AR104676A1 - Composición media para preparar toxina botulínica - Google Patents
Composición media para preparar toxina botulínicaInfo
- Publication number
- AR104676A1 AR104676A1 ARP160101184A ARP160101184A AR104676A1 AR 104676 A1 AR104676 A1 AR 104676A1 AR P160101184 A ARP160101184 A AR P160101184A AR P160101184 A ARP160101184 A AR P160101184A AR 104676 A1 AR104676 A1 AR 104676A1
- Authority
- AR
- Argentina
- Prior art keywords
- medium
- hydrolyzate
- botulinum toxin
- composition
- medium composition
- Prior art date
Links
- 108030001720 Bontoxilysin Proteins 0.000 title abstract 5
- 239000013028 medium composition Substances 0.000 title abstract 3
- 239000003053 toxin Substances 0.000 title 1
- 231100000765 toxin Toxicity 0.000 title 1
- 229940053031 botulinum toxin Drugs 0.000 abstract 4
- 241000196324 Embryophyta Species 0.000 abstract 3
- 239000001888 Peptone Substances 0.000 abstract 3
- 108010080698 Peptones Proteins 0.000 abstract 3
- 235000019319 peptone Nutrition 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 2
- 239000005018 casein Substances 0.000 abstract 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 2
- 235000021240 caseins Nutrition 0.000 abstract 2
- AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical class CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 abstract 2
- 229940066779 peptones Drugs 0.000 abstract 2
- 241000193155 Clostridium botulinum Species 0.000 abstract 1
- 241000193464 Clostridium sp. Species 0.000 abstract 1
- 108010068370 Glutens Proteins 0.000 abstract 1
- 240000004713 Pisum sativum Species 0.000 abstract 1
- 235000016816 Pisum sativum subsp sativum Nutrition 0.000 abstract 1
- 241000209140 Triticum Species 0.000 abstract 1
- 235000021307 Triticum Nutrition 0.000 abstract 1
- 235000012343 cottonseed oil Nutrition 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 235000021312 gluten Nutrition 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente se refiere a una composición de medio para la producción de toxina botulínica y más específicamente, a una composición de medio para el cultivo de Clostridium sp. capaz de producir toxina botulínica. La composición del medio de la presente comprende un hidrolizado de caseína y al menos una peptona de origen vegetal seleccionada del grupo compuesto por un hidrolizado de guisante de jardín, un hidrolizado de semilla de algodón y un hidrolizado de gluten de trigo. Cuando se utiliza el medio de acuerdo con la presente, que contiene peptonas de origen vegetal, hidrolizados de caseína y minerales para el cultivo de Clostridium botulinum, la tasa de crecimiento de la bacteria en el medio es mayor a la de cada uno de los medios utilizados en ia actualidad y a la del medio que comprende peptonas de origen vegetal solamente. Además, cuando se utiliza el medio de la presente, se puede producir una alta concentración de toxina botulínica mediante el cultivo de la bacteria en una forma segura. Método para producir la toxina botulínica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150059655A KR101729251B1 (ko) | 2015-04-28 | 2015-04-28 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR104676A1 true AR104676A1 (es) | 2017-08-09 |
Family
ID=57199640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101184A AR104676A1 (es) | 2015-04-28 | 2016-04-27 | Composición media para preparar toxina botulínica |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10117927B2 (es) |
| EP (1) | EP3289070B1 (es) |
| JP (2) | JP2018506262A (es) |
| KR (1) | KR101729251B1 (es) |
| CN (1) | CN107109353B (es) |
| AR (1) | AR104676A1 (es) |
| AU (1) | AU2016253789B2 (es) |
| CA (1) | CA2968044C (es) |
| DK (1) | DK3289070T3 (es) |
| ES (1) | ES2805726T3 (es) |
| HR (1) | HRP20201067T1 (es) |
| HU (1) | HUE050244T2 (es) |
| MX (1) | MX381868B (es) |
| PL (1) | PL3289070T3 (es) |
| PT (1) | PT3289070T (es) |
| RU (1) | RU2689705C2 (es) |
| SA (1) | SA517381722B1 (es) |
| TW (1) | TWI592485B (es) |
| WO (1) | WO2016175566A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101723167B1 (ko) * | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| KR101723168B1 (ko) * | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| KR102209159B1 (ko) * | 2019-03-29 | 2021-01-29 | (주)제테마 | 독소의 제조방법 |
| KR20250090758A (ko) | 2023-12-13 | 2025-06-20 | 주식회사 알에프바이오 | 클로스트리디움 보툴리눔(Clostridium botulinum) 균주의 독소 생산성을 높이는 배지 조성물 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB790521A (en) * | 1955-11-15 | 1958-02-12 | Bristol Lab Inc | Improvements in or relating to antibiotics |
| CA2336363A1 (en) * | 1998-07-03 | 2000-01-13 | Dsm N.V. | Fermentation process to produce clavulanic acid at a low concentration of free amino acids |
| US6558926B1 (en) * | 1999-07-16 | 2003-05-06 | Massachusetts Institute Of Technology | Method for production of tetanus toxin using media substantially free of animal products |
| RU2230325C2 (ru) * | 2002-08-15 | 2004-06-10 | Научно-исследовательский институт микробиологии Министерства обороны Российской Федерации | Способ приготовления очищенного препарата ботулинического токсина типа а |
| US7160699B2 (en) | 2003-09-25 | 2007-01-09 | Allergan, Inc. | Media for clostridium bacterium and processes for obtaining a clostridial toxin |
| US7148041B2 (en) * | 2003-09-25 | 2006-12-12 | Allergan, Inc. | Animal product free media and processes for obtaining a botulinum toxin |
| WO2005038009A2 (en) * | 2003-10-17 | 2005-04-28 | Ranbaxy Laboratories Limited | Production of tacrolimus (fk-506) using new streptomyces species |
| WO2006042542A2 (en) * | 2004-10-19 | 2006-04-27 | Statens Serum Institut | Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin |
| MXPA06009853A (es) * | 2005-03-03 | 2007-03-29 | Allergan Inc | Medios para bacteria de clostridium y procesos para obtener una toxina clostridial. |
| FR2918671B1 (fr) * | 2007-07-10 | 2010-10-15 | Sanofi Pasteur | Milieu de culture d'haemophilus influenzae type b. |
| CN101698826A (zh) * | 2007-12-19 | 2010-04-28 | 杨宇 | 胰酪胨肉毒梭菌增菌肉汤 |
| KR20090120222A (ko) * | 2008-05-19 | 2009-11-24 | (주)메디톡스 | 식물 유래 성분 함유 배지 및 가요성 폐쇄 용기를 이용하여클로스트리디움 보툴리눔 독소를 생산하는 방법 |
| US8236356B2 (en) * | 2008-06-11 | 2012-08-07 | Roche Diagnostics Operations, Inc. | Growth medium for Clostridium histolyticum |
| US8129139B2 (en) | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
| WO2012125948A1 (en) * | 2011-03-16 | 2012-09-20 | Biospecifics Technologies Corp. | Compositions and methods for producing clostridial collagenases |
| BR122016023101B1 (pt) * | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| CN103215310B (zh) * | 2013-03-27 | 2015-01-21 | 中棉紫光生物科技（上海）有限公司 | 用于发酵的棉籽蛋白及其制备方法和应用 |
| KR101339349B1 (ko) | 2013-08-02 | 2013-12-09 | 주식회사 대웅 | 보툴리눔 독소의 제조방법 |
-
2015
- 2015-04-28 KR KR1020150059655A patent/KR101729251B1/ko active Active
-
2016
- 2016-04-27 TW TW105113081A patent/TWI592485B/zh active
- 2016-04-27 AR ARP160101184A patent/AR104676A1/es unknown
- 2016-04-28 JP JP2017524477A patent/JP2018506262A/ja active Pending
- 2016-04-28 EP EP16786752.2A patent/EP3289070B1/en active Active
- 2016-04-28 CN CN201680004193.5A patent/CN107109353B/zh active Active
- 2016-04-28 DK DK16786752.2T patent/DK3289070T3/da active
- 2016-04-28 AU AU2016253789A patent/AU2016253789B2/en active Active
- 2016-04-28 RU RU2017120813A patent/RU2689705C2/ru active
- 2016-04-28 PT PT167867522T patent/PT3289070T/pt unknown
- 2016-04-28 PL PL16786752T patent/PL3289070T3/pl unknown
- 2016-04-28 US US15/521,833 patent/US10117927B2/en active Active
- 2016-04-28 HU HUE16786752A patent/HUE050244T2/hu unknown
- 2016-04-28 MX MX2017008199A patent/MX381868B/es unknown
- 2016-04-28 WO PCT/KR2016/004431 patent/WO2016175566A1/en not_active Ceased
- 2016-04-28 HR HRP20201067TT patent/HRP20201067T1/hr unknown
- 2016-04-28 CA CA2968044A patent/CA2968044C/en active Active
- 2016-04-28 ES ES16786752T patent/ES2805726T3/es active Active
-
2017
- 2017-06-14 SA SA517381722A patent/SA517381722B1/ar unknown
-
2019
- 2019-06-26 JP JP2019118235A patent/JP6887467B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112017012889A2 (pt) | 2018-01-30 |
| HRP20201067T1 (hr) | 2021-02-05 |
| AU2016253789B2 (en) | 2018-12-06 |
| WO2016175566A1 (en) | 2016-11-03 |
| SA517381722B1 (ar) | 2021-03-07 |
| ES2805726T3 (es) | 2021-02-15 |
| AU2016253789A1 (en) | 2017-06-01 |
| RU2689705C2 (ru) | 2019-05-28 |
| RU2017120813A3 (es) | 2018-12-14 |
| CA2968044A1 (en) | 2016-11-03 |
| CN107109353B (zh) | 2025-10-10 |
| RU2017120813A (ru) | 2018-12-14 |
| JP6887467B2 (ja) | 2021-06-16 |
| PL3289070T3 (pl) | 2020-11-16 |
| KR20160127998A (ko) | 2016-11-07 |
| JP2018506262A (ja) | 2018-03-08 |
| CA2968044C (en) | 2022-08-09 |
| DK3289070T3 (da) | 2020-07-27 |
| CN107109353A (zh) | 2017-08-29 |
| PT3289070T (pt) | 2020-07-16 |
| MX2017008199A (es) | 2017-12-04 |
| JP2020072649A (ja) | 2020-05-14 |
| HUE050244T2 (hu) | 2020-11-30 |
| EP3289070A1 (en) | 2018-03-07 |
| TW201638329A (zh) | 2016-11-01 |
| US10117927B2 (en) | 2018-11-06 |
| MX381868B (es) | 2025-03-13 |
| TWI592485B (zh) | 2017-07-21 |
| EP3289070A4 (en) | 2018-09-26 |
| EP3289070B1 (en) | 2020-05-06 |
| US20170252431A1 (en) | 2017-09-07 |
| KR101729251B1 (ko) | 2017-04-21 |
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