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TR200001262T2 - Alzheimer tipi yaşlılık demansının tedavisi için aktif muhteviyatların kombinasyonu - Google Patents

Alzheimer tipi yaşlılık demansının tedavisi için aktif muhteviyatların kombinasyonu

Info

Publication number
TR200001262T2
TR200001262T2 TR2000/01262T TR200001262T TR200001262T2 TR 200001262 T2 TR200001262 T2 TR 200001262T2 TR 2000/01262 T TR2000/01262 T TR 2000/01262T TR 200001262 T TR200001262 T TR 200001262T TR 200001262 T2 TR200001262 T2 TR 200001262T2
Authority
TR
Turkey
Prior art keywords
alkyl
active ingredients
alkoxy
alzheimer
treatment
Prior art date
Application number
TR2000/01262T
Other languages
English (en)
Inventor
Maffrand Jean-Pierre
Soubrie Philippe
Terranova Jean-Paul
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9714322A external-priority patent/FR2771007B1/fr
Priority claimed from FR9714324A external-priority patent/FR2771006B1/fr
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of TR200001262T2 publication Critical patent/TR200001262T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Mevcut bulus; aktif muhteviyatlar olarak, asagidakilerden olusan farmasötik bir kompozisyon ile ilgildir; 1-(2-naft-2-iletil)-4-(3-triflorometilfenil)-1, 2, 3, 6-tetrahidro-piridinden seçilen bir bilesik (a) ve formül (I)'deki bir bilesik, istege bagli olarak da bunun farmasötik olarak kabul edilebilen tuzlarindan biri formunda olani olup, söz konusu formüldeki, Y;-CH- veya-N-'dir; R1; halojen, bir CF3, (C3-C4) alkil veya (C1-C4) alkoksi grubudur, R2; hidrojen, halojen, hidroksil, CF3, (C3-C4) alkil veya (C1-C4 ) alkoksi grubudur, R3 ve R4'ünher biri; hidrojen veya (C1-C3) alkildir; X; (a) (C3-C6) alkil; (C3-C6) alkoksi; (C3-C7) karboksialkil; (C1-C4) alkoksikarbonil (C3-C6) alkil; (C3-C7) karboksilalkoksi veya (C1-C4) alkoksikarbonil (C3-C6) alkoksi'dir; (b) (C3-C7) sikloalkil, (C3-C7) sikloalkiloksi, (C3-C7) sikloalkilmetil, (C3-C7) sikloalkilamino ve siklohekzenil'den seçilen bir radikal olup, bahsedilen radikal; halojen, hidroksi, (C1-C4) alkoksi, karboksi, (C1-C4)(DEVAMI VAR..)
TR2000/01262T 1997-11-14 1998-11-09 Alzheimer tipi yaşlılık demansının tedavisi için aktif muhteviyatların kombinasyonu TR200001262T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9714322A FR2771007B1 (fr) 1997-11-14 1997-11-14 Association de principes actifs pour le traitement de la demence senile du type alzheimer
FR9714324A FR2771006B1 (fr) 1997-11-14 1997-11-14 Association de principes actifs pour le traitement de la demence senile du type alzheimer

Publications (1)

Publication Number Publication Date
TR200001262T2 true TR200001262T2 (tr) 2001-01-22

Family

ID=26233932

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01262T TR200001262T2 (tr) 1997-11-14 1998-11-09 Alzheimer tipi yaşlılık demansının tedavisi için aktif muhteviyatların kombinasyonu

Country Status (27)

Country Link
EP (1) EP1030671A1 (tr)
JP (1) JP2001523642A (tr)
KR (1) KR100599350B1 (tr)
CN (1) CN1243540C (tr)
AU (1) AU743228B2 (tr)
BG (1) BG64819B1 (tr)
BR (1) BR9814035A (tr)
CA (1) CA2309966A1 (tr)
CO (1) CO4980891A1 (tr)
DZ (1) DZ2649A1 (tr)
EA (1) EA003255B1 (tr)
EE (1) EE04235B1 (tr)
HU (1) HUP0100098A3 (tr)
ID (1) ID24933A (tr)
IL (2) IL136122A0 (tr)
IS (1) IS5482A (tr)
MY (1) MY120461A (tr)
NO (1) NO20002450L (tr)
NZ (1) NZ504420A (tr)
OA (1) OA11464A (tr)
PL (1) PL194597B1 (tr)
SA (1) SA98190747B1 (tr)
SK (1) SK286040B6 (tr)
TR (1) TR200001262T2 (tr)
TW (1) TW585766B (tr)
UY (1) UY25247A1 (tr)
WO (1) WO1999025363A1 (tr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2389937B1 (en) * 2002-06-14 2018-08-15 Toyama Chemical Co., Ltd. Medicinal composition for improving brain function
ES2327914T3 (es) * 2002-08-07 2009-11-05 Novartis Ag Metodo para pronosticar la sensibilidad al tratamiento con ravastigmina basado en el genotipo apoe de pacintes con demencia.
CN1520818A (zh) * 2003-02-09 2004-08-18 山东绿叶天然药物研究开发有限公司 治疗老年性痴呆的胆碱酯酶抑制剂药物组合物
EP1830886B1 (en) 2004-12-27 2016-04-13 Eisai R&D Management Co., Ltd. Method for stabilizing anti-dementia drug
CA2938212C (en) 2014-01-31 2023-03-14 Cognition Therapeutics, Inc. Isoindoline compositions and methods for treating neurodegenerative disease
CA3061787A1 (en) * 2017-05-15 2018-11-22 Cognition Therapeutics, Inc. Compositions for treating neurodegenerative diseases
WO2019182319A1 (ko) * 2018-03-20 2019-09-26 (주)인벤티지랩 인지 장애 관련 질병의 예방 또는 치료용 약학적 조성물의 제조 방법 및 이의 제조 방법으로 제조된 인지 장애 관련 질병의 예방 또는 치료용 약학적 조성물
KR102224918B1 (ko) 2018-03-20 2021-03-09 (주)인벤티지랩 도네페질 및 메만틴을 포함하는 인지 장애 관련 질병의 예방 또는 치료용 약학적 복합 조성물 및 이의 제조 방법
CN109265391B (zh) * 2018-11-13 2021-11-19 枣庄学院 联苯多取代1,2,5,6-四氢吡啶化合物及其合成方法与应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
US5453428A (en) * 1991-02-14 1995-09-26 The Mount Sinai School Of Medicine Of The City Of New York Method and composition for the treatment of apathy-amotivation syndrome
ES2244968T3 (es) * 1995-03-06 2005-12-16 Interneuron Pharmaceuticals Incorporated Reduccion del volumen de infarto usando citocolina.
FR2736053B1 (fr) * 1995-06-28 1997-09-19 Sanofi Sa Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines

Also Published As

Publication number Publication date
DZ2649A1 (fr) 2004-12-28
KR20010032099A (ko) 2001-04-16
CN1243540C (zh) 2006-03-01
NZ504420A (en) 2003-08-29
SK286040B6 (sk) 2008-01-07
KR100599350B1 (ko) 2006-07-12
IL136122A0 (en) 2001-05-20
IL136122A (en) 2006-07-05
JP2001523642A (ja) 2001-11-27
PL340500A1 (en) 2001-02-12
UY25247A1 (es) 2001-05-31
NO20002450D0 (no) 2000-05-11
PL194597B1 (pl) 2007-06-29
OA11464A (en) 2003-11-18
AU743228B2 (en) 2002-01-24
AU1160999A (en) 1999-06-07
EE04235B1 (et) 2004-02-16
EP1030671A1 (fr) 2000-08-30
EA200000412A1 (ru) 2000-12-25
BR9814035A (pt) 2000-09-26
CO4980891A1 (es) 2000-11-27
SK7112000A3 (en) 2000-10-09
HUP0100098A2 (hu) 2001-07-30
MY120461A (en) 2005-10-31
WO1999025363A1 (fr) 1999-05-27
HUP0100098A3 (en) 2001-12-28
EE200000290A (et) 2001-06-15
NO20002450L (no) 2000-07-14
CN1285742A (zh) 2001-02-28
CA2309966A1 (en) 1999-05-27
BG64819B1 (bg) 2006-05-31
SA98190747B1 (ar) 2006-11-04
IS5482A (is) 2000-05-09
ID24933A (id) 2000-08-31
BG104428A (en) 2001-08-31
EA003255B1 (ru) 2003-02-27
TW585766B (en) 2004-05-01

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