BR0009765B1 - Compostos de ésteres de l-carnitina ou alcanoil l-carnitinase, uso dos mesmos, lipossomas contendo os referidos compostos e composições farmacêuticas e cosméticas contendo os ditos lipossomas. - Google Patents

Compostos de ésteres de l-carnitina ou alcanoil l-carnitinase, uso dos mesmos, lipossomas contendo os referidos compostos e composições farmacêuticas e cosméticas contendo os ditos lipossomas.

Info

Publication number: BR0009765B1
Authority: BR; Brazil
Prior art keywords: liposomes; compounds; carnitine; carnitinase; alcanoil
Prior art date: 1999-04-13

Application number

BRPI0009765-9B1A

Other languages

English (en)

Other versions

BR0009765A (pt

Inventor

Claudio Pisano

Maria Ornella Tinti

Mose Santaniello

Luciana Critelli

Giovanni Salvatori

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-13

Filing date

2000-04-11

Publication date

2013-11-05

2000-04-11 Application filed filed Critical

2000-04-11 Priority to BRPI0017460A priority Critical patent/BRPI0017460B1/pt

2002-01-02 Publication of BR0009765A publication Critical patent/BR0009765A/pt

2013-11-05 Publication of BR0009765B1 publication Critical patent/BR0009765B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Dispersion Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Birds (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Biotechnology (AREA)
Dermatology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)

BRPI0009765-9B1A 1999-04-13 2000-04-11 Compostos de ésteres de l-carnitina ou alcanoil l-carnitinase, uso dos mesmos, lipossomas contendo os referidos compostos e composições farmacêuticas e cosméticas contendo os ditos lipossomas. BR0009765B1 (pt)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
BRPI0017460A BRPI0017460B1 (pt)	1999-04-13	2000-04-11	uso de lipossomos consistindo de ésteres de l-carnitina

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999RM000220A IT1306129B1 (it)	1999-04-13	1999-04-13	Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
PCT/IT2000/000137 WO2000061543A2 (en)	1999-04-13	2000-04-11	Esters of l-carnitine or alkanoyl l-carnitines

Publications (2)

Publication Number	Publication Date
BR0009765A BR0009765A (pt)	2002-01-02
BR0009765B1 true BR0009765B1 (pt)	2013-11-05

Family

ID=11406659

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BRPI0017460A BRPI0017460B1 (pt)	1999-04-13	2000-04-11	uso de lipossomos consistindo de ésteres de l-carnitina
BRPI0009765-9B1A BR0009765B1 (pt)	1999-04-13	2000-04-11	Compostos de ésteres de l-carnitina ou alcanoil l-carnitinase, uso dos mesmos, lipossomas contendo os referidos compostos e composições farmacêuticas e cosméticas contendo os ditos lipossomas.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
BRPI0017460A BRPI0017460B1 (pt)	1999-04-13	2000-04-11	uso de lipossomos consistindo de ésteres de l-carnitina

Country Status (34)

Country	Link
US (4)	US6797281B1 (pt)
EP (3)	EP1435232A1 (pt)
JP (2)	JP4703855B2 (pt)
KR (2)	KR100684378B1 (pt)
CN (2)	CN100402017C (pt)
AT (2)	ATE317257T1 (pt)
AU (2)	AU776301B2 (pt)
BG (3)	BG65501B1 (pt)
BR (2)	BRPI0017460B1 (pt)
CA (2)	CA2650202C (pt)
CZ (1)	CZ302628B6 (pt)
DE (2)	DE60025961T2 (pt)
DK (2)	DK1426044T3 (pt)
EA (2)	EA004459B1 (pt)
EE (2)	EE05719B1 (pt)
ES (2)	ES2234591T3 (pt)
HK (1)	HK1045145B (pt)
HR (1)	HRP20010740B1 (pt)
HU (1)	HU229366B1 (pt)
IL (4)	IL145765A0 (pt)
IS (2)	IS2476B (pt)
IT (1)	IT1306129B1 (pt)
ME (2)	ME00113B (pt)
MX (1)	MXPA01010359A (pt)
NO (2)	NO327742B1 (pt)
NZ (2)	NZ528874A (pt)
PL (2)	PL211710B1 (pt)
PT (2)	PT1183228E (pt)
RS (3)	RS50911B (pt)
SI (2)	SI1183228T1 (pt)
SK (2)	SK288246B6 (pt)
TR (2)	TR200202358T2 (pt)
WO (1)	WO2000061543A2 (pt)
ZA (1)	ZA200109291B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7151191B2 (en) *	2000-01-13	2006-12-19	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
DE10113446A1 (de) †	2001-03-19	2002-09-26	Schwarzkopf Gmbh Hans	Haarbehandlungsmittel mit Betainen
DK2286795T3 (en) *	2002-06-26	2017-02-06	Syncore Biotechnology Co Ltd	PROCEDURE FOR PREPARING A Cationic LIPOSOMAL PREPARATION INCLUDING A LIPOPHIL COMPOUND
DK2108362T3 (da) *	2002-06-26	2013-09-02	Medigene Ag	Kationisk liposomal-fremstilling omfattende en taxan
ITRM20040288A1 (it) *	2004-06-11	2004-09-11	Sigma Tau Ind Farmaceuti	Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
GT200500310A (es) *	2004-11-19	2006-06-19		Compuestos organicos
US20080095834A1 (en) *	2005-03-02	2008-04-24	Volkmar Weissig	Mitochondriotropic Phospholipid Vesicles
SA06270147B1 (ar)	2005-06-09	2009-12-22	نوفارتيس ايه جي	عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
MX2008001965A (es) *	2005-08-10	2008-03-26	Novartis Ag	Composiciones en microparticulas del inhibidor de topoisomerasa i 7-ter-butoxiiminometilcamptotecina.
JP2009504615A (ja) *	2005-08-10	2009-02-05	ノバルティスアクチエンゲゼルシャフト	７−（ｔ−ブトキシ）イミノメチルカンプトテシンのための製剤
US20100178325A1 (en) *	2006-08-23	2010-07-15	Biodelivery Sciences International, Inc.	Amphiphilic nucleotide cochleate compositions and methods of using the same
EP2107903A1 (en) *	2007-02-01	2009-10-14	SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.	Pharmaceutical composition comprising a campothecin derivative
WO2008101173A2 (en) *	2007-02-16	2008-08-21	Cornell University	Biodegradable compositions and materials
US20100204432A1 (en) *	2007-05-28	2010-08-12	Husam Younes	Biodegradable elastomers prepared by the condensation of an organic di-, tri- or tetra-carboxylic acid and an organic diol
JP4827986B2 (ja)	2007-06-08	2011-11-30	マンカインドコーポレ−ション	ＩＲＥ−１αインヒビター
CA2718276A1 (en) *	2008-03-13	2009-09-17	Perkinelmer Las, Inc.	Enzymatic substrates for multiple detection systems
EP2532649B1 (en) *	2011-06-07	2015-04-08	Incella GmbH	Amino lipids, their synthesis and uses thereof
WO2013032643A2 (en) *	2011-08-31	2013-03-07	Dicerna Pharmaceuticals, Inc.	Lipids capable of conformational change and their use in formulations to deliver therapeutic agents to cells
US20140274798A1 (en)	2013-03-15	2014-09-18	University Of Washington Through Its Center For Commercialization	Compounds and methods relating to lysosomal storage disorders
JP2019511483A (ja)	2016-03-02	2019-04-25	ザボードオブリージェンツオブザユニバーシティーオブテキサスシステム	免疫療法のためのｓｔｉｎｇ活性化ナノワクチン
JP2020522534A (ja) *	2017-06-06	2020-07-30	ウェインステートユニバーシティＷａｙｎｅＳｔａｔｅＵｎｉｖｅｒｓｉｔｙ	カルニチン由来材料に関する方法および組成物
CN115177608B (zh) *	2022-07-26	2023-12-05	南方医科大学南方医院	长链酰基肉碱类化合物在制备预防和/或治疗肝癌的药物中的应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008288A (en) *	1986-01-06	1991-04-16	Alfred Stracher	Carnitine directed pharmaceutical agents
US4866040A (en) *	1986-01-06	1989-09-12	Alfred Stracher	Aminocarnitine directed pharmaceutical agents
IT1230142B (it) *	1989-05-03	1991-10-14	Fidia Spa	Derivati della carnitina, processo per la loro preparazione e impiego in terapia umana
JPH05507929A (ja) *	1990-06-15	1993-11-11	ウェイク　フォレスト　ユニバーシティー	エーテル脂質―ヌクレオシド共有結合体
IT1248321B (it) *	1991-05-15	1995-01-05	Sigma Tau Ind Farmaceuti	Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie
IT1258370B (it) *	1992-03-02	1996-02-26	Sigma Tau Ind Farmaceuti	Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.
US5972600A (en) *	1992-04-03	1999-10-26	The Regents Of The University Of California	Separation of active complexes
IT1263013B (it) *	1992-10-20	1996-07-23	Avantgarde Spa	Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
US5552156A (en) *	1992-10-23	1996-09-03	Ohio State University	Liposomal and micellular stabilization of camptothecin drugs
US5512671A (en) *	1993-02-16	1996-04-30	Wake Forest University	Ether lipid-nucleoside covalent conjugates
IT1261984B (it) *	1993-06-22	1996-06-11	Avantgarde Spa	Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
JPH08512056A (ja) *	1993-06-30	1996-12-17	ジェネンテク・インコーポレイテッド	リポソームの製造法
IT1273987B (it) *	1994-09-29	1997-07-14	Sigma Tau Ind Farmaceuti	Uso di esteri ftalidilidenici della carnitina e di alcanoil carnitine per il trattamento dello shock endotossico
US6008202A (en) *	1995-01-23	1999-12-28	University Of Pittsburgh	Stable lipid-comprising drug delivery complexes and methods for their production
US6316652B1 (en) *	1995-06-06	2001-11-13	Kosta Steliou	Drug mitochondrial targeting agents
WO1996040265A1 (en) *	1995-06-07	1996-12-19	The Regents Of The University Of California	Stabilization of polynucleotide complexes
US5811406A (en) *	1995-06-07	1998-09-22	Regents Of The University Of California	Dry powder formulations of polynucleotide complexes
IT1283955B1 (it) *	1996-03-20	1998-05-07	Sigma Tau Ind Farmaceuti	Bis alcanoil esteri della carnitina ad attivita' antibatterica, antimicotica ed antiprotozoaria.
US6294378B1 (en) *	1996-07-26	2001-09-25	Sloan-Kettering Institute For Cancer Research	Method and reagents for genetic immunization
US6056973A (en) *	1996-10-11	2000-05-02	Sequus Pharmaceuticals, Inc.	Therapeutic liposome composition and method of preparation
US6071532A (en) *	1996-10-15	2000-06-06	Emory University	Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
IT1299172B1 (it) *	1998-05-06	2000-02-29	Sigma Tau Ind Farmaceuti	Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti

1999
- 1999-04-13 IT IT1999RM000220A patent/IT1306129B1/it active
2000
- 2000-04-11 PT PT00922852T patent/PT1183228E/pt unknown
- 2000-04-11 DK DK03020049T patent/DK1426044T3/da active
- 2000-04-11 HR HR20010740A patent/HRP20010740B1/xx not_active IP Right Cessation
- 2000-04-11 IL IL14576500A patent/IL145765A0/xx active IP Right Grant
- 2000-04-11 RS YUP-702/01A patent/RS50911B/sr unknown
- 2000-04-11 CA CA2650202A patent/CA2650202C/en not_active Expired - Fee Related
- 2000-04-11 JP JP2000610820A patent/JP4703855B2/ja not_active Expired - Fee Related
- 2000-04-11 NZ NZ528874A patent/NZ528874A/en not_active IP Right Cessation
- 2000-04-11 AT AT03020049T patent/ATE317257T1/de active
- 2000-04-11 ME MEP-2008-240A patent/ME00113B/me unknown
- 2000-04-11 EA EA200101076A patent/EA004459B1/ru not_active IP Right Cessation
- 2000-04-11 KR KR1020017013018A patent/KR100684378B1/ko not_active Expired - Fee Related
- 2000-04-11 BR BRPI0017460A patent/BRPI0017460B1/pt not_active IP Right Cessation
- 2000-04-11 PL PL386640A patent/PL211710B1/pl unknown
- 2000-04-11 SI SI200030596T patent/SI1183228T1/xx unknown
- 2000-04-11 EE EEP201100028A patent/EE05719B1/et not_active IP Right Cessation
- 2000-04-11 SK SK5094-2008A patent/SK288246B6/sk not_active IP Right Cessation
- 2000-04-11 CZ CZ20013617A patent/CZ302628B6/cs not_active IP Right Cessation
- 2000-04-11 WO PCT/IT2000/000137 patent/WO2000061543A2/en not_active Ceased
- 2000-04-11 EP EP04006990A patent/EP1435232A1/en not_active Withdrawn
- 2000-04-11 KR KR1020067021555A patent/KR100798499B1/ko not_active Expired - Fee Related
- 2000-04-11 DK DK00922852T patent/DK1183228T3/da active
- 2000-04-11 DE DE60025961T patent/DE60025961T2/de not_active Expired - Lifetime
- 2000-04-11 ES ES00922852T patent/ES2234591T3/es not_active Expired - Lifetime
- 2000-04-11 BR BRPI0009765-9B1A patent/BR0009765B1/pt not_active IP Right Cessation
- 2000-04-11 MX MXPA01010359A patent/MXPA01010359A/es active IP Right Grant
- 2000-04-11 NZ NZ515270A patent/NZ515270A/xx not_active IP Right Cessation
- 2000-04-11 EP EP00922852A patent/EP1183228B1/en not_active Expired - Lifetime
- 2000-04-11 DE DE60017388T patent/DE60017388T2/de not_active Expired - Lifetime
- 2000-04-11 SI SI200030799T patent/SI1426044T1/sl unknown
- 2000-04-11 CN CNB2005101295985A patent/CN100402017C/zh not_active Expired - Fee Related
- 2000-04-11 RS RS20090448A patent/RS52682B/sr unknown
- 2000-04-11 AT AT00922852T patent/ATE286873T1/de active
- 2000-04-11 BG BG109876A patent/BG65501B1/bg unknown
- 2000-04-11 EP EP03020049A patent/EP1426044B1/en not_active Expired - Lifetime
- 2000-04-11 PL PL351112A patent/PL204418B1/pl unknown
- 2000-04-11 HK HK02104388.0A patent/HK1045145B/en not_active IP Right Cessation
- 2000-04-11 HU HU0201446A patent/HU229366B1/hu not_active IP Right Cessation
- 2000-04-11 CA CA2370143A patent/CA2370143C/en not_active Expired - Fee Related
- 2000-04-11 ME MEP-240/08A patent/MEP24008A/xx unknown
- 2000-04-11 TR TR2002/02358T patent/TR200202358T2/xx unknown
- 2000-04-11 CN CNB008070539A patent/CN1263730C/zh not_active Expired - Fee Related
- 2000-04-11 ES ES03020049T patent/ES2258688T3/es not_active Expired - Lifetime
- 2000-04-11 PT PT03020049T patent/PT1426044E/pt unknown
- 2000-04-11 EA EA200300745A patent/EA006021B1/ru not_active IP Right Cessation
- 2000-04-11 EE EEP200100518A patent/EE05514B1/xx not_active IP Right Cessation
- 2000-04-11 TR TR2001/02941T patent/TR200102941T2/xx unknown
- 2000-04-11 SK SK1431-2001A patent/SK287253B6/sk not_active IP Right Cessation
- 2000-04-11 RS RSP-2009/0448A patent/RS20090448A/sr unknown
- 2000-04-11 AU AU43123/00A patent/AU776301B2/en not_active Ceased
- 2000-11-04 US US09/958,328 patent/US6797281B1/en not_active Expired - Lifetime
2001
- 2001-09-28 IS IS6095A patent/IS2476B/is unknown
- 2001-10-03 BG BG105971A patent/BG65312B1/bg unknown
- 2001-10-03 BG BG109876A patent/BG109876A/en unknown
- 2001-10-04 IL IL145765A patent/IL145765A/en not_active IP Right Cessation
- 2001-10-12 NO NO20014985A patent/NO327742B1/no not_active IP Right Cessation
- 2001-11-12 ZA ZA200109291A patent/ZA200109291B/en unknown
2003
- 2003-07-23 US US10/624,645 patent/US7629003B2/en not_active Expired - Fee Related
2004
- 2004-01-28 US US10/765,091 patent/US20040186175A1/en not_active Abandoned
- 2004-10-29 AU AU2004224958A patent/AU2004224958B2/en not_active Ceased
2006
- 2006-05-01 IL IL175366A patent/IL175366A/en not_active IP Right Cessation
2007
- 2007-03-27 US US11/727,526 patent/US7585519B2/en not_active Expired - Fee Related
- 2007-08-23 IL IL185486A patent/IL185486A0/en not_active IP Right Cessation
2008
- 2008-03-07 IS IS8719A patent/IS2539B/is unknown
- 2008-12-30 NO NO20085413A patent/NO336949B1/no not_active IP Right Cessation
2010
- 2010-09-21 JP JP2010210849A patent/JP5420507B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2234591T3 (es)	2005-07-01
HK1092732A1 (en)	2007-02-16
SI1426044T1 (sl)	2006-04-30
BG65312B1 (bg)	2008-01-31
CZ302628B6 (cs)	2011-08-10
SI1183228T1 (en)	2005-04-30
BG105971A (en)	2002-08-30
IS2476B (is)	2008-12-15
CA2370143C (en)	2011-06-21
JP5420507B2 (ja)	2014-02-19
HK1045145B (en)	2006-01-27
IS8719A (is)	2008-03-07
HUP0201446A3 (en)	2002-11-28
NZ515270A (en)	2004-02-27
PL351112A1 (en)	2003-03-24
KR100798499B1 (ko)	2008-01-28
ATE286873T1 (de)	2005-01-15
SK14312001A3 (sk)	2002-02-05
MEP24008A (en)	2010-06-10
EP1183228A2 (en)	2002-03-06
EE200100518A (et)	2002-12-16
DE60017388D1 (de)	2005-02-17
IL175366A (en)	2010-12-30
ATE317257T1 (de)	2006-02-15
EA200300745A1 (ru)	2003-12-25
PT1183228E (pt)	2005-04-29
CN100402017C (zh)	2008-07-16
ZA200109291B (en)	2002-08-16
SK287253B6 (sk)	2010-04-07
DK1183228T3 (da)	2005-05-17
EE201100028A (et)	2011-08-15
SK288246B6 (sk)	2015-03-03
IL185486A0 (en)	2008-01-06
HU229366B1 (en)	2013-11-28
YU70201A (sh)	2004-07-15
CZ20013617A3 (cs)	2002-02-13
DE60025961D1 (de)	2006-04-20
NO20085413L (no)	2001-10-12
EP1435232A1 (en)	2004-07-07
IT1306129B1 (it)	2001-05-30
DK1426044T3 (da)	2006-06-12
NZ528874A (en)	2005-09-30
RS50911B (sr)	2010-08-31
IL175366A0 (en)	2006-09-05
ES2258688T3 (es)	2006-09-01
RS20090448A (sr)	2010-06-30
US20070190128A1 (en)	2007-08-16
EP1426044A1 (en)	2004-06-09
DE60025961T2 (de)	2006-08-17
HK1045145A1 (en)	2002-11-15
KR20060113799A (ko)	2006-11-02
JP4703855B2 (ja)	2011-06-15
ITRM990220A1 (it)	2000-10-13
RS52682B (sr)	2013-08-30
WO2000061543A2 (en)	2000-10-19
US7629003B2 (en)	2009-12-08
EA006021B1 (ru)	2005-08-25
EE05514B1 (et)	2012-02-15
HUP0201446A2 (en)	2002-08-28
US7585519B2 (en)	2009-09-08
BRPI0017460B1 (pt)	2016-04-19
TR200202358T2 (tr)	2002-12-23
AU776301B2 (en)	2004-09-02
JP2002541238A (ja)	2002-12-03
KR20010113794A (ko)	2001-12-28
NO20014985D0 (no)	2001-10-12
EP1183228B1 (en)	2005-01-12
EE05719B1 (et)	2014-08-15
IS6095A (is)	2001-09-28
IL145765A (en)	2007-07-04
PL204418B1 (pl)	2010-01-29
CA2370143A1 (en)	2000-10-19
BG65501B1 (bg)	2008-10-31
CN1359370A (zh)	2002-07-17
US20050079209A1 (en)	2005-04-14
EP1426044B1 (en)	2006-02-08
IL145765A0 (en)	2002-07-25
CA2650202A1 (en)	2000-10-19
NO327742B1 (no)	2009-09-14
ME00113B (me)	2010-10-10
AU4312300A (en)	2000-11-14
KR100684378B1 (ko)	2007-02-20
CN1263730C (zh)	2006-07-12
PL211710B1 (pl)	2012-06-29
BG109876A (en)	2008-02-29
BR0009765A (pt)	2002-01-02
WO2000061543A3 (en)	2001-01-11
AU2004224958A1 (en)	2004-11-25
EA200101076A1 (ru)	2002-04-25
DE60017388T2 (de)	2006-03-30
HRP20010740A2 (en)	2002-10-31
MXPA01010359A (es)	2002-05-06
US20040186175A1 (en)	2004-09-23
NO20014985L (no)	2001-10-12
CN1823731A (zh)	2006-08-30
JP2011042657A (ja)	2011-03-03
US6797281B1 (en)	2004-09-28
NO336949B1 (no)	2015-11-30
TR200102941T2 (tr)	2002-05-21
AU2004224958B2 (en)	2007-11-22
PT1426044E (pt)	2006-06-30
CA2650202C (en)	2012-12-11
IS2539B (is)	2009-09-15
EA004459B1 (ru)	2004-04-29
HRP20010740B1 (en)	2005-08-31

Publication	Publication Date	Title
BR0009765B1 (pt)	2013-11-05	Compostos de ésteres de l-carnitina ou alcanoil l-carnitinase, uso dos mesmos, lipossomas contendo os referidos compostos e composições farmacêuticas e cosméticas contendo os ditos lipossomas.
CO4940469A1 (es)	2000-07-24	Composicion oral de estabilidad mejorada que comprende un derivado de indolinona y una mezcla de gliceridos o esteres de polietilenglicol
IT1281337B1 (it)	1998-02-18	Preparazione farmaceutica orale contenente ciclosporina come sostanza attiva ed un preconcentrato di emulsione multipla
AU5879798A (en)	1998-09-08	Agents inhibiting progress of pterygium and postoperative recurrence of the same
AU3846599A (en)	1999-11-23	Perfluorinated esters of alkanoyl l-carnitine for the preparation of cationic lipids for the intracellular delivery of pharmacologically active compounds
AU3542697A (en)	1998-02-09	Pharmaceutical formulations for topical application containing as an active ingredient carbazolyl-(4)-oxy-propanol amine derivate

Legal Events

Date	Code	Title	Description
2008-02-19	B15K	Others concerning applications: alteration of classification	Ipc: C07C 229/22 (2008.01), A61K 9/127 (2008.01)
2009-06-23	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2010-01-26	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2010-09-08	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 13 E 25 DA LPI.
2011-01-25	B12B	Appeal against refusal [chapter 12.2 patent gazette]
2012-07-24	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2013-11-05	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 05/11/2013, OBSERVADAS AS CONDICOES LEGAIS.
2018-02-06	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
2018-05-22	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)