MA27012A1 - Derives de dihydro-benzo [b] [1,4] diazepin-2-one en tant qu'antagonistes ii de mglur2 - Google Patents

Derives de dihydro-benzo [b] [1,4] diazepin-2-one en tant qu'antagonistes ii de mglur2

Info

Publication number: MA27012A1
Authority: MA; Morocco
Prior art keywords: mglur2; diazepin; agonists; benzo; dihydro
Prior art date: 2001-04-12

Application number

MA27346A

Other languages

English (en)

Inventor

Geo Adam

Erwin Goetschi

Vincent Mutel

Juergen Wichmann

Thomas Johannes Woltering

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2003-10-08

Publication date

2004-12-20

2003-10-08 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-12-20 Publication of MA27012A1 publication Critical patent/MA27012A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

MA27346A 2001-04-12 2003-10-08 Derives de dihydro-benzo [b] [1,4] diazepin-2-one en tant qu'antagonistes ii de mglur2 MA27012A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01109125		2001-04-12

Publications (1)

Publication Number	Publication Date
MA27012A1 true MA27012A1 (fr)	2004-12-20

Family

ID=8177126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA27346A MA27012A1 (fr)	2001-04-12	2003-10-08	Derives de dihydro-benzo [b] [1,4] diazepin-2-one en tant qu'antagonistes ii de mglur2

Country Status (37)

Country	Link
US (1)	US6544985B2 (fr)
EP (1)	EP1379511B1 (fr)
JP (1)	JP4071115B2 (fr)
KR (1)	KR100566171B1 (fr)
CN (1)	CN1264825C (fr)
AR (1)	AR035816A1 (fr)
AT (1)	ATE299868T1 (fr)
AU (1)	AU2002312788B2 (fr)
BG (1)	BG108254A (fr)
BR (1)	BR0208891A (fr)
CA (1)	CA2442557C (fr)
CZ (1)	CZ20033003A3 (fr)
DE (1)	DE60205100T2 (fr)
DK (1)	DK1379511T3 (fr)
EC (1)	ECSP034797A (fr)
ES (1)	ES2246012T3 (fr)
GT (1)	GT200200073A (fr)
HR (1)	HRP20030792A2 (fr)
HU (1)	HUP0400851A3 (fr)
IL (2)	IL157873A0 (fr)
JO (1)	JO2285B1 (fr)
MA (1)	MA27012A1 (fr)
MX (1)	MXPA03009311A (fr)
MY (1)	MY140271A (fr)
NO (1)	NO20034576L (fr)
NZ (1)	NZ528315A (fr)
PA (1)	PA8543301A1 (fr)
PE (1)	PE20021041A1 (fr)
PL (1)	PL367064A1 (fr)
PT (1)	PT1379511E (fr)
RU (1)	RU2263112C2 (fr)
SI (1)	SI1379511T1 (fr)
SK (1)	SK13682003A3 (fr)
UY (1)	UY27258A1 (fr)
WO (1)	WO2002083652A1 (fr)
YU (1)	YU79003A (fr)
ZA (1)	ZA200307243B (fr)

Families Citing this family (53)

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ATE261945T1 (de)	1999-10-15	2004-04-15	Hoffmann La Roche	Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
PT1459765E (pt) *	2001-12-27	2008-10-03	Taisho Pharmaceutical Co Ltd	Derivados de 6-fluorobiciclo [3.1.0] hexano
EP1925614A1 (fr) *	2002-03-28	2008-05-28	Wisys Technology Foundation, Inc.	Agents anxiolytiques avec effets ataxiques et sédatifs réduits
IL163958A0 (en)	2002-03-28	2005-12-18	Wisys Technology Foundation	Anxiolytic agents with reduced sedative and ataxideffects
ATE374030T1 (de) *	2003-07-25	2007-10-15	Hoffmann La Roche	Kombination eines mglur2 antagonists und eines ache inhibitors zur behandlung von akuten und/oder chronischen neurologischen krankheiten
US7329662B2 (en)	2003-10-03	2008-02-12	Hoffmann-La Roche Inc.	Pyrazolo-pyridine
US20060160823A1 (en) *	2004-05-28	2006-07-20	Leonore Witchey-Lakshmanan	Particulate-stabilized injectable pharmaceutical compositions of Posaconazole
JP4608542B2 (ja) *	2004-06-21	2011-01-12	エフ．ホフマン−ラロシュアーゲー	ピラゾロピリミジン誘導体
WO2006084634A1 (fr) *	2005-02-11	2006-08-17	F.Hoffmann-La Roche Ag	Derives de pyrazolopyrimidine en tant qu’antagonistes de mglur2
DE602006012815D1 (de)	2005-03-23	2010-04-22	Hoffmann La Roche	Acetylenylpyrazolopyrimidinderivate als mglur2-antagonsten
JP5237798B2 (ja) *	2005-06-23	2013-07-17	アレイバイオファーマ、インコーポレイテッド	ベンズイミダゾール化合物の調製方法
JP5048675B2 (ja)	2005-09-27	2012-10-17	エフ．ホフマン−ラロシュアーゲー	ｍＧｌｕＲ２アンタゴニストとしてのオキサジアゾリルピラゾロ−ピリミジン類
GB0600228D0 (en) *	2006-01-06	2006-02-15	Fermentas Uab	Inactivation method
TWI417095B (zh)	2006-03-15	2013-12-01	Janssen Pharmaceuticals Inc	１，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200808751A (en) *	2006-04-13	2008-02-16	Astrazeneca Ab	New compounds
MX2009002538A (es) *	2006-09-20	2009-03-20	Hoffmann La Roche	Derivados de 4-oxo-2,3,4,5-tetrahidro-benzo[b][1,4]diazepina.
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en)	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
AU2008240802B2 (en)	2007-04-19	2012-07-05	F. Hoffmann-La Roche Ag	Dihydro-benzo[B][1,4]diazepin-2-one sulfonamide derivatives
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CA2697399C (fr)	2007-09-14	2016-01-19	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	4-(aryl-x-phenyl)-1h-pyridine-2-ones 1,3-disubstituees
MY152078A (en)	2007-09-14	2014-08-15	Ortho Mcneil Janssen Pharm	1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
RU2492170C9 (ru)	2007-11-14	2013-12-27	Орто-Макнейл-Янссен Фармасьютикалз, Инк.	Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2
AU2009289784B2 (en)	2008-09-02	2012-03-22	Addex Pharma S.A.	3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
ES2466341T3 (es)	2008-10-16	2014-06-10	Janssen Pharmaceuticals, Inc.	Derivados de indol y benzomorfolina como moduladores de receptores de glutamato metabotrópicos
WO2010060589A1 (fr)	2008-11-28	2010-06-03	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	Dérivés d'indole et de benzoxazine comme modulateurs des récepteurs métabotropiques au glutamate
AU2010246609B2 (en)	2009-05-12	2013-09-05	Addex Pharma S.A.	1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
NZ596053A (en)	2009-05-12	2013-05-31	Janssen Pharmaceuticals Inc	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2593447B1 (fr)	2010-07-15	2016-08-17	Bayer Intellectual Property GmbH	Composés de 3-pyridyl-heteroarylcarboxamide comme d'agents de lutte contre les nuisibles
WO2012059432A1 (fr)	2010-11-01	2012-05-10	Abbott Gmbh & Co. Kg	Composés de type n-phényl-(homo)pipérazinyl-benzènesulfonyle ou benzènesulfonamide appropriés pour le traitement de troubles qui répondent à la modulation du récepteur 5-ht6
WO2012059431A1 (fr)	2010-11-01	2012-05-10	Abbott Gmbh & Co. Kg	Composés de type benzènesulfonyle ou sulfonamide appropriés pour le traitement de troubles qui répondent à la modulation du récepteur 5-ht6 de la sérotonine
CN103298810B (zh)	2010-11-08	2016-03-16	杨森制药公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
EP2643320B1 (fr)	2010-11-08	2015-03-04	Janssen Pharmaceuticals, Inc.	Dérivés de la 1,2,4-triazolo [4,3-a] pyridine et leur utilisation en tant que modulateurs allostériques positifs des récepteurs mglur2
EP2661435B1 (fr)	2010-11-08	2015-08-19	Janssen Pharmaceuticals, Inc.	Dérivés 1,2,4-triazolo[4,3-a]pyridine et leur utilisation en tant que modulateurs allostériques positifs des récepteurs mglur2
WO2012149540A1 (fr)	2011-04-28	2012-11-01	The Broad Institute Inc	Inhibiteurs de l'histone désacétylase
JP5790195B2 (ja) *	2011-06-22	2015-10-07	セントラル硝子株式会社	ピラゾール化合物の製造方法
CA2847247C (fr) *	2011-08-29	2019-10-15	Sanford-Burnham Medical Research Institute	Benzodiazepinones en tant que modulateurs de fonctions d'un recepteur metabotropique du glutamate, et utilisations neurologiques de ceux-ci
CA2880117C (fr)	2012-07-27	2021-04-06	The Broad Institute, Inc.	Inhibiteurs d'histone-desacetylases
EP2925292A1 (fr)	2012-10-23	2015-10-07	F. Hoffmann-La Roche AG	Antagonistes de mglu2/3 pour le traitement de troubles autistiques
US9914717B2 (en)	2012-12-20	2018-03-13	The Broad Institute, Inc.	Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
EP2940014B1 (fr) *	2012-12-28	2018-09-26	Crystalgenomics, Inc.	Dérivé 2,3-dihydro-isoindole-1-one utilisé comme suppresseur de kinase btk, et composition pharmaceutique associée
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
DK3096790T3 (da)	2014-01-21	2019-10-07	Janssen Pharmaceutica Nv	Kombinationer omfattende positive allosteriske modulatorer eller orthosteriske agonister af metabotrop glutamaterg subtype 2-receptor og anvendelse af disse
KR20220038826A (ko)	2014-01-21	2022-03-29	얀센 파마슈티카 엔.브이.	대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
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US9969726B2 (en)	2014-06-10	2018-05-15	Sanford-Burnham Medical Research Institute	Metabotropic glutamate receptor negative allosteric modulators (NAMS) and uses thereof
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JP2021510733A (ja)	2018-01-12	2021-04-30	ケーディーエーシーセラピューティクス，インコーポレーテッドＫｄａｃＴｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ．	がんの処置のための選択的ヒストンデアセチラーゼ３（ｈｄａｃ３）インヒビターと免疫治療剤との組み合わせ
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SK283859B6 (sk) *	1995-02-09	2004-03-02	Egis Gy�Gyszergy�R Rt.	1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie
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ATE261945T1 (de) *	1999-10-15	2004-04-15	Hoffmann La Roche	Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
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2002
- 2002-04-02 HU HU0400851A patent/HUP0400851A3/hu unknown
- 2002-04-02 NZ NZ528315A patent/NZ528315A/en unknown
- 2002-04-02 ES ES02737911T patent/ES2246012T3/es not_active Expired - Lifetime
- 2002-04-02 CN CNB028081811A patent/CN1264825C/zh not_active Expired - Fee Related
- 2002-04-02 JP JP2002581408A patent/JP4071115B2/ja not_active Expired - Fee Related
- 2002-04-02 PL PL02367064A patent/PL367064A1/xx not_active Application Discontinuation
- 2002-04-02 KR KR1020037013300A patent/KR100566171B1/ko not_active Expired - Fee Related
- 2002-04-02 YU YU79003A patent/YU79003A/sh unknown
- 2002-04-02 AU AU2002312788A patent/AU2002312788B2/en not_active Ceased
- 2002-04-02 CA CA002442557A patent/CA2442557C/fr not_active Expired - Fee Related
- 2002-04-02 HR HR20030792A patent/HRP20030792A2/hr not_active Application Discontinuation
- 2002-04-02 SK SK1368-2003A patent/SK13682003A3/sk unknown
- 2002-04-02 PT PT02737911T patent/PT1379511E/pt unknown
- 2002-04-02 DE DE60205100T patent/DE60205100T2/de not_active Expired - Lifetime
- 2002-04-02 CZ CZ20033003A patent/CZ20033003A3/cs unknown
- 2002-04-02 SI SI200230163T patent/SI1379511T1/xx unknown
- 2002-04-02 DK DK02737911T patent/DK1379511T3/da active
- 2002-04-02 WO PCT/EP2002/003644 patent/WO2002083652A1/fr not_active Ceased
- 2002-04-02 EP EP02737911A patent/EP1379511B1/fr not_active Expired - Lifetime
- 2002-04-02 BR BR0208891-6A patent/BR0208891A/pt not_active Application Discontinuation
- 2002-04-02 RU RU2003130637/04A patent/RU2263112C2/ru not_active IP Right Cessation
- 2002-04-02 MX MXPA03009311A patent/MXPA03009311A/es active IP Right Grant
- 2002-04-02 IL IL15787302A patent/IL157873A0/xx active IP Right Grant
- 2002-04-02 AT AT02737911T patent/ATE299868T1/de not_active IP Right Cessation
- 2002-04-03 US US10/115,826 patent/US6544985B2/en not_active Expired - Fee Related
- 2002-04-09 AR ARP020101290A patent/AR035816A1/es not_active Application Discontinuation
- 2002-04-09 PA PA20028543301A patent/PA8543301A1/es unknown
- 2002-04-10 JO JO200232A patent/JO2285B1/en active
- 2002-04-10 PE PE2002000291A patent/PE20021041A1/es not_active Application Discontinuation
- 2002-04-11 GT GT200200073A patent/GT200200073A/es unknown
- 2002-04-11 UY UY27258A patent/UY27258A1/es not_active Application Discontinuation
- 2002-04-11 MY MYPI20021345A patent/MY140271A/en unknown
2003
- 2003-09-11 IL IL157873A patent/IL157873A/en not_active IP Right Cessation
- 2003-09-16 ZA ZA200307243A patent/ZA200307243B/en unknown
- 2003-10-08 EC EC2003004797A patent/ECSP034797A/es unknown
- 2003-10-08 MA MA27346A patent/MA27012A1/fr unknown
- 2003-10-10 BG BG108254A patent/BG108254A/bg unknown
- 2003-10-10 NO NO20034576A patent/NO20034576L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2442557C (fr)	2008-12-23
DE60205100D1 (de)	2005-08-25
HK1068888A1 (en)	2005-05-06
CZ20033003A3 (cs)	2004-05-12
PL367064A1 (en)	2005-02-21
YU79003A (sh)	2006-05-25
ES2246012T3 (es)	2006-02-01
CN1535266A (zh)	2004-10-06
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NO20034576D0 (no)	2003-10-10
AR035816A1 (es)	2004-07-14
PT1379511E (pt)	2005-10-31
HUP0400851A3 (en)	2010-03-29
EP1379511B1 (fr)	2005-07-20
HUP0400851A2 (hu)	2004-07-28
US6544985B2 (en)	2003-04-08
IL157873A (en)	2008-11-26
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JP2004529925A (ja)	2004-09-30
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