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AR114921A2 - Método para preparar 2-amino-n-(2,2,2-trifluoroetil)acetamida - Google Patents

Método para preparar 2-amino-n-(2,2,2-trifluoroetil)acetamida

Info

Publication number
AR114921A2
AR114921A2 ARP190101556A ARP190101556A AR114921A2 AR 114921 A2 AR114921 A2 AR 114921A2 AR P190101556 A ARP190101556 A AR P190101556A AR P190101556 A ARP190101556 A AR P190101556A AR 114921 A2 AR114921 A2 AR 114921A2
Authority
AR
Argentina
Prior art keywords
preparing
formula
trifluoroethyl
acetamide
amino
Prior art date
Application number
ARP190101556A
Other languages
English (en)
Inventor
Joerg Bruening
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of AR114921A2 publication Critical patent/AR114921A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Reivindicación 1: Un método para preparar un compuesto de la fórmula (1), en donde X es Cl, Br, CF₃CO₂, CH₃SO₃, (SO₄)₁/₂ o (PO₄)₁/₃, caracterizado porque el método comprende (A1) contactar un compuesto de la fórmula (2) con un compuesto de la fórmula (3) y un reactivo de acoplamiento para formar un intermedio de la fórmula (4) en presencia de una base, y (B1) contactar el intermedio de la fórmula (4) con un ácido de la fórmula HX.
ARP190101556A 2010-09-27 2019-06-06 Método para preparar 2-amino-n-(2,2,2-trifluoroetil)acetamida AR114921A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38667310P 2010-09-27 2010-09-27

Publications (1)

Publication Number Publication Date
AR114921A2 true AR114921A2 (es) 2020-10-28

Family

ID=44741725

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP110103504A AR083105A1 (es) 2010-09-27 2011-09-26 Metodo para preparar 2-amino-n-(2,2,2-trifluoroetil)acetamida
ARP190101555A AR114920A2 (es) 2010-09-27 2019-06-06 Método para preparar 2-amino-n-(2,2,2-trifluoroetil)acetamida
ARP190101556A AR114921A2 (es) 2010-09-27 2019-06-06 Método para preparar 2-amino-n-(2,2,2-trifluoroetil)acetamida

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ARP110103504A AR083105A1 (es) 2010-09-27 2011-09-26 Metodo para preparar 2-amino-n-(2,2,2-trifluoroetil)acetamida
ARP190101555A AR114920A2 (es) 2010-09-27 2019-06-06 Método para preparar 2-amino-n-(2,2,2-trifluoroetil)acetamida

Country Status (20)

Country Link
US (4) US10202332B2 (es)
EP (2) EP2621894B1 (es)
JP (2) JP5859010B2 (es)
KR (1) KR101901466B1 (es)
CN (1) CN103124721B (es)
AR (3) AR083105A1 (es)
AU (3) AU2011312599B2 (es)
BR (3) BR122018074306B8 (es)
CA (4) CA3111132C (es)
ES (2) ES2962793T3 (es)
IL (3) IL225147A (es)
LT (2) LT2621894T (es)
MX (2) MX346782B (es)
MY (1) MY161570A (es)
PT (2) PT3150575T (es)
RU (1) RU2581841C2 (es)
TW (3) TW201720792A (es)
UA (1) UA113615C2 (es)
WO (1) WO2012047543A1 (es)
ZA (1) ZA201301830B (es)

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WO2020222158A1 (en) * 2019-04-30 2020-11-05 Hikal Limited Process for the preparation of 2-amino-n-(2,2,2-trifluoroethyl)-acetamide and salts thereof
CN114057594B (zh) * 2020-07-31 2025-04-15 广东东阳光药业股份有限公司 2-氨基-n-(2,2,2-三氟乙基)乙酰胺或其盐的制备方法
CN115710185B (zh) * 2021-08-23 2024-05-03 中国石油化工股份有限公司 利用金属碳化物催化剂生产甲胺的方法
CN114414678B (zh) * 2021-12-27 2023-05-30 丽珠集团新北江制药股份有限公司 一种异噁唑啉类兽药中间体铵盐有关杂质的分析方法
US20250109093A1 (en) * 2022-01-28 2025-04-03 Nippon Soda Co., Ltd. Method for producing amide compound
CN115536541A (zh) * 2022-10-13 2022-12-30 湖北美天生物科技股份有限公司 氟雷拉纳和阿福拉纳共同中间体的合成方法
CN116253658B (zh) * 2022-11-25 2023-08-11 济南久隆医药科技有限公司 一种阿福拉纳中间体合成方法
CN115772091B (zh) * 2023-01-05 2023-06-23 济南久隆医药科技有限公司 一种2-氨基-n-(2,2,2-三氟乙基)乙酰胺的合成方法
CN116143652B (zh) * 2023-01-13 2024-06-28 四川青木制药有限公司 一种阿福拉纳中间体及其制备方法和应用
CN119899156A (zh) * 2023-10-27 2025-04-29 华北制药集团动物保健品有限责任公司 一种阿福拉纳的制备方法

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US5952497A (en) * 1996-07-10 1999-09-14 University Of Georgia Research Foundation N.sup.α -Bpoc amino acid pentafluorophenyl (Pfp) esters and 3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl (ODhbt) esters
JP2979139B2 (ja) * 1998-03-11 1999-11-15 東北大学長 Ｌ−パラボロノフェニルアラニンの製造方法
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TW200643015A (en) * 2005-03-11 2006-12-16 Akzo Nobel Nv 2-(4-oxo-4H-quinazolin-3-yl)acetamide derivatives
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Also Published As

Publication number Publication date
BR122018074319B1 (pt) 2020-02-27
CN103124721A (zh) 2013-05-29
RU2581841C2 (ru) 2016-04-20
LT2621894T (lt) 2017-01-25
TW201720792A (zh) 2017-06-16
EP2621894B1 (en) 2016-11-16
AU2011312599B2 (en) 2016-02-25
TW201213281A (en) 2012-04-01
CA3111132C (en) 2023-06-20
PT3150575T (pt) 2023-11-13
LT3150575T (lt) 2023-12-27
BR112013007040B8 (pt) 2022-11-08
MX346782B (es) 2017-03-31
AU2018201421A1 (en) 2018-03-22
CA2812718C (en) 2018-11-27
ZA201301830B (en) 2014-04-28
AU2016202641B2 (en) 2017-11-30
EP3150575A1 (en) 2017-04-05
AU2016202641A1 (en) 2016-05-19
JP2016117720A (ja) 2016-06-30
WO2012047543A1 (en) 2012-04-12
US20130267729A1 (en) 2013-10-10
AR083105A1 (es) 2013-01-30
BR122018074319B8 (pt) 2022-12-06
TW201623220A (zh) 2016-07-01
US20230303482A1 (en) 2023-09-28
US20190144373A1 (en) 2019-05-16
MX341417B (es) 2016-08-19
CA3021290A1 (en) 2012-04-12
AR114920A2 (es) 2020-10-28
CA3111132A1 (en) 2012-04-12
KR20130099121A (ko) 2013-09-05
BR112013007040B1 (pt) 2019-04-02
JP5859010B2 (ja) 2016-02-10
CA2812718A1 (en) 2012-04-12
ES2962793T3 (es) 2024-03-21
US11613516B2 (en) 2023-03-28
AU2018201421B2 (en) 2019-05-02
JP2013537914A (ja) 2013-10-07
CA3021290C (en) 2021-05-25
IL270711B (en) 2021-09-30
BR112013007040A2 (pt) 2016-06-14
IL225147A (en) 2017-04-30
IL270711A (en) 2020-01-30
MY161570A (en) 2017-04-28
US10745344B2 (en) 2020-08-18
US10202332B2 (en) 2019-02-12
BR122018074306B8 (pt) 2022-12-06
EP2621894A1 (en) 2013-08-07
IL250489A0 (en) 2017-03-30
IL250489B (en) 2019-12-31
RU2013119617A (ru) 2014-11-10
US20190144374A1 (en) 2019-05-16
EP3150575B1 (en) 2023-08-09
CA3197676A1 (en) 2012-04-12
JP6175122B2 (ja) 2017-08-02
MX2013003462A (es) 2013-05-28
BR122018074306B1 (pt) 2020-02-27
KR101901466B1 (ko) 2018-09-21
ES2614812T3 (es) 2017-06-02
TWI591046B (zh) 2017-07-11
UA113615C2 (xx) 2017-02-27
PT2621894T (pt) 2017-01-04
AU2011312599A1 (en) 2013-03-28
TWI535685B (zh) 2016-06-01
CN103124721B (zh) 2015-06-03

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