IT1283955B1 - Bis alcanoil esteri della carnitina ad attivita' antibatterica, antimicotica ed antiprotozoaria. - Google Patents
Bis alcanoil esteri della carnitina ad attivita' antibatterica, antimicotica ed antiprotozoaria.Info
- Publication number
- IT1283955B1 IT1283955B1 IT96RM000180A ITRM960180A IT1283955B1 IT 1283955 B1 IT1283955 B1 IT 1283955B1 IT 96RM000180 A IT96RM000180 A IT 96RM000180A IT RM960180 A ITRM960180 A IT RM960180A IT 1283955 B1 IT1283955 B1 IT 1283955B1
- Authority
- IT
- Italy
- Prior art keywords
- activity
- carnitine
- esters
- antiprotzoary
- alcanoil
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 title 1
- 230000000416 anti-micotic effect Effects 0.000 title 1
- 229960004203 carnitine Drugs 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical class C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 210000000883 ear external Anatomy 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000004877 mucosa Anatomy 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96RM000180A IT1283955B1 (it) | 1996-03-20 | 1996-03-20 | Bis alcanoil esteri della carnitina ad attivita' antibatterica, antimicotica ed antiprotozoaria. |
| TW086103027A TW491828B (en) | 1996-03-20 | 1997-03-10 | Bis alkanoyl esters of carnitine having bactericidal, fungicidal and antiprotozoal activity |
| US08/818,737 US5925369A (en) | 1996-03-20 | 1997-03-14 | Bis alkanoyl esters of carnitine having bactericidal, fungicidal and antiprotozoal activity |
| ES97830118T ES2147663T3 (es) | 1996-03-20 | 1997-03-14 | Bisalcanoilesteres de carnitina que tienen actividad bactericida, fungicida y antiprotozoica. |
| AT97830118T ATE193521T1 (de) | 1996-03-20 | 1997-03-14 | Carnitine-bisalkanoylester mit bakterizider, fungizider und antiprotozoischer wirkung |
| PT97830118T PT796841E (pt) | 1996-03-20 | 1997-03-14 | Esteres bis alcanoilo de carnitina com actividade bactericida fungicida e anriprotozoaria |
| EP97830118A EP0796841B1 (en) | 1996-03-20 | 1997-03-14 | Bis alkanoyl esters of carnitine having bactericidal, fungicidal and antiprotozoal activity |
| DK97830118T DK0796841T3 (da) | 1996-03-20 | 1997-03-14 | Bis-alkanoylestere af carnitin, der har baktericid, svampedræbende og antiprotozoal aktivitet |
| DE69702158T DE69702158T2 (de) | 1996-03-20 | 1997-03-14 | Carnitine-Bisalkanoylester mit bakterizider, fungizider und antiprotozoischer Wirkung |
| MXPA/A/1997/002043A MXPA97002043A (en) | 1996-03-20 | 1997-03-18 | Bis alcanoil carnitine esters that have bactericidactivity, fungicide yantiprotozoar |
| ZA9702374A ZA972374B (en) | 1996-03-20 | 1997-03-19 | Bis alkanoyl esters of carnitine having bactericidal, fungicidal and antiprotozoal activity. |
| CA002200409A CA2200409C (en) | 1996-03-20 | 1997-03-19 | Bis alkanoyl esters of carnitine having bactericidal, fungicidal and antiprotozoal activity |
| KR1019970009443A KR100491099B1 (ko) | 1996-03-20 | 1997-03-20 | 살균,살진균및항-원생동물활성을가지는비스알카노일에스테르 |
| JP06784297A JP4077052B2 (ja) | 1996-03-20 | 1997-03-21 | 抗菌、抗真菌および抗原虫活性を有するカルニチンのビスアルカノイルエステル |
| GR20000401930T GR3034243T3 (en) | 1996-03-20 | 2000-08-23 | Bis alkanoyl esters of carnitine having bactericidal, fungicidal and antiprotozoal activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96RM000180A IT1283955B1 (it) | 1996-03-20 | 1996-03-20 | Bis alcanoil esteri della carnitina ad attivita' antibatterica, antimicotica ed antiprotozoaria. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM960180A0 ITRM960180A0 (it) | 1996-03-20 |
| ITRM960180A1 ITRM960180A1 (it) | 1997-09-20 |
| IT1283955B1 true IT1283955B1 (it) | 1998-05-07 |
Family
ID=11404010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT96RM000180A IT1283955B1 (it) | 1996-03-20 | 1996-03-20 | Bis alcanoil esteri della carnitina ad attivita' antibatterica, antimicotica ed antiprotozoaria. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5925369A (it) |
| EP (1) | EP0796841B1 (it) |
| JP (1) | JP4077052B2 (it) |
| KR (1) | KR100491099B1 (it) |
| AT (1) | ATE193521T1 (it) |
| CA (1) | CA2200409C (it) |
| DE (1) | DE69702158T2 (it) |
| DK (1) | DK0796841T3 (it) |
| ES (1) | ES2147663T3 (it) |
| GR (1) | GR3034243T3 (it) |
| IT (1) | IT1283955B1 (it) |
| PT (1) | PT796841E (it) |
| TW (1) | TW491828B (it) |
| ZA (1) | ZA972374B (it) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1306129B1 (it) * | 1999-04-13 | 2001-05-30 | Sigma Tau Ind Farmaceuti | Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti |
| CN101448482B (zh) | 2006-05-19 | 2013-10-09 | 玫琳凯有限公司 | 甘油基和二元醇酸化合物 |
| CN105142400B (zh) | 2013-03-12 | 2018-02-13 | 玫琳凯有限公司 | 防腐体系 |
| CN105017045B (zh) * | 2015-06-09 | 2017-11-07 | 中北大学 | 一种连接基含双酯基的双季铵盐及其作为杀菌剂的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2497673A (en) * | 1946-04-16 | 1950-02-14 | Du Pont | Reaction of alpha-beta unsaturated compounds with aromatic hydrocarbons and products obtained |
| US2712025A (en) * | 1951-09-26 | 1955-06-28 | Chessie E Rehberg | Production of dicarboxylic acid esters of alpha-hydroxycarboxylic acid esters |
| IT1201481B (it) * | 1985-10-08 | 1989-02-02 | Prodotti Antibiotici Spa | Pantotenil derivati |
| IT1254135B (it) * | 1992-01-16 | 1995-09-08 | Sigma Tau Ind Farmaceuti | Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica. |
| IT1254136B (it) * | 1992-01-16 | 1995-09-08 | Sigma Tau Ind Farmaceuti | Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica. |
| AU4534593A (en) * | 1992-06-12 | 1994-01-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
-
1996
- 1996-03-20 IT IT96RM000180A patent/IT1283955B1/it active IP Right Grant
-
1997
- 1997-03-10 TW TW086103027A patent/TW491828B/zh not_active IP Right Cessation
- 1997-03-14 DK DK97830118T patent/DK0796841T3/da active
- 1997-03-14 AT AT97830118T patent/ATE193521T1/de not_active IP Right Cessation
- 1997-03-14 PT PT97830118T patent/PT796841E/pt unknown
- 1997-03-14 DE DE69702158T patent/DE69702158T2/de not_active Expired - Lifetime
- 1997-03-14 ES ES97830118T patent/ES2147663T3/es not_active Expired - Lifetime
- 1997-03-14 US US08/818,737 patent/US5925369A/en not_active Expired - Fee Related
- 1997-03-14 EP EP97830118A patent/EP0796841B1/en not_active Expired - Lifetime
- 1997-03-19 CA CA002200409A patent/CA2200409C/en not_active Expired - Fee Related
- 1997-03-19 ZA ZA9702374A patent/ZA972374B/xx unknown
- 1997-03-20 KR KR1019970009443A patent/KR100491099B1/ko not_active Expired - Fee Related
- 1997-03-21 JP JP06784297A patent/JP4077052B2/ja not_active Expired - Fee Related
-
2000
- 2000-08-23 GR GR20000401930T patent/GR3034243T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ITRM960180A1 (it) | 1997-09-20 |
| GR3034243T3 (en) | 2000-12-29 |
| ES2147663T3 (es) | 2000-09-16 |
| CA2200409A1 (en) | 1997-09-20 |
| JP4077052B2 (ja) | 2008-04-16 |
| JPH107631A (ja) | 1998-01-13 |
| PT796841E (pt) | 2000-09-29 |
| CA2200409C (en) | 2006-11-28 |
| KR100491099B1 (ko) | 2006-01-12 |
| ITRM960180A0 (it) | 1996-03-20 |
| DE69702158D1 (de) | 2000-07-06 |
| KR970065506A (ko) | 1997-10-13 |
| ZA972374B (en) | 1997-10-20 |
| DK0796841T3 (da) | 2000-11-13 |
| DE69702158T2 (de) | 2000-10-19 |
| TW491828B (en) | 2002-06-21 |
| US5925369A (en) | 1999-07-20 |
| MX9702043A (es) | 1998-03-31 |
| EP0796841A1 (en) | 1997-09-24 |
| ATE193521T1 (de) | 2000-06-15 |
| EP0796841B1 (en) | 2000-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU4541689A (en) | Quinazolinonederivatives which are bronchodilators and vasodilators | |
| ATE260255T1 (de) | 5-oxo-pyrrolidine-2-carbonsäure- hydroxamidderivate | |
| TR199801642T2 (xx) | Tedavide faydal� olan karbamik asitlerin azabisiklik esterleri. | |
| ATE252385T1 (de) | Vorbeugende oder heilende mittel für krankheiten, die durch mangel an stickoxid-synthase (nos) ausgelöst sind | |
| GR3032311T3 (en) | Stilbene derivatives and pharmaceutical compositions containing them | |
| DE69425304D1 (de) | Zyklische antimikrobielle Peptide und deren Herstellung | |
| SE9904508D0 (sv) | New compounds | |
| GR3005990T3 (it) | ||
| IL134894A (en) | 2-substituted-1,3,4,5-tetrahydro-2h-gamma-carbolines, their preparation and pharmaceutical compositions containing them | |
| PT90034A (pt) | Processo para a preparacao de tetra-hidroimidazo-{1,4}benzodiazepina-2-onas | |
| AU5236293A (en) | Antidepressant and antiparkinsonian compounds | |
| ES2107279T3 (es) | Diesteres de fosfato para el tratamiento de enfermedades proliferativas de la epidermis. | |
| IT1283955B1 (it) | Bis alcanoil esteri della carnitina ad attivita' antibatterica, antimicotica ed antiprotozoaria. | |
| AU3583989A (en) | New cephem compounds and processes for preparation thereof | |
| NZ324447A (en) | 1-methyl-carbapenem substituted by a 4-pyrrolidinylthio group and medicaments | |
| EP0342587A3 (en) | Thienotriazolodiazepine compounds and pharmaceutical uses thereof | |
| ZA858659B (en) | Use of spergualin derivatives for the preparation of medicaments having immunosuppressive activity | |
| ITRM910327A1 (it) | Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie | |
| CA2380455A1 (en) | 9a-azalides with antibacterial activity | |
| DK526087A (da) | Antikonvulsive aminosyrederivater | |
| HU9400908D0 (en) | Pharmaceutical compositions for treatng skin disorders | |
| ES2000681A6 (es) | Un procedimiento para preparar nuevos compuestos de bencilpiperazina | |
| GR3031709T3 (en) | Octahydro-2-naphthalenecarboxylic acid derivative, its production and use. | |
| PT1264836E (pt) | Processos para a preparacao de derivados de indolopirrolocarbazole | |
| ES2073871T3 (es) | Tiazolidin-2,4-dionas en el tratamiento de la hipertension. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |