[go: up one dir, main page]

BR0006978A - Processo para preparação de 1,5-diaril-3-pirazóis substituìdos - Google Patents

Processo para preparação de 1,5-diaril-3-pirazóis substituìdos

Info

Publication number
BR0006978A
BR0006978A BR0006978-7A BR0006978A BR0006978A BR 0006978 A BR0006978 A BR 0006978A BR 0006978 A BR0006978 A BR 0006978A BR 0006978 A BR0006978 A BR 0006978A
Authority
BR
Brazil
Prior art keywords
formula
diaryl
compound
pyrazoles
preparing substituted
Prior art date
Application number
BR0006978-7A
Other languages
English (en)
Other versions
BR0006978B1 (pt
Inventor
Ahmed F Abdel-Magid
Bruce D Harris
Cynthia A Maryanoff
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of BR0006978A publication Critical patent/BR0006978A/pt
Publication of BR0006978B1 publication Critical patent/BR0006978B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/083—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA PREPARAçãO DE 1,5-DIARIL-3-PIRAZóIS SUBSTITUìDOS"<D>. Processo para fabricação de um composto de fórmula (I) onde os substituintes são como descritos no relatório descritivo compreendendo reação de uma cetona de fórmula (II) com anidrido succínico e uma base alcóxido para formar um composto de fórmula (III) que é reagido com um composto de fórmula (IV) para formar um composto de fórmula (V) e reagindo com um álcool para formar o correspondente éster de fórmula (VI) e reagindo o éster com N-metil hidroxil amina.
BRPI0006978-7A 1999-08-03 2000-08-01 processos para preparação de 1,5-diaril-3-pirazóis substituìdos e processo para preparação de intermediário. BR0006978B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14699799P 1999-08-03 1999-08-03
US60/146,997 1999-08-03
PCT/US2000/020917 WO2001009102A2 (en) 1999-08-03 2000-08-01 Process for preparing 1,5-diaryl-3-substituted pyrazoles

Publications (2)

Publication Number Publication Date
BR0006978A true BR0006978A (pt) 2001-06-19
BR0006978B1 BR0006978B1 (pt) 2010-11-30

Family

ID=22519936

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0006978-7A BR0006978B1 (pt) 1999-08-03 2000-08-01 processos para preparação de 1,5-diaril-3-pirazóis substituìdos e processo para preparação de intermediário.

Country Status (26)

Country Link
US (4) US6384233B1 (pt)
EP (2) EP1413575B1 (pt)
JP (2) JP4886951B2 (pt)
KR (1) KR100646883B1 (pt)
CN (1) CN1219771C (pt)
AR (1) AR032589A1 (pt)
AT (2) ATE281437T1 (pt)
AU (2) AU779353B2 (pt)
BR (1) BR0006978B1 (pt)
CA (2) CA2346142C (pt)
CZ (2) CZ299710B6 (pt)
DE (2) DE60015496T2 (pt)
DK (1) DK1413575T3 (pt)
ES (2) ES2274171T3 (pt)
HK (1) HK1040081B (pt)
HU (1) HU228678B1 (pt)
IL (2) IL142341A0 (pt)
MY (1) MY122496A (pt)
NO (1) NO318467B1 (pt)
NZ (1) NZ510890A (pt)
PL (1) PL201799B1 (pt)
PT (2) PT1144382E (pt)
RU (1) RU2243967C2 (pt)
TW (1) TWI234562B (pt)
WO (1) WO2001009102A2 (pt)
ZA (1) ZA200103533B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ510890A (en) * 1999-08-03 2003-09-26 Ortho Mcneil Pharm Inc Process for preparing 1,5-diaryl-3-substituted pyrazoles
CA2520870A1 (en) * 2003-04-03 2004-10-21 Merck & Co., Inc. Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5
MXPA06003121A (es) * 2003-08-19 2006-06-27 Day Glo Color Corp Colorantes polimericos.
EP2805957A1 (de) 2013-05-23 2014-11-26 hameln rds gmbh Kristalline Formen von Trinatrium-Zink-Diethylen-triaminpentaessigsäure
CN111018785B (zh) * 2019-12-26 2022-02-11 武汉科技大学 一种1-（4-氯苯基）-3-吡唑醇的合成方法及应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826868A (en) * 1986-05-29 1989-05-02 Ortho Pharmaceutical Corporation 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use
US5164381A (en) 1986-05-29 1992-11-17 Ortho Pharmaceutical Corporation Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same
DE3775527D1 (de) 1986-10-22 1992-02-06 Ciba Geigy Ag 1,5-diphenylpyrazol-3-carbonsaeurederivate zum schuetzen von kulturpflanzen.
US4808613A (en) * 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition
US4898952A (en) * 1987-05-29 1990-02-06 Ortho Pharmaceutical Corporation Regioselective synthesis of a 1,5-disubstituted pyrazole
JPH0699382B2 (ja) * 1987-06-17 1994-12-07 富士写真フイルム株式会社 Ｎ−メチル−α−ジアルキルアミノアセトヒドロキサム酸誘導体
US5130421A (en) * 1988-03-24 1992-07-14 Bristol-Myers Company Production of 2',3'-dideoxy-2',3'-didehydronucleosides
US4896952A (en) * 1988-04-22 1990-01-30 International Business Machines Corporation Thin film beamsplitter optical element for use in an image-forming lens system
US5154381A (en) * 1988-12-02 1992-10-13 Malinao Michael M Microphone boom holder
US5032588A (en) * 1989-12-08 1991-07-16 Abbott Laboratories Thiazole lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids
US5236938A (en) * 1991-04-30 1993-08-17 Rhone-Poulenc Inc. Pesticidal 1-aryl-5-(substituted alkylideneimino)pyrazoles
US5117054A (en) * 1991-09-26 1992-05-26 Ortho Pharmaceutical Corporation N-hydroxy, N-methyl propanamides
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5387602A (en) 1993-08-30 1995-02-07 Ortho Pharmaceutical Corporation 1.5-diphenyl-3-(N-hydroxycarbamoyloxyalkyl)pyrazoles
US5412151A (en) * 1993-10-22 1995-05-02 Eastman Chemical Company Thermosetting coating compositions
JPH0944014A (ja) * 1995-08-03 1997-02-14 Canon Inc 加熱用フィルム、加熱加圧部材、加熱装置及び画像形成装置
US5843958A (en) * 1996-11-27 1998-12-01 Ortho Pharmaceutical Corporation Arylpyrazoles as leukotriene inhibitors
NZ510890A (en) * 1999-08-03 2003-09-26 Ortho Mcneil Pharm Inc Process for preparing 1,5-diaryl-3-substituted pyrazoles

Also Published As

Publication number Publication date
AU2005201660A1 (en) 2005-05-12
CZ299710B6 (cs) 2008-10-29
KR20010075571A (ko) 2001-08-09
MY122496A (en) 2006-04-29
NZ510890A (en) 2003-09-26
WO2001009102A2 (en) 2001-02-08
ATE342254T1 (de) 2006-11-15
US20040230060A1 (en) 2004-11-18
DE60015496D1 (de) 2004-12-09
EP1144382A2 (en) 2001-10-17
HUP0103778A2 (hu) 2002-05-29
DE60031315T2 (de) 2007-04-26
CA2636755A1 (en) 2001-02-08
EP1413575A3 (en) 2004-10-06
JP2012051929A (ja) 2012-03-15
NO318467B1 (no) 2005-03-21
US6613914B2 (en) 2003-09-02
HU228678B1 (en) 2013-05-28
PL347025A1 (en) 2002-03-11
CZ299711B6 (cs) 2008-10-29
CN1219771C (zh) 2005-09-21
DK1413575T3 (da) 2006-12-27
RU2243967C2 (ru) 2005-01-10
AU6752600A (en) 2001-02-19
US6953860B2 (en) 2005-10-11
PT1144382E (pt) 2005-02-28
CN1337951A (zh) 2002-02-27
KR100646883B1 (ko) 2006-11-17
US20020128487A1 (en) 2002-09-12
AU779353B2 (en) 2005-01-20
US7247745B2 (en) 2007-07-24
EP1413575A2 (en) 2004-04-28
CA2346142C (en) 2008-10-14
ZA200103533B (en) 2002-05-02
ATE281437T1 (de) 2004-11-15
US6384233B1 (en) 2002-05-07
CZ20011202A3 (cs) 2001-09-12
TWI234562B (en) 2005-06-21
NO20011652L (no) 2001-05-23
WO2001009102A3 (en) 2001-08-16
ES2274171T3 (es) 2007-05-16
PL201799B1 (pl) 2009-05-29
EP1413575B1 (en) 2006-10-11
NO20011652D0 (no) 2001-04-02
JP4886951B2 (ja) 2012-02-29
AR032589A1 (es) 2003-11-19
IL142341A0 (en) 2002-03-10
US20020032336A1 (en) 2002-03-14
EP1144382A3 (en) 2002-09-11
BR0006978B1 (pt) 2010-11-30
CA2636755C (en) 2010-10-19
PT1413575E (pt) 2006-12-29
US20060004208A1 (en) 2006-01-05
ES2232482T3 (es) 2005-06-01
EP1144382B1 (en) 2004-11-03
IL171712A (en) 2010-04-29
JP2003506359A (ja) 2003-02-18
DE60015496T2 (de) 2005-10-27
CA2346142A1 (en) 2001-02-08
EP1413575A9 (en) 2005-06-29
HK1040081A1 (en) 2002-05-24
HK1040081B (en) 2005-05-13
HUP0103778A3 (en) 2002-07-29
DE60031315D1 (de) 2006-11-23

Similar Documents

Publication Publication Date Title
BR9910326A (pt) Processo para preeparar isoxazóis, composto, processo para preparar compostos, uso de compostos, e, processo para preparar tioéteres
BR0314227A (pt) Derivados de amido de hidroxialquila
BR0206433A (pt) Composto, composição farmacêutica, processo para a prepapação de um composto, e, uso de um composto
BR0210464A (pt) Composto, composição farmacêutica, processo para preparar um composto, e, uso de um composto
BRPI0108990B8 (pt) processo para preparação de derivados de pirimidona com atividade antifungos
BRPI0414059B8 (pt) síntese seletiva de pirimidinas substituídas em cf3
MY145819A (en) Process and intermediates useful in the preparation of pharmaceutical compounds as fulvestrant
BR9708233A (pt) Processo para sìntese de um composto e composto.
BR0006978A (pt) Processo para preparação de 1,5-diaril-3-pirazóis substituìdos
BR9807988A (pt) Processo para a preparação de um composto, e, composto.
BR9911250A (pt) Processo para preparação de compostos
BR0205683A (pt) Processo para a preparação de derivados de piperazina, e, mesilato de um composto
PT1225174E (pt) Cristais de mirtazapina anidros e processo para a sua producao
BR0016638B1 (pt) compostos anÁlogos de homopiperidilbenzimidazàis substituÍdos como relaxantes féndicos, processo para preparar os mesmos, composiÇço farmacÊutica e processo para preparÁ-la.
ATE231177T1 (de) Thixotropiermittel auf alkydharzbasis
BRPI0401037A (pt) Processo para a preparação de n-metil-dialquilaminas a partir de dialquilaminas secundárias e formaldeìdo
DK1347965T3 (da) Hidtil ukendte desloratidinsalte, fremgangsmåde til syntese deraf samt farmaceutiske præparater deraf
BR0004787A (pt) Processo para a preparação de compostos pirazolo[4,3-d] pirimidin-7-onas-3-piridilsulfonila bem como intermediários dos mesmos
BR0214173A (pt) Processo para reagir alcalóides, produto de reação, mistura de produtos de reação, e, uso de produtos de reação
BR0114258A (pt) Esteróides de 17alfa-fluoroalquila, processo para sua produção e composições farmacêuticas que contêm estes compostos
AR057555A1 (es) Un inhibidor de fosfodiesterasa-4 4-oxo-1-(3-sustituido fenil-1,4-dihidro-1,8-naftiridin-3-carboxamida y un procedimiento de preparacion del mismo
PT1250335E (pt) Processo e intermediarios para a preparacao de imidazopiridinas
BRPI0411717A (pt) processo para a preparação de acilsulfamoibenzamidas
BR9900997A (pt) Processos para preparar um cloroalquino e uma alquinil amina.
BR9902525A (pt) Processo para compostos de ácido pirrolidinil-hidroxâmico

Legal Events

Date Code Title Description
PC Transfer

Free format text: JOHNSON & JOHNSON (US)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/11/2010, OBSERVADAS AS CONDICOES LEGAIS.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 30.11.2020