conditions |