BG64819B1 - Комбиниране на тетрахидропиридини и средства, инхибиращи ацетилхолинестераза, за лечение на сенилнадеменция от алцхаймеров тип - Google Patents

Комбиниране на тетрахидропиридини и средства, инхибиращи ацетилхолинестераза, за лечение на сенилнадеменция от алцхаймеров тип Download PDF

Info

Publication number: BG64819B1
Authority: BG; Bulgaria
Prior art keywords: tetrahydropyridine; compound; pharmaceutically acceptable; composition according; trifluoromethylphenyl
Prior art date: 1997-11-14

Application number

BG104428A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG104428A (en

Inventor

Jean-Pierre Maffrand

Philippe Soubrie

Jean-Paul Terranova

Original Assignee

Sanofi-Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-14

Filing date

2000-05-11

Publication date

2006-05-31

1997-11-14 Priority claimed from FR9714324A external-priority patent/FR2771006B1/fr

1997-11-14 Priority claimed from FR9714322A external-priority patent/FR2771007B1/fr

2000-05-11 Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo

2001-08-31 Publication of BG104428A publication Critical patent/BG104428A/xx

2006-05-31 Publication of BG64819B1 publication Critical patent/BG64819B1/bg

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
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BG104428A 1997-11-14 2000-05-11 Комбиниране на тетрахидропиридини и средства, инхибиращи ацетилхолинестераза, за лечение на сенилнадеменция от алцхаймеров тип BG64819B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9714324A FR2771006B1 (fr)	1997-11-14	1997-11-14	Association de principes actifs pour le traitement de la demence senile du type alzheimer
FR9714322A FR2771007B1 (fr)	1997-11-14	1997-11-14	Association de principes actifs pour le traitement de la demence senile du type alzheimer

Publications (2)

Publication Number	Publication Date
BG104428A BG104428A (en)	2001-08-31
BG64819B1 true BG64819B1 (bg)	2006-05-31

Family

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Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG104428A BG64819B1 (bg)	1997-11-14	2000-05-11	Комбиниране на тетрахидропиридини и средства, инхибиращи ацетилхолинестераза, за лечение на сенилнадеменция от алцхаймеров тип

Country Status (27)

Country	Link
EP (1)	EP1030671A1 (et)
JP (1)	JP2001523642A (et)
KR (1)	KR100599350B1 (et)
CN (1)	CN1243540C (et)
AU (1)	AU743228B2 (et)
BG (1)	BG64819B1 (et)
BR (1)	BR9814035A (et)
CA (1)	CA2309966A1 (et)
CO (1)	CO4980891A1 (et)
DZ (1)	DZ2649A1 (et)
EA (1)	EA003255B1 (et)
EE (1)	EE04235B1 (et)
HU (1)	HUP0100098A3 (et)
ID (1)	ID24933A (et)
IL (2)	IL136122A0 (et)
IS (1)	IS5482A (et)
MY (1)	MY120461A (et)
NO (1)	NO20002450L (et)
NZ (1)	NZ504420A (et)
OA (1)	OA11464A (et)
PL (1)	PL194597B1 (et)
SA (1)	SA98190747B1 (et)
SK (1)	SK286040B6 (et)
TR (1)	TR200001262T2 (et)
TW (1)	TW585766B (et)
UY (1)	UY25247A1 (et)
WO (1)	WO1999025363A1 (et)

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JP4675103B2 (ja) *	2002-06-14	2011-04-20	富山化学工業株式会社	脳機能を改善する医薬組成物および脳機能を改善するための方法
CA2494585A1 (en) *	2002-08-07	2004-02-19	Novartis Ag	Methods for the treatment of dementia based on apo e genotype
CN1520818A (zh) *	2003-02-09	2004-08-18	山东绿叶天然药物研究开发有限公司	治疗老年性痴呆的胆碱酯酶抑制剂药物组合物
CA2592605C (en)	2004-12-27	2010-12-07	Eisai R&D Management Co., Ltd.	Method for stabilizing anti-dementia drug
CN106163516B (zh)	2014-01-31	2019-05-28	考格尼申治疗股份有限公司	异吲哚啉组合物和治疗神经变性疾病的方法
CN110869011B (zh)	2017-05-15	2024-01-05	考格尼申治疗股份有限公司	用于治疗神经退行性疾病的组合物
KR102224918B1 (ko)	2018-03-20	2021-03-09	(주)인벤티지랩	도네페질 및 메만틴을 포함하는 인지 장애 관련 질병의 예방 또는 치료용 약학적 복합 조성물 및 이의 제조 방법
WO2019182319A1 (ko) *	2018-03-20	2019-09-26	(주)인벤티지랩	인지 장애 관련 질병의 예방 또는 치료용 약학적 조성물의 제조 방법 및 이의 제조 방법으로 제조된 인지 장애 관련 질병의 예방 또는 치료용 약학적 조성물
CN109265391B (zh) *	2018-11-13	2021-11-19	枣庄学院	联苯多取代1,2,5,6-四氢吡啶化合物及其合成方法与应用

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EP0458696A2 (fr) *	1990-05-22	1991-11-27	Sanofi	Utilisation d'une 1-(2-naphtyléthyl)-4-(3-trifluorométhylphényl)-1,2,3,6-tétrahydropyridine pour la préparation de médicaments destinés au traitement de troubles cérébraux et neuronaux
WO1997001536A1 (fr) *	1995-06-28	1997-01-16	Sanofi	4-aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines ayant une activite neurotrophique et neuroprotectrice

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US5453428A (en) *	1991-02-14	1995-09-26	The Mount Sinai School Of Medicine Of The City Of New York	Method and composition for the treatment of apathy-amotivation syndrome
JPH11511732A (ja) *	1995-03-06	1999-10-12	インターニューロンファーマシューティカルズ，インコーポレーテッド	シチコリンを用いる梗塞容積の低減

1998
- 1998-10-26 CO CO98062479A patent/CO4980891A1/es unknown
- 1998-10-28 TW TW087117874A patent/TW585766B/zh not_active IP Right Cessation
- 1998-11-09 CA CA002309966A patent/CA2309966A1/en not_active Abandoned
- 1998-11-09 KR KR1020007005231A patent/KR100599350B1/ko not_active Expired - Fee Related
- 1998-11-09 PL PL98340500A patent/PL194597B1/pl not_active IP Right Cessation
- 1998-11-09 TR TR2000/01262T patent/TR200001262T2/xx unknown
- 1998-11-09 IL IL13612298A patent/IL136122A0/xx not_active IP Right Cessation
- 1998-11-09 HU HU0100098A patent/HUP0100098A3/hu unknown
- 1998-11-09 WO PCT/FR1998/002384 patent/WO1999025363A1/fr not_active Ceased
- 1998-11-09 EP EP98954538A patent/EP1030671A1/fr not_active Withdrawn
- 1998-11-09 SK SK711-2000A patent/SK286040B6/sk unknown
- 1998-11-09 CN CNB988130947A patent/CN1243540C/zh not_active Expired - Fee Related
- 1998-11-09 AU AU11609/99A patent/AU743228B2/en not_active Ceased
- 1998-11-09 JP JP2000520796A patent/JP2001523642A/ja not_active Withdrawn
- 1998-11-09 BR BR9814035-3A patent/BR9814035A/pt not_active Application Discontinuation
- 1998-11-09 EE EEP200000290A patent/EE04235B1/et not_active IP Right Cessation
- 1998-11-09 ID IDW20000860A patent/ID24933A/id unknown
- 1998-11-09 EA EA200000412A patent/EA003255B1/ru not_active IP Right Cessation
- 1998-11-09 NZ NZ504420A patent/NZ504420A/en unknown
- 1998-11-11 DZ DZ980259A patent/DZ2649A1/xx active
- 1998-11-12 UY UY25247A patent/UY25247A1/es not_active IP Right Cessation
- 1998-11-14 SA SA98190747A patent/SA98190747B1/ar unknown
- 1998-11-14 MY MYPI98005180A patent/MY120461A/en unknown
2000
- 2000-05-09 IS IS5482A patent/IS5482A/is unknown
- 2000-05-11 BG BG104428A patent/BG64819B1/bg unknown
- 2000-05-11 NO NO20002450A patent/NO20002450L/no unknown
- 2000-05-12 OA OA1200000141A patent/OA11464A/en unknown
- 2000-05-14 IL IL136122A patent/IL136122A/en unknown

Patent Citations (2)

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Publication number	Priority date	Publication date	Assignee	Title
EP0458696A2 (fr) *	1990-05-22	1991-11-27	Sanofi	Utilisation d'une 1-(2-naphtyléthyl)-4-(3-trifluorométhylphényl)-1,2,3,6-tétrahydropyridine pour la préparation de médicaments destinés au traitement de troubles cérébraux et neuronaux
WO1997001536A1 (fr) *	1995-06-28	1997-01-16	Sanofi	4-aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines ayant une activite neurotrophique et neuroprotectrice

Also Published As

Publication number	Publication date
DZ2649A1 (fr)	2004-12-28
KR20010032099A (ko)	2001-04-16
AU743228B2 (en)	2002-01-24
SA98190747B1 (ar)	2006-11-04
IS5482A (is)	2000-05-09
CA2309966A1 (en)	1999-05-27
TW585766B (en)	2004-05-01
ID24933A (id)	2000-08-31
IL136122A (en)	2006-07-05
SK286040B6 (sk)	2008-01-07
HUP0100098A2 (hu)	2001-07-30
EA200000412A1 (ru)	2000-12-25
TR200001262T2 (tr)	2001-01-22
BG104428A (en)	2001-08-31
SK7112000A3 (en)	2000-10-09
HUP0100098A3 (en)	2001-12-28
EA003255B1 (ru)	2003-02-27
KR100599350B1 (ko)	2006-07-12
PL340500A1 (en)	2001-02-12
NO20002450L (no)	2000-07-14
AU1160999A (en)	1999-06-07
CN1285742A (zh)	2001-02-28
OA11464A (en)	2003-11-18
IL136122A0 (en)	2001-05-20
EP1030671A1 (fr)	2000-08-30
NZ504420A (en)	2003-08-29
PL194597B1 (pl)	2007-06-29
MY120461A (en)	2005-10-31
NO20002450D0 (no)	2000-05-11
EE04235B1 (et)	2004-02-16
EE200000290A (et)	2001-06-15
WO1999025363A1 (fr)	1999-05-27
CO4980891A1 (es)	2000-11-27
JP2001523642A (ja)	2001-11-27
CN1243540C (zh)	2006-03-01
UY25247A1 (es)	2001-05-31
BR9814035A (pt)	2000-09-26

Publication	Publication Date	Title
DE60122928T2 (de)	2007-09-06	Therapeutische zusammensetzung von amlodipin und benazepril / benazeprilat
AU743609B2 (en)	2002-01-31	Use of cholinesterase inhibitors to treat disorders of attention
US20030144255A1 (en)	2003-07-31	Compositions for prevention and treatment of dementia
CA2690110A1 (en)	2009-01-22	Ampa receptor antagonists for neuropathic pain
MXPA02011610A (es)	2003-05-14	Combinacion de sustancia activa que contiene un opioide que tiene una estructura tipo fentanilo y cetamina.
AU2004283425A1 (en)	2005-05-06	Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor
BG64819B1 (bg)	2006-05-31	Комбиниране на тетрахидропиридини и средства, инхибиращи ацетилхолинестераза, за лечение на сенилнадеменция от алцхаймеров тип
AU2006321907A1 (en)	2007-06-14	Use of a CB1 antagonist for treating negative symptoms of schizophrenia
US20050148614A1 (en)	2005-07-07	Combination of active ingredients for the treatment of senile dementia of the Alzheimer type
US20060287325A1 (en)	2006-12-21	Combinations of paroxetine and 2-(r)-(4-fluoro-2-methyl-phenyl)-4-(s)-((8as)-6-oxo-hexahydro-pyrrolo'1,2-a!-pyrazin-2-yl)-piperidine-1-carboxylicacid'1-(r)-(3,5-bis-trifluoromethyl-phenyl)-
US4797404A (en)	1989-01-10	Pharmaceutical preparation comprising co-dergocrine and a calcium antagonist
JP2002504134A (ja)	2002-02-05	疼痛を治療するためのドラフラジン類似体の使用
MXPA00004600A (en)	2001-05-07	Combination of active principles, in particular of tetrahydropyridins and acetylcholinesterase inhibiting agents, for treating senile dementia such as alzheimer dementia
CZ20001734A3 (cs)	2000-08-16	Farmaceutická kompozice a její použití
RS20060505A (sr)	2008-09-29	Kombinovani farmaceutski preparat za inhibiciju opadanja kognitivnih funkcija
US4363809A (en)	1982-12-14	Organic compounds
JPS6144816A (ja)	1986-03-04	組み合わせ生成物およびその調製方法
JP2003226642A (ja)	2003-08-12	眼疾患予防及び／又は治療薬
FR2771007A1 (fr)	1999-05-21	Association de principes actifs pour le traitement de la demence senile du type alzheimer