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BG104938A - Заместени индолинони, тяхното получаване и тяхното приложение като лекарствени средства - Google Patents

Заместени индолинони, тяхното получаване и тяхното приложение като лекарствени средства

Info

Publication number
BG104938A
BG104938A BG104938A BG10493800A BG104938A BG 104938 A BG104938 A BG 104938A BG 104938 A BG104938 A BG 104938A BG 10493800 A BG10493800 A BG 10493800A BG 104938 A BG104938 A BG 104938A
Authority
BG
Bulgaria
Prior art keywords
substituted
indonalines
receiving
medicinal products
relates
Prior art date
Application number
BG104938A
Other languages
English (en)
Inventor
Armin Heckel
Rainer Walter
Wolfgang Grell
Meel Jacobus Van
Norbert Redemann
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co.Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co.Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co.Kg
Publication of BG104938A publication Critical patent/BG104938A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретението се отнася до заместени индолинони собща формула@@в която R1 до R5 и Х имат значенията, посочени в описанието, до техните изомери и соли, по-специално техните физиологично поносими соли, които имат ценни фармакологични свойства, по-специално инхибиращо въздействие върху различни кинази и циклин/CDK-комплекси, както и върху пролиферацията на различни туморни клетки. Изобретението се отнася и до лекарствени средства, съдържащи тези съединения, до приложението им и до методи за получаването им.
BG104938A 1998-06-04 2000-11-13 Заместени индолинони, тяхното получаване и тяхното приложение като лекарствени средства BG104938A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19824922A DE19824922A1 (de) 1998-06-04 1998-06-04 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1999/003692 WO1999062882A1 (de) 1998-06-04 1999-05-28 Substituierte indolinone, ihre herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
BG104938A true BG104938A (bg) 2001-06-29

Family

ID=7869856

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104938A BG104938A (bg) 1998-06-04 2000-11-13 Заместени индолинони, тяхното получаване и тяхното приложение като лекарствени средства

Country Status (23)

Country Link
EP (1) EP1100779A1 (bg)
JP (1) JP2002516906A (bg)
KR (1) KR20010043973A (bg)
CN (1) CN1303374A (bg)
AU (1) AU764782B2 (bg)
BG (1) BG104938A (bg)
BR (1) BR9910898A (bg)
CA (1) CA2328291A1 (bg)
CO (1) CO5050294A1 (bg)
DE (1) DE19824922A1 (bg)
EA (1) EA003514B1 (bg)
EE (1) EE200000723A (bg)
HR (1) HRP20000831A2 (bg)
HU (1) HUP0102210A3 (bg)
ID (1) ID27035A (bg)
IL (1) IL138702A0 (bg)
NO (1) NO20006138L (bg)
PL (1) PL344467A1 (bg)
SK (1) SK18222000A3 (bg)
TR (1) TR200003515T2 (bg)
WO (1) WO1999062882A1 (bg)
YU (1) YU73900A (bg)
ZA (1) ZA200005435B (bg)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19816624A1 (de) * 1998-04-15 1999-10-21 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
UA75054C2 (uk) * 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
US6762180B1 (en) 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
JP2004517049A (ja) * 2000-09-01 2004-06-10 グラクソ　グループ　リミテッド チロシンキナーゼ阻害剤としての置換オキシインドール誘導体
WO2002020513A1 (en) * 2000-09-01 2002-03-14 Glaxo Group Limited Oxindole derivatives
DE10117204A1 (de) 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
JP2005500041A (ja) 2001-06-29 2005-01-06 アブ サイエンス 強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤
JP2004537542A (ja) 2001-06-29 2004-12-16 アブ サイエンス 炎症性腸疾患（ｉｂｄ）を治療するための、チロシンキナーゼ阻害剤の使用
WO2003002106A2 (en) 2001-06-29 2003-01-09 Ab Science Use of tyrosine kinase inhibitions for treating allergic diseases
ES2266553T3 (es) * 2001-06-29 2007-03-01 Ab Science Utilizacion de derivados de la n-fenil-2-pirimidina-amina para tratar las enfermedades inflamatorias.
DE60227709D1 (de) * 2001-06-29 2008-08-28 Ab Science Die verwendung von c-kithemmern zur behandlung von autoimmunerkrankungen
AU2002341881B2 (en) * 2001-09-27 2008-05-08 Allergan, Inc. 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
DE102004012070A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
PE20060777A1 (es) * 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
US8299241B2 (en) * 2006-12-05 2012-10-30 Arena Pharmaceuticals, Inc. Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof
GB0706072D0 (en) * 2007-03-28 2007-05-09 Sterix Ltd Compound
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
CN101735071A (zh) * 2009-12-04 2010-06-16 大连凯飞精细化工有限公司 一种生产4-n,n-二甲胺基甲基苯胺的方法
CN103102352B (zh) * 2011-11-15 2015-08-12 山东亨利医药科技有限责任公司 酪氨酸激酶抑制剂吲哚满酮衍生物
CN103130775B (zh) * 2011-11-22 2015-09-30 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的吲哚满酮衍生物
GB201208775D0 (en) 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds
CN103848814B (zh) * 2012-12-06 2016-08-17 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的取代吲哚满酮衍生物
JP7593947B2 (ja) 2019-05-10 2024-12-03 デシフェラ・ファーマシューティカルズ，エルエルシー フェニルアミノピリミジンアミドオートファジー阻害剤およびその使用方法
LT3966206T (lt) 2019-05-10 2023-11-10 Deciphera Pharmaceuticals, Llc Heteroarilaminopirimidino amido autofagijos inhibitoriai ir jų naudojimo būdai
EP3983081A1 (en) 2019-06-17 2022-04-20 Deciphera Pharmaceuticals, LLC Aminopyrimidine amide autophagy inhibitors and methods of use thereof
EP4581014A1 (en) * 2022-09-02 2025-07-09 Deciphera Pharmaceuticals, LLC Ulk inhibitors and methods of use thereof

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BE838623A (fr) * 1976-02-16 1976-06-16 Derives de 3-hydroxymethylene-2-indolinone et procede pour leur production
US4145422A (en) * 1977-09-06 1979-03-20 Abbott Laboratories Aminomethylene oxindoles
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GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Also Published As

Publication number Publication date
HUP0102210A3 (en) 2002-12-28
EP1100779A1 (de) 2001-05-23
BR9910898A (pt) 2001-02-13
PL344467A1 (en) 2001-11-05
YU73900A (sh) 2003-04-30
JP2002516906A (ja) 2002-06-11
AU4370799A (en) 1999-12-20
SK18222000A3 (sk) 2001-08-06
HRP20000831A2 (en) 2001-12-31
TR200003515T2 (tr) 2001-06-21
HUP0102210A2 (hu) 2001-11-28
NO20006138D0 (no) 2000-12-01
CA2328291A1 (en) 1999-12-09
IL138702A0 (en) 2001-10-31
CN1303374A (zh) 2001-07-11
EA003514B1 (ru) 2003-06-26
DE19824922A1 (de) 1999-12-09
EE200000723A (et) 2002-04-15
EA200100001A1 (ru) 2001-08-27
NO20006138L (no) 2001-02-01
KR20010043973A (ko) 2001-05-25
WO1999062882A1 (de) 1999-12-09
CO5050294A1 (es) 2001-06-27
ZA200005435B (en) 2002-01-07
ID27035A (id) 2001-02-22
AU764782B2 (en) 2003-08-28

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