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AR094125A2 - Anticuerpo aislado anti il-12 - Google Patents

Anticuerpo aislado anti il-12

Info

Publication number
AR094125A2
AR094125A2 ARP100102574A ARP100102574A AR094125A2 AR 094125 A2 AR094125 A2 AR 094125A2 AR P100102574 A ARP100102574 A AR P100102574A AR P100102574 A ARP100102574 A AR P100102574A AR 094125 A2 AR094125 A2 AR 094125A2
Authority
AR
Argentina
Prior art keywords
hil
antibodies
activity
human antibodies
recombinant human
Prior art date
Application number
ARP100102574A
Other languages
English (en)
Inventor
Roguska Michael
Kaymakcalan Zehra
Sakorafas Paul
W Warne Nicholas
Widom Angela
Gawain Elvin John
Robert Duncan Alexander
J Derbyshire Elaine
Carmen Sara
Smith Stephen
Las Holtet Thor
L Du Fou Sarah
Banerjee Subhashis
Edward Tracey Daniel
Venturini Amy
Labkovsky Boris
G Salfeld Jochen
White Michael
M Veldman Geertruida
Friedrich Stuart
Myles Angela
Paskind Michael
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22425740&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR094125(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of AR094125A2 publication Critical patent/AR094125A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Urology & Nephrology (AREA)
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  • Virology (AREA)

Abstract

Se describen los anticuerpos humanos, preferentemente anticuerpos humanos recombinante, que específicamente enlazan a interleuquina-12 (hIL-12). Los anticuerpos preferidos posee alta afinidad a hIL-12 y neutralizan la actividad de hIL-12 en in vitro y in vivo. Un anticuerpo de longitud completa o una parte que se enlaza a un antígeno del mismo. Los anticuerpos, o las partes de anticuerpo, son útiles para detectar hIL-12 y para inhibir la actividad hIL-12, por ejemplo, en un sujeto humano que sufre de un desorden en el cual la actividad de hIL-12 es perniciosa. Ácidos nucleicos, vectores y células anfitrionas para expresar los anticuerpos humanos recombinantes; y métodos para sintetizar los anticuerpos humanos recombinantes.
ARP100102574A 1999-03-25 2010-07-15 Anticuerpo aislado anti il-12 AR094125A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12660399P 1999-03-25 1999-03-25

Publications (1)

Publication Number Publication Date
AR094125A2 true AR094125A2 (es) 2015-07-15

Family

ID=22425740

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP000101321A AR043274A1 (es) 1999-03-25 2000-03-24 Anticuerpos humanos que enlazan a il-12 humana y metodos para producirlos
ARP070104977A AR063780A2 (es) 1999-03-25 2007-11-08 Un anticuerpo aislado composicion farmaceutica que lo comprende y metodo para inhibir la actividad de y detectar una interleuquina
ARP100102574A AR094125A2 (es) 1999-03-25 2010-07-15 Anticuerpo aislado anti il-12

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ARP000101321A AR043274A1 (es) 1999-03-25 2000-03-24 Anticuerpos humanos que enlazan a il-12 humana y metodos para producirlos
ARP070104977A AR063780A2 (es) 1999-03-25 2007-11-08 Un anticuerpo aislado composicion farmaceutica que lo comprende y metodo para inhibir la actividad de y detectar una interleuquina

Country Status (28)

Country Link
EP (4) EP2319870A3 (es)
JP (3) JP4841038B2 (es)
KR (6) KR20060127247A (es)
CN (4) CN101333256A (es)
AR (3) AR043274A1 (es)
AU (1) AU3921600A (es)
BG (2) BG66399B1 (es)
BR (1) BR0009323A (es)
CA (3) CA2796140A1 (es)
CY (2) CY1113326T1 (es)
CZ (1) CZ303725B6 (es)
DK (1) DK2168984T3 (es)
ES (1) ES2390849T3 (es)
HU (1) HUP0200575A3 (es)
IL (3) IL145134A0 (es)
LU (1) LU92159I2 (es)
MX (1) MXPA01009645A (es)
MY (2) MY142984A (es)
NO (3) NO334828B1 (es)
NZ (5) NZ529571A (es)
PL (2) PL218748B1 (es)
PT (1) PT2168984E (es)
SI (1) SI2168984T1 (es)
SK (1) SK288082B6 (es)
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