IT1204461B - Derivati eterociclici - Google Patents
Derivati eterocicliciInfo
- Publication number
- IT1204461B IT1204461B IT8619485A IT1948586A IT1204461B IT 1204461 B IT1204461 B IT 1204461B IT 8619485 A IT8619485 A IT 8619485A IT 1948586 A IT1948586 A IT 1948586A IT 1204461 B IT1204461 B IT 1204461B
- Authority
- IT
- Italy
- Prior art keywords
- sub
- alkyl
- group
- straight
- branched
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 2
- 229910001424 calcium ion Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000004941 influx Effects 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 150000002825 nitriles Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8619485A IT1204461B (it) | 1986-02-20 | 1986-02-20 | Derivati eterociclici |
| IL81565A IL81565A (en) | 1986-02-20 | 1987-02-13 | Dihydropyridine-dicarboxylic acid esters,their preparation and pharmaceutical compositions containing them |
| EP87301434A EP0238211B1 (en) | 1986-02-20 | 1987-02-19 | Dihydropyridines, process for their preparation and their use as medicaments |
| AT87301434T ATE100083T1 (de) | 1986-02-20 | 1987-02-19 | Dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. |
| DE87301434T DE3788738T2 (de) | 1986-02-20 | 1987-02-19 | Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel. |
| JP62035944A JPS62252782A (ja) | 1986-02-20 | 1987-02-20 | 複素環誘導体 |
| US07/587,159 US5051432A (en) | 1986-02-20 | 1990-09-19 | Heterocyclic 1,4 dihydropyridine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8619485A IT1204461B (it) | 1986-02-20 | 1986-02-20 | Derivati eterociclici |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8619485A0 IT8619485A0 (it) | 1986-02-20 |
| IT1204461B true IT1204461B (it) | 1989-03-01 |
Family
ID=11158424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT8619485A IT1204461B (it) | 1986-02-20 | 1986-02-20 | Derivati eterociclici |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5051432A (it) |
| EP (1) | EP0238211B1 (it) |
| JP (1) | JPS62252782A (it) |
| AT (1) | ATE100083T1 (it) |
| DE (1) | DE3788738T2 (it) |
| IL (1) | IL81565A (it) |
| IT (1) | IT1204461B (it) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080089947A1 (en) * | 2006-08-18 | 2008-04-17 | Knox Clayton D | Calcium Influx Inhibitors in the Treatment of Ischemia |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3455945A (en) * | 1967-06-07 | 1969-07-15 | Smithkline Corp | 4-(carboxy (and carbo-lower alkoxy)phenyl)-1,4-dihydropyridines |
| JPS55301A (en) * | 1978-02-14 | 1980-01-05 | Yamanouchi Pharmaceut Co Ltd | 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation |
| DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| JPS57171968A (en) * | 1981-04-17 | 1982-10-22 | Kyowa Hakko Kogyo Co Ltd | 1,4-dihydropyridine derivative |
| NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
| DE3207982A1 (de) * | 1982-03-05 | 1983-09-08 | Bayer Ag, 5090 Leverkusen | Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln |
| NZ212895A (en) * | 1984-08-22 | 1988-07-28 | Glaxo Spa | 1,4-dihydropyridine derivatives and pharmaceutical compositions |
-
1986
- 1986-02-20 IT IT8619485A patent/IT1204461B/it active
-
1987
- 1987-02-13 IL IL81565A patent/IL81565A/xx not_active IP Right Cessation
- 1987-02-19 AT AT87301434T patent/ATE100083T1/de active
- 1987-02-19 DE DE87301434T patent/DE3788738T2/de not_active Expired - Fee Related
- 1987-02-19 EP EP87301434A patent/EP0238211B1/en not_active Expired - Lifetime
- 1987-02-20 JP JP62035944A patent/JPS62252782A/ja active Pending
-
1990
- 1990-09-19 US US07/587,159 patent/US5051432A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0238211A3 (en) | 1988-09-07 |
| JPS62252782A (ja) | 1987-11-04 |
| ATE100083T1 (de) | 1994-01-15 |
| IT8619485A0 (it) | 1986-02-20 |
| EP0238211B1 (en) | 1994-01-12 |
| US5051432A (en) | 1991-09-24 |
| IL81565A (en) | 1991-09-16 |
| DE3788738T2 (de) | 1994-04-28 |
| EP0238211A2 (en) | 1987-09-23 |
| DE3788738D1 (de) | 1994-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19940218 |