[go: up one dir, main page]

NO20006138D0 - Substituerte indolinoner, fremstilling og anvendelse derav som medikamenter - Google Patents

Substituerte indolinoner, fremstilling og anvendelse derav som medikamenter

Info

Publication number
NO20006138D0
NO20006138D0 NO20006138A NO20006138A NO20006138D0 NO 20006138 D0 NO20006138 D0 NO 20006138D0 NO 20006138 A NO20006138 A NO 20006138A NO 20006138 A NO20006138 A NO 20006138A NO 20006138 D0 NO20006138 D0 NO 20006138D0
Authority
NO
Norway
Prior art keywords
drugs
preparation
substituted indolinones
indolinones
substituted
Prior art date
Application number
NO20006138A
Other languages
English (en)
Other versions
NO20006138L (no
Inventor
Armin Heckel
Rainer Walter
Wolfgang Grell
Jacobus C A Van Meel
Norbert Redemann
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20006138D0 publication Critical patent/NO20006138D0/no
Publication of NO20006138L publication Critical patent/NO20006138L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO20006138A 1998-06-04 2000-12-01 Substituerte indolinoner, fremstilling og anvendelse derav som medikamenter NO20006138L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19824922A DE19824922A1 (de) 1998-06-04 1998-06-04 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1999/003692 WO1999062882A1 (de) 1998-06-04 1999-05-28 Substituierte indolinone, ihre herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
NO20006138D0 true NO20006138D0 (no) 2000-12-01
NO20006138L NO20006138L (no) 2001-02-01

Family

ID=7869856

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20006138A NO20006138L (no) 1998-06-04 2000-12-01 Substituerte indolinoner, fremstilling og anvendelse derav som medikamenter

Country Status (23)

Country Link
EP (1) EP1100779A1 (no)
JP (1) JP2002516906A (no)
KR (1) KR20010043973A (no)
CN (1) CN1303374A (no)
AU (1) AU764782B2 (no)
BG (1) BG104938A (no)
BR (1) BR9910898A (no)
CA (1) CA2328291A1 (no)
CO (1) CO5050294A1 (no)
DE (1) DE19824922A1 (no)
EA (1) EA003514B1 (no)
EE (1) EE200000723A (no)
HR (1) HRP20000831A2 (no)
HU (1) HUP0102210A3 (no)
ID (1) ID27035A (no)
IL (1) IL138702A0 (no)
NO (1) NO20006138L (no)
PL (1) PL344467A1 (no)
SK (1) SK18222000A3 (no)
TR (1) TR200003515T2 (no)
WO (1) WO1999062882A1 (no)
YU (1) YU73900A (no)
ZA (1) ZA200005435B (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19816624A1 (de) * 1998-04-15 1999-10-21 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
UA75054C2 (uk) * 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
US6762180B1 (en) 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
JP2004508366A (ja) * 2000-09-01 2004-03-18 グラクソ　グループ　リミテッド オキシインドール誘導体
EP1339680A1 (en) 2000-09-01 2003-09-03 Glaxo Group Limited Substituted oxindole derivatives as tyrosine kinase inhibitors
DE10117204A1 (de) 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DK1401415T3 (da) 2001-06-29 2006-10-16 Ab Science Anvendelse af N-phenyl-2-pyrimidinamin-derivater til behandling af inflammatoriske sygdomme
US7727731B2 (en) 2001-06-29 2010-06-01 Ab Science Potent, selective and non toxic c-kit inhibitors
US20050176687A1 (en) * 2001-06-29 2005-08-11 Alain Moussy Use of tyrosine kinase inhibitors for treating autoimmune diseases
ATE343415T1 (de) * 2001-06-29 2006-11-15 Ab Science Die verwendung von c-kit hemmer zur behandlung von entzündlichen darmerkrankungen
JP2004537536A (ja) 2001-06-29 2004-12-16 アブ サイエンス アレルギー疾患を治療するためのチロシンキナーゼ阻害剤の使用方法
US20030225152A1 (en) 2001-09-27 2003-12-04 Andrews Steven W. 3-(Arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
DE102004012070A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
PE20060777A1 (es) * 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
JP5404414B2 (ja) * 2006-12-05 2014-01-29 アリーナ ファーマシューティカルズ， インコーポレイテッド （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンおよびその中間体を調製するための方法
GB0706072D0 (en) * 2007-03-28 2007-05-09 Sterix Ltd Compound
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
CN101735071A (zh) * 2009-12-04 2010-06-16 大连凯飞精细化工有限公司 一种生产4-n,n-二甲胺基甲基苯胺的方法
CN103102352B (zh) * 2011-11-15 2015-08-12 山东亨利医药科技有限责任公司 酪氨酸激酶抑制剂吲哚满酮衍生物
CN103130775B (zh) * 2011-11-22 2015-09-30 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的吲哚满酮衍生物
GB201208775D0 (en) 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds
CN103848814B (zh) * 2012-12-06 2016-08-17 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的取代吲哚满酮衍生物
CN114127057B (zh) 2019-05-10 2024-07-12 德西费拉制药有限责任公司 苯基氨基嘧啶酰胺自噬抑制剂及其使用方法
EP4295846A3 (en) 2019-05-10 2024-02-28 Deciphera Pharmaceuticals, LLC Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof
US11590134B2 (en) 2019-06-17 2023-02-28 Deciphera Pharmaceuticals, Llc Aminopyrimidine amide autophagy inhibitors and methods of use thereof
CN120112514A (zh) * 2022-09-02 2025-06-06 德西费拉制药有限责任公司 Ulk抑制剂及其使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE838623A (fr) * 1976-02-16 1976-06-16 Derives de 3-hydroxymethylene-2-indolinone et procede pour leur production
US4145422A (en) * 1977-09-06 1979-03-20 Abbott Laboratories Aminomethylene oxindoles
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
DE69734521T9 (de) * 1996-08-23 2006-12-07 Sugen, Inc., South San Francisco Kombinatorische indolinonbibliotheken und verwandte produkte und verfahren zur behandlung von erkrankungen
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Also Published As

Publication number Publication date
AU764782B2 (en) 2003-08-28
PL344467A1 (en) 2001-11-05
IL138702A0 (en) 2001-10-31
CN1303374A (zh) 2001-07-11
EP1100779A1 (de) 2001-05-23
ID27035A (id) 2001-02-22
WO1999062882A1 (de) 1999-12-09
EA200100001A1 (ru) 2001-08-27
SK18222000A3 (sk) 2001-08-06
CA2328291A1 (en) 1999-12-09
HRP20000831A2 (en) 2001-12-31
NO20006138L (no) 2001-02-01
HUP0102210A2 (hu) 2001-11-28
EE200000723A (et) 2002-04-15
ZA200005435B (en) 2002-01-07
EA003514B1 (ru) 2003-06-26
TR200003515T2 (tr) 2001-06-21
YU73900A (sh) 2003-04-30
AU4370799A (en) 1999-12-20
BG104938A (bg) 2001-06-29
JP2002516906A (ja) 2002-06-11
DE19824922A1 (de) 1999-12-09
CO5050294A1 (es) 2001-06-27
HUP0102210A3 (en) 2002-12-28
BR9910898A (pt) 2001-02-13
KR20010043973A (ko) 2001-05-25

Similar Documents

Publication Publication Date Title
NO20006138D0 (no) Substituerte indolinoner, fremstilling og anvendelse derav som medikamenter
DK1119557T3 (da) Indeno-, naphto- og benzocyclohepta-dihydrothiazolderivater, fremstilling deraf og anvendelse deraf som anorektiske medikamenter
DK1095025T3 (da) Benzimidazoler, deres fremstilling og deres anvendelse som lægemidler
NO20021719L (no) 6-posisjon substituerte indoliner, fremstilling og anvendelse derav som medikament
NO20012567D0 (no) Azepinoindolderivater, fremstilling og anvendelse derav
NO20005146D0 (no) Tienylazolylalkoksyetanaminer, deres fremstilling og deres anvendelse som medikamenter
DK1083171T3 (da) Pyrazolinderivater, deres fremstilling og anvendelse som medikamenter
DK0966454T3 (da) Disubstituerede bicykliske heterocykler, deres fremstilling og deres anvendelse som lægemidler
DK1112251T3 (da) Azetidinderivater, deres fremstilling og medikamenter indeholdende disse derivater
NO20021379D0 (no) Benzodiazepin-derivater, fremstilling og anvendelse derav
PT1177178E (pt) Benzimidazois hetereciclicos substituidos, sua preparacao e aplicacao
NO20024175D0 (no) Azetidinderivater, deres fremstilling og farmasöytiske forbindelser inneholdende de samme
NO20011216L (no) Azetidinderivater, deres fremstilling og medikamenter inneholdende forbindelsene
NO20015156L (no) 5-pyridyl-1,3-azolforbindelser, deres fremstilling og anvendelse
NO991815L (no) Oksadiazoler, fremgangsmÕter for deres fremstilling og deres anvendelse som medikamenter
NO20014603D0 (no) Tienopyrimidinforbindelser, deres fremstilling og anvendelse
IS2076B (is) Asýl-píperasínil-pýrimídínafleiður, framleiðsla og notkun þeirra sem lyfja
DK1073672T3 (da) Antipicornavirale forbindelser, deres fremstilling og anvendelse
DK1043307T3 (da) 3-amino-3-arylpropan-1-ol-derivater, deres fremstilling og anvendelse
NO20020156L (no) Titanavledede forbindelser, fremstilling og anvendelse derav
NO20016247D0 (no) Streptograminderivater, deres fremstilling og preparater inneholdende derivatene
DK1025100T3 (da) 3-substituerede tetrahydropyridopyrimidinonderivater, fremstilling og anvendelsen heraf
DK1086077T3 (da) Hidtil ukendte antiestrogener, fremgangsmåde til deres fremstilling og deres farmaceutiske anvendelse
NO20000066D0 (no) 6-pyrrolidin-2-ylpyrindin-derivater, deres fremstilling og deres farmasoeytiske anvendelse
NO20006479D0 (no) Tienopyridinforbindelser, deres fremstilling og anvendelse

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application