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AR104906A1 - Anticuerpos dirigidos a la proteína morfogenética ósea 9 (bmp9) y métodos a partir de estos - Google Patents

Anticuerpos dirigidos a la proteína morfogenética ósea 9 (bmp9) y métodos a partir de estos

Info

Publication number
AR104906A1
AR104906A1 ARP160101663A ARP160101663A AR104906A1 AR 104906 A1 AR104906 A1 AR 104906A1 AR P160101663 A ARP160101663 A AR P160101663A AR P160101663 A ARP160101663 A AR P160101663A AR 104906 A1 AR104906 A1 AR 104906A1
Authority
AR
Argentina
Prior art keywords
seq
sequences
lcdr2
hcdr2
hcdr1
Prior art date
Application number
ARP160101663A
Other languages
English (en)
Inventor
Luo Xiao
Xiangyang Lu Chris
Li Qian
Kugler Markus
He Yun
Deng Sujun
Chen Zijun
Huang Dagang
Ulrike Tissot-Daguette Kathrin
Shan Yongqiang
Wu Jing
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR104906A1 publication Critical patent/AR104906A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Reivindicación 1: Un anticuerpo aislado o su fragmento de unión a antígeno, el cual une a BMP9 humana y comprende: (a) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 21, 22 y 23, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 31, 32 y 33, respectivamente; (b) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 24, 25 y 26, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 34, 35 y 36, respectivamente; (c) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 1, 2 y 3, respectivamente, y. las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 11, 12 y 13, respectivamente; (d) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 4, 5 y 6, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 14, 15 y 16, respectivamente; (e) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 41, 42 y 43, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 51, 52 y 53, respectivamente; (f) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 44, 45 y 46, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 54, 55 y 56, respectivamente; (g) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 61, 62 y 63, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 71, 72 y 73, respectivamente; (h) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 64, 65 y 66, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 74, 75 y 76, respectivamente; (i) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 81, 82 y 83, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 91, 92 y 93, respectivamente; (j) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 84, 85 y 86, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 94, 95 y 96, respectivamente; (k) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 101, 102 y 103, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 111, 112 y 113, respectivamente; (l) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 104, 105 y 106, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 114, 115 y 116, respectivamente; (m) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 121, 122 y 123, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 131, 132 y 133, respectivamente; (n) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 124, 125 y 126, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 134, 135 y 136, respectivamente; (o) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 141, 142 y 143, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 151, 152 y 153, respectivamente; (p) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ 1D Nº 144, 145 y 146, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 154, 155 y 156, respectivamente; (q) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 161, 162 y 163, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 171, 172 y 173, respectivamente; (r) las secuencias HCDR1, HCDR2 y HCDR3 de SEQ ID Nº 164, 165 y 166, respectivamente, y las secuencias LCDR1, LCDR2 y LCDR3 de SEQ ID Nº 174, 175 y 176, respectivamente. Reivindicación 28: Una composición que comprende un anticuerpo aislado o su fragmento de unión a antígeno de cualquiera de las reivindicaciones anteriores, y (a) un vehículo farmacéuticamente aceptable; (b) un agente terapéutico adicional; o (c) combinaciones de los mismos. Reivindicación 44: Un polinucleótido aislado que comprende una secuencia de ácido nucleico que codifica un anticuerpo o su fragmento de unión a antígeno de cualquiera de las reivindicaciones 1 a 27. Reivindicación 58: El uso de un anticuerpo aislado o su fragmento de unión a antígeno de cualquiera de las reivindicaciones 1 - 27, una composición de cualquiera de las reivindicaciones 28 - 32, un polinucleótido aislado de cualquiera de las reivindicaciones 44 - 55, un vector de la reivindicación 56, o una célula de reivindicación 57 en la fabricación de un medicamento.
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3448987A4 (en) 2016-04-29 2020-05-27 Voyager Therapeutics, Inc. COMPOSITIONS FOR TREATING A DISEASE
EP3448874A4 (en) 2016-04-29 2020-04-22 Voyager Therapeutics, Inc. COMPOSITIONS FOR TREATING A DISEASE
CN106994181A (zh) * 2017-03-10 2017-08-01 上海交通大学医学院附属第九人民医院 Bmp9在制备延缓肝纤维化药物中的应用
CN107760779B (zh) * 2017-11-03 2020-10-16 中国医学科学院阜外医院 肺动脉高压相关的突变型bmp9基因及其应用
IL293894A (en) 2019-12-20 2022-08-01 Novartis Ag Combination treatment of liver diseases using integrin inhibitors
WO2022101853A1 (en) 2020-11-16 2022-05-19 Novartis Ag Method of determining liver fibrosis
KR102780923B1 (ko) * 2021-10-22 2025-03-17 고려대학교 산학협력단 Bmp 유래 신규 펩타이드 및 이의 용도
IL316700A (en) 2022-05-31 2024-12-01 Pfizer ANTI-BMP9 antibodies and methods of using them
CN115040638A (zh) * 2022-06-14 2022-09-13 上海市东方医院（同济大学附属东方医院） Bmp9在制备mafld、nash、nash相关肝纤维化/肝硬化的药物中的用途
CN116058335B (zh) * 2022-11-25 2025-07-25 中国医学科学院阜外医院 一种自发强直性脊柱炎模型的构建方法和应用
CN116115736A (zh) * 2022-12-09 2023-05-16 上海交通大学医学院附属瑞金医院 一种bmp9在制备抑制成骨细胞衰老的制剂或药物中的应用
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
CA1247080A (en) 1983-03-08 1988-12-20 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4881175A (en) 1986-09-02 1989-11-14 Genex Corporation Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
JPH02500329A (ja) 1987-05-21 1990-02-08 クリエイテイブ・バイオマリキユールズ・インコーポレーテツド ターゲット化多機能蛋白質
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
US5336603A (en) 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
US5476996A (en) 1988-06-14 1995-12-19 Lidak Pharmaceuticals Human immune system in non-human animal
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
KR900005995A (ko) 1988-10-31 1990-05-07 우메모또 요시마사 변형 인터류킨-2 및 그의 제조방법
EP0401384B1 (en) 1988-12-22 1996-03-13 Kirin-Amgen, Inc. Chemically modified granulocyte colony stimulating factor
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5112946A (en) 1989-07-06 1992-05-12 Repligen Corporation Modified pf4 compositions and methods of use
FR2650598B1 (fr) 1989-08-03 1994-06-03 Rhone Poulenc Sante Derives de l'albumine a fonction therapeutique
WO1991006570A1 (en) 1989-10-25 1991-05-16 The University Of Melbourne HYBRID Fc RECEPTOR MOLECULES
ES2284161T3 (es) 1990-01-12 2007-11-01 Amgen Fremont Inc. Generacion de anticuerpos xenogenicos.
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5349053A (en) 1990-06-01 1994-09-20 Protein Design Labs, Inc. Chimeric ligand/immunoglobulin molecules and their uses
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DE69133476T2 (de) 1990-08-29 2006-01-05 GenPharm International, Inc., Palo Alto Transgene Mäuse fähig zur Produktion heterologer Antikörper
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
AU643109B2 (en) 1990-12-14 1993-11-04 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
JP3485917B2 (ja) 1991-06-25 2004-01-13 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Ｂｍｐ−９蛋白
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
JP4157160B2 (ja) 1991-12-13 2008-09-24 ゾーマ テクノロジー リミテッド 改変抗体可変領域の調製のための方法
US5622929A (en) 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
FR2686901A1 (fr) 1992-01-31 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux polypeptides antithrombotiques, leur preparation et compositions pharmaceutiques les contenant.
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US5447851B1 (en) 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
CA2118508A1 (en) 1992-04-24 1993-11-11 Elizabeth S. Ward Recombinant production of immunoglobulin-like domains in prokaryotic cells
PT1589107E (pt) 1992-08-21 2010-03-29 Univ Bruxelles Imunoglobulinas desprovidas de cadeias leves
CA2161351C (en) 1993-04-26 2010-12-21 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
JPH08511420A (ja) 1993-06-16 1996-12-03 セルテック・セラピューテイクス・リミテッド 抗 体
SE9400088D0 (sv) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
CN1117155C (zh) 1994-07-29 2003-08-06 史密丝克莱恩比彻姆有限公司 新型化合物
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
EP0904107B1 (en) 1996-03-18 2004-10-20 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
WO1998023289A1 (en) 1996-11-27 1998-06-04 The General Hospital Corporation MODULATION OF IgG BINDING TO FcRn
US6423501B2 (en) 1996-12-13 2002-07-23 Beth Israel Deaconess Medical Center Calcium-independent negative regulation by CD81 of receptor signaling
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
US6034062A (en) 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses
DE69833755T2 (de) 1997-05-21 2006-12-28 Biovation Ltd. Verfahren zur herstellung von nicht-immunogenen proteinen
DE69827507T2 (de) 1997-06-11 2006-03-09 Borean Pharma A/S Trimerisierendes modul
DE69839147T2 (de) 1997-06-12 2009-02-19 Novartis International Pharmaceutical Ltd. Künstliche antikörperpolypeptide
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
DK1071700T3 (da) 1998-04-20 2010-06-07 Glycart Biotechnology Ag Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
US6818418B1 (en) 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
KR100887482B1 (ko) 1999-01-15 2009-03-10 제넨테크, 인크. 효과기 기능이 변화된 폴리펩티드 변이체
ES2569919T3 (es) 1999-04-09 2016-05-13 Kyowa Hakko Kirin Co., Ltd. Procedimiento para controlar la actividad de una molécula inmunofuncional
DE19932688B4 (de) 1999-07-13 2009-10-08 Scil Proteins Gmbh Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen
PT1144607E (pt) 1999-07-20 2009-04-22 Morphosys Ag Novos métodos para apresentar (poli)peptídeos/ proteínas em partículas bacteriofágicas através de ligações dissulfureto
EP1212422B1 (en) 1999-08-24 2007-02-21 Medarex, Inc. Human ctla-4 antibodies and their uses
ES2484966T3 (es) 2000-04-12 2014-08-12 Novozymes Biopharma Dk A/S Proteínas de fusión de albúmina
WO2002057445A1 (en) 2000-05-26 2002-07-25 National Research Council Of Canada Single-domain brain-targeting antibody fragments derived from llama antibodies
CA2412494C (en) 2000-06-22 2012-10-23 Genentech, Inc. Agonist anti-trk-c monoclonal antibodies
IL155977A0 (en) 2000-11-30 2003-12-23 Medarex Inc Transgenic transchromosomal rodents for making human antibodies
US20050048512A1 (en) 2001-04-26 2005-03-03 Avidia Research Institute Combinatorial libraries of monomer domains
US20040175756A1 (en) 2001-04-26 2004-09-09 Avidia Research Institute Methods for using combinatorial libraries of monomer domains
US20050053973A1 (en) 2001-04-26 2005-03-10 Avidia Research Institute Novel proteins with targeted binding
JP2004532038A (ja) 2001-05-17 2004-10-21 ディヴァーサ コーポレイション 新規抗原結合分子の治療、診断、予防、酵素、産業ならびに農業各分野への応用とそのための新規抗原結合分子の作製とスクリーニングの方法
PL213948B1 (pl) 2001-10-25 2013-05-31 Genentech Inc Kompozycje zawierajace glikoproteine, czasteczka kwasu nukleinowego kodujaca te glikoproteine, komórka gospodarza, sposób wytwarzania glikoproteiny, kompozycja do zastosowania do leczenia, zastosowanie kompozycji i zestaw zawierajacy kompozycje
DE60226641D1 (de) 2001-12-03 2008-06-26 Amgen Fremont Inc Antikörperkategorisierung auf der grundlage von bindungseigenschaften
US20030157579A1 (en) 2002-02-14 2003-08-21 Kalobios, Inc. Molecular sensors activated by disinhibition
US7335478B2 (en) 2002-04-18 2008-02-26 Kalobios Pharmaceuticals, Inc. Reactivation-based molecular interaction sensors
WO2003074679A2 (en) 2002-03-01 2003-09-12 Xencor Antibody optimization
US7816497B2 (en) 2002-10-30 2010-10-19 University Of Kentucky Compositions and methods for inhibiting drusen complement components C3a and C5a for the treatment of age-related macular degeneration
WO2004072266A2 (en) 2003-02-13 2004-08-26 Kalobios Inc. Antibody affinity engineering by serial epitope-guided complementarity replacement
DE10324447A1 (de) 2003-05-28 2004-12-30 Scil Proteins Gmbh Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
US7745585B2 (en) 2003-09-02 2010-06-29 Boehringer Ingelheim International Gmbh Antibodies to interleukin-like epithelial-mesenchymal transition inducer (ILEI)
AU2004308482A1 (en) 2003-12-23 2005-07-14 Rinat Neuroscience Corp. Agonist anti-trkC antibodies and methods using same
AU2005207003C1 (en) 2004-01-20 2013-06-13 Humanigen, Inc. Antibody specificity transfer using minimal essential binding determinants
EP1571159A1 (en) 2004-03-04 2005-09-07 Bayerische Julius-Maximilians-Universität Würzburg Mutein of a bone morphogenetic protein and use thereof
US20060008844A1 (en) 2004-06-17 2006-01-12 Avidia Research Institute c-Met kinase binding proteins
CN102443627B (zh) 2004-08-10 2014-10-29 加的夫生物学有限公司 用于乳腺癌的预后的试剂盒
JP4696237B2 (ja) 2005-03-03 2011-06-08 国立大学法人 岡山大学 糖尿病性腎症の治療用医薬組成物
SI1933871T1 (sl) 2005-09-07 2013-10-30 Amgen Fremont Inc. Humana monoklonska protitelesa proti aktivin receptorju podobni kinazi-1
WO2007034753A1 (ja) 2005-09-22 2007-03-29 Keiichi Fukuda コンドロモジュリン-iを有効成分とする血管新生関連疾患治療剤
CN1844391A (zh) 2006-04-26 2006-10-11 嘉兴波亿生物科技开发有限公司 人骨形态发生蛋白9重组蛋白质核苷酸序列及生产方法和用途
EP2418223A3 (en) 2006-06-12 2013-01-16 Emergent Product Development Seattle, LLC Single-chain multivalent binding proteins with effector function
EP1873157A1 (en) 2006-06-21 2008-01-02 Bayer Schering Pharma Aktiengesellschaft Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
US8088895B2 (en) 2006-10-18 2012-01-03 Chemocentryx, Inc. Antibodies that bind CXCR7 epitopes
CN101652387A (zh) 2006-11-02 2010-02-17 阿塞勒隆制药公司 Alk1受体和配体拮抗剂及其用途
US8642031B2 (en) * 2006-11-02 2014-02-04 Acceleron Pharma, Inc. Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses thereof
JP2008225462A (ja) 2007-02-14 2008-09-25 Asahi Kasei Chemicals Corp 積層光学フィルム
US8318135B2 (en) 2007-03-19 2012-11-27 National Research Council Of Canada Antagonist of ligands and uses thereof
US20090017019A1 (en) 2007-06-01 2009-01-15 Wyeth Methods and compositions for modulating bmp-10 activity
WO2009139891A2 (en) 2008-05-15 2009-11-19 Acceleron Pharma, Inc. Antagonists of bmp9, bmp10, alk1 and other alk1 ligands, and uses thereof
WO2010126169A1 (ja) 2009-04-30 2010-11-04 協和発酵キリン株式会社 Alk1阻害剤を有効成分とする血管障害を抑制するための医薬組成物
US20160228509A9 (en) * 2009-05-08 2016-08-11 Novartis Ag Diagnostic BioMarkers for Fibrotic Disorders
EP2427494B1 (en) 2009-05-08 2017-10-18 Novartis AG Methods of modulating fibrosis using bone morphogenetic protein-9 (bmp-9) modulators
AU2011292810B2 (en) 2010-08-20 2015-04-30 Wyeth Llc Designer osteogenic proteins
BR112013005116A2 (pt) 2010-09-03 2019-09-24 Stem Centrx Inc moduladores e métodos de uso
FR2971250A1 (fr) 2011-02-07 2012-08-10 Univ Nantes Anticorps anti-gb3 utiles dans le traitement des maladies associees a l'angiogenese
RU2633638C2 (ru) 2012-02-02 2017-10-16 Акселерон Фарма Инк. Антагонисты alk1 и их применение в лечении почечно-клеточной карциномы
US9809636B2 (en) 2012-04-06 2017-11-07 Acceleron Pharma Inc. Methods for increasing red blood cell levels comprising administering BMP9
JP6325527B2 (ja) 2012-05-02 2018-05-16 シムフォゲン・アクティーゼルスカブＳｙｍｐｈｏｇｅｎ Ａ／Ｓ ヒト化ｐａｎ−ｈｅｒ抗体組成物
CN103387605B (zh) 2012-05-08 2018-06-12 复旦大学 一种rtn4b多肽、其单抗、产生单抗的杂交瘤细胞株及他们的制备与应用
KR102143476B1 (ko) * 2012-07-02 2020-08-12 쿄와 기린 가부시키가이샤 항ｂｍｐ９ 항체를 유효 성분으로 하는, 신장성 빈혈, 암성 빈혈 등의 빈혈에 대한 치료제
FR2993278B1 (fr) 2012-07-13 2016-02-19 Coatex Sas Utilisation d'un polymere peigne pour preparer une suspension contenant du carbonate de calcium et presentant une sensibilite a la temperature reduite.
JPWO2014051109A1 (ja) 2012-09-28 2016-08-25 協和発酵キリン株式会社 抗ヒトｂｍｐ９抗体および該抗体を有効成分とする異所性骨化疾患の治療剤
EA202090707A1 (ru) * 2013-10-25 2020-12-30 Акселерон Фарма, Инк. Эндоглиновые пептиды для лечения фиброзных заболеваний

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