BG60912B1 - Заместени 4-фенил-4-пиперидинкарбоксамиди с локален обезболя- ващ и болкоуспокояващ ефект и метод за получаването им - Google Patents

Заместени 4-фенил-4-пиперидинкарбоксамиди с локален обезболя- ващ и болкоуспокояващ ефект и метод за получаването им Download PDF

Info

Publication number: BG60912B1
Authority: BG; Bulgaria
Prior art keywords: formula; compound; compound according; compounds; phenyl
Prior art date: 1989-12-21

Application number

BG96513A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG96513A (bg

Inventor

Anna-Lena Ask

Rune Sandberg

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-21

Filing date

1992-06-19

Publication date

1996-06-28

1992-06-19 Application filed by Astra Ab filed Critical Astra Ab

1993-12-24 Publication of BG96513A publication Critical patent/BG96513A/bg

1996-06-28 Publication of BG60912B1 publication Critical patent/BG60912B1/bg

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cosmetics (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

BG96513A 1989-12-21 1992-06-19 Заместени 4-фенил-4-пиперидинкарбоксамиди с локален обезболя- ващ и болкоуспокояващ ефект и метод за получаването им BG60912B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE8904298A SE8904298D0 (sv)	1989-12-21	1989-12-21	New compounds
PCT/SE1990/000818 WO1991009845A1 (en)	1989-12-21	1990-12-17	Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation

Publications (2)

Publication Number	Publication Date
BG96513A BG96513A (bg)	1993-12-24
BG60912B1 true BG60912B1 (bg)	1996-06-28

Family

ID=20377821

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG96513A BG60912B1 (bg)	1989-12-21	1992-06-19	Заместени 4-фенил-4-пиперидинкарбоксамиди с локален обезболя- ващ и болкоуспокояващ ефект и метод за получаването им

Country Status (40)

Country	Link
US (2)	US5227389A (xx)
EP (1)	EP0506778B1 (xx)
JP (1)	JP2656152B2 (xx)
KR (1)	KR0179382B1 (xx)
CN (1)	CN1037841C (xx)
AT (1)	ATE138650T1 (xx)
AU (1)	AU647068B2 (xx)
BG (1)	BG60912B1 (xx)
BR (1)	BR1100379A (xx)
CA (1)	CA2069608C (xx)
CZ (1)	CZ278035B6 (xx)
DE (1)	DE69027221T2 (xx)
DK (1)	DK0506778T3 (xx)
DZ (1)	DZ1468A1 (xx)
EG (1)	EG19361A (xx)
ES (1)	ES2087280T3 (xx)
FI (1)	FI100881B (xx)
HK (1)	HK22997A (xx)
HR (1)	HRP920591B1 (xx)
HU (1)	HU213110B (xx)
IE (1)	IE74855B1 (xx)
IL (1)	IL96636A (xx)
IS (1)	IS1664B (xx)
LT (1)	LT4005B (xx)
LV (2)	LV10949B (xx)
NO (1)	NO178858C (xx)
NZ (1)	NZ236293A (xx)
PL (1)	PL163591B1 (xx)
PT (1)	PT96303B (xx)
RO (1)	RO112864B1 (xx)
RU (1)	RU2039043C1 (xx)
SA (1)	SA91110209B1 (xx)
SE (1)	SE8904298D0 (xx)
SG (1)	SG46413A1 (xx)
SI (1)	SI9012346B (xx)
SK (1)	SK658190A3 (xx)
UA (1)	UA26403A (xx)
WO (1)	WO1991009845A1 (xx)
YU (1)	YU48086B (xx)
ZA (1)	ZA909903B (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3916092B2 (ja) *	1993-09-17	2007-05-16	杏林製薬株式会社	イミダゾリジノン誘導体とその酸付加塩及び老年性痴呆症の治療薬
SE9400447D0 (sv) *	1994-02-11	1994-02-11	Astra Ab	New compounds
SE9404438D0 (sv) *	1994-12-21	1994-12-21	Astra Ab	New process
US5931809A (en) *	1995-07-14	1999-08-03	Depotech Corporation	Epidural administration of therapeutic compounds with sustained rate of release
GB9600235D0 (en) *	1996-01-05	1996-03-06	Pfizer Ltd	Therapeutic agents
DE19642591A1 (de) *	1996-10-15	1998-04-16	Basf Ag	Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung
SE9604786D0 (sv) *	1996-12-20	1996-12-20	Astra Pharma Inc	New compounds
TW548271B (en) *	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
RU2125878C1 (ru) *	1996-12-26	1999-02-10	Новокузнецкий научно-исследовательский химико-фармацевтический институт	Анальгетическое средство
RU2117481C1 (ru) *	1997-07-15	1998-08-20	Государственный научно-исследовательский институт органической химии и технологии	Анальгетическое средство и способ его приготовления
US7799337B2 (en)	1997-07-21	2010-09-21	Levin Bruce H	Method for directed intranasal administration of a composition
US20020102291A1 (en) *	1997-12-15	2002-08-01	Noven Pharmaceuticals, Inc.	Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate
SE9803239D0 (sv) *	1998-09-24	1998-09-24	Diabact Ab	Composition for the treatment of acute pain
SE9803240D0 (sv) *	1998-09-24	1998-09-24	Diabact Ab	A pharmaceutical composition having a rapid action
PE20021081A1 (es) *	2001-04-12	2002-12-18	Pharmacopeia Drug Discovery	Aril y biaril piperidinas con actividad moduladora mch
RU2203041C1 (ru) *	2001-12-27	2003-04-27	Закрытое акционерное общество "Брынцалов-А"	Спазмолитические таблетки бралангин
PL215006B1 (pl) *	2002-02-08	2013-10-31	Ono Pharmaceutical Co	Krystaliczna postac pochodnej piperydyny oraz jej zastosowanie
CN1744899A (zh) *	2002-12-13	2006-03-08	史密丝克莱恩比彻姆公司	作为ccr5拮抗剂的哌啶衍生物
US20100210633A1 (en) *	2006-10-12	2010-08-19	Epix Delaware, Inc.	Carboxamide compounds and their use
EP2280766A1 (en)	2007-12-11	2011-02-09	CytoPathfinder, Inc.	Carboxamide compounds and their use as chemokine receptor agonists
US8473062B2 (en)	2008-05-01	2013-06-25	Autonomic Technologies, Inc.	Method and device for the treatment of headache
US8412336B2 (en)	2008-12-29	2013-04-02	Autonomic Technologies, Inc.	Integrated delivery and visualization tool for a neuromodulation system
US9320908B2 (en)	2009-01-15	2016-04-26	Autonomic Technologies, Inc.	Approval per use implanted neurostimulator
US8494641B2 (en)	2009-04-22	2013-07-23	Autonomic Technologies, Inc.	Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
WO2020152212A1 (en)	2019-01-22	2020-07-30	Icm (Institut Du Cerveau Et De La Moelle Épinière)	Local anesthetic for the treatment of neurological symptoms resulting from brain dysfunctions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE96980C1 (xx)
US2486796A (en) *	1943-06-25	1949-11-01	Ciba Pharm Prod Inc	Esters of 1-alkyl-4-hydroxyphenylpiperidyl-4-ketones
US3334106A (en) *	1964-10-20	1967-08-01	Aldrich Chem Co Inc	N(aryl)n(hydrocarbyl)-omega-(4-phenyl-4-piperidinocarbonylheteroamine) alkanoamide
US3539580A (en) *	1967-06-26	1970-11-10	Janssen Pharm	4-aryl-4-aminoalkoxy-piperidines
CH502338A (de) *	1968-12-20	1971-01-31	Ciba Geigy Ag	Verfahren zur Herstellung von neuen Piperidinderivaten
US3737538A (en) *	1968-12-30	1973-06-05	Ciba Geigy Corp	Antitussive compositions and method with isonipecotic acid derivatives
FR2156470A2 (en) *	1971-10-21	1973-06-01	Synthelabo	1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
ZA899436B (en) *	1988-12-12	1990-08-29	Ciba Geigy	Piperidine derivatives
US5100903A (en) *	1989-05-12	1992-03-31	Anaquest, Inc.	N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds

1989
- 1989-12-21 SE SE8904298A patent/SE8904298D0/xx unknown
1990
- 1990-11-30 NZ NZ236293A patent/NZ236293A/xx unknown
- 1990-12-10 ZA ZA909903A patent/ZA909903B/xx unknown
- 1990-12-11 IL IL9663690A patent/IL96636A/en not_active IP Right Cessation
- 1990-12-12 SI SI9012346A patent/SI9012346B/sl not_active IP Right Cessation
- 1990-12-12 YU YU234690A patent/YU48086B/sh unknown
- 1990-12-12 DZ DZ900223A patent/DZ1468A1/xx active
- 1990-12-17 CA CA002069608A patent/CA2069608C/en not_active Expired - Fee Related
- 1990-12-17 JP JP3501896A patent/JP2656152B2/ja not_active Expired - Fee Related
- 1990-12-17 DE DE69027221T patent/DE69027221T2/de not_active Expired - Fee Related
- 1990-12-17 AU AU69783/91A patent/AU647068B2/en not_active Ceased
- 1990-12-17 HU HU9202044A patent/HU213110B/hu unknown
- 1990-12-17 WO PCT/SE1990/000818 patent/WO1991009845A1/en not_active Ceased
- 1990-12-17 UA UA5052485A patent/UA26403A/uk unknown
- 1990-12-17 IE IE453490A patent/IE74855B1/en not_active IP Right Cessation
- 1990-12-17 ES ES91901571T patent/ES2087280T3/es not_active Expired - Lifetime
- 1990-12-17 SG SG1996004491A patent/SG46413A1/en unknown
- 1990-12-17 IS IS3659A patent/IS1664B/is unknown
- 1990-12-17 EP EP91901571A patent/EP0506778B1/en not_active Expired - Lifetime
- 1990-12-17 DK DK91901571.9T patent/DK0506778T3/da active
- 1990-12-17 AT AT91901571T patent/ATE138650T1/de not_active IP Right Cessation
- 1990-12-17 KR KR1019920701484A patent/KR0179382B1/ko not_active Expired - Fee Related
- 1990-12-17 RO RO92-0832A patent/RO112864B1/ro unknown
- 1990-12-20 EG EG74690A patent/EG19361A/xx active
- 1990-12-20 PT PT96303A patent/PT96303B/pt active IP Right Grant
- 1990-12-21 SK SK6581-90A patent/SK658190A3/sk unknown
- 1990-12-21 US US07/633,246 patent/US5227389A/en not_active Expired - Lifetime
- 1990-12-21 CZ CS906581A patent/CZ278035B6/cs not_active IP Right Cessation
- 1990-12-21 CN CN90106009A patent/CN1037841C/zh not_active Expired - Fee Related
- 1990-12-21 PL PL90288409A patent/PL163591B1/pl not_active IP Right Cessation
1991
- 1991-01-09 SA SA91110209A patent/SA91110209B1/ar unknown
1992
- 1992-06-17 FI FI922806A patent/FI100881B/fi not_active IP Right Cessation
- 1992-06-17 NO NO922380A patent/NO178858C/no unknown
- 1992-06-19 RU SU925052485A patent/RU2039043C1/ru not_active IP Right Cessation
- 1992-06-19 BG BG96513A patent/BG60912B1/bg unknown
- 1992-09-29 HR HRP-2346/90A patent/HRP920591B1/xx not_active IP Right Cessation
1993
- 1993-07-12 US US08/090,416 patent/US5360805A/en not_active Expired - Lifetime
- 1993-08-27 LV LVP-93-1042A patent/LV10949B/lv unknown
- 1993-12-30 LT LTIP1731A patent/LT4005B/lt not_active IP Right Cessation
1996
- 1996-07-17 LV LV960262A patent/LV5766B4/xx unknown
1997
- 1997-02-27 HK HK22997A patent/HK22997A/en not_active IP Right Cessation
- 1997-04-30 BR BR1100379-0A patent/BR1100379A/pt active IP Right Grant

Also Published As

Publication number	Publication date
NZ236293A (en)	1992-10-28
SK278283B6 (en)	1996-08-07
UA26403A (uk)	1999-08-30
BR1100379A (pt)	1999-12-07
CN1037841C (zh)	1998-03-25
CN1053605A (zh)	1991-08-07
SI9012346A (sl)	1998-08-31
NO922380D0 (no)	1992-06-17
FI100881B (fi)	1998-03-13
LV10949B (en)	1996-06-20
PL163591B1 (pl)	1994-04-29
KR0179382B1 (ko)	1999-03-20
US5227389A (en)	1993-07-13
HRP920591A2 (en)	1997-08-31
FI922806L (fi)	1992-06-17
IS3659A7 (is)	1991-06-22
CZ278035B6 (en)	1993-07-14
SA91110209B1 (ar)	2004-05-08
AU647068B2 (en)	1994-03-17
PT96303B (pt)	1998-07-31
RU2039043C1 (ru)	1995-07-09
HUT64518A (en)	1994-01-28
SK658190A3 (en)	1996-08-07
YU234690A (sh)	1993-10-20
LTIP1731A (en)	1995-07-25
DK0506778T3 (da)	1996-10-07
SE8904298D0 (sv)	1989-12-21
HRP920591B1 (en)	1998-12-31
ZA909903B (en)	1991-08-28
PT96303A (pt)	1991-09-30
ATE138650T1 (de)	1996-06-15
WO1991009845A1 (en)	1991-07-11
LT4005B (en)	1996-07-25
PL288409A1 (en)	1991-12-02
BG96513A (bg)	1993-12-24
DZ1468A1 (fr)	2004-09-13
EP0506778A1 (en)	1992-10-07
JP2656152B2 (ja)	1997-09-24
SG46413A1 (en)	1998-02-20
EG19361A (en)	1994-12-30
IS1664B (is)	1997-07-04
CA2069608C (en)	2001-07-10
NO178858B (no)	1996-03-11
NO922380L (no)	1992-06-17
KR927003531A (ko)	1992-12-18
IL96636A (en)	1994-11-28
SI9012346B (sl)	1999-08-31
CA2069608A1 (en)	1991-06-22
ES2087280T3 (es)	1996-07-16
EP0506778B1 (en)	1996-05-29
CZ658190A3 (en)	1993-01-13
NO178858C (no)	1996-06-19
RO112864B1 (ro)	1998-01-30
HK22997A (en)	1997-02-27
YU48086B (sh)	1997-01-08
DE69027221T2 (de)	1996-10-10
HU213110B (en)	1997-02-28
LV5766A4 (lv)	1996-12-20
IE74855B1 (en)	1997-08-13
JPH05502869A (ja)	1993-05-20
US5360805A (en)	1994-11-01
AU6978391A (en)	1991-07-24
FI922806A0 (fi)	1992-06-17
IL96636A0 (en)	1991-09-16
LV10949A (lv)	1995-12-20
IE904534A1 (en)	1991-07-03
DE69027221D1 (de)	1996-07-04
LV5766B4 (lv)	1997-06-20
HU9202044D0 (en)	1992-09-28

Publication	Publication Date	Title
BG60912B1 (bg)	1996-06-28	Заместени 4-фенил-4-пиперидинкарбоксамиди с локален обезболя- ващ и болкоуспокояващ ефект и метод за получаването им
US6303601B2 (en)	2001-10-16	Arylgycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds
KR100459746B1 (ko)	2005-05-31	아릴글리신아미드유도체및이의제조방법
EP1858867B1 (en)	2009-01-07	Trifluoromethylbenzamide derivatives and therapeutic uses thereof
US5965734A (en)	1999-10-12	Processes and intermediates for preparing 2-substituted piperidine stereoisomers
KR20050101541A (ko)	2005-10-24	진통 작용을 가진 인다졸아마이드
IL45995A (en)	1977-06-30	4-pyridylthiazole-2-carboxamides and acetamides their preparation and pharmaceutical compositions containing them
ES2858404T3 (es)	2021-09-30	Nuevos intermedios para la preparación de clorhidrato de remifentanilo
US3058986A (en)	1962-10-16	N-ammoalkyl-x-phenyl-x-lower alkyl-z-
JP2720167B2 (ja)	1998-02-25	アルキレンジアミン誘導体
JPH0160026B2 (xx)	1989-12-20
KR100245980B1 (ko)	2000-04-01	호모바닐릭아미드 유도체 및 이의 제조방법
JPS637179B2 (xx)	1988-02-15