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BR0009323A - Anticorpos humanos que ligam a il-12 humana e métodos para a produção - Google Patents

Anticorpos humanos que ligam a il-12 humana e métodos para a produção

Info

Publication number
BR0009323A
BR0009323A BR0009323-8A BR0009323A BR0009323A BR 0009323 A BR0009323 A BR 0009323A BR 0009323 A BR0009323 A BR 0009323A BR 0009323 A BR0009323 A BR 0009323A
Authority
BR
Brazil
Prior art keywords
hil
human
antibodies
human antibodies
methods
Prior art date
Application number
BR0009323-8A
Other languages
English (en)
Inventor
Jochen G Salfeld
Michael Roguska
Michael Paskind
Subhashis Banerjee
Daniel E Tracey
Michael White
Zehra Kaymakcalan
Boris Labkovsky
Paul Sakorafas
Stuart Friedrich
Angela Myles
Geertruida M Veldman
Amy Venturini
Nicholas W Warne
Angela Widom
John G Elvin
Alexander R Duncan
Elaine J Derbyshire
Sara Carmen
Stephen Smith
Thor Las Holtet
Sarah L Du Fou
Original Assignee
Knoll Gmbh
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22425740&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0009323(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Knoll Gmbh, Genetics Inst filed Critical Knoll Gmbh
Publication of BR0009323A publication Critical patent/BR0009323A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

"ANTICORPOS HUMANOS QUE LIGAM A IL-12 HUMANA E MéTODOS PARA A PRODUçãO". São divulgados anticorpos humanos, preferivelmente os anticorpos humanos recombinantes, que especificamente se ligam à interleucina-12 humana (hIL-12). Os anticorpos preferidos têm alta afinidade por hIL-12 e neutralizam a atividade da hIL-12 in vitro e in vivo. Um anticorpo da invenção pode ser um anticorpo de tamanho natural ou uma porção de ligação ao antígeno do mesmo. Os anticorpos, ou as porções de anticorpos, da invenção são úteis para detectar a hIL-12 e para inibir a atividade da hIL-12, p.ex., em um paciente humano sofrendo de um distúrbio no qual a atividade da hIL-12 seja prejudicial. Os ácidos nucléicos, os vetores e as células hospedeiras para expressar os anticorpos humanos recombinantes da invenção, e os métodos de sintetizar os anticorpos humanos recombinantes, são também incluídos pela invenção.
BR0009323-8A 1999-03-25 2000-03-24 Anticorpos humanos que ligam a il-12 humana e métodos para a produção BR0009323A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12660399P 1999-03-25 1999-03-25
PCT/US2000/007946 WO2000056772A1 (en) 1999-03-25 2000-03-24 Human antibodies that bind human il-12 and methods for producing

Publications (1)

Publication Number Publication Date
BR0009323A true BR0009323A (pt) 2002-01-08

Family

ID=22425740

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009323-8A BR0009323A (pt) 1999-03-25 2000-03-24 Anticorpos humanos que ligam a il-12 humana e métodos para a produção

Country Status (28)

Country Link
EP (4) EP2301970A1 (pt)
JP (3) JP4841038B2 (pt)
KR (6) KR20060127247A (pt)
CN (4) CN101921772B (pt)
AR (3) AR043274A1 (pt)
AU (1) AU3921600A (pt)
BG (2) BG66399B1 (pt)
BR (1) BR0009323A (pt)
CA (3) CA2796140A1 (pt)
CY (2) CY1113326T1 (pt)
CZ (1) CZ303725B6 (pt)
DK (1) DK2168984T3 (pt)
ES (1) ES2390849T3 (pt)
HU (1) HUP0200575A3 (pt)
IL (3) IL145134A0 (pt)
LU (1) LU92159I2 (pt)
MX (1) MXPA01009645A (pt)
MY (2) MY142984A (pt)
NO (3) NO334828B1 (pt)
NZ (5) NZ592550A (pt)
PL (2) PL409839A1 (pt)
PT (1) PT2168984E (pt)
SI (1) SI2168984T1 (pt)
SK (1) SK288082B6 (pt)
TR (5) TR200503572T2 (pt)
TW (5) TWI280980B (pt)
WO (1) WO2000056772A1 (pt)
ZA (1) ZA200107774B (pt)

Families Citing this family (167)

* Cited by examiner, † Cited by third party
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