ATE299868T1 - Dihydro-benzo (b) (1,4) diazepin-2-on-derivate als mglur2 antagonisten - Google Patents

Dihydro-benzo (b) (1,4) diazepin-2-on-derivate als mglur2 antagonisten

Info

Publication number: ATE299868T1
Authority: AT; Austria
Prior art keywords: diazepine; benzo; dihydro; derivatives; mglur2 antagonists
Prior art date: 2001-04-12

Application number

AT02737911T

Other languages

English (en)

Inventor

Geo Adam

Erwin Goetschi

Vincent Mutel

Juergen Wichmann

Thomas Johannes Woltering

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2002-04-02

Publication date

2005-08-15

2002-04-02 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-08-15 Application granted granted Critical

2005-08-15 Publication of ATE299868T1 publication Critical patent/ATE299868T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT02737911T 2001-04-12 2002-04-02 Dihydro-benzo (b) (1,4) diazepin-2-on-derivate als mglur2 antagonisten ATE299868T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01109125		2001-04-12
PCT/EP2002/003644 WO2002083652A1 (en)	2001-04-12	2002-04-02	DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II

Publications (1)

Publication Number	Publication Date
ATE299868T1 true ATE299868T1 (de)	2005-08-15

Family

ID=8177126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02737911T ATE299868T1 (de)	2001-04-12	2002-04-02	Dihydro-benzo (b) (1,4) diazepin-2-on-derivate als mglur2 antagonisten

Country Status (37)

Country	Link
US (1)	US6544985B2 (de)
EP (1)	EP1379511B1 (de)
JP (1)	JP4071115B2 (de)
KR (1)	KR100566171B1 (de)
CN (1)	CN1264825C (de)
AR (1)	AR035816A1 (de)
AT (1)	ATE299868T1 (de)
AU (1)	AU2002312788B2 (de)
BG (1)	BG108254A (de)
BR (1)	BR0208891A (de)
CA (1)	CA2442557C (de)
CZ (1)	CZ20033003A3 (de)
DE (1)	DE60205100T2 (de)
DK (1)	DK1379511T3 (de)
EC (1)	ECSP034797A (de)
ES (1)	ES2246012T3 (de)
GT (1)	GT200200073A (de)
HR (1)	HRP20030792A2 (de)
HU (1)	HUP0400851A3 (de)
IL (2)	IL157873A0 (de)
JO (1)	JO2285B1 (de)
MA (1)	MA27012A1 (de)
MX (1)	MXPA03009311A (de)
MY (1)	MY140271A (de)
NO (1)	NO20034576L (de)
NZ (1)	NZ528315A (de)
PA (1)	PA8543301A1 (de)
PE (1)	PE20021041A1 (de)
PL (1)	PL367064A1 (de)
PT (1)	PT1379511E (de)
RU (1)	RU2263112C2 (de)
SI (1)	SI1379511T1 (de)
SK (1)	SK13682003A3 (de)
UY (1)	UY27258A1 (de)
WO (1)	WO2002083652A1 (de)
YU (1)	YU79003A (de)
ZA (1)	ZA200307243B (de)

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US7329662B2 (en)	2003-10-03	2008-02-12	Hoffmann-La Roche Inc.	Pyrazolo-pyridine
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JP4608542B2 (ja) *	2004-06-21	2011-01-12	エフ．ホフマン−ラロシュアーゲー	ピラゾロピリミジン誘導体
WO2006084634A1 (en) *	2005-02-11	2006-08-17	F.Hoffmann-La Roche Ag	Pyrazolo-pyrimidine derivatives as mglur2 antagonists
DE602006012815D1 (de)	2005-03-23	2010-04-22	Hoffmann La Roche	Acetylenylpyrazolopyrimidinderivate als mglur2-antagonsten
JP5237798B2 (ja) *	2005-06-23	2013-07-17	アレイバイオファーマ、インコーポレイテッド	ベンズイミダゾール化合物の調製方法
JP5048675B2 (ja)	2005-09-27	2012-10-17	エフ．ホフマン−ラロシュアーゲー	ｍＧｌｕＲ２アンタゴニストとしてのオキサジアゾリルピラゾロ−ピリミジン類
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TWI417095B (zh)	2006-03-15	2013-12-01	Janssen Pharmaceuticals Inc	１，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
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WO2010060589A1 (en)	2008-11-28	2010-06-03	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
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EP2593447B1 (de)	2010-07-15	2016-08-17	Bayer Intellectual Property GmbH	3-pyridyl-heteroarylcarboxamidverbindungen als schädlingsbekämpfungsmittel
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CN103298810B (zh)	2010-11-08	2016-03-16	杨森制药公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
EP2643320B1 (de)	2010-11-08	2015-03-04	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridinderivate und ihre verwendung als positiv allosterische modulatoren des mglur2 receptors
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EP2925292A1 (de)	2012-10-23	2015-10-07	F. Hoffmann-La Roche AG	Mglu2/3-antagonisten zur behandlung von autistischen störungen
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2002
- 2002-04-02 HU HU0400851A patent/HUP0400851A3/hu unknown
- 2002-04-02 NZ NZ528315A patent/NZ528315A/en unknown
- 2002-04-02 ES ES02737911T patent/ES2246012T3/es not_active Expired - Lifetime
- 2002-04-02 CN CNB028081811A patent/CN1264825C/zh not_active Expired - Fee Related
- 2002-04-02 JP JP2002581408A patent/JP4071115B2/ja not_active Expired - Fee Related
- 2002-04-02 PL PL02367064A patent/PL367064A1/xx not_active Application Discontinuation
- 2002-04-02 KR KR1020037013300A patent/KR100566171B1/ko not_active Expired - Fee Related
- 2002-04-02 YU YU79003A patent/YU79003A/sh unknown
- 2002-04-02 AU AU2002312788A patent/AU2002312788B2/en not_active Ceased
- 2002-04-02 CA CA002442557A patent/CA2442557C/en not_active Expired - Fee Related
- 2002-04-02 HR HR20030792A patent/HRP20030792A2/hr not_active Application Discontinuation
- 2002-04-02 SK SK1368-2003A patent/SK13682003A3/sk unknown
- 2002-04-02 PT PT02737911T patent/PT1379511E/pt unknown
- 2002-04-02 DE DE60205100T patent/DE60205100T2/de not_active Expired - Lifetime
- 2002-04-02 CZ CZ20033003A patent/CZ20033003A3/cs unknown
- 2002-04-02 SI SI200230163T patent/SI1379511T1/xx unknown
- 2002-04-02 DK DK02737911T patent/DK1379511T3/da active
- 2002-04-02 WO PCT/EP2002/003644 patent/WO2002083652A1/en not_active Ceased
- 2002-04-02 EP EP02737911A patent/EP1379511B1/de not_active Expired - Lifetime
- 2002-04-02 BR BR0208891-6A patent/BR0208891A/pt not_active Application Discontinuation
- 2002-04-02 RU RU2003130637/04A patent/RU2263112C2/ru not_active IP Right Cessation
- 2002-04-02 MX MXPA03009311A patent/MXPA03009311A/es active IP Right Grant
- 2002-04-02 IL IL15787302A patent/IL157873A0/xx active IP Right Grant
- 2002-04-02 AT AT02737911T patent/ATE299868T1/de not_active IP Right Cessation
- 2002-04-03 US US10/115,826 patent/US6544985B2/en not_active Expired - Fee Related
- 2002-04-09 AR ARP020101290A patent/AR035816A1/es not_active Application Discontinuation
- 2002-04-09 PA PA20028543301A patent/PA8543301A1/es unknown
- 2002-04-10 JO JO200232A patent/JO2285B1/en active
- 2002-04-10 PE PE2002000291A patent/PE20021041A1/es not_active Application Discontinuation
- 2002-04-11 GT GT200200073A patent/GT200200073A/es unknown
- 2002-04-11 UY UY27258A patent/UY27258A1/es not_active Application Discontinuation
- 2002-04-11 MY MYPI20021345A patent/MY140271A/en unknown
2003
- 2003-09-11 IL IL157873A patent/IL157873A/en not_active IP Right Cessation
- 2003-09-16 ZA ZA200307243A patent/ZA200307243B/en unknown
- 2003-10-08 EC EC2003004797A patent/ECSP034797A/es unknown
- 2003-10-08 MA MA27346A patent/MA27012A1/fr unknown
- 2003-10-10 BG BG108254A patent/BG108254A/bg unknown
- 2003-10-10 NO NO20034576A patent/NO20034576L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2442557C (en)	2008-12-23
DE60205100D1 (de)	2005-08-25
MA27012A1 (fr)	2004-12-20
HK1068888A1 (en)	2005-05-06
CZ20033003A3 (cs)	2004-05-12
PL367064A1 (en)	2005-02-21
YU79003A (sh)	2006-05-25
ES2246012T3 (es)	2006-02-01
CN1535266A (zh)	2004-10-06
SK13682003A3 (sk)	2004-07-07
NO20034576D0 (no)	2003-10-10
AR035816A1 (es)	2004-07-14
PT1379511E (pt)	2005-10-31
HUP0400851A3 (en)	2010-03-29
EP1379511B1 (de)	2005-07-20
HUP0400851A2 (hu)	2004-07-28
US6544985B2 (en)	2003-04-08
IL157873A (en)	2008-11-26
NZ528315A (en)	2005-04-29
RU2263112C2 (ru)	2005-10-27
HRP20030792A2 (en)	2005-10-31
KR20030087076A (ko)	2003-11-12
RU2003130637A (ru)	2005-04-10
DE60205100T2 (de)	2006-06-01
ZA200307243B (en)	2004-12-16
US20020193367A1 (en)	2002-12-19
PA8543301A1 (es)	2003-01-24
JP2004529925A (ja)	2004-09-30
MXPA03009311A (es)	2004-02-12
WO2002083652A1 (en)	2002-10-24
CA2442557A1 (en)	2002-10-24
IL157873A0 (en)	2004-03-28
JO2285B1 (en)	2005-09-12
UY27258A1 (es)	2002-10-31
DK1379511T3 (da)	2005-11-07
NO20034576L (no)	2003-11-12
GT200200073A (es)	2002-11-07
EP1379511A1 (de)	2004-01-14
BR0208891A (pt)	2004-04-20
MY140271A (en)	2009-12-31
AU2002312788B2 (en)	2005-11-10
ECSP034797A (es)	2003-12-01
KR100566171B1 (ko)	2006-03-29
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