BR0117054A - Formas cristalinas do ácido 4-[4-[4-hidroxidifenilmetil)-1-piperidinil]-1-hidroxibuti l]-alfa, alfa-dimetilbenzeno acético e seu cloridrato - Google Patents
Formas cristalinas do ácido 4-[4-[4-hidroxidifenilmetil)-1-piperidinil]-1-hidroxibuti l]-alfa, alfa-dimetilbenzeno acético e seu cloridratoInfo
- Publication number
- BR0117054A BR0117054A BR0117054-6A BR0117054A BR0117054A BR 0117054 A BR0117054 A BR 0117054A BR 0117054 A BR0117054 A BR 0117054A BR 0117054 A BR0117054 A BR 0117054A
- Authority
- BR
- Brazil
- Prior art keywords
- alpha
- hydrochloride
- hydroxydiphenylmethyl
- hydroxybutyl
- piperidinyl
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title abstract 2
- 229960003592 fexofenadine Drugs 0.000 abstract 2
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- RRJFVPUCXDGFJB-UHFFFAOYSA-N Fexofenadine hydrochloride Chemical compound Cl.C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RRJFVPUCXDGFJB-UHFFFAOYSA-N 0.000 abstract 1
- 229960000354 fexofenadine hydrochloride Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"FORMAS CRISTALINAS DO áCIDO 4-[4-[4-HIDROXIDIFENILMETIL)-1-PIPERIDINIL]-1-HIDROXIBUTI L]-ALFA,ALFA-DIMETIL-BENZENO ACéTICO E SEU CLORIDRATO". A presente invenção refere-se a novas formas polimorfas de Fexofenadina e de cloridrato de Fexofenadina de fórmula 1 e a processo de preparação das mesmas. A presente invenção também é direcionada para proporcionar novas formas polimorfas puras de Fexofenadina e de seu cloridrato por um processo simples que é custo efetivo, comercialmente viável e ambientalmente conveniente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN484MA2001 | 2001-06-18 | ||
| PCT/US2001/023994 WO2002102777A2 (en) | 2001-06-18 | 2001-07-31 | NOVEL CRYSTALLINE FORMS OF 4-[4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERINDINYL]-1-HYDROXYBUTYL]-α, α-DIMETHYLBENZENE ACETIC ACID AND ITS HYDROCHLORIDE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0117054A true BR0117054A (pt) | 2004-07-27 |
Family
ID=34566868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0117054-6A BR0117054A (pt) | 2001-06-18 | 2001-07-31 | Formas cristalinas do ácido 4-[4-[4-hidroxidifenilmetil)-1-piperidinil]-1-hidroxibuti l]-alfa, alfa-dimetilbenzeno acético e seu cloridrato |
Country Status (20)
| Country | Link |
|---|---|
| EP (2) | EP2261209A1 (pt) |
| JP (2) | JP2005507374A (pt) |
| KR (1) | KR20040015734A (pt) |
| CN (1) | CN100390145C (pt) |
| AU (1) | AU2001278094B2 (pt) |
| BG (1) | BG108435A (pt) |
| BR (1) | BR0117054A (pt) |
| CA (2) | CA2450858C (pt) |
| CO (1) | CO5540340A2 (pt) |
| CZ (1) | CZ20033358A3 (pt) |
| EE (1) | EE200400010A (pt) |
| HU (1) | HUP0401546A2 (pt) |
| IL (2) | IL159266A0 (pt) |
| MX (1) | MXPA03011728A (pt) |
| NZ (1) | NZ530118A (pt) |
| PL (1) | PL367632A1 (pt) |
| RU (1) | RU2269516C2 (pt) |
| SK (1) | SK15372003A3 (pt) |
| WO (1) | WO2002102777A2 (pt) |
| ZA (1) | ZA200309557B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002305162A1 (en) * | 2001-04-09 | 2002-10-21 | Teva Pharmaceutical Industries Ltd. | Polymorphs of fexofenadine hydrochloride |
| AU2003248657A1 (en) * | 2002-06-10 | 2003-12-22 | Teva Pharmaceutical Industries Ltd. | Polymorphic form xvi of fexofenadine hydrochloride |
| GB0319935D0 (en) | 2003-08-26 | 2003-09-24 | Cipla Ltd | Polymorphs |
| MXPA06012281A (es) * | 2004-04-26 | 2007-07-18 | Teva Pharma | Formas cristalinas de clorhidrato de fexofenadina y procesos para su preparacion. |
| ITMI20041143A1 (it) * | 2004-06-08 | 2004-09-08 | Dipharma Spa | Polimorfi di fexofenadina e procedimento per la loro preparazione |
| ITMI20041568A1 (it) * | 2004-07-30 | 2004-10-30 | Dipharma Spa | "polimorfi di fexofenadina base" |
| JP2008514641A (ja) * | 2004-09-28 | 2008-05-08 | テバ ファーマシューティカル インダストリーズ リミティド | 結晶形フェキソフェナジン、およびその調製方法 |
| WO2007007347A1 (en) * | 2005-07-07 | 2007-01-18 | Wockhardt Limited | Industrial process of fexofenadine hydrochloride with controlled side products |
| RU2283649C1 (ru) * | 2005-10-27 | 2006-09-20 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Фармацевтическая композиция для лечения аллергических заболеваний |
| US20090306135A1 (en) | 2008-03-24 | 2009-12-10 | Mukesh Kumar Sharma | Stable amorphous fexofenadine hydrochloride |
| CN104072402B (zh) * | 2014-07-16 | 2016-08-17 | 昆山龙灯瑞迪制药有限公司 | 一种新结晶形式的盐酸非索非那定化合物及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4254129A (en) | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| DK0701443T4 (da) * | 1992-08-03 | 2000-12-18 | Sepracor Inc | Terfenadinmetabolitter og deres optisk rene isomerer til behandling af allergiske lidelser |
| EP1178041A1 (en) * | 1994-05-18 | 2002-02-06 | Aventis Pharmaceuticals Inc. | Process for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives |
| US6153754A (en) * | 1995-12-21 | 2000-11-28 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| IN191492B (pt) | 1999-05-25 | 2003-12-06 | Ranbaxy Lab Ltd | |
| GB0018691D0 (en) * | 2000-07-28 | 2000-09-20 | Rolabo Sl | Process |
-
2001
- 2001-07-31 IL IL15926601A patent/IL159266A0/xx unknown
- 2001-07-31 CA CA002450858A patent/CA2450858C/en not_active Expired - Fee Related
- 2001-07-31 BR BR0117054-6A patent/BR0117054A/pt not_active Application Discontinuation
- 2001-07-31 EP EP10010066A patent/EP2261209A1/en not_active Withdrawn
- 2001-07-31 KR KR10-2003-7016163A patent/KR20040015734A/ko not_active Ceased
- 2001-07-31 SK SK1537-2003A patent/SK15372003A3/sk unknown
- 2001-07-31 EE EEP200400010A patent/EE200400010A/xx unknown
- 2001-07-31 CZ CZ20033358A patent/CZ20033358A3/cs unknown
- 2001-07-31 RU RU2004101045/04A patent/RU2269516C2/ru not_active IP Right Cessation
- 2001-07-31 WO PCT/US2001/023994 patent/WO2002102777A2/en not_active Ceased
- 2001-07-31 JP JP2003505320A patent/JP2005507374A/ja active Pending
- 2001-07-31 EP EP01956057A patent/EP1399422A2/en not_active Withdrawn
- 2001-07-31 AU AU2001278094A patent/AU2001278094B2/en not_active Ceased
- 2001-07-31 CN CNB018233791A patent/CN100390145C/zh not_active Expired - Fee Related
- 2001-07-31 NZ NZ530118A patent/NZ530118A/en unknown
- 2001-07-31 HU HU0401546A patent/HUP0401546A2/hu unknown
- 2001-07-31 MX MXPA03011728A patent/MXPA03011728A/es active IP Right Grant
- 2001-07-31 CA CA002646802A patent/CA2646802A1/en not_active Abandoned
- 2001-07-31 PL PL01367632A patent/PL367632A1/xx not_active Application Discontinuation
-
2003
- 2003-12-09 ZA ZA200309557A patent/ZA200309557B/xx unknown
- 2003-12-09 IL IL159266A patent/IL159266A/en not_active IP Right Cessation
- 2003-12-11 BG BG108435A patent/BG108435A/xx unknown
- 2003-12-18 CO CO03110519A patent/CO5540340A2/es not_active Application Discontinuation
-
2007
- 2007-11-06 JP JP2007289084A patent/JP2008094848A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002102777A8 (en) | 2003-10-30 |
| JP2005507374A (ja) | 2005-03-17 |
| KR20040015734A (ko) | 2004-02-19 |
| RU2004101045A (ru) | 2005-06-27 |
| RU2269516C2 (ru) | 2006-02-10 |
| CN100390145C (zh) | 2008-05-28 |
| EE200400010A (et) | 2004-02-16 |
| JP2008094848A (ja) | 2008-04-24 |
| CA2646802A1 (en) | 2002-12-27 |
| IL159266A0 (en) | 2004-06-01 |
| CN1518540A (zh) | 2004-08-04 |
| CA2450858A1 (en) | 2002-12-27 |
| CA2450858C (en) | 2009-04-07 |
| IL159266A (en) | 2010-11-30 |
| WO2002102777A2 (en) | 2002-12-27 |
| AU2001278094B2 (en) | 2006-01-12 |
| EP1399422A2 (en) | 2004-03-24 |
| ZA200309557B (en) | 2004-09-14 |
| NZ530118A (en) | 2007-05-31 |
| HUP0401546A2 (hu) | 2004-12-28 |
| WO2002102777A3 (en) | 2003-02-27 |
| SK15372003A3 (sk) | 2004-08-03 |
| PL367632A1 (en) | 2005-03-07 |
| BG108435A (en) | 2004-12-30 |
| CO5540340A2 (es) | 2005-07-29 |
| CZ20033358A3 (en) | 2004-04-14 |
| EP2261209A1 (en) | 2010-12-15 |
| MXPA03011728A (es) | 2004-07-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0117054A (pt) | Formas cristalinas do ácido 4-[4-[4-hidroxidifenilmetil)-1-piperidinil]-1-hidroxibuti l]-alfa, alfa-dimetilbenzeno acético e seu cloridrato | |
| BRPI0812625A2 (pt) | processo para preparar um sal de cis-atracúrio | |
| US20050153963A1 (en) | N-[phenyl (piperidin-2-yl) methyl]benzamide derivatives, preparation thereof, and use thereof in therapy | |
| DK153709B (da) | Analogifremgangsmaade til fremstilling af 4-substituerede piperidinoalkanolderivater | |
| BR0213931A (pt) | Forma polimórfica de rimonabant, processo para sua preparação e composições farmacêuticas contendo-as | |
| BRPI0500585B8 (pt) | processo para a síntese de ivabradina e sais de adição desta com um ácido farmaceuticamente aceitável | |
| BRPI0519106A2 (pt) | compostos, uso destes, processo para sua fabricaÇço, composiÇÕes farmacÊuticas, mÉtodo para o tratamento e/ou profilaxia de doenÇas que sço associadas com a dpp-iv | |
| US20200000792A1 (en) | 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds | |
| DK152670B (da) | Analogifremgangsmaade til fremstilling af 1-(4-aryl-4-cyano-cyclohexyl)-4-aryl-4-piperidincarboxylsyre-derivater eller farmaceutisk acceptable syreadditionssalte og stereokemiske isomere deraf | |
| DE602005000334D1 (de) | Verfahren zur herstellung von oxycodon | |
| JP2007507443A5 (pt) | ||
| EA200801518A1 (ru) | Новый способ получения высокочистого полиморфа (i) донепезила гидрохлорида | |
| ES2275066T3 (es) | Procedimiento para la preparacion de donepezilo. | |
| AU2284095A (en) | Process and diastereomeric salts useful for the optical resolution of racemic alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl )-1-piperidinebutanol and derivative compounds | |
| DE60325766D1 (de) | Verfahren zur Herstellung von Glycidylphthalimide | |
| BR0316702A (pt) | xprocesso para preparação de (s)-pantoprazol | |
| DE60335865D1 (de) | Verfahren zur herstellung von cilostazol | |
| DE60203142D1 (de) | Verfahren zur Herstellung von 4-[1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-butyl]-alpha, alpha-dimethylphenylessigsäure | |
| DE602004025132D1 (de) | Asymmetrische reduktive aminierung von ketosäurederivaten zur herstellung von aminosäurederivaten | |
| BR0317594A (pt) | Processo para a preparação de uma forma "i" de olanzapina polimórfica farmaceuticamente pura, produto resultante e processo para remoção da impureza "s" a partir da forma i polimórfica de olanzapina | |
| ATE348821T1 (de) | Verfahren zum herstellen von salzen des tolperison | |
| BR0006978A (pt) | Processo para preparação de 1,5-diaril-3-pirazóis substituìdos | |
| NO330965B1 (no) | Fremgangsmate for fremstilling av substituerte imidazolderivater, mellomprodukter anvendt i fremgangsmaten samt fremgangsmate for fremstilling av mellomprodukt | |
| Huber et al. | Some dialkylaminoalkylamines | |
| KR100954755B1 (ko) | (ｒ)-(-)-1-[(4-클로로페닐)페닐메틸]피페라진의 제조방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |