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AR095977A1 - Un procedimiento para aumentar la formación de ácido piroglutámico de una proteína - Google Patents

Un procedimiento para aumentar la formación de ácido piroglutámico de una proteína

Info

Publication number
AR095977A1
AR095977A1 ARP140101455A ARP140101455A AR095977A1 AR 095977 A1 AR095977 A1 AR 095977A1 AR P140101455 A ARP140101455 A AR P140101455A AR P140101455 A ARP140101455 A AR P140101455A AR 095977 A1 AR095977 A1 AR 095977A1
Authority
AR
Argentina
Prior art keywords
protein
procedure
formation
increase
pyroglutamic acid
Prior art date
Application number
ARP140101455A
Other languages
English (en)
Inventor
Thorne Barbara
Waugh Stephen
Rose Van Schravendijk Marie
Original Assignee
Mabxience S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mabxience S A filed Critical Mabxience S A
Publication of AR095977A1 publication Critical patent/AR095977A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Un procedimiento para la conversión de un residuo de glutamina y/o ácido glutámico N-terminal de una proteína en ácido piroglutámico en un procedimiento de purificación.
ARP140101455A 2013-04-04 2014-04-01 Un procedimiento para aumentar la formación de ácido piroglutámico de una proteína AR095977A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13162241 2013-04-04

Publications (1)

Publication Number Publication Date
AR095977A1 true AR095977A1 (es) 2015-11-25

Family

ID=48044678

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140101455A AR095977A1 (es) 2013-04-04 2014-04-01 Un procedimiento para aumentar la formación de ácido piroglutámico de una proteína

Country Status (18)

Country Link
US (1) US10400042B2 (es)
EP (1) EP2981553A1 (es)
JP (1) JP2016523812A (es)
KR (1) KR20150138273A (es)
CN (1) CN105121469A (es)
AR (1) AR095977A1 (es)
AU (1) AU2014247034B2 (es)
BR (1) BR112015025106A2 (es)
CA (1) CA2907766A1 (es)
EC (1) ECSP15043422A (es)
HK (1) HK1221472A1 (es)
MX (1) MX2015014038A (es)
RU (1) RU2015147187A (es)
SA (1) SA515361251B1 (es)
SG (2) SG10201708088WA (es)
TW (1) TW201444863A (es)
UY (1) UY35517A (es)
WO (1) WO2014161940A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA034776B1 (ru) 2015-05-20 2020-03-19 Эмджен Инк. Триазоловые агонисты рецептора apj
US9988369B2 (en) 2016-05-03 2018-06-05 Amgen Inc. Heterocyclic triazole compounds as agonists of the APJ receptor
US11020395B2 (en) 2016-11-16 2021-06-01 Amgen Inc. Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
US10906890B2 (en) 2016-11-16 2021-02-02 Amgen Inc. Triazole phenyl compounds as agonists of the APJ receptor
EP3541792B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole furan compounds as agonists of the apj receptor
US11191762B2 (en) 2016-11-16 2021-12-07 Amgen Inc. Alkyl substituted triazole compounds as agonists of the APJ Receptor
EP3541805B1 (en) 2016-11-16 2020-10-14 Amgen Inc. Heteroaryl-substituted triazoles as apj receptor agonists
WO2018093580A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Triazole pyridyl compounds as agonists of the apj receptor
JOP20190100A1 (ar) * 2016-11-19 2019-05-01 Potenza Therapeutics Inc بروتينات ربط مولد ضد مضاد لـ gitr وطرق استخدامها
WO2019043096A1 (en) * 2017-08-30 2019-03-07 Fresenius Kabi Deutschland Gmbh METHOD FOR PURIFYING IL-6 ANTI-RECEPTOR ANTIBODIES
US11149040B2 (en) 2017-11-03 2021-10-19 Amgen Inc. Fused triazole agonists of the APJ receptor
WO2019213006A1 (en) 2018-05-01 2019-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the apj receptor
EP3643322A1 (en) * 2018-10-26 2020-04-29 Mabion SA Low aggregate anti cd20 ligand formulation
CN112110983A (zh) * 2019-06-21 2020-12-22 正大天晴药业集团股份有限公司 蛋白质的纯化方法
CN112725398B (zh) * 2019-10-29 2022-07-01 中国食品发酵工业研究院有限公司 一种具有辅助降血糖功能的豌豆肽及其制备方法
US11598116B1 (en) 2020-10-01 2023-03-07 Florida Aluminum Systems, Llc Mounting system for separating and connecting fencing slabs
HUP2400216A1 (hu) * 2024-04-17 2025-10-28 Richter Gedeon Nyrt N-terminális glutamint tartalmazó immunglobulinok tisztítására szolgáló eljárások

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040132101A1 (en) * 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US8084582B2 (en) 2003-03-03 2011-12-27 Xencor, Inc. Optimized anti-CD20 monoclonal antibodies having Fc variants
ATE506433T1 (de) 2003-12-19 2011-05-15 Novo Nordisk As Prozessierung von peptiden und proteinen
US20060286629A1 (en) * 2003-12-19 2006-12-21 Norby Inga S N Processing of Peptides and Proteins
EP1787126B1 (en) 2004-07-20 2009-09-23 Symphogen A/S A procedure for characterization of a polyclonal cell line
US20080312425A1 (en) * 2004-08-30 2008-12-18 Lonza Biologics Plc. Ion Exchange Chromatography and Purification of Antibodies
WO2007064911A1 (en) * 2005-12-02 2007-06-07 Biogen Idec Inc. Anti-mouse cd20 antibodies and uses thereof
MX2010004740A (es) * 2007-10-30 2010-05-27 Genentech Inc Purificacion de anticuerpos por cromatografia de intercambio cationico.
WO2010138184A2 (en) 2009-05-27 2010-12-02 Synageva Biopharma Corp. Avian derived antibodies
CN102492040B (zh) 2011-12-29 2014-06-25 嘉和生物药业有限公司 一种抗her2或/和抗her3抗体蛋白的纯化方法

Also Published As

Publication number Publication date
WO2014161940A1 (en) 2014-10-09
JP2016523812A (ja) 2016-08-12
TW201444863A (zh) 2014-12-01
MX2015014038A (es) 2016-06-02
BR112015025106A2 (pt) 2017-10-10
CA2907766A1 (en) 2014-10-09
US10400042B2 (en) 2019-09-03
SA515361251B1 (ar) 2018-07-01
RU2015147187A (ru) 2017-05-23
SG11201507815XA (en) 2015-10-29
SG10201708088WA (en) 2017-10-30
EP2981553A1 (en) 2016-02-10
AU2014247034A1 (en) 2015-10-01
AU2014247034B2 (en) 2018-08-23
UY35517A (es) 2014-10-31
US20160060349A1 (en) 2016-03-03
RU2015147187A3 (es) 2018-02-28
KR20150138273A (ko) 2015-12-09
HK1221472A1 (zh) 2017-06-02
CN105121469A (zh) 2015-12-02
ECSP15043422A (es) 2017-03-31

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