BG104938A - Заместени индолинони, тяхното получаване и тяхното приложение като лекарствени средства - Google Patents
Заместени индолинони, тяхното получаване и тяхното приложение като лекарствени средстваInfo
- Publication number
- BG104938A BG104938A BG104938A BG10493800A BG104938A BG 104938 A BG104938 A BG 104938A BG 104938 A BG104938 A BG 104938A BG 10493800 A BG10493800 A BG 10493800A BG 104938 A BG104938 A BG 104938A
- Authority
- BG
- Bulgaria
- Prior art keywords
- substituted
- indonalines
- receiving
- medicinal products
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19824922A DE19824922A1 (de) | 1998-06-04 | 1998-06-04 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP1999/003692 WO1999062882A1 (fr) | 1998-06-04 | 1999-05-28 | Indolinones substituees, leur production et leur utilisation comme medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG104938A true BG104938A (bg) | 2001-06-29 |
Family
ID=7869856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG104938A BG104938A (bg) | 1998-06-04 | 2000-11-13 | Заместени индолинони, тяхното получаване и тяхното приложение като лекарствени средства |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1100779A1 (fr) |
| JP (1) | JP2002516906A (fr) |
| KR (1) | KR20010043973A (fr) |
| CN (1) | CN1303374A (fr) |
| AU (1) | AU764782B2 (fr) |
| BG (1) | BG104938A (fr) |
| BR (1) | BR9910898A (fr) |
| CA (1) | CA2328291A1 (fr) |
| CO (1) | CO5050294A1 (fr) |
| DE (1) | DE19824922A1 (fr) |
| EA (1) | EA003514B1 (fr) |
| EE (1) | EE200000723A (fr) |
| HR (1) | HRP20000831A2 (fr) |
| HU (1) | HUP0102210A3 (fr) |
| ID (1) | ID27035A (fr) |
| IL (1) | IL138702A0 (fr) |
| NO (1) | NO20006138L (fr) |
| PL (1) | PL344467A1 (fr) |
| SK (1) | SK18222000A3 (fr) |
| TR (1) | TR200003515T2 (fr) |
| WO (1) | WO1999062882A1 (fr) |
| YU (1) | YU73900A (fr) |
| ZA (1) | ZA200005435B (fr) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19816624A1 (de) * | 1998-04-15 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| UA75054C2 (uk) * | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
| US6762180B1 (en) | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
| JP2004508366A (ja) * | 2000-09-01 | 2004-03-18 | グラクソ グループ リミテッド | オキシインドール誘導体 |
| EP1339680A1 (fr) | 2000-09-01 | 2003-09-03 | Glaxo Group Limited | Derives d'oxindole substitues utilises comme inhibiteurs de la tyrosine kinase |
| DE10117204A1 (de) | 2001-04-06 | 2002-10-10 | Boehringer Ingelheim Pharma | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DK1401415T3 (da) | 2001-06-29 | 2006-10-16 | Ab Science | Anvendelse af N-phenyl-2-pyrimidinamin-derivater til behandling af inflammatoriske sygdomme |
| US7727731B2 (en) | 2001-06-29 | 2010-06-01 | Ab Science | Potent, selective and non toxic c-kit inhibitors |
| US20050176687A1 (en) * | 2001-06-29 | 2005-08-11 | Alain Moussy | Use of tyrosine kinase inhibitors for treating autoimmune diseases |
| ATE343415T1 (de) * | 2001-06-29 | 2006-11-15 | Ab Science | Die verwendung von c-kit hemmer zur behandlung von entzündlichen darmerkrankungen |
| JP2004537536A (ja) | 2001-06-29 | 2004-12-16 | アブ サイエンス | アレルギー疾患を治療するためのチロシンキナーゼ阻害剤の使用方法 |
| US20030225152A1 (en) | 2001-09-27 | 2003-12-04 | Andrews Steven W. | 3-(Arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors |
| US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
| JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
| DE102004012070A1 (de) * | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
| PE20060777A1 (es) * | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| JP5404414B2 (ja) * | 2006-12-05 | 2014-01-29 | アリーナ ファーマシューティカルズ， インコーポレイテッド | （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンおよびその中間体を調製するための方法 |
| GB0706072D0 (en) * | 2007-03-28 | 2007-05-09 | Sterix Ltd | Compound |
| US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
| CN101735071A (zh) * | 2009-12-04 | 2010-06-16 | 大连凯飞精细化工有限公司 | 一种生产4-n,n-二甲胺基甲基苯胺的方法 |
| CN103102352B (zh) * | 2011-11-15 | 2015-08-12 | 山东亨利医药科技有限责任公司 | 酪氨酸激酶抑制剂吲哚满酮衍生物 |
| CN103130775B (zh) * | 2011-11-22 | 2015-09-30 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的吲哚满酮衍生物 |
| GB201208775D0 (en) | 2012-05-18 | 2012-07-04 | Uni I Oslo | Chemical compounds |
| CN103848814B (zh) * | 2012-12-06 | 2016-08-17 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的取代吲哚满酮衍生物 |
| CN114127057B (zh) | 2019-05-10 | 2024-07-12 | 德西费拉制药有限责任公司 | 苯基氨基嘧啶酰胺自噬抑制剂及其使用方法 |
| EP4295846A3 (fr) | 2019-05-10 | 2024-02-28 | Deciphera Pharmaceuticals, LLC | Hétéroarylaminopyrimidine amides inhibiteurs d'autophagie et leurs procédés d'utilisation |
| US11590134B2 (en) | 2019-06-17 | 2023-02-28 | Deciphera Pharmaceuticals, Llc | Aminopyrimidine amide autophagy inhibitors and methods of use thereof |
| CN120112514A (zh) * | 2022-09-02 | 2025-06-06 | 德西费拉制药有限责任公司 | Ulk抑制剂及其使用方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE838623A (fr) * | 1976-02-16 | 1976-06-16 | Derives de 3-hydroxymethylene-2-indolinone et procede pour leur production | |
| US4145422A (en) * | 1977-09-06 | 1979-03-20 | Abbott Laboratories | Aminomethylene oxindoles |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| DE69734521T9 (de) * | 1996-08-23 | 2006-12-07 | Sugen, Inc., South San Francisco | Kombinatorische indolinonbibliotheken und verwandte produkte und verfahren zur behandlung von erkrankungen |
| GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
-
1998
- 1998-06-04 DE DE19824922A patent/DE19824922A1/de not_active Withdrawn
-
1999
- 1999-05-28 CN CN99806884A patent/CN1303374A/zh active Pending
- 1999-05-28 BR BR9910898-4A patent/BR9910898A/pt not_active IP Right Cessation
- 1999-05-28 EA EA200100001A patent/EA003514B1/ru not_active IP Right Cessation
- 1999-05-28 CA CA002328291A patent/CA2328291A1/fr not_active Abandoned
- 1999-05-28 YU YU73900A patent/YU73900A/sh unknown
- 1999-05-28 ID IDW20002523A patent/ID27035A/id unknown
- 1999-05-28 KR KR1020007013597A patent/KR20010043973A/ko not_active Withdrawn
- 1999-05-28 JP JP2000552094A patent/JP2002516906A/ja active Pending
- 1999-05-28 TR TR2000/03515T patent/TR200003515T2/xx unknown
- 1999-05-28 SK SK1822-2000A patent/SK18222000A3/sk unknown
- 1999-05-28 HU HU0102210A patent/HUP0102210A3/hu unknown
- 1999-05-28 PL PL99344467A patent/PL344467A1/xx unknown
- 1999-05-28 EP EP99926454A patent/EP1100779A1/fr not_active Withdrawn
- 1999-05-28 AU AU43707/99A patent/AU764782B2/en not_active Ceased
- 1999-05-28 EE EEP200000723A patent/EE200000723A/xx unknown
- 1999-05-28 IL IL13870299A patent/IL138702A0/xx unknown
- 1999-05-28 HR HR20000831A patent/HRP20000831A2/hr not_active Application Discontinuation
- 1999-05-28 WO PCT/EP1999/003692 patent/WO1999062882A1/fr not_active Ceased
- 1999-06-04 CO CO99035396A patent/CO5050294A1/es unknown
-
2000
- 2000-10-05 ZA ZA200005435A patent/ZA200005435B/en unknown
- 2000-11-13 BG BG104938A patent/BG104938A/xx unknown
- 2000-12-01 NO NO20006138A patent/NO20006138L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU764782B2 (en) | 2003-08-28 |
| PL344467A1 (en) | 2001-11-05 |
| IL138702A0 (en) | 2001-10-31 |
| CN1303374A (zh) | 2001-07-11 |
| EP1100779A1 (fr) | 2001-05-23 |
| ID27035A (id) | 2001-02-22 |
| WO1999062882A1 (fr) | 1999-12-09 |
| EA200100001A1 (ru) | 2001-08-27 |
| SK18222000A3 (sk) | 2001-08-06 |
| CA2328291A1 (fr) | 1999-12-09 |
| HRP20000831A2 (en) | 2001-12-31 |
| NO20006138L (no) | 2001-02-01 |
| HUP0102210A2 (hu) | 2001-11-28 |
| NO20006138D0 (no) | 2000-12-01 |
| EE200000723A (et) | 2002-04-15 |
| ZA200005435B (en) | 2002-01-07 |
| EA003514B1 (ru) | 2003-06-26 |
| TR200003515T2 (tr) | 2001-06-21 |
| YU73900A (sh) | 2003-04-30 |
| AU4370799A (en) | 1999-12-20 |
| JP2002516906A (ja) | 2002-06-11 |
| DE19824922A1 (de) | 1999-12-09 |
| CO5050294A1 (es) | 2001-06-27 |
| HUP0102210A3 (en) | 2002-12-28 |
| BR9910898A (pt) | 2001-02-13 |
| KR20010043973A (ko) | 2001-05-25 |
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