MEP24008A - Esters of l-carnitine or alkanoyl l-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds - Google Patents

Esters of l-carnitine or alkanoyl l-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds

Info

Publication number: MEP24008A
Authority: ME; Montenegro
Prior art keywords: carnitine; alkanoyl; esters; active compounds; pharmacologically active
Prior art date: 1999-04-13

Application number

MEP-240/08A

Other languages

Bosnian (bs)

English (en)

Inventor

Claudio Pisano

Maria Ornella Tinti

Mose Santaniello

Luciana Critelli

Giovanni Salvatori

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-13

Filing date

2000-04-11

Publication date

2010-06-10

2000-04-11 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

2010-06-10 Publication of MEP24008A publication Critical patent/MEP24008A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Dispersion Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Birds (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Biotechnology (AREA)
Dermatology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)

MEP-240/08A 1999-04-13 2000-04-11 Esters of l-carnitine or alkanoyl l-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds MEP24008A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT1999RM000220A IT1306129B1 (it)	1999-04-13	1999-04-13	Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
YUP-702/01A RS50911B (sr)	1999-04-13	2000-04-11	Estri l-karnitina ili alkanoil l-karnitina korisni kao katjonski lipidi za unutarćelijsko oslobađanje farmakološki aktivnih jedinjenja
PCT/IT2000/000137 WO2000061543A2 (en)	1999-04-13	2000-04-11	Esters of l-carnitine or alkanoyl l-carnitines

Publications (1)

Publication Number	Publication Date
MEP24008A true MEP24008A (en)	2010-06-10

Family

ID=11406659

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
MEP-2008-240A ME00113B (me)	1999-04-13	2000-04-11	Estri l-karnitina ili alkanoil l-karnitina korisni kao katjonski lipidi za unutarćelijsko oslobađanje farmakološki aktivnih jedinjenja
MEP-240/08A MEP24008A (en)	1999-04-13	2000-04-11	Esters of l-carnitine or alkanoyl l-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
MEP-2008-240A ME00113B (me)	1999-04-13	2000-04-11	Estri l-karnitina ili alkanoil l-karnitina korisni kao katjonski lipidi za unutarćelijsko oslobađanje farmakološki aktivnih jedinjenja

Country Status (34)

Country	Link
US (4)	US6797281B1 (xx)
EP (3)	EP1435232A1 (xx)
JP (2)	JP4703855B2 (xx)
KR (2)	KR100684378B1 (xx)
CN (2)	CN100402017C (xx)
AT (2)	ATE317257T1 (xx)
AU (2)	AU776301B2 (xx)
BG (3)	BG65501B1 (xx)
BR (2)	BRPI0017460B1 (xx)
CA (2)	CA2650202C (xx)
CZ (1)	CZ302628B6 (xx)
DE (2)	DE60025961T2 (xx)
DK (2)	DK1426044T3 (xx)
EA (2)	EA004459B1 (xx)
EE (2)	EE05719B1 (xx)
ES (2)	ES2234591T3 (xx)
HK (1)	HK1045145B (xx)
HR (1)	HRP20010740B1 (xx)
HU (1)	HU229366B1 (xx)
IL (4)	IL145765A0 (xx)
IS (2)	IS2476B (xx)
IT (1)	IT1306129B1 (xx)
ME (2)	ME00113B (xx)
MX (1)	MXPA01010359A (xx)
NO (2)	NO327742B1 (xx)
NZ (2)	NZ528874A (xx)
PL (2)	PL211710B1 (xx)
PT (2)	PT1183228E (xx)
RS (3)	RS50911B (xx)
SI (2)	SI1183228T1 (xx)
SK (2)	SK288246B6 (xx)
TR (2)	TR200202358T2 (xx)
WO (1)	WO2000061543A2 (xx)
ZA (1)	ZA200109291B (xx)

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DE10113446A1 (de) †	2001-03-19	2002-09-26	Schwarzkopf Gmbh Hans	Haarbehandlungsmittel mit Betainen
DK2286795T3 (en) *	2002-06-26	2017-02-06	Syncore Biotechnology Co Ltd	PROCEDURE FOR PREPARING A Cationic LIPOSOMAL PREPARATION INCLUDING A LIPOPHIL COMPOUND
DK2108362T3 (da) *	2002-06-26	2013-09-02	Medigene Ag	Kationisk liposomal-fremstilling omfattende en taxan
ITRM20040288A1 (it) *	2004-06-11	2004-09-11	Sigma Tau Ind Farmaceuti	Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
GT200500310A (es) *	2004-11-19	2006-06-19		Compuestos organicos
US20080095834A1 (en) *	2005-03-02	2008-04-24	Volkmar Weissig	Mitochondriotropic Phospholipid Vesicles
SA06270147B1 (ar)	2005-06-09	2009-12-22	نوفارتيس ايه جي	عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
MX2008001965A (es) *	2005-08-10	2008-03-26	Novartis Ag	Composiciones en microparticulas del inhibidor de topoisomerasa i 7-ter-butoxiiminometilcamptotecina.
JP2009504615A (ja) *	2005-08-10	2009-02-05	ノバルティスアクチエンゲゼルシャフト	７−（ｔ−ブトキシ）イミノメチルカンプトテシンのための製剤
US20100178325A1 (en) *	2006-08-23	2010-07-15	Biodelivery Sciences International, Inc.	Amphiphilic nucleotide cochleate compositions and methods of using the same
EP2107903A1 (en) *	2007-02-01	2009-10-14	SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.	Pharmaceutical composition comprising a campothecin derivative
WO2008101173A2 (en) *	2007-02-16	2008-08-21	Cornell University	Biodegradable compositions and materials
US20100204432A1 (en) *	2007-05-28	2010-08-12	Husam Younes	Biodegradable elastomers prepared by the condensation of an organic di-, tri- or tetra-carboxylic acid and an organic diol
JP4827986B2 (ja)	2007-06-08	2011-11-30	マンカインドコーポレ−ション	ＩＲＥ−１αインヒビター
CA2718276A1 (en) *	2008-03-13	2009-09-17	Perkinelmer Las, Inc.	Enzymatic substrates for multiple detection systems
EP2532649B1 (en) *	2011-06-07	2015-04-08	Incella GmbH	Amino lipids, their synthesis and uses thereof
WO2013032643A2 (en) *	2011-08-31	2013-03-07	Dicerna Pharmaceuticals, Inc.	Lipids capable of conformational change and their use in formulations to deliver therapeutic agents to cells
US20140274798A1 (en)	2013-03-15	2014-09-18	University Of Washington Through Its Center For Commercialization	Compounds and methods relating to lysosomal storage disorders
JP2019511483A (ja)	2016-03-02	2019-04-25	ザボードオブリージェンツオブザユニバーシティーオブテキサスシステム	免疫療法のためのｓｔｉｎｇ活性化ナノワクチン
JP2020522534A (ja) *	2017-06-06	2020-07-30	ウェインステートユニバーシティＷａｙｎｅＳｔａｔｅＵｎｉｖｅｒｓｉｔｙ	カルニチン由来材料に関する方法および組成物
CN115177608B (zh) *	2022-07-26	2023-12-05	南方医科大学南方医院	长链酰基肉碱类化合物在制备预防和/或治疗肝癌的药物中的应用

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US4866040A (en) *	1986-01-06	1989-09-12	Alfred Stracher	Aminocarnitine directed pharmaceutical agents
IT1230142B (it) *	1989-05-03	1991-10-14	Fidia Spa	Derivati della carnitina, processo per la loro preparazione e impiego in terapia umana
JPH05507929A (ja) *	1990-06-15	1993-11-11	ウェイク　フォレスト　ユニバーシティー	エーテル脂質―ヌクレオシド共有結合体
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IT1261984B (it) *	1993-06-22	1996-06-11	Avantgarde Spa	Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
JPH08512056A (ja) *	1993-06-30	1996-12-17	ジェネンテク・インコーポレイテッド	リポソームの製造法
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US5811406A (en) *	1995-06-07	1998-09-22	Regents Of The University Of California	Dry powder formulations of polynucleotide complexes
IT1283955B1 (it) *	1996-03-20	1998-05-07	Sigma Tau Ind Farmaceuti	Bis alcanoil esteri della carnitina ad attivita' antibatterica, antimicotica ed antiprotozoaria.
US6294378B1 (en) *	1996-07-26	2001-09-25	Sloan-Kettering Institute For Cancer Research	Method and reagents for genetic immunization
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US6071532A (en) *	1996-10-15	2000-06-06	Emory University	Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
IT1299172B1 (it) *	1998-05-06	2000-02-29	Sigma Tau Ind Farmaceuti	Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti

1999
- 1999-04-13 IT IT1999RM000220A patent/IT1306129B1/it active
2000
- 2000-04-11 PT PT00922852T patent/PT1183228E/pt unknown
- 2000-04-11 DK DK03020049T patent/DK1426044T3/da active
- 2000-04-11 HR HR20010740A patent/HRP20010740B1/xx not_active IP Right Cessation
- 2000-04-11 IL IL14576500A patent/IL145765A0/xx active IP Right Grant
- 2000-04-11 RS YUP-702/01A patent/RS50911B/sr unknown
- 2000-04-11 CA CA2650202A patent/CA2650202C/en not_active Expired - Fee Related
- 2000-04-11 JP JP2000610820A patent/JP4703855B2/ja not_active Expired - Fee Related
- 2000-04-11 NZ NZ528874A patent/NZ528874A/en not_active IP Right Cessation
- 2000-04-11 AT AT03020049T patent/ATE317257T1/de active
- 2000-04-11 ME MEP-2008-240A patent/ME00113B/me unknown
- 2000-04-11 EA EA200101076A patent/EA004459B1/ru not_active IP Right Cessation
- 2000-04-11 KR KR1020017013018A patent/KR100684378B1/ko not_active Expired - Fee Related
- 2000-04-11 BR BRPI0017460A patent/BRPI0017460B1/pt not_active IP Right Cessation
- 2000-04-11 PL PL386640A patent/PL211710B1/pl unknown
- 2000-04-11 SI SI200030596T patent/SI1183228T1/xx unknown
- 2000-04-11 EE EEP201100028A patent/EE05719B1/et not_active IP Right Cessation
- 2000-04-11 SK SK5094-2008A patent/SK288246B6/sk not_active IP Right Cessation
- 2000-04-11 CZ CZ20013617A patent/CZ302628B6/cs not_active IP Right Cessation
- 2000-04-11 WO PCT/IT2000/000137 patent/WO2000061543A2/en not_active Ceased
- 2000-04-11 EP EP04006990A patent/EP1435232A1/en not_active Withdrawn
- 2000-04-11 KR KR1020067021555A patent/KR100798499B1/ko not_active Expired - Fee Related
- 2000-04-11 DK DK00922852T patent/DK1183228T3/da active
- 2000-04-11 DE DE60025961T patent/DE60025961T2/de not_active Expired - Lifetime
- 2000-04-11 ES ES00922852T patent/ES2234591T3/es not_active Expired - Lifetime
- 2000-04-11 BR BRPI0009765-9B1A patent/BR0009765B1/pt not_active IP Right Cessation
- 2000-04-11 MX MXPA01010359A patent/MXPA01010359A/es active IP Right Grant
- 2000-04-11 NZ NZ515270A patent/NZ515270A/xx not_active IP Right Cessation
- 2000-04-11 EP EP00922852A patent/EP1183228B1/en not_active Expired - Lifetime
- 2000-04-11 DE DE60017388T patent/DE60017388T2/de not_active Expired - Lifetime
- 2000-04-11 SI SI200030799T patent/SI1426044T1/sl unknown
- 2000-04-11 CN CNB2005101295985A patent/CN100402017C/zh not_active Expired - Fee Related
- 2000-04-11 RS RS20090448A patent/RS52682B/sr unknown
- 2000-04-11 AT AT00922852T patent/ATE286873T1/de active
- 2000-04-11 BG BG109876A patent/BG65501B1/bg unknown
- 2000-04-11 EP EP03020049A patent/EP1426044B1/en not_active Expired - Lifetime
- 2000-04-11 PL PL351112A patent/PL204418B1/pl unknown
- 2000-04-11 HK HK02104388.0A patent/HK1045145B/en not_active IP Right Cessation
- 2000-04-11 HU HU0201446A patent/HU229366B1/hu not_active IP Right Cessation
- 2000-04-11 CA CA2370143A patent/CA2370143C/en not_active Expired - Fee Related
- 2000-04-11 ME MEP-240/08A patent/MEP24008A/xx unknown
- 2000-04-11 TR TR2002/02358T patent/TR200202358T2/xx unknown
- 2000-04-11 CN CNB008070539A patent/CN1263730C/zh not_active Expired - Fee Related
- 2000-04-11 ES ES03020049T patent/ES2258688T3/es not_active Expired - Lifetime
- 2000-04-11 PT PT03020049T patent/PT1426044E/pt unknown
- 2000-04-11 EA EA200300745A patent/EA006021B1/ru not_active IP Right Cessation
- 2000-04-11 EE EEP200100518A patent/EE05514B1/xx not_active IP Right Cessation
- 2000-04-11 TR TR2001/02941T patent/TR200102941T2/xx unknown
- 2000-04-11 SK SK1431-2001A patent/SK287253B6/sk not_active IP Right Cessation
- 2000-04-11 RS RSP-2009/0448A patent/RS20090448A/sr unknown
- 2000-04-11 AU AU43123/00A patent/AU776301B2/en not_active Ceased
- 2000-11-04 US US09/958,328 patent/US6797281B1/en not_active Expired - Lifetime
2001
- 2001-09-28 IS IS6095A patent/IS2476B/is unknown
- 2001-10-03 BG BG105971A patent/BG65312B1/bg unknown
- 2001-10-03 BG BG109876A patent/BG109876A/en unknown
- 2001-10-04 IL IL145765A patent/IL145765A/en not_active IP Right Cessation
- 2001-10-12 NO NO20014985A patent/NO327742B1/no not_active IP Right Cessation
- 2001-11-12 ZA ZA200109291A patent/ZA200109291B/en unknown
2003
- 2003-07-23 US US10/624,645 patent/US7629003B2/en not_active Expired - Fee Related
2004
- 2004-01-28 US US10/765,091 patent/US20040186175A1/en not_active Abandoned
- 2004-10-29 AU AU2004224958A patent/AU2004224958B2/en not_active Ceased
2006
- 2006-05-01 IL IL175366A patent/IL175366A/en not_active IP Right Cessation
2007
- 2007-03-27 US US11/727,526 patent/US7585519B2/en not_active Expired - Fee Related
- 2007-08-23 IL IL185486A patent/IL185486A0/en not_active IP Right Cessation
2008
- 2008-03-07 IS IS8719A patent/IS2539B/is unknown
- 2008-12-30 NO NO20085413A patent/NO336949B1/no not_active IP Right Cessation
2010
- 2010-09-21 JP JP2010210849A patent/JP5420507B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2234591T3 (es)	2005-07-01
HK1092732A1 (en)	2007-02-16
SI1426044T1 (sl)	2006-04-30
BG65312B1 (bg)	2008-01-31
CZ302628B6 (cs)	2011-08-10
SI1183228T1 (en)	2005-04-30
BG105971A (en)	2002-08-30
IS2476B (is)	2008-12-15
CA2370143C (en)	2011-06-21
JP5420507B2 (ja)	2014-02-19
HK1045145B (en)	2006-01-27
IS8719A (is)	2008-03-07
HUP0201446A3 (en)	2002-11-28
NZ515270A (en)	2004-02-27
PL351112A1 (en)	2003-03-24
KR100798499B1 (ko)	2008-01-28
ATE286873T1 (de)	2005-01-15
SK14312001A3 (sk)	2002-02-05
EP1183228A2 (en)	2002-03-06
EE200100518A (et)	2002-12-16
DE60017388D1 (de)	2005-02-17
IL175366A (en)	2010-12-30
ATE317257T1 (de)	2006-02-15
EA200300745A1 (ru)	2003-12-25
PT1183228E (pt)	2005-04-29
CN100402017C (zh)	2008-07-16
ZA200109291B (en)	2002-08-16
SK287253B6 (sk)	2010-04-07
DK1183228T3 (da)	2005-05-17
EE201100028A (et)	2011-08-15
SK288246B6 (sk)	2015-03-03
IL185486A0 (en)	2008-01-06
HU229366B1 (en)	2013-11-28
YU70201A (sh)	2004-07-15
CZ20013617A3 (cs)	2002-02-13
DE60025961D1 (de)	2006-04-20
NO20085413L (no)	2001-10-12
EP1435232A1 (en)	2004-07-07
IT1306129B1 (it)	2001-05-30
DK1426044T3 (da)	2006-06-12
NZ528874A (en)	2005-09-30
RS50911B (sr)	2010-08-31
IL175366A0 (en)	2006-09-05
ES2258688T3 (es)	2006-09-01
RS20090448A (sr)	2010-06-30
US20070190128A1 (en)	2007-08-16
EP1426044A1 (en)	2004-06-09
DE60025961T2 (de)	2006-08-17
HK1045145A1 (en)	2002-11-15
KR20060113799A (ko)	2006-11-02
JP4703855B2 (ja)	2011-06-15
ITRM990220A1 (it)	2000-10-13
RS52682B (sr)	2013-08-30
WO2000061543A2 (en)	2000-10-19
US7629003B2 (en)	2009-12-08
EA006021B1 (ru)	2005-08-25
EE05514B1 (et)	2012-02-15
HUP0201446A2 (en)	2002-08-28
US7585519B2 (en)	2009-09-08
BRPI0017460B1 (pt)	2016-04-19
TR200202358T2 (tr)	2002-12-23
AU776301B2 (en)	2004-09-02
JP2002541238A (ja)	2002-12-03
KR20010113794A (ko)	2001-12-28
BR0009765B1 (pt)	2013-11-05
NO20014985D0 (no)	2001-10-12
EP1183228B1 (en)	2005-01-12
EE05719B1 (et)	2014-08-15
IS6095A (is)	2001-09-28
IL145765A (en)	2007-07-04
PL204418B1 (pl)	2010-01-29
CA2370143A1 (en)	2000-10-19
BG65501B1 (bg)	2008-10-31
CN1359370A (zh)	2002-07-17
US20050079209A1 (en)	2005-04-14
EP1426044B1 (en)	2006-02-08
IL145765A0 (en)	2002-07-25
CA2650202A1 (en)	2000-10-19
NO327742B1 (no)	2009-09-14
ME00113B (me)	2010-10-10
AU4312300A (en)	2000-11-14
KR100684378B1 (ko)	2007-02-20
CN1263730C (zh)	2006-07-12
PL211710B1 (pl)	2012-06-29
BG109876A (en)	2008-02-29
BR0009765A (pt)	2002-01-02
WO2000061543A3 (en)	2001-01-11
AU2004224958A1 (en)	2004-11-25
EA200101076A1 (ru)	2002-04-25
DE60017388T2 (de)	2006-03-30
HRP20010740A2 (en)	2002-10-31
MXPA01010359A (es)	2002-05-06
US20040186175A1 (en)	2004-09-23
NO20014985L (no)	2001-10-12
CN1823731A (zh)	2006-08-30
JP2011042657A (ja)	2011-03-03
US6797281B1 (en)	2004-09-28
NO336949B1 (no)	2015-11-30
TR200102941T2 (tr)	2002-05-21
AU2004224958B2 (en)	2007-11-22
PT1426044E (pt)	2006-06-30
CA2650202C (en)	2012-12-11
IS2539B (is)	2009-09-15
EA004459B1 (ru)	2004-04-29
HRP20010740B1 (en)	2005-08-31

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