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BE903103A - Derives heterocycliques - Google Patents

Derives heterocycliques

Info

Publication number
BE903103A
BE903103A BE0/215493A BE215493A BE903103A BE 903103 A BE903103 A BE 903103A BE 0/215493 A BE0/215493 A BE 0/215493A BE 215493 A BE215493 A BE 215493A BE 903103 A BE903103 A BE 903103A
Authority
BE
Belgium
Prior art keywords
heterocyclic derivatives
alkyls
branched
alkyl
independently represent
Prior art date
Application number
BE0/215493A
Other languages
English (en)
Original Assignee
Glaxo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT22383/84A external-priority patent/IT1175620B/it
Priority claimed from IT21460/85A external-priority patent/IT1187678B/it
Application filed by Glaxo Spa filed Critical Glaxo Spa
Publication of BE903103A publication Critical patent/BE903103A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B2205/00—Fibre drawing or extruding details
    • C03B2205/44—Monotoring or regulating the preform feed rate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Dérivés hétérocycliques répondant à la formule (I), dans laquelle R1 et R4 représentent indépendamment des alkyles en C1-C4; R2 et R3 représentent indépendamment des alkyles en C1-C6 linéaires ou ramifiés, éventuellement interrompus par un atome d'oxygène; R5 représente un alkyle en C1-C13 linéaire ou ramifié ou un cycloalkyle en C5-C8 qui peut etre substitué par un alkyle en C1-C3. Ces composés réduisent la concentration en ions calcium intracellulaires en limitant l'influx d'ions calcium transmembraneux et à ce titre, ils sont intéressants pour le traitement de troubles cardiovasculaires, y compris l'angine de poitrine, l'ischémie du myocarde et autres.
BE0/215493A 1984-08-22 1985-08-22 Derives heterocycliques BE903103A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22383/84A IT1175620B (it) 1984-08-22 1984-08-22 Derivati piridinici
IT21460/85A IT1187678B (it) 1985-07-05 1985-07-05 Procedimento di preparazione di derivati eterociclici

Publications (1)

Publication Number Publication Date
BE903103A true BE903103A (fr) 1986-02-24

Family

ID=26327905

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215493A BE903103A (fr) 1984-08-22 1985-08-22 Derives heterocycliques

Country Status (33)

Country Link
US (2) US4801599A (fr)
JP (2) JPS6193162A (fr)
KR (1) KR920004482B1 (fr)
AT (1) AT394042B (fr)
AU (1) AU578724B2 (fr)
BE (1) BE903103A (fr)
BG (1) BG60409B2 (fr)
CA (1) CA1268180A (fr)
CH (1) CH666684A5 (fr)
CS (1) CS403091A3 (fr)
CY (1) CY1494A (fr)
DE (1) DE3529997C2 (fr)
DK (1) DK165949C (fr)
ES (5) ES8703839A1 (fr)
FI (1) FI81568C (fr)
FR (1) FR2569402B1 (fr)
GB (1) GB2164336B (fr)
GR (1) GR852016B (fr)
HK (1) HK52990A (fr)
HU (1) HU196754B (fr)
IE (1) IE58486B1 (fr)
LU (2) LU86047A1 (fr)
MX (1) MX159974A (fr)
NL (2) NL193065C (fr)
NO (2) NO167142C (fr)
NZ (1) NZ212895A (fr)
PH (1) PH22014A (fr)
PT (1) PT81000B (fr)
SA (1) SA91120277B1 (fr)
SE (1) SE459920B (fr)
SG (1) SG40889G (fr)
SK (1) SK278327B6 (fr)
ZW (1) ZW13185A1 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions
IE59632B1 (en) * 1985-08-21 1994-03-09 Glaxo Spa Heterocyclic derivatives
DE3675747D1 (de) * 1985-08-21 1991-01-03 Glaxo Spa 1,4-dihydropyridinverbindungen und ihre herstellung und pharmazeutische formulierung.
IT1204460B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204461B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204462B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1233370B (it) * 1988-11-21 1992-03-27 Glaxo Spa Procedimento di preparazione di derivati diidropipiridinici utili nel trattamento di disturbi cardiovascolari
US5102709A (en) 1989-04-27 1992-04-07 Canon Kabushiki Kaisha Optical recording medium and process for production thereof
US5196529A (en) * 1990-10-09 1993-03-23 Merck & Co., Inc. 2-phenanthrenyl carbapenem intermediates
US5177202A (en) * 1990-10-09 1993-01-05 Merck & Co., Inc. 2-phenanthrenyl-carbapenems
US5132422A (en) * 1990-10-09 1992-07-21 Merck & Co., Inc. 2-naphthyl-carbapenem intermediates
US5132421A (en) * 1990-10-09 1992-07-21 Merck & Co., Inc. 2-naphthyl-carbapenem intermediates
US5144028A (en) * 1990-10-09 1992-09-01 Merck & Co., Inc. 2-(9-fluorenonyl)-carbapenem intermediates
US5356889A (en) * 1990-08-01 1994-10-18 Merck & Co., Inc. 2-(9-fluorenonyl)-carbapenem intermediates
US5208329A (en) * 1990-10-09 1993-05-04 Merck & Co., Inc. 2-biphenyl carbapenem intermediates
IT1244728B (it) * 1991-02-13 1994-08-08 Glaxo Spa Impiego medicamentoso di derivati diidropiridinici
TW483763B (en) * 1994-09-02 2002-04-21 Astra Ab Pharmaceutical composition comprising of ramipril and dihydropyridine compound
WO2000027397A1 (fr) * 1998-11-06 2000-05-18 Glaxo Group Limited Medicaments antihypertenseurs a base de lacidipine et de telmisartan
KR100668539B1 (ko) 2002-08-19 2007-01-16 화이자 프로덕츠 인크. 과증식성 질환에 대한 조합요법
CA2526730A1 (fr) * 2003-05-30 2004-12-09 Ranbaxy Laboratories Limited Derives pyrroliques substitues
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
KR20070054644A (ko) * 2004-07-26 2007-05-29 액테리온 파마슈티칼 리미티드 미립자 제형으로 흡입된 일로프로스트에 의한 폐고혈압의치료
EP1868577A4 (fr) 2005-04-15 2009-12-09 Reddys Lab Inc Dr Particules de lacidipine
US20070043088A1 (en) * 2005-08-16 2007-02-22 Eswaraiah Sajja Process for preparing lacidipine
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7893050B2 (en) * 2005-10-26 2011-02-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP2351569B1 (fr) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil dans des thérapies combinées pour le traitement de l'hypertension artérielle pulmonaire
JP2009514851A (ja) * 2005-11-08 2009-04-09 ランバクシー ラボラトリーズ リミテッド （３ｒ，５ｒ）−７−［２−（４−フルオロフェニル）−５−イソプロピル−３−フェニル−４−［（４−ヒドロキシメチルフェニルアミノ）カルボニル］−ピロール−１−イル］−３，５−ジヒドロキシ−ヘプタン酸ヘミカルシウム塩の製法
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
WO2008020314A2 (fr) * 2006-03-14 2008-02-21 Ranbaxy Laboratories Limited Formulations de dosage stabilisantes à base de statine
AR063469A1 (es) * 2006-07-14 2009-01-28 Ranbaxy Lab Ltd Formas polimorficas de ácido (3r,5r)-7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]-pirrol-1-il]-3, 5-dihidroxi-heptanoico, sal hemicalcio, metodos de preparacion de las mismas, una composicion farmaceutica que las comprende y su uso en el tratamiento de enfermedades
US20080089947A1 (en) * 2006-08-18 2008-04-17 Knox Clayton D Calcium Influx Inhibitors in the Treatment of Ischemia
WO2008070496A2 (fr) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company Inhibiteurs d'amino cetp étendus
WO2012037665A1 (fr) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Oxyde nitrique libérant un ester d'acide aminé pour le traitement de l'hypertension pulmonaire et autres états respiratoires
ITMI20131485A1 (it) 2012-09-10 2014-03-11 Rivopharm Sa Composizione farmaceutica comprendente lacipidina e processo di preparazione
BR112015026513A2 (pt) 2013-04-17 2017-07-25 Pfizer derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
MA54261B1 (fr) 2019-01-18 2025-03-28 Astrazeneca Ab Inhibiteurs de pcsk9 et leurs procédés d'utilisation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455945A (en) * 1967-06-07 1969-07-15 Smithkline Corp 4-(carboxy (and carbo-lower alkoxy)phenyl)-1,4-dihydropyridines
DE2228363A1 (de) * 1972-06-10 1974-01-03 Bayer Ag 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
DE3018259A1 (de) * 1980-05-13 1981-11-19 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
NL8502296A (nl) 1986-03-17
NL193065B (nl) 1998-05-06
NO167142C (no) 1991-10-09
ES552049A0 (es) 1988-07-01
NL980037I2 (nl) 1999-03-01
JPS6479152A (en) 1989-03-24
KR870002073A (ko) 1987-03-28
GB2164336B (en) 1988-06-08
HU196754B (en) 1989-01-30
DK165949C (da) 1993-07-05
GB2164336A (en) 1986-03-19
ES8707931A1 (es) 1987-09-01
FR2569402A1 (fr) 1986-02-28
AU578724B2 (en) 1988-11-03
FI81568C (fi) 1990-11-12
GR852016B (fr) 1985-12-19
BG60409B2 (bg) 1995-02-28
ZW13185A1 (en) 1986-03-19
ES546324A0 (es) 1987-03-01
ES552048A0 (es) 1987-09-01
SK278327B6 (en) 1996-11-06
PT81000B (pt) 1988-03-03
NL193065C (nl) 1998-09-08
AT394042B (de) 1992-01-27
DE3529997A1 (de) 1986-03-06
FR2569402B1 (fr) 1989-09-22
IE58486B1 (en) 1993-09-22
ES552050A0 (es) 1987-09-01
PT81000A (en) 1985-09-01
NO853293L (no) 1986-02-24
JPH0686430B2 (ja) 1994-11-02
JPH0550506B2 (fr) 1993-07-29
FI853206L (fi) 1986-02-23
ES8703839A1 (es) 1987-03-01
LU88267I2 (fr) 1994-02-03
GB8520924D0 (en) 1985-09-25
PH22014A (en) 1988-05-02
KR920004482B1 (ko) 1992-06-05
ES8707932A1 (es) 1987-09-01
NO1999007I1 (no) 1999-04-23
HK52990A (en) 1990-07-20
CH666684A5 (de) 1988-08-15
IE852054L (en) 1986-02-22
LU86047A1 (fr) 1986-02-28
SA91120277B1 (ar) 2006-05-15
SE8503888L (sv) 1986-02-23
ES8802497A1 (es) 1988-07-01
DK378085D0 (da) 1985-08-20
JPS6193162A (ja) 1986-05-12
AU4657685A (en) 1986-02-27
US5011848A (en) 1991-04-30
SG40889G (en) 1989-12-22
HUT40625A (en) 1987-01-28
NO167142B (no) 1991-07-01
SE459920B (sv) 1989-08-21
DK165949B (da) 1993-02-15
FI81568B (fi) 1990-07-31
ES552051A0 (es) 1987-09-01
MX159974A (es) 1989-10-17
NZ212895A (en) 1988-07-28
CY1494A (en) 1990-02-16
SE8503888D0 (sv) 1985-08-20
NL980037I1 (nl) 1999-02-01
CA1268180A (fr) 1990-04-24
FI853206A0 (fi) 1985-08-21
ATA245485A (de) 1991-07-15
ES8707930A1 (es) 1987-09-01
DK378085A (da) 1986-02-23
US4801599A (en) 1989-01-31
CS403091A3 (en) 1992-06-17
DE3529997C2 (de) 1996-01-18

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